Assistant Professor, Ophthalmology
School of Medicine

genome editing; CRISPR; protein engineering; genetic ocular disease; structural biology; enzyme kinetics

Group Webpage

Preparation of high-purity RNPs of CRISPR-based DNA base editors
MJ McAndrew, MB King, A Lapinaite
Academic Press (2025)

Dimerization of the deaminase domain and locking interactions with Cas9 boost base editing efficiency in ABE8e
PR Arantes, X Chen, S Sinha, A Saha, AC Patel, M Sample, L Nierzwicki, A Lapinaite, G Palermo
Nucleic Acids Research (2024) 52 (22), 13931-13944

Unlocking the secrets of ABEs: the molecular mechanism behind their specificity
X Chen, MJ McAndrew, A Lapinaite
Biochemical Society Transactions (2023) 51 (4), 1635-1646

DNA capture by a CRISPR-Cas9–guided adenine base editor
A Lapinaite, GJ Knott, CM Palumbo, E Lin-Shiao, MF Richter, KT Zhao, PA Beal, DR Liu, JA Doudna
Science (2020) 369 (6503), 566-571

NIH DP2GM149550 Engineering Novel Precision Genome Editing Tools

RNA Society

Biomedical Engineering

Center for Translational Vision Research at the Gavin Herbert Eye Institute

Link to this profile
https://faculty.uci.edu/profile/?facultyId=7303

Last updated
03/04/2025