Kevin Wang
Associate Professor of Teaching, Department of Clinical Pharmacy Practice
School of Pharmacy & Pharmaceutical Sciences
School of Pharmacy & Pharmaceutical Sciences
Ph.D., Chinese University of Hong Kong, 2007, Pharmacokinetics and Pharmacogentics
University of California, Irvine
289 West Peltason Dr.
Mail Code: 4625
Irvine, CA 92697
289 West Peltason Dr.
Mail Code: 4625
Irvine, CA 92697
Research Interests
Pharmacokinetics; Bioanalytical assay development; Pharmaceutics; Herbal medicine; Drug delivery
Appointments
Western University of Health Sciences, Pomona, CA 2008 - 2012
Awards and Honors
College of Pharmacy P1 Teacher of the Year Award, 2023, Marshall B. Ketchum University
College of Pharmacy Research and Scholarship Award, 2023, Marshall B. Ketchum University
College of Pharmacy Research and Scholarship Award, 2023, Marshall B. Ketchum University
Short Biography
Dr. Wang has a wide range of research interests, including pharmacokinetics, herbal medicine, and formulation development. He has been the principal Investigator or co-investigator for various projects and authored many peer-reviewed articles and book chapters.
Dr. Wang possesses expertise in preclinical and clinical pharmacokinetic studies. He has conducted and supervised multiple studies, gaining expertise in various aspects of pharmacokinetics studies, including animal handling, sample collection, bioanalytical assay development and validation, and data analysis. Furthermore, Dr. Wang has a strong background in pharmacokinetic modeling, with a specific emphasis on predicting drug pharmacokinetics in human subjects by utilizing Physiologically-Based Pharmacokinetic (PBPK) models.
Dr. Wang is also interested in the study of herbal medicines, including quality control, functional studies, and complementary or alternative treatments that involve using herbal medicine in combination with other drugs. His previous studies have identified several herbal extracts and their active components capable of enhancing the cytotoxicity of chemotherapeutical agents.
Furthermore, Dr. Wang has experience in developing new formulations to achieve improved therapeutic outcomes, such as sublingual formulation development and nanoparticle. This involves optimizing drug delivery systems to enhance drug stability, bioavailability, targeting, and therapeutic efficacy.
Dr. Wang possesses expertise in preclinical and clinical pharmacokinetic studies. He has conducted and supervised multiple studies, gaining expertise in various aspects of pharmacokinetics studies, including animal handling, sample collection, bioanalytical assay development and validation, and data analysis. Furthermore, Dr. Wang has a strong background in pharmacokinetic modeling, with a specific emphasis on predicting drug pharmacokinetics in human subjects by utilizing Physiologically-Based Pharmacokinetic (PBPK) models.
Dr. Wang is also interested in the study of herbal medicines, including quality control, functional studies, and complementary or alternative treatments that involve using herbal medicine in combination with other drugs. His previous studies have identified several herbal extracts and their active components capable of enhancing the cytotoxicity of chemotherapeutical agents.
Furthermore, Dr. Wang has experience in developing new formulations to achieve improved therapeutic outcomes, such as sublingual formulation development and nanoparticle. This involves optimizing drug delivery systems to enhance drug stability, bioavailability, targeting, and therapeutic efficacy.
Publications
Peer-review articles
(1) Mercado A, Pham A, Wang Z, Huang W, Chan P, Ibrahim H, Gogineni H, Huang Y, Wang J: Effects of bariatric surgery on drug pharmacokinetics-Preclinical studies. Front Pharmacol, 14, 1133415 (2023).
(2) Yeung S, Chen Q, Yu Y, Zhou B, Wu W, Li X, Huang Y, Wang Z: Quality evaluation of commercial products of Ganoderma lucidum made from its fruiting body and spore. Acta Chromatographica, 34, 100-113 (2022).
(3) Wang Z, Yeung S, Yang S, Huang Y, Sum Chow MS: Chemosensitizing Effect and Efficacy of Wilforlide A in Combination With Docetaxel in Drug-resistant Prostate Cancer. In Vivo, 36, 2020-2031 (2022).
(4) Yan G, Yu L, Chen X, Tran T, Nguyen L, Wang Z, Wang L: A rapid and sensitive High-Performance Liquid Chromatography-tandem Mass Spectrometry method for determining apremilast in beagle dog plasma and urine: Application in a pharmacokinetic study. Acta Chromatographica Acta Chromatographica, 33, 112-119 (2021).
(5) Xie C, Wang Z, Su Y, Wang J, Shen W-C: Discovery of An Orally Effective Factor IX-Transferrin Fusion Protein for Hemophilia B. International journal of molecular sciences, 21, E21 (2020).
(6) Desai P, Wang KZ, Ann D, Wang J, Prabhu S: Efficacy and Pharmacokinetic Considerations of Loratadine Nanoformulations and its Combinations for Pancreatic Cancer Chemoprevention. Pharmaceutical research, 37, 21-21 (2020).
(7) Wang Z, Xie C, Yeung S, Wang J, Chow MSS: Development of a simple and rapid HPLC-MS/MS method for quantification of streptomycin in mice and its application to plasma pharmacokinetic studies. Biomed. Chromatogr., 33, e4408 (2019).
(8) Xie C, Ramirez A, Wang Z, Chow MSS, Hao J: A simple and sensitive HPLC–MS/MS method for quantification of eggmanone in rat plasma and its application to pharmacokinetics. J. Pharm. Biomed. Anal., 153, 37-43 (2018).
(9) Wang Z, Yeung S, Chen S, Moatazedi Y, Chow MSS: Bioavailability of wilforlide A in mice and its concentration determination using an HPLC-APCI-MS/MS method. Journal of Chromatography B, 1090, 65-72 (2018).
(10) Wang Z, Olenyuk BZ, Shih JC, Wang J: Quantification and pharmacokinetic study of tumor-targeting agent MHI148-clorgyline amide in mouse plasma using liquid chromatography-electrospray ionization tandem mass spectrometry. Journal of Pharmaceutical Analysis, 8, 7 (2018).
(11) Liu MM, Huang KM, Qian L, Chatterjee P, Zhang S, Li R, Zhou S, Wang Z, Luo Y, Huang Y: Effects of bioactive constituents in the Traditional Chinese Medicinal formula Si-Wu-Tang on Nrf2 signaling and neoplastic cellular transformation. Phytomedicine, 40, 9 (2018).
(12) Li C, Wang Z, Wang Q, Ka Yan Ho RL, Huang Y, Chow MSS, Kei Lam CW, Zuo Z: Enhanced anti-tumor efficacy and mechanisms associated with docetaxel-piperine combination- in vitro and in vivo investigation using a taxane-resistant prostate cancer model. Oncotarget, 9, 3338-3352 (2018).
(13) Chen X, Zhang W, Rios S, Morkos MB, Ye X, Li G, Jiang X, Wang Z, Wang L: An HPLC tandem mass spectrometry for quantification of ET-26-HCl and its major metabolite in plasma and application to a pharmacokinetic study in rats. J. Pharm. Biomed. Anal., 149, 381-386 (2018).
(14) Ding B, Wahid MA, Wang Z, Xie C, Thakkar A, Prabhu S, Wang J: Triptolide and celastrol loaded silk fibroin nanoparticles show synergistic effect against human pancreatic cancer cells. Nanoscale, 9, 15 (2017).
(15) Wang Z, Ravula R, Shi L, Song Y, Yeung S, Liu M, Lau B, Hao J, Wang J, Lam CWK, Chow MSS, Huang Y: Overcoming chemoresistance in prostate cancer with Chinese medicine Tripterygium wilfordii via multiple mechanisms. Oncotarget, 7, 61246-61261 (2016).
(16) Wang Z, Liu X, Ho R, Lam C, Chow M: Precision or Personalized Medicine for Cancer Chemotherapy: Is there a Role for Herbal Medicine. Molecules, 21, 889 (2016).
(17) Nekkanti V, Rueda J, Wang Z, Betageri GV: Comparative evaluation of proliposomes and self micro-emulsifying drug delivery system for improved oral bioavailability of nisoldipine. Int. J. Pharm., 505, 79-88 (2016).
(18) Chinison J, Aguilar JS, Avalos A, Huang Y, Wang Z, Cameron DJ, Hao J: Triptonide Effectively Inhibits Wnt/beta-Catenin Signaling via C-terminal Transactivation Domain of beta-catenin. Sci Rep, 6, 32779 (2016).
(19) Tingting Li ZW, Haiyan Liu, Huiru Xie, Xuehua Jiang, Ling Wang: Reversal of multidrug resistance in cancer treatment by regulating multidrug resistance gene1: focus on nuclear receptors and epigenetics. Journal of Chinese Pharmaceutical Sciences, 24, 273-284 (2015).
(20) Nekkanti V, Wang Z, Betageri G: Pharmacokinetic Evaluation of Improved Oral Bioavailability of Valsartan: Proliposomes Versus Self-Nanoemulsifying Drug Delivery System. AAPS PharmSciTech, 1-12 (2015).
(21) Nekkanti V, Venkatesan N, Wang Z, Betageri GV: Improved oral bioavailability of valsartan using proliposomes: design, characterization and in vivo pharmacokinetics. Drug Dev Ind Pharm, 18, 1-12 (2015).
(22) Du Q, Wang T, Wang Z, Jiang X, Wang L: Rapid Determination of Glutamine in Human Plasma by High-Performance Liquid Chromatographic–Tandem Mass Spectrometry and Its Application in Pharmacokinetic Studies. Journal of Chromatographic Science, 53, 79-84 (2015).
(23) Yanamandra S, Venkatesan N, Kadajji VG, Wang Z, Issar M, Betageri GV: Proliposomes as a drug delivery system to decrease the hepatic first-pass metabolism: Case study using a model drug. Eur. J. Pharm. Sci., 64, 26-36 (2014).
(24) Xie H, Wang Z, Deng K, Jiang X, Wang L, Lv G: An HPLC–MS/MS method for simultaneous determination of the active metabolites of febuxostat (67M-1, 67M-2 and 67M-4) in human plasma. Journal of Chromatography B, 970, 24-30 (2014).
(25) Wang Z, Chow SSM, Pon D. "Pharmacologic treatment of prostate cancer ": http://formularyjournal.modernmedicine.com/formulary-journal/news/RC/pharmacologic-treatment-prostate-cancer.
(26) Wang Z, Chow MS: Overview and appraisal of the current concept and technologies for improvement of sublingual drug delivery. Therapeutic Delivery, 5, 807-816 (2014).
(27) Moussata J, Wang Z, Wang J: Development and validation of an HPLC method for the simultaneous quantification of indole-3-carbinol acetate, indole-3-carbinol, and 3,3'-diindolylmethane in mouse plasma, liver, and kidney tissues. Journal of Chromatography B, 958, 1-9 (2014).
(28) Liu M, Ravula R, Wang Z, Zuo Z, Chow MS, Thakkar A, Prabhu S, Andresen B, Huang Y: Traditional Chinese medicinal formula Si-Wu-Tang prevents oxidative damage by activating Nrf2-mediated detoxifying/antioxidant genes. Cell & Bioscience, 4, 8 (2014).
(29) Chen S, Wang Z, Huang Y, O'Barr SA, Wong RA, Yeung S, Chow MS: Ginseng and anticancer drug combination to improve cancer chemotherapy: a critical review. Evidence-based Complementary & Alternative Medicine, 2014, 168940 (2014).
(30) Xie C, Wang Z, Wang C, Xu J, Wen Z, Wang H, Shi L, Chow MS, Huang Y, Zuo Z: Utilization of Gene Expression Signature for Quality Control of Traditional Chinese Medicine Formula Si-Wu-Tang. AAPS J, (2013).
(31) Wang Z, Xie C, Huang Y, Lam C, Chow MS: Overcoming chemotherapy resistance with herbal medicines: past, present and future perspectives. Phytochem. Rev., 1-15 (2013).
(32) Wang Z, Wang J, Chan P: Treating type 2 diabetes mellitus with traditional chinese and Indian medicinal herbs. Evid Based Complement Alternat Med, 2013, 343594 (2013).
(33) Wang Z, Fan J, Liu M, Yeung S, Chang A, Chow MS, Pon D, Huang Y: Nutraceuticals for prostate cancer chemoprevention: from molecular mechanisms to clinical application. Expert Opinion on Investigational Drugs, 22, 1613-1626 (2013).
(34) Wang Y, Wang Z, Zuo Z, Tomlinson B, Lee BK, Bolger M, Chow MS: Clinical Pharmacokinetics of Buffered Propranolol Sublingual Tablet (Promptol™)—Application of a New “Physiologically Based” Model to Assess Absorption and Disposition. The AAPS Journal, 1-10 (2013).
(35) Wang Y, Jin Z, Wang Z, Jiang X, Wang L: Pharmacokinetic properties of isradipine after single-dose and multiple-dose oral administration in Chinese volunteers: a randomized, open-label, parallel-group phase I study. Biomed. Chromatogr., n/a-n/a (2013).
(36) McAfee L, Tung C, Espinosa-Silva Y, Rahman M, Fatima K, Clark R, Wang Z, Pearce D: A survey of a small sample of emergency department and admitted patients asking whether they expect to be tested for HIV routinely. Journal of the International Association of Providers of AIDS Care (JIAPAC), 12, 247-252 (2013).
(37) Liu M, Fan J, Wang S, Wang Z, Wang C, Zuo Z, Chow MS, Shi L, Wen Z, Huang Y: Transcriptional profiling of Chinese medicinal formula Si-Wu-Tang on breast cancer cells reveals phytoestrogenic activity. BMC Complement Altern Med, 13, 11 (2013).
(38) Du Q-q, Wang Z-j, He L, Jiang X-h, Wang L: PXR polymorphisms and their impact on pharmacokinetics/pharmacodynamics of repaglinide in healthy Chinese volunteers. Eur. J. Clin. Pharmacol., 1-9 (2013).
(39) Che CT, Wang ZJ, Chow MS, Lam CW: Herb-herb combination for therapeutic enhancement and advancement: theory, practice and future perspectives. Molecules., 18, 5125-5141. doi: 5110.3390/molecules18055125. (2013).
(40) Wang Z, Lee B, Pearce D, Qian S, Wang Y, Zhang Q, Chow MSS: Meclizine Metabolism and Pharmacokinetics: Formulation on Its Absorption. The Journal of Clinical Pharmacology, 52, 1343-1349 (2012).
(41) Angelo KA, Dalinkus CD, Wang Z, Pearce DP. Correlations of HIV-related Morbidity and Mortality at a Hospital for the Indigent in California. Priory Medical Journals p.^pp. (2012).
(42) Zhang X, Wang Z, Huang Y, Wang J: Effects of chronic administration of alogliptin on the development of diabetes and ß-cell function in high fat diet/streptozotocin diabetic mice. Diabetes, Obesity and Metabolism, 13, 337-347 (2011).
(43) Wen Z, Wang Z, Wang S, Ravula R, Yang L, Xu J, Wang C, Zuo Z, Chow MSS, Shi L, Huang Y: Discovery of Molecular Mechanisms of Traditional Chinese Medicinal Formula Si-Wu-Tang Using Gene Expression Microarray and Connectivity Map. PLoS ONE, 6, e18278 (2011).
(44) Wang Z, Qian S, Zhang Q, Chow MSS: Quantification of meclizine in human plasma by high performance liquid chromatography-mass spectrometry. Journal of Chromatography B, 879, 95-99 (2011).
(45) Wang L, Wang Z, Wo S, Lau CBS, Chen X, Huang M, Lee VHL, Chow MSS, Zuo Z: A bio-activity guided in vitro pharmacokinetic method to improve the quality control of Chinese medicines, application to Si Wu Tang. Int. J. Pharm., 406, 99-105 (2011).
(46) Wang Z, Ravula R, Cao M, Chow M, Huang Y: Transporter-mediated multidrug resistance and its modulation by Chinese medicines and other herbal products. Curr Drug Discov Technol, 7, 54-66 (2010).
(47) Pon D, Wang Z, Bao Le KN, Sum Chow MS: Harnessing traditional Chinese medicine to improve cancer therapy: issues for future development. Therapeutic Delivery, 1, 335-344 (2010).
(48) Wang Z-J, Wo S-K, Wang L, Lau CBS, Lee VHL, Chow MSS, Zuo Z: Simultaneous quantification of active components in the herbs and products of Si-Wu-Tang by high performance liquid chromatography-mass spectrometry. J. Pharm. Biomed. Anal., 50, 232-244 (2009).
(49) Wang ZJ, Yin OQ, Tomlinson B, Chow MS: OCT2 polymorphisms and in-vivo renal functional consequence: studies with metformin and cimetidine. Pharmacogenet Genomics, 18, 637-645 (2008).
(50) Yin OQ, Wing YK, Cheung Y, Wang ZJ, Lam SL, Chiu HF, Chow MS: Phenotype-genotype relationship and clinical effects of citalopram in Chinese patients. Journal of Clinical Psychopharmacology, 26, 367-372 (2006).
Book chapters
[1] Vadlapatla R, Wang Z, Kumar P, Pavuluri N. Use of Physical Approaches for Systemic Drug Delivery. Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications. (Rattan SIS. Spinger, Cham, Switzerland, p.^pp. 299-318 (2020).
[2] Wang Z, Liu X, Ho RLKY, Lam CWK, Chow MSS. The Road from Nanomedicine to Precision Medicine. CRC Press, Taylor & Francis Group(2019).
[3] Wang Z, Chan P, Xie C, Huang Y, Wang J. Antioxidant Nutraceuticals: Preventative and Healthcare Applications. NY: CRC Press, New York (2018).
[4] Xie C, Wang Z. Bioanalytical Assay for Characterization of Antibody-Drug Conjugates (ADCs). Antibody-Drug Conjugates. (Wang J, Shen W-C, Zaro JL ed.)^eds.) Vol. 17. Springer International Publishing, p.^pp. 97-115 (2015).
[5] Wang Z, Chan P, Wang J. The Preventive Effect of Traditional Chinese Medicinal Herbs on Type 2 Diabetes Mellitus. Traditional Chinese Medicine: Scientifi c Basis for Its Use. (Adams JD, Lien EJ ed.)^eds.). RSC publishing, Lundon, p.^pp. 268-312 (2013).
(1) Mercado A, Pham A, Wang Z, Huang W, Chan P, Ibrahim H, Gogineni H, Huang Y, Wang J: Effects of bariatric surgery on drug pharmacokinetics-Preclinical studies. Front Pharmacol, 14, 1133415 (2023).
(2) Yeung S, Chen Q, Yu Y, Zhou B, Wu W, Li X, Huang Y, Wang Z: Quality evaluation of commercial products of Ganoderma lucidum made from its fruiting body and spore. Acta Chromatographica, 34, 100-113 (2022).
(3) Wang Z, Yeung S, Yang S, Huang Y, Sum Chow MS: Chemosensitizing Effect and Efficacy of Wilforlide A in Combination With Docetaxel in Drug-resistant Prostate Cancer. In Vivo, 36, 2020-2031 (2022).
(4) Yan G, Yu L, Chen X, Tran T, Nguyen L, Wang Z, Wang L: A rapid and sensitive High-Performance Liquid Chromatography-tandem Mass Spectrometry method for determining apremilast in beagle dog plasma and urine: Application in a pharmacokinetic study. Acta Chromatographica Acta Chromatographica, 33, 112-119 (2021).
(5) Xie C, Wang Z, Su Y, Wang J, Shen W-C: Discovery of An Orally Effective Factor IX-Transferrin Fusion Protein for Hemophilia B. International journal of molecular sciences, 21, E21 (2020).
(6) Desai P, Wang KZ, Ann D, Wang J, Prabhu S: Efficacy and Pharmacokinetic Considerations of Loratadine Nanoformulations and its Combinations for Pancreatic Cancer Chemoprevention. Pharmaceutical research, 37, 21-21 (2020).
(7) Wang Z, Xie C, Yeung S, Wang J, Chow MSS: Development of a simple and rapid HPLC-MS/MS method for quantification of streptomycin in mice and its application to plasma pharmacokinetic studies. Biomed. Chromatogr., 33, e4408 (2019).
(8) Xie C, Ramirez A, Wang Z, Chow MSS, Hao J: A simple and sensitive HPLC–MS/MS method for quantification of eggmanone in rat plasma and its application to pharmacokinetics. J. Pharm. Biomed. Anal., 153, 37-43 (2018).
(9) Wang Z, Yeung S, Chen S, Moatazedi Y, Chow MSS: Bioavailability of wilforlide A in mice and its concentration determination using an HPLC-APCI-MS/MS method. Journal of Chromatography B, 1090, 65-72 (2018).
(10) Wang Z, Olenyuk BZ, Shih JC, Wang J: Quantification and pharmacokinetic study of tumor-targeting agent MHI148-clorgyline amide in mouse plasma using liquid chromatography-electrospray ionization tandem mass spectrometry. Journal of Pharmaceutical Analysis, 8, 7 (2018).
(11) Liu MM, Huang KM, Qian L, Chatterjee P, Zhang S, Li R, Zhou S, Wang Z, Luo Y, Huang Y: Effects of bioactive constituents in the Traditional Chinese Medicinal formula Si-Wu-Tang on Nrf2 signaling and neoplastic cellular transformation. Phytomedicine, 40, 9 (2018).
(12) Li C, Wang Z, Wang Q, Ka Yan Ho RL, Huang Y, Chow MSS, Kei Lam CW, Zuo Z: Enhanced anti-tumor efficacy and mechanisms associated with docetaxel-piperine combination- in vitro and in vivo investigation using a taxane-resistant prostate cancer model. Oncotarget, 9, 3338-3352 (2018).
(13) Chen X, Zhang W, Rios S, Morkos MB, Ye X, Li G, Jiang X, Wang Z, Wang L: An HPLC tandem mass spectrometry for quantification of ET-26-HCl and its major metabolite in plasma and application to a pharmacokinetic study in rats. J. Pharm. Biomed. Anal., 149, 381-386 (2018).
(14) Ding B, Wahid MA, Wang Z, Xie C, Thakkar A, Prabhu S, Wang J: Triptolide and celastrol loaded silk fibroin nanoparticles show synergistic effect against human pancreatic cancer cells. Nanoscale, 9, 15 (2017).
(15) Wang Z, Ravula R, Shi L, Song Y, Yeung S, Liu M, Lau B, Hao J, Wang J, Lam CWK, Chow MSS, Huang Y: Overcoming chemoresistance in prostate cancer with Chinese medicine Tripterygium wilfordii via multiple mechanisms. Oncotarget, 7, 61246-61261 (2016).
(16) Wang Z, Liu X, Ho R, Lam C, Chow M: Precision or Personalized Medicine for Cancer Chemotherapy: Is there a Role for Herbal Medicine. Molecules, 21, 889 (2016).
(17) Nekkanti V, Rueda J, Wang Z, Betageri GV: Comparative evaluation of proliposomes and self micro-emulsifying drug delivery system for improved oral bioavailability of nisoldipine. Int. J. Pharm., 505, 79-88 (2016).
(18) Chinison J, Aguilar JS, Avalos A, Huang Y, Wang Z, Cameron DJ, Hao J: Triptonide Effectively Inhibits Wnt/beta-Catenin Signaling via C-terminal Transactivation Domain of beta-catenin. Sci Rep, 6, 32779 (2016).
(19) Tingting Li ZW, Haiyan Liu, Huiru Xie, Xuehua Jiang, Ling Wang: Reversal of multidrug resistance in cancer treatment by regulating multidrug resistance gene1: focus on nuclear receptors and epigenetics. Journal of Chinese Pharmaceutical Sciences, 24, 273-284 (2015).
(20) Nekkanti V, Wang Z, Betageri G: Pharmacokinetic Evaluation of Improved Oral Bioavailability of Valsartan: Proliposomes Versus Self-Nanoemulsifying Drug Delivery System. AAPS PharmSciTech, 1-12 (2015).
(21) Nekkanti V, Venkatesan N, Wang Z, Betageri GV: Improved oral bioavailability of valsartan using proliposomes: design, characterization and in vivo pharmacokinetics. Drug Dev Ind Pharm, 18, 1-12 (2015).
(22) Du Q, Wang T, Wang Z, Jiang X, Wang L: Rapid Determination of Glutamine in Human Plasma by High-Performance Liquid Chromatographic–Tandem Mass Spectrometry and Its Application in Pharmacokinetic Studies. Journal of Chromatographic Science, 53, 79-84 (2015).
(23) Yanamandra S, Venkatesan N, Kadajji VG, Wang Z, Issar M, Betageri GV: Proliposomes as a drug delivery system to decrease the hepatic first-pass metabolism: Case study using a model drug. Eur. J. Pharm. Sci., 64, 26-36 (2014).
(24) Xie H, Wang Z, Deng K, Jiang X, Wang L, Lv G: An HPLC–MS/MS method for simultaneous determination of the active metabolites of febuxostat (67M-1, 67M-2 and 67M-4) in human plasma. Journal of Chromatography B, 970, 24-30 (2014).
(25) Wang Z, Chow SSM, Pon D. "Pharmacologic treatment of prostate cancer ": http://formularyjournal.modernmedicine.com/formulary-journal/news/RC/pharmacologic-treatment-prostate-cancer.
(26) Wang Z, Chow MS: Overview and appraisal of the current concept and technologies for improvement of sublingual drug delivery. Therapeutic Delivery, 5, 807-816 (2014).
(27) Moussata J, Wang Z, Wang J: Development and validation of an HPLC method for the simultaneous quantification of indole-3-carbinol acetate, indole-3-carbinol, and 3,3'-diindolylmethane in mouse plasma, liver, and kidney tissues. Journal of Chromatography B, 958, 1-9 (2014).
(28) Liu M, Ravula R, Wang Z, Zuo Z, Chow MS, Thakkar A, Prabhu S, Andresen B, Huang Y: Traditional Chinese medicinal formula Si-Wu-Tang prevents oxidative damage by activating Nrf2-mediated detoxifying/antioxidant genes. Cell & Bioscience, 4, 8 (2014).
(29) Chen S, Wang Z, Huang Y, O'Barr SA, Wong RA, Yeung S, Chow MS: Ginseng and anticancer drug combination to improve cancer chemotherapy: a critical review. Evidence-based Complementary & Alternative Medicine, 2014, 168940 (2014).
(30) Xie C, Wang Z, Wang C, Xu J, Wen Z, Wang H, Shi L, Chow MS, Huang Y, Zuo Z: Utilization of Gene Expression Signature for Quality Control of Traditional Chinese Medicine Formula Si-Wu-Tang. AAPS J, (2013).
(31) Wang Z, Xie C, Huang Y, Lam C, Chow MS: Overcoming chemotherapy resistance with herbal medicines: past, present and future perspectives. Phytochem. Rev., 1-15 (2013).
(32) Wang Z, Wang J, Chan P: Treating type 2 diabetes mellitus with traditional chinese and Indian medicinal herbs. Evid Based Complement Alternat Med, 2013, 343594 (2013).
(33) Wang Z, Fan J, Liu M, Yeung S, Chang A, Chow MS, Pon D, Huang Y: Nutraceuticals for prostate cancer chemoprevention: from molecular mechanisms to clinical application. Expert Opinion on Investigational Drugs, 22, 1613-1626 (2013).
(34) Wang Y, Wang Z, Zuo Z, Tomlinson B, Lee BK, Bolger M, Chow MS: Clinical Pharmacokinetics of Buffered Propranolol Sublingual Tablet (Promptol™)—Application of a New “Physiologically Based” Model to Assess Absorption and Disposition. The AAPS Journal, 1-10 (2013).
(35) Wang Y, Jin Z, Wang Z, Jiang X, Wang L: Pharmacokinetic properties of isradipine after single-dose and multiple-dose oral administration in Chinese volunteers: a randomized, open-label, parallel-group phase I study. Biomed. Chromatogr., n/a-n/a (2013).
(36) McAfee L, Tung C, Espinosa-Silva Y, Rahman M, Fatima K, Clark R, Wang Z, Pearce D: A survey of a small sample of emergency department and admitted patients asking whether they expect to be tested for HIV routinely. Journal of the International Association of Providers of AIDS Care (JIAPAC), 12, 247-252 (2013).
(37) Liu M, Fan J, Wang S, Wang Z, Wang C, Zuo Z, Chow MS, Shi L, Wen Z, Huang Y: Transcriptional profiling of Chinese medicinal formula Si-Wu-Tang on breast cancer cells reveals phytoestrogenic activity. BMC Complement Altern Med, 13, 11 (2013).
(38) Du Q-q, Wang Z-j, He L, Jiang X-h, Wang L: PXR polymorphisms and their impact on pharmacokinetics/pharmacodynamics of repaglinide in healthy Chinese volunteers. Eur. J. Clin. Pharmacol., 1-9 (2013).
(39) Che CT, Wang ZJ, Chow MS, Lam CW: Herb-herb combination for therapeutic enhancement and advancement: theory, practice and future perspectives. Molecules., 18, 5125-5141. doi: 5110.3390/molecules18055125. (2013).
(40) Wang Z, Lee B, Pearce D, Qian S, Wang Y, Zhang Q, Chow MSS: Meclizine Metabolism and Pharmacokinetics: Formulation on Its Absorption. The Journal of Clinical Pharmacology, 52, 1343-1349 (2012).
(41) Angelo KA, Dalinkus CD, Wang Z, Pearce DP. Correlations of HIV-related Morbidity and Mortality at a Hospital for the Indigent in California. Priory Medical Journals p.^pp. (2012).
(42) Zhang X, Wang Z, Huang Y, Wang J: Effects of chronic administration of alogliptin on the development of diabetes and ß-cell function in high fat diet/streptozotocin diabetic mice. Diabetes, Obesity and Metabolism, 13, 337-347 (2011).
(43) Wen Z, Wang Z, Wang S, Ravula R, Yang L, Xu J, Wang C, Zuo Z, Chow MSS, Shi L, Huang Y: Discovery of Molecular Mechanisms of Traditional Chinese Medicinal Formula Si-Wu-Tang Using Gene Expression Microarray and Connectivity Map. PLoS ONE, 6, e18278 (2011).
(44) Wang Z, Qian S, Zhang Q, Chow MSS: Quantification of meclizine in human plasma by high performance liquid chromatography-mass spectrometry. Journal of Chromatography B, 879, 95-99 (2011).
(45) Wang L, Wang Z, Wo S, Lau CBS, Chen X, Huang M, Lee VHL, Chow MSS, Zuo Z: A bio-activity guided in vitro pharmacokinetic method to improve the quality control of Chinese medicines, application to Si Wu Tang. Int. J. Pharm., 406, 99-105 (2011).
(46) Wang Z, Ravula R, Cao M, Chow M, Huang Y: Transporter-mediated multidrug resistance and its modulation by Chinese medicines and other herbal products. Curr Drug Discov Technol, 7, 54-66 (2010).
(47) Pon D, Wang Z, Bao Le KN, Sum Chow MS: Harnessing traditional Chinese medicine to improve cancer therapy: issues for future development. Therapeutic Delivery, 1, 335-344 (2010).
(48) Wang Z-J, Wo S-K, Wang L, Lau CBS, Lee VHL, Chow MSS, Zuo Z: Simultaneous quantification of active components in the herbs and products of Si-Wu-Tang by high performance liquid chromatography-mass spectrometry. J. Pharm. Biomed. Anal., 50, 232-244 (2009).
(49) Wang ZJ, Yin OQ, Tomlinson B, Chow MS: OCT2 polymorphisms and in-vivo renal functional consequence: studies with metformin and cimetidine. Pharmacogenet Genomics, 18, 637-645 (2008).
(50) Yin OQ, Wing YK, Cheung Y, Wang ZJ, Lam SL, Chiu HF, Chow MS: Phenotype-genotype relationship and clinical effects of citalopram in Chinese patients. Journal of Clinical Psychopharmacology, 26, 367-372 (2006).
Book chapters
[1] Vadlapatla R, Wang Z, Kumar P, Pavuluri N. Use of Physical Approaches for Systemic Drug Delivery. Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications. (Rattan SIS. Spinger, Cham, Switzerland, p.^pp. 299-318 (2020).
[2] Wang Z, Liu X, Ho RLKY, Lam CWK, Chow MSS. The Road from Nanomedicine to Precision Medicine. CRC Press, Taylor & Francis Group(2019).
[3] Wang Z, Chan P, Xie C, Huang Y, Wang J. Antioxidant Nutraceuticals: Preventative and Healthcare Applications. NY: CRC Press, New York (2018).
[4] Xie C, Wang Z. Bioanalytical Assay for Characterization of Antibody-Drug Conjugates (ADCs). Antibody-Drug Conjugates. (Wang J, Shen W-C, Zaro JL ed.)^eds.) Vol. 17. Springer International Publishing, p.^pp. 97-115 (2015).
[5] Wang Z, Chan P, Wang J. The Preventive Effect of Traditional Chinese Medicinal Herbs on Type 2 Diabetes Mellitus. Traditional Chinese Medicine: Scientifi c Basis for Its Use. (Adams JD, Lien EJ ed.)^eds.). RSC publishing, Lundon, p.^pp. 268-312 (2013).
Professional Societies
AACP
AAPS
Link to this profile
https://faculty.uci.edu/profile/?facultyId=7195
https://faculty.uci.edu/profile/?facultyId=7195
Last updated
03/17/2024
03/17/2024