Bryan Sun

Picture of Bryan Sun
Associate Professor, Dermatology
School of Medicine
B.S., Stanford, 1997, Biological Sciences
B.A., Stanford, 1997, English
M.D., Harvard Medical School, 2008
Ph.D., Harvard Medical School, 2006
University of California, Irvine
Plumwood House
829 Health Sciences Rd
Irvine, CA 92697
Research Interests
epidermis; epidermal differentiation; skin; skin biology; organoids; stem cell biology; cellular differentiation; noncoding RNAs; enhancers; noncoding genome; mosaicism; genodermatoses; genetic disease
Academic Distinctions
Phi Beta Kappa
Research Abstract
Genetic disruption of skin development and differentiation is responsible for diseases that affect >20% of the population. In the Sun Lab, we use primary skin cells, human skin organoids, and xenograft models to decipher the genomic regulators and molecular pathways that govern skin development and disease. We integrate laboratory and patient-originated approaches. Some of our current interests include:

• Determining the function of non-protein coding genomic elements in the skin with a focus on non-coding RNAs (ncRNAs).
• Discovering new disease-causing genetic mutations in the coding and non-coding genome and understanding their molecular mechanisms. We have a particular interest in subjects with genetic mosaic skin conditions.
• Understanding the genetic and epigenetic impacts of medications on the skin.
Awards and Honors
NIH DP2 New Innovator Award
American Society for Clinical Investigation - Young Investigator Award
Doris Duke Clinician Scientist Development Award
LEO Foundation Research Award
National Eczema Association Research Award
National Psoriasis Foundation Research Award
Eugene Bauer Physician-Scientist Award
James Shipley Research Prize, Harvard Medical School
Dean's Award for Public Service
Non-coding RNAs as skin disease biomarkers, molecular signatures, and therapeutic targets. Roso-Mares A, Andujar I, Diaz Corpas T, and BK Sun. Human Genetics (2023).
A pilot study using immunohistochemical staining to characterize dihydropyrimidine dehydrogenase expression in keratinocyte neoplasms. Ikediobi O, Sui J, Kellogg C, Roso Mares A, Takashima S, Bertini JD, Daniels B, Hinds B, and BK Sun. J Am Acad Dermatol Int (2023).
Association of physician burnout with perceived EHR work stress and potentially actionable factors. Tai-Seale M, Baxter S, Millen M, Cheung M, Zisook S, Celebi J, Polston G, Sun BK, et al. J Am Med Inform Assoc (2023).
The long noncoding RNA PRANCR is associated with alternative splicing of Fibronectin-1 in keratinocytes. Otten ABC, Amarbayar O, Cai P, Cheng B, Qu K, and BK Sun. J Invest Dermatol (2023)
Temporal Association of Reduced Serum Vitamin D with COVID-19 Infection: Two Single-Institution Case–Control Studies. Gupta D, Menon S, Criqui MH, and BK Sun. Nutrients (2022).
Glucocorticoids promote CCL20 expression in keratinocytes. Wang L, Yang M, Wang X, Cheng B, Ju Q, Eichenfield DZ, Sun BK. Br J Dermatol (2021).
Spectrum of severe ocular complications following dupilumab exposure: A perspective from the ophthalmology clinic. Ahn GS, Acuff K, Sun BK, and SL Baxter. J Am Acad Dermatol (2021).
AhR regulates peptidoglycan-induced inflammatory gene expression in human keratinocytes. Wang L, Cheng B, Ju Q, Sun BK. J Innate Immunity (2021).
A genome-wide long noncoding RNA CRISPRi screen identifies PRANCR as a novel regulator of epidermal homeostasis. Cai P, Otten ABC, Cheng B, Ishii MA, Zhang W, Huang B, Qu K, Sun BK. Genome Research (2020).
Research Techniques Made Simple: CRISPR Genetic Screens. Otten ABC and BK Sun. J Invest Dermatol (2020)
HOPX Is a ZNF750 Target that Promotes Late Epidermal Differentiation. Chen SY, Ishii MA, Cheng B, Otten ABC, Sun BK. J Invest Dermatol (2019)
Agminated blue nevus with a GNAQ mutation: A case report and review of the literature. Eichenfield DZ, Cotter D, Thorson J, Hinds B, Sun BK. J Cutan Pathol (2019)
Aging-Associated Decline of Epidermal PSMD8 Contributes to Impaired Skin Function. Ishii MA, Miyachi KJ, Cheng B, Sun BK. J Invest Dermatol (2018).
Postzygotic Mutations in Beta-Actin Are Associated with Becker's Nevus and Becker's Nevus Syndrome. Cai ED*, Sun BK*, Chiang A, Rogers A, Bernet L, Cheng B, Teng J, Rieger KE, Sarin KY. J Invest Dermatol (2017).
Mutational profile of primary dermal melanoma: A case series. Sun BK, Wang H, Kim J, Chen JK, Sun L, Zhang Y, Swetter SM. J Am Acad Dermatol (2016).
CALML5 is a ZNF750- and TINCR-induced protein that binds stratifin to regulate epidermal differentiation. Sun BK, Boxer LD, Ransohoff JD, Siprashvili Z, Qu K, Lopez-Pajares V, Hollmig ST, Khavari PA. Genes and Development (2015).
Advances in skin grafting and treatment of cutaneous wounds. Sun BK, Siprashvili Z, Khavari PA. Science (2014).
Mosaic activating RAS mutations in nevus sebaceus and nevus sebaceus syndrome. Sun BK, Saggini A, Sarin KY, Kim J, Benjamin L, LeBoit PE, Khavari PA. J Invest Dermatol (2013).
Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome. Zhao J, Sun BK, Erwin JA, Song JJ, Lee JT. Science (2008).
Intersection of the RNA interference and X-inactivation pathways.
Ogawa Y, Sun BK, Lee JT. Science (2008).
A transient heterochromatic state in Xist preempts X inactivation choice without RNA stabilization. Sun BK, Deaton AM, Lee JT. Molecular Cell (2006).
Determination of ancestral alleles for human single-nucleotide polymorphisms using high-density oligonucleotide arrays. Hacia JG, Fan JB, Ryder O, Jin L, Edgemon K, Ghandour G, Mayer RA, Sun B, Hsie L, Robbins CM, Brody LC, Wang D, Lander ES, Lipshutz R, Fodor SP, Collins FS. Nature Genetics (1999).
Professional Societies
American Academy of Dermatology
Society for Investigative Dermatology
RNA Society+
Graduate Programs
Cellular and Molecular Biosciences
Research Centers
Center for Epigenetics and Metabolism
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