Kapil Mishra

Picture of Kapil Mishra
Assistant Clinical Professor, Department of Ophthalmology & Visual Sciences
School of Medicine
M.D., Icahn School of Medicine at Mount Sinai, 2016
Phone: (949) 824-2020
Fax: (949) 824-8580
Email: kmishra@uci.edu
University of California, Irvine
850 Health Sciences Rd.
Mail Code: 4076
Irvine, CA 92697
Research Interests
Big data studies on vitreoretinal diseases and ocular oncology, surgical education, artificial intelligence for vitreoretinal surgery, intraoperative retinal surgery metrics, global health in ophthalmology
Research Abstract
Dr. Mishra’s research is focused on big data in vitreoretinal diseases and ocular oncology, surgical education, vitreoretinal surgery and ocular oncology pathology, and global health ophthalmology initiatives. Dr. Mishra is working on improving vitrectomy system cloud platforms in order to track intraoperative surgeon data and correlate this with surgical outcomes. He has also been a co-collaborator on big data research projects including the IRIS Registry as well as Medicare claims data for vitreoretinal surgery and ocular oncology. He has partnered with large eye hospitals in India including Aravind Eye Hospital and LV Prasad Eye Institute on several research projects including manual small-incision cataract surgery, creating a patent for a cataract extraction device, utilizing heads-up display for retinal surgery. He is also part of a multi-institution group on creating sickle cell retinopathy screening in Ghana.
Awards and Honors
2019 - Wilmer Research Association Mitchell Prize Finalist
2019 - The Wilmer Macula Research Award, Wilmer Eye Institute
2020 - Johns Hopkins Frank L. Coulson, Jr. Award for Clinical Excellence
2020 - Wilmer Eye Institute Iliff-Kress Excellence in Patient Care Resident Award
2021 - Stanford Byers Eye Institute Fellow Teaching Award of the Year
2022 - Inducted into Alpha Omega Alpha Honor Society, Stanford University School of Medicine
2023 - Wilmer Eye Institute’s FAME Award
Short Biography
Dr. Kapil Mishra is a board-certified UCI Health ophthalmologist with fellowship training in medical and surgical diseases of the retina and ocular oncology. His clinical interests include medical retinal and surgical diseases, intraocular tumors and ocular side effects from systemic chemotherapy. A trained ocular oncology specialist, he created the plaque brachytherapy program for uveal melanoma in coordination with colleagues at the UCI School of Medicine's Department of Radiation Oncology.

Mishra earned his medical degree at Icahn School of Medicine at Mount Sinai in New York City. He completed a residency in ophthalmology at The Wilmer Eye Institute at Johns Hopkins University School of Medicine in Baltimore, Md., followed by a fellowship in vitreoretinal surgery at Byers Eye Institute at Stanford University School of Medicine in Palo Alto, Calif. He was selected to return to the Wilmer Eye Institute as the Assistant Chief of Service and Director of Ocular Trauma.

In addition to caring for patients with vitreoretinal disorders, Mishra also teaches medical students, residents and fellows. He conducts research on surgical devices and techniques, as well as vitreoretinal diseases and oncological diseases.
Publications
Journal Articles
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Hassan M, Mishra K, Amarikwa L, Gupta OP, Srivastava S, Scott AW, Ferrone PJ, Leiderman YI, Mruthyunjaya P. Assessing Surgical Competency among Fellows in Vitreoretinal Surgery: A Survey of Fellowship Program Directors and Fellows. Ophthalmol Retina. 2025 Jan 15:S2468-6530(25)00008-9. doi: 10.1016/j.oret.2025.01.008. Epub ahead of print. PMID: 39824306.

Khanani AM, Aziz AA, Khanani ZA, Khan H, Mojumder O, Sulahria H, Khanani I, Khan H, Gahn GM, Mishra K. Reply to Comment on: Subretinal Gene Therapy for Treatment of Retinal and Choroidal Vascular Diseases. Am J Ophthalmol. 2025 Jan 14:S0002-9394(25)00025-X. doi: 10.1016/j.ajo.2025.01.009. Epub ahead of print. PMID: 39814095.

Fujimoto D, Yee P, Noh S, Mishra K, Mosaed S. Streptococcus pneumoniae endophthalmitis after exposed glaucoma drainage implant. Am J Ophthalmol Case Rep. 2024 Sep 17;36:102175. doi: 10.1016/j.ajoc.2024.102175. PMID: 39802165; PMCID: PMC11723178.

Khanani AM, Aziz AA, Khanani ZA, Khan H, Mojumder O, Sulahria H, Khanani I, Khan H, Gahn GM, Mishra K. Subretinal Gene Therapy for Treatment of Retinal and Choroidal Vascular Diseases. Am J Ophthalmol. 2024 Dec 7:S0002-9394(24)00561-0. doi: 10.1016/j.ajo.2024.12.002. Epub ahead of print. PMID: 39653319.

Edalat C, Kirupaharan N, Dalvin LA, Mishra K, Marshall R, Xu H, Francis JH, Berkenstock M. Evaluating Large Language Models on their Accuracy and Completeness: Immune Checkpoint Inhibitors and their Ocular Toxicities. Retina. 2024 Sep 18. doi: 10.1097/IAE.0000000000004271. Epub ahead of print. PMID: 39312883

Wai KM, Mishra K, Koo E, Ludwig CA, Parikh R, Mruthyunjaya P, Rahimy E. Reply to Comment On: Impact of GLP-1 Agonists and SGLT-2 Inhibitors on Diabetic Retinopathy Progression: An Aggregated Electronic Health Record Data Study. Am J Ophthalmol. 2024 Sep 5:S0002-9394(24)00407-0. doi: 10.1016/j.ajo.2024.08.036. Epub ahead of print. PMID: 39241978.

Mishra K, Mruthyunjaya P. Video: A mystery choroidal mass. Am. J. Ophthalmology Case Reports. 2024 Aug, 36(2024):102115. doi: 10.1016/j.ajoc.2024.102115.

Marshall R, Xu H, Dalvin LA, Mishra K, Edalat C, Kirupaharan N, Francis JH, Berkenstock M. Accuracy and Completeness of Large Language Models About Antibody-Drug Conjugates and Associated Ocular Adverse Effects. Cornea. 2024 Aug 7. doi: 10.1097/ICO.0000000000003664. Epub ahead of print. PMID: 39110155.

Yu G, Michalak S, Mishra K, Yu M, Pan C. Trends of Ophthalmic Surgery Cancellations at a County Hospital Before and During COVID-19: A 10-Year Retrospective Study. Semin Ophthalmol. 2024 May;39(4):305-311. doi:10.1080/08820538.2023.2293032. Epub 2023 Dec 10. PMID: 38073109.

Wai KM, Mishra K, Koo E, Ludwig CA, Parikh R, Mruthyunjaya P, Rahimy E. Impact of GLP-1 Agonists and SGLT-2 Inhibitors on Diabetic Retinopathy Progression: An Aggregated Electronic Health Record Data Study. Am J Ophthalmol. 2024 Apr 17;265:39-47. doi: 10.1016/j.ajo.2024.04.010. Epub ahead of print. PMID: 38636788.

Oncel D, Oncel D, Mishra K, Oncel M, Arevalo JF. Current Management of Subretinal Hemorrhage in Neovascular Age-Related Macular Degeneration. Ophthalmologica. 2023;246(5-6):295-305. doi: 10.1159/000534440. Epub 2023 Oct 7. PMID: 37806303.

Thangamathesvaran L, Mishra K, Handa JT. Intraretinal granuloma in neurocysticercosis. Can J Ophthalmol. 2023 Oct;58(5):e202-e203. doi:10.1016/j.jcjo.2023.01.020. Epub 2023 Feb 23. PMID: 36841258.
Mishra K, Roybal CN, Mahajan VB. Simultaneous Bilateral Open-Globe Repair and Vitreoretinal Surgery for Explosive-Related Ocular Injury. J Vitreoretin Dis. 2023 Sep 30;7(6):540-544. doi: 10.1177/24741264231202073. PMID: 37974922; PMCID: PMC10649449.

Ghoraba H, Rittiphairoj T, Akhavanrezayat A, Karaca I, Matsumiya W, Pham B, Mishra K, Yasar C, Mobasserian A, Abdelkarem AA, Nguyen QD. Pars plana vitrectomy with internal limiting membrane flap versus pars plana vitrectomy with conventional internal limiting membrane peeling for large macular hole. Cochrane Database Syst Rev. 2023 Aug 7;8(8):CD015031. doi:10.1002/14651858.CD015031.pub2. PMID: 37548231; PMCID: PMC10558045.

Dow ER, Khan NC, Chen KM, Mishra K, Perera C, Narala R, Basina M, Dang J, Kim M, Levine M, Phadke A, Tan M, Weng K, Do DV, Moshfeghi DM, Mahajan VB, Mruthyunjaya P, Leng T, Myung D. AI-Human Hybrid Workflow Enhances Teleophthalmology for the Detection of Diabetic Retinopathy. Ophthalmol Sci. 2023 May 12;3(4):100330. doi: 10.1016/j.xops.2023.100330. PMID: 37449051; PMCID: PMC10336195.

Guo LY, Mishra K, Leung LB. Severe progression of pentosan maculopathy over a decade. Am J Ophthalmol Case Rep. 2023 Mar 8;30:101826. doi:10.1016/j.ajoc.2023.101826. PMID: 36941944; PMCID: PMC10023981.

Zafar S, Mishra K, Sachdeva MM. Syphilitic Outer Retinopathy: A Masquerading Diagnosis Revealed After Steroid-Induced Progression To Panuveitis. Retin Cases Brief Rep. 2023 Jan 1;17(1):9-12. doi: 10.1097/ICB.0000000000001106. PMID:33323897.

Mishra K, Velez G, Chemudupati T, Tang PH, Mruthyunjaya P, Sanislo SR,Mahajan VB. Intraoperative Complications With Vitreous Biopsy for Molecular Proteomics. Ophthalmic Surg Lasers Imaging Retina. 2023 Jan;54(1):32-36. doi:10.3928/23258160-20221214-02. epub 2023 Jan 1. PMID: 36626208; PMCID: PMC10790578.

Azad AD, Mishra K, Lee EB, Chen E, Nguyen A, Parikh R, Mruthyunjaya P. Impact of Early COVID-19 Pandemic on Common Ophthalmic Procedures Volumes: A US Claims-Based Analysis. Ophthalmic Epidemiol. 2022 Dec;29(6):604-612. doi: 10.1080/09286586.2021.2015394. Epub 2021 Dec 22. PMID: 34935591.

Burton E, Mishra K, Arsiwala LT, Zafar S, Justin GA, Mruthyunjaya P, Woreta FA. Applicant Characteristics Associated with Retina Fellowship Match from 2010-2019. Ophthalmol Retina. 2022 Dec;6(12):1253-1259. doi:10.1016/j.oret.2022.06.008. Epub 2022 Jun 27. PMID: 35772695; PMCID: PMC9887683.

Li AS, Korot E, Mishra K, Perlroth A, Do DV. Wide-Field Swept-Source Optical Coherence Tomography of Optic Disc Pit Maculopathy Demonstrates Connection Between Vitreous and Subretinal Fluid. Ophthalmic Surg Lasers Imaging Retina. 2022 Oct;53(10):579-581. doi: 10.3928/23258160-20220819-01. Epub 2022 Oct 1. PMID: 36239681.

Tsou BC, Aguwa UT, Arsiwala LT, Burton E, Mishra K, Zafar S, Woreta F. Trends in Cornea Fellowship Applications and Applicant Characteristics: A San Francisco Match Analysis. J Acad Ophthalmol (2017). 2022 Sep 23;14(2):e216-e223. doi: 10.1055/s-0042-1756199. PMID: 37388181; PMCID: PMC9927986.

Zaidi M, Mishra K, Nguyen HV, Miller PP, Ghoraba H, Karaca I, Matsumiya W, Nguyen QD, Leung LB. C3 glomerulopathy associated with both hypertensive retinopathy and purtscher-like retinopathy. Am J Ophthalmol Case Rep. 2022 Aug 6;27:101683. doi: 10.1016/j.ajoc.2022.101683. PMID: 36016724; PMCID: PMC9395975.

Nath S, Korot E, Fu DJ, Zhang G, Mishra K, Lee AY, Keane PA. Reinforcement learning in ophthalmology: potential applications and challenges to implementation. Lancet Digit Health. 2022 Sep;4(9):e692-e697. doi: 10.1016/S2589-7500(22)00128-5. Epub 2022 Jul 26. PMID: 35906132.

Ghoraba HH, Akhavanrezayat A, Karaca I, Yavari N, Lajevardi S, Hwang J, Regenold J, Matsumiya W, Pham B, Zaidi M, Mobasserian A, DongChau AT, Or C, Yasar C, Mishra K, Do D, Nguyen QD. Ocular Gene Therapy: A Literature Review with Special Focus on Immune and Inflammatory Responses. Clin Ophthalmol. 2022 Jun 3;16:1753-1771. doi: 10.2147/OPTH.S364200. PMID: 35685379; PMCID: PMC9173725.

Mishra K, Mahajan VB. Bacillary Layer Detachment after Photodynamic Therapy. Ophthalmol Retina. 2022 Jun;6(6):500. doi: 10.1016/j.oret.2022.02.012. PMID: 35680235; PMCID: PMC10593128.

Villegas NC, Mishra K, Steinle N, Liu W, Beadle B, Mruthyunjaya P. Intravitreal brolucizumab as treatment of early onset radiation retinopathy secondary to plaque brachytherapy for choroidal melanoma. Am J Ophthalmol Case Rep. 2022 May 14;27:101581. doi: 10.1016/j.ajoc.2022.101581. PMID: 35599950; PMCID: PMC9121253.

Jain N, Liao A, Garg SJ, Patel SN, Wykoff CC, Yu HJ, London NJS, Khurana RN, Zacks DN; Macula Society Pentosan Polysulfate Maculopathy Study Group. Expanded Clinical Spectrum of Pentosan Polysulfate Maculopathy: A Macula Society Collaborative Study. Ophthalmol Retina. 2022 Mar;6(3):219-227. doi:10.1016/j.oret.2021.07.004. Epub 2021 Jul 21. PMID: 34298229.

Ghoraba H, Or C, Karaca I, Mishra K, Akhavanrezayat A, Park S, Than N, Leung LS, Sanislo S, Dong Nguyen Q. Immunotherapy-induced retinopathy mimicking cancer associated retinopathy. Am J Ophthalmol Case Rep. 2022 Mar 1;26:101449. doi: 10.1016/j.ajoc.2022.101449. PMID: 35265774; PMCID: PMC8899240.

Li AS, Pasricha MV, Mishra K, Nguyen QD, Beres SJ, Wood EH. CRB1-associated retinal dystrophy presenting as self-resolving opsoclonus and posterior uveitis. Am J Ophthalmol Case Rep. 2022 Feb 20;26:101444. doi: 10.1016/j.ajoc.2022.101444. PMID: 35243176; PMCID: PMC8881377.

Mishra K, Velez G, Roybal CN, Mahajan VB. Surgical management of acanthamoeba chorioretinitis. Am J Ophthalmol Case Rep. 2022 Jan 31;25:101388. doi: 10.1016/j.ajoc.2022.101388. PMID: 35243145; PMCID: PMC8859787.

Lagstein O, Milante RR, Mishra K, Doyle JJ. Accessory iris membranes: Removing the veil. Am J Ophthalmol Case Rep. 2022 Jan 30;25:101364. doi: 10.1016/j.ajoc.2022.101364. PMID: 35198802; PMCID: PMC8851097.

Davila JR, Mishra K, Leung LS. Macular Edema and Serous Macular Detachment After a Standard Dose of Intracameral Cefuroxime. Ophthalmic Surg Lasers Imaging Retina. 2021 Nov;52(11):615-618. doi: 10.3928/23258160-20211027-01. Epub 2021Nov 1. PMID: 34766852.

Mishra K, Leng T. Artificial intelligence and ophthalmic surgery. Curr Opin Ophthalmol. 2021 Sep 1;32(5):425-430. doi: 10.1097/ICU.0000000000000788. PMID: 34397576; PMCID: PMC10655904.

Mishra K, Bajaj R, Scott AW. Variable Practice Patterns for Management of Sickle Cell Retinopathy. Ophthalmol Retina. 2021 Jul;5(7):715-717. doi: 10.1016/j.oret.2020.11.017. Epub 2020 Dec 7. PMID: 33301951.

Khanna V, Christy J, Jayarajan AP, Chhabra K, Mishra K. A rare case of infectious crystalline keratopathy caused by Burkholderia cepacia. Indian J Ophthal. - Case Reports. 2021 Apr-Jun; 1(2):244-245. DOI: 10.4103/ijo.IJO_1402_20

Mishra K, Boland MV, Woreta FA. Incorporating a virtual curriculum into ophthalmology education in the coronavirus disease-2019 era. Curr Opin Ophthalmol. 2020 Sep;31(5):380-385. doi: 10.1097/ICU.0000000000000681. PMID: 32694267.

Mishra K, Iftikhar M, Channa R. A Case of Traumatic Choroidopathy With Subretinal Fluid. J Vitreoretin Dis. 2020 Sep 17;5(2):165-169. doi: 10.1177/2474126420951976. PMID: 37009084; PMCID: PMC9979056.

Gurnani B, Kaur K, Mishra K, Venkatesh R. A simple solution to prevent microscope eyepiece fogging and spectacle fogging in COVID-19 era. Indian J Ophthalmol. 2020 Aug;68(8):1712-1713. doi: 10.4103/ijo.IJO_1500_20. PMID: 32709835; PMCID: PMC7640865.

Mishra K, Patel TP, Singh MS. Choroidal Neovascularization Associated with Pentosan Polysulfate Toxicity. Ophthalmol Retina. 2020 Jan;4(1):111-113. doi:10.1016/j.oret.2019.08.006. Epub 2019 Aug 23. PMID: 31570285.

Mishra K, Zafar S, Vedula SS, Sikder S. Can we efficiently use structured rating scales to objectively assess global technical skill in cataract surgery? J Cataract Refract Surg. 2019 Nov;45(11):1682-1683. 8doi: 10.1016/j.jcrs.2019.07.030. PMID: 31706522.

Berk J, Hall D, Stroh I, Armstrong C, Mishra K, Pecker LH, Lau BW. A Child With Pancytopenia and Optic Disc Swelling. Pediatrics. 2019 Nov;144(5):e20182887. doi: 10.1542/peds.2018-2887. Epub 2019 Oct 8. PMID: 31594907.

Mishra K, Mathai M, Della Rocca RC, Reddy HS. Improving Resident Performance in Oculoplastic Surgery: A New Curriculum Using Surgical Wet Laboratory Videos. J Surg Educ. 2017 Sep-Oct;74(5):837-842. doi: 10.1016/j.jsurg.2017.02.009. Epub 2017 Mar 9. PMID: 28284655.

Tenzel PA, Mishra K, Andron A, Della Rocca RC, Reddy HS. Extramedullary plasmacytoma of the lateral rectus muscle. Orbit. 2017 Apr;36(2):78-80. doi: 10.1080/01676830.2017.1279656. Epub 2017 Mar 7. PMID: 28267386.

Mishra K, Hu KY, Kamal S, Andron A, Della Rocca RC, Ali MJ, Nair AG. Dacryolithiasis: A Review. Ophthalmic Plast Reconstr Surg. 2017 Mar/Apr;33(2):83-89. doi: 0.1097/IOP.0000000000000769. PMID: 27533513.

Uhr JH, Mishra K, Wei C, Wu AY. Awareness and Knowledge of Emergent Ophthalmic Disease Among Patients in an Internal Medicine Clinic. JAMA Ophthalmol. 2016 Apr;134(4):424-31. doi: 10.1001/jamaophthalmol.2015.6212. PMID: 26892039.

Nair AG, Kamal S, Dave TV, Mishra K, Reddy HS, Della Rocca D, Della Rocca RC, Andron A, Jain V. Surgeon point-of-view recording: Using a high-definition head-mounted video camera in the operating room. Indian J Ophthalmol. 2015 Oct;63(10):771-4. doi: 10.4103/0301-4738.171506. PMID: 26655001; PMCID: PMC4728975.

Book Chapters
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Mishra K, Rahimy E. Paraneoplastic Syndromes. In Ocular Manifestation of Systemic Disease, an Ophthalmology Manual for Every Medical Practitioner. [In Press]

Mishra K, Scott AW. Management of Vitreomacular Traction. Albert and Jakobiec’s Principles and Practices of Ophthalmology. 3399-3416 Apr 22 2022 https://doi.org/10.1007/978-3-030-42634-7_104#DOI

Mishra K, Kraus CL. Evaluation and Management of Congenital NLD Obstruction. In Sindwani: Endoscopic Surgery of the Orbit, 1st edition. Elsevier July 28 2020 https://doi.org/10.1016/B978-0-323-61329-3.00011-1
Professional Societies
American Academy of Ophthalmology
American Society of Retina Specialists
Other Experience
Ophthalmology Residency
Wilmer Eye Institute, Johns Hopkins University School of Medicine
Vitreoretinal Surgery Fellowship
Byers Eye Institute, Stanford University School of Medicine
Assistant Chief of Service
Wilmer Eye Institute, Johns Hopkins University School of Medicine
Last updated
05/16/2025