Ran Jing
Assistant Professor, Biological Chemistry
School of Medicine
School of Medicine
Ph.D.
Email: ran.jing@uci.edu
University of California, Irvine
Room 2008, Gross Hall, 845 Health Sciences Road
Irvine, CA 92697
Room 2008, Gross Hall, 845 Health Sciences Road
Irvine, CA 92697
Research Interests
• Stem Cell Biology • Hematopoiesis • Lymphoid Development • Immunotherapy • CAR T Cell Therapy
Research Abstract
• Investigate mechanisms of hematopoietic development to guide the differentiation of human pluripotent stem cells (iPSCs) into immune cells
• Dissect molecular programs governing human lymphocyte development and function
• Engineer iPSC-derived immune cells for personalized and off-the-shelf cancer immunotherapy
• Dissect molecular programs governing human lymphocyte development and function
• Engineer iPSC-derived immune cells for personalized and off-the-shelf cancer immunotherapy
Publications
Mout R, Jing R, Tanaka-Yano M, Egan ED, Eisenach H, Kononov MA, Windisch R, Najia MAT, Tompkins A, Hensch L, Bingham T, Gunage R, Zhao Y, Edman NI, Li C, Wang D, Schlaeger TM, Zon LI, North TE, Lendahl U, Rowe RG, Baker D, Blacklow SC, Daley GQ. Design of soluble Notch agonists that drive T cell development and boost immunity. Cell. 2025. Epub 20250729. DOI: 10.1016/j.cell.2025.07.009 . PMID: 40752493.
Jing R, Falchetti M, Han T, Najia M, Hensch L, Meader E, Lummertz da Rocha E, Kononov M, Bingham T, Wang S, Li Z, Zhao Y, Frenis K, Kubaczka C, Yang S, Jha D, Rowe R, Schlaeger TM, Maus MV, North TE, Zon LI, Daley GQ. Maturation and Persistence of CAR T Cells Derived from Pluripotent Stem Cells via Chemical Inhibition of G9a/GLP. Cell Stem Cell, 2025 Jan 2, 32(1) 71-85 e5. PMID: 39504968. DOI: 10.1016/j.stem.2024.10.004
Munera JO, Kechele DO, Bouffi C, Qu N, Jing R, Maity P, Enriquez JR, Han L, Campbell I, Mahe MM, McCauley HA, Zhang X, Sundaram N, Hudson JR, Zarsozo-Lacoste A, Pradhan S, Tominaga K, Sanchez JG, Weiss AA, Chatuvedi P, Spence JR, Hachimi M, North T, Daley GQ, Mayhew CN, Hu YC, Takebe T, Helmrath MA and Wells JM. Development of Functional Resident Macrophages in Human Pluripotent Stem Cell-Derived Colonic Organoids and Human Fetal Colon. Cell Stem Cell 2023 Nov 2 30(11): 1434-51 e9. PMID: 37922878. DOI: 10.1016/j.stem.2023.10.002
Jing R, Scarfo I, Najia MA, Lummertz da Rocha E, Han A, Sanborn M, Bingham T, Kubaczka C, Jha D, Falchetti M, Schlaeger TM, North TE, Maus MV, Daley GQ. EZH1 Repression Generates Mature iPSC-derived CAR T Cells with Enhanced Antitumor Activity. Cell Stem Cell, 2022 Aug 4, 29(8):1181-1196 PMID: 35931029. DOI: 10.1016/j.stem.2022.06.014
Lummertz da Rocha E, Kubaczka C, Sugden WW, Najia MA, Jing R, Markel A, LeBlanc, ZC, Dos Santos Peixoto R, Falchetti M, Collins, JJ, North TE, Daley GQ. CellComm Infers Cellular Crosstalk that Drives Hematopoietic Stem and Progenitor Cell Development. Nat Cell Biol, 2022 Apr 24, 579–589. PMID: 35414020. DOI: 10.1038/s41556-022-00884-1
Frame JM, Kubaczka C, Long TL, Esain V, Soto RA, Hachimi, M, Jing R, Shwartz A, Goessling W, Daley GQ, North TE. Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production. Developmental Cell, 2020 Aug 10;S1534-5807(20)30589; PMID: 32810442. DOI: 10.1016/j.devcel.2020.07.015
DeLaForest A, Di FUrio F, Jing R, Ludwig-Kubinski A, Twaroski K, Urick A, Pulakanti K, Rao S, Duncan SA. HNF4A Regulates the Formation of Hepatic Progenitor Cells from Human iPSC-Derived Endoderm by Facilitating Efficient Recruitment of RNA Pol II. Genes, 2018 Dec 28; 10(1); PMID: 30597922. DOI: 10.3390/genes10010021
Jing R, Corbett JL, Cai J, Beeson GC, Beeson CC, Chan SS, Dimmock DP, Lazcares L, Geurts AM, Lemasters JJ, Duncan SA. A Screen Using iPSC-Derived Hepatocytes Reveals NAD+ as a Potential Treatment for Mitochondrial DNA Depletion Syndrome. Cell Reports. 2018 Nov 6; 25:1469-1484. PMID: 30404003. DOI: 10.1016/j.celrep.2018.10.036
Cayo MA, Mallanna SK, Di Furio F, Jing R, Tolliver LB, Bures M, Urick A, Noto FK, Pashos EE, Greseth MD, Czarnecki M, Traktman P, Yang W, Morrisey EE, Grompe M, Rader DJ, Duncan SA. A Drug Screen Using Human iPSC-Derived Hepatocyte-like Cells Reveals Cardiac Glycosides as a Potential Treatment for Hypercholesterolemia. Cell Stem Cell. 2017 Apr 6;20(4):478-489.e5. PubMed PMID: 28388428. DOI: 10.1016/j.stem.2017.01.011
Jing R, Duncan CB, Duncan SA. A Small-molecule Screen Reveals that HSP90ß Promotes the Conversion of Induced Pluripotent Stem Cell-derived Endoderm to a Hepatic Fate and Regulates HNF4A Turnover. Development. 2017 May 15;144(10):1764-1774. PubMed PMID: 28360131. DOI: 10.1242/dev.146845
Twaroski K, Mallanna SK, Jing R, DiFurio F, Urick A, Duncan SA. FGF2 Mediates Hepatic Progenitor Cell Formation during Human Pluripotent Stem Cell Differentiation by Inducing the WNT Antagonist NKD1. Genes Dev. 2015 Dec 1;29(23):2463-74. PubMed PMID: 26637527. DOI: 10.1101/gad.268961.115
Jing R, Falchetti M, Han T, Najia M, Hensch L, Meader E, Lummertz da Rocha E, Kononov M, Bingham T, Wang S, Li Z, Zhao Y, Frenis K, Kubaczka C, Yang S, Jha D, Rowe R, Schlaeger TM, Maus MV, North TE, Zon LI, Daley GQ. Maturation and Persistence of CAR T Cells Derived from Pluripotent Stem Cells via Chemical Inhibition of G9a/GLP. Cell Stem Cell, 2025 Jan 2, 32(1) 71-85 e5. PMID: 39504968. DOI: 10.1016/j.stem.2024.10.004
Munera JO, Kechele DO, Bouffi C, Qu N, Jing R, Maity P, Enriquez JR, Han L, Campbell I, Mahe MM, McCauley HA, Zhang X, Sundaram N, Hudson JR, Zarsozo-Lacoste A, Pradhan S, Tominaga K, Sanchez JG, Weiss AA, Chatuvedi P, Spence JR, Hachimi M, North T, Daley GQ, Mayhew CN, Hu YC, Takebe T, Helmrath MA and Wells JM. Development of Functional Resident Macrophages in Human Pluripotent Stem Cell-Derived Colonic Organoids and Human Fetal Colon. Cell Stem Cell 2023 Nov 2 30(11): 1434-51 e9. PMID: 37922878. DOI: 10.1016/j.stem.2023.10.002
Jing R, Scarfo I, Najia MA, Lummertz da Rocha E, Han A, Sanborn M, Bingham T, Kubaczka C, Jha D, Falchetti M, Schlaeger TM, North TE, Maus MV, Daley GQ. EZH1 Repression Generates Mature iPSC-derived CAR T Cells with Enhanced Antitumor Activity. Cell Stem Cell, 2022 Aug 4, 29(8):1181-1196 PMID: 35931029. DOI: 10.1016/j.stem.2022.06.014
Lummertz da Rocha E, Kubaczka C, Sugden WW, Najia MA, Jing R, Markel A, LeBlanc, ZC, Dos Santos Peixoto R, Falchetti M, Collins, JJ, North TE, Daley GQ. CellComm Infers Cellular Crosstalk that Drives Hematopoietic Stem and Progenitor Cell Development. Nat Cell Biol, 2022 Apr 24, 579–589. PMID: 35414020. DOI: 10.1038/s41556-022-00884-1
Frame JM, Kubaczka C, Long TL, Esain V, Soto RA, Hachimi, M, Jing R, Shwartz A, Goessling W, Daley GQ, North TE. Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production. Developmental Cell, 2020 Aug 10;S1534-5807(20)30589; PMID: 32810442. DOI: 10.1016/j.devcel.2020.07.015
DeLaForest A, Di FUrio F, Jing R, Ludwig-Kubinski A, Twaroski K, Urick A, Pulakanti K, Rao S, Duncan SA. HNF4A Regulates the Formation of Hepatic Progenitor Cells from Human iPSC-Derived Endoderm by Facilitating Efficient Recruitment of RNA Pol II. Genes, 2018 Dec 28; 10(1); PMID: 30597922. DOI: 10.3390/genes10010021
Jing R, Corbett JL, Cai J, Beeson GC, Beeson CC, Chan SS, Dimmock DP, Lazcares L, Geurts AM, Lemasters JJ, Duncan SA. A Screen Using iPSC-Derived Hepatocytes Reveals NAD+ as a Potential Treatment for Mitochondrial DNA Depletion Syndrome. Cell Reports. 2018 Nov 6; 25:1469-1484. PMID: 30404003. DOI: 10.1016/j.celrep.2018.10.036
Cayo MA, Mallanna SK, Di Furio F, Jing R, Tolliver LB, Bures M, Urick A, Noto FK, Pashos EE, Greseth MD, Czarnecki M, Traktman P, Yang W, Morrisey EE, Grompe M, Rader DJ, Duncan SA. A Drug Screen Using Human iPSC-Derived Hepatocyte-like Cells Reveals Cardiac Glycosides as a Potential Treatment for Hypercholesterolemia. Cell Stem Cell. 2017 Apr 6;20(4):478-489.e5. PubMed PMID: 28388428. DOI: 10.1016/j.stem.2017.01.011
Jing R, Duncan CB, Duncan SA. A Small-molecule Screen Reveals that HSP90ß Promotes the Conversion of Induced Pluripotent Stem Cell-derived Endoderm to a Hepatic Fate and Regulates HNF4A Turnover. Development. 2017 May 15;144(10):1764-1774. PubMed PMID: 28360131. DOI: 10.1242/dev.146845
Twaroski K, Mallanna SK, Jing R, DiFurio F, Urick A, Duncan SA. FGF2 Mediates Hepatic Progenitor Cell Formation during Human Pluripotent Stem Cell Differentiation by Inducing the WNT Antagonist NKD1. Genes Dev. 2015 Dec 1;29(23):2463-74. PubMed PMID: 26637527. DOI: 10.1101/gad.268961.115
Research Centers
Sue and Bill Gross Stem Cell Research Center
Link to this profile
https://faculty.uci.edu/profile/?facultyId=7347
https://faculty.uci.edu/profile/?facultyId=7347
Last updated
01/26/2026
01/26/2026