Maheswari Senthil
Clinical Professor, Surgery
School of Medicine
School of Medicine
Director Peritoneal Malignancy Program, Chao Family Comprehensive Cancer Center
Chief, Division of Surgical Oncology, Surgery
School of Medicine
School of Medicine
Vice Chair of Research, Surgery
School of Medicine
School of Medicine
Associate Director, Institute for Clinical and Translational Science
School of Medicine
School of Medicine
M.D., Madurai Medical College, 1998
ORCiD: 0000-0002-0339-8558
University of California, Irvine
333 City Blvd West, Suite 850
Orange, CA 92697
333 City Blvd West, Suite 850
Orange, CA 92697
Research Interests
Peritoneal Carcinomatosis, Gastric cancer, Liquid Biopsy
Academic Distinctions
University First Rank – Pharmacology, MGR University of Medicine, Tamilnadu, India 1995
Graduated Top 1% of the class, Madurai Medical College, Madurai, India 1998
Academic Excellence Award, UMDNJ – Department of Surgery 2003
Outstanding Manuscript Award, Basic Science Category, American College of Surgeons, NJ Chapter 2004
Academic Excellence Award, UMDNJ – Department of Surgery 2004
Joseph Susman Memorial Award for Best Paper, Surgical Infection Society of North America & Europe. 2005
Academic Excellence Award, UMDNJ – Department of Surgery 2005
Outstanding Trauma Resident Award, UMDNJ – 2006
Academic Excellence Award, UMDNJ – Department of Surgery 2006
Outstanding Resident Award, Hackensack University Medical Center, NJ 2008
Academic Excellence Award, UMDNJ – Department of Surgery 2008
Graduated Top 1% of the class, Madurai Medical College, Madurai, India 1998
Academic Excellence Award, UMDNJ – Department of Surgery 2003
Outstanding Manuscript Award, Basic Science Category, American College of Surgeons, NJ Chapter 2004
Academic Excellence Award, UMDNJ – Department of Surgery 2004
Joseph Susman Memorial Award for Best Paper, Surgical Infection Society of North America & Europe. 2005
Academic Excellence Award, UMDNJ – Department of Surgery 2005
Outstanding Trauma Resident Award, UMDNJ – 2006
Academic Excellence Award, UMDNJ – Department of Surgery 2006
Outstanding Resident Award, Hackensack University Medical Center, NJ 2008
Academic Excellence Award, UMDNJ – Department of Surgery 2008
Appointments
Professor of Clinical Surgery, University of California, Irvine - Dec 2020 to present
Professor of Surgery, University of California, Irvine - May 2020 to Dec 2020
Associate Professor, Loma Linda School of Medicine - Sep 2013 to Dec 2019
Assistant Professor, Loma Linda School of Medicine - Sep 2010 to Aug 2013
Professor of Surgery, University of California, Irvine - May 2020 to Dec 2020
Associate Professor, Loma Linda School of Medicine - Sep 2013 to Dec 2019
Assistant Professor, Loma Linda School of Medicine - Sep 2010 to Aug 2013
Research Abstract
The overarching goal of Dr. Senthil's research is to improve the outcomes of patients with peritoneal malignancies through innovation, research, and technical excellence. Her research is focused on changing the treatment and diagnostic paradigms of peritoneal carcinomatosis through translational and clinical research. She collaborates with an outstanding team of scientists at UCI and other reputed institutions to develop an in-vitro, 3-D vascularized microtumor model of peritoneal carcinomatosis to assess treatment response of peritoneal metastases. This work has been funded by National Cancer institute (NCI) with a R01 grant in 2024. She is also developing a liquid biopsy utilizing exosomal biomarkers in patients with gastrointestinal cancers. Dr. Senthil and her team have developed a novel exosomes isolation reagent ( EXO-PEG-TR) for which she has a provisional patent. Dr. Senthil is the principal investigator of NCI funded, EA 2234 STOPGAP-II a phase II/III clinical trial that is evaluating a new strategy of combining intraperitoneal chemotherapy with systemic therapy to treat patients with gastric peritoneal carcinomatosis. This is the first peritoneal carcinomatosis trial funded by NCI. Dr. Senthil has also launched a biobank for the entire UCI health enterprise to promote translational research and acclerate bench to bedside translation of meaninful discoveries.
Awards and Honors
Excellence in Teaching Award, UMDNJ – Department of Surgery 2006
Excellence in Medical Student Teaching, UMDNJ – Department of Surgery 2007
Alpha Omega Alpha - New Jersey Medical School 2008
Golden Apple Award for Excellence in Teaching, UMDNJ 2008
Arnold P. Gold Award for leadership and Humanism, NJ 2008
Excellence in Medical Student Teaching, UMDNJ 2008
Healing Hands Award 2017
Healing Hands Award 2018
Excellence in Education – Loma Linda University Health 2019
John Connolly Teacher of the year award - University of California Irvine 2021
Excellence in Medical Student Teaching, UMDNJ – Department of Surgery 2007
Alpha Omega Alpha - New Jersey Medical School 2008
Golden Apple Award for Excellence in Teaching, UMDNJ 2008
Arnold P. Gold Award for leadership and Humanism, NJ 2008
Excellence in Medical Student Teaching, UMDNJ 2008
Healing Hands Award 2017
Healing Hands Award 2018
Excellence in Education – Loma Linda University Health 2019
John Connolly Teacher of the year award - University of California Irvine 2021
Short Biography
Dr. Senthil is a internationally recognized surgeon-scientist, leader, and educator with a clinical expertise in the management of patients with peritoneal carcinomatosis and advanced malignancies. She leads the peritoneal malignancy program at UCI and has successfully performed several hundreds of Cytoreductive surgery and HIPEC. Her treatment principle is to provide the highest quality of care through innovation, research, collaboration, and technical excellence. She is committed to help patients achieve healthy survivorship by healing their mind, body, and spirit.
Dr. Senthil is a highly-respected educator and has received numerous awards for excellence in teaching including Golden apple award, Arnold P. Gold award for humanism and leadership, and John Connolly teacher of the year award. She founded the ACGME accredited, Complex General Surgical Oncology fellowship at University of California, Irvine, in 2021, first of its kind in the entire UC health system. Dr. Senthil also founded the surgical oncology fellowship at Loma Linda University Health in 2015. She has received numerous awards for her commitment and dedication to educational excellence. Dr. Senthil is the Chair of the inclusive excellence - Education and Advocacy workgroup of American College of Surgeons. Dr. Senthil is an editorial board member of Annals of Surgical Oncology and Surgical Oncology Insights. She has a comprehensive research program that spans the spectrum of translational research, clinical trials, and deep machine learning/AI models to address the most critical challenges in managment of patients with advanced cancers. She has over 130 peer -reviewed publications, several of which are published in JAMA Surgery and Annals of Surgical Oncology.
Dr. Senthil is a highly-respected educator and has received numerous awards for excellence in teaching including Golden apple award, Arnold P. Gold award for humanism and leadership, and John Connolly teacher of the year award. She founded the ACGME accredited, Complex General Surgical Oncology fellowship at University of California, Irvine, in 2021, first of its kind in the entire UC health system. Dr. Senthil also founded the surgical oncology fellowship at Loma Linda University Health in 2015. She has received numerous awards for her commitment and dedication to educational excellence. Dr. Senthil is the Chair of the inclusive excellence - Education and Advocacy workgroup of American College of Surgeons. Dr. Senthil is an editorial board member of Annals of Surgical Oncology and Surgical Oncology Insights. She has a comprehensive research program that spans the spectrum of translational research, clinical trials, and deep machine learning/AI models to address the most critical challenges in managment of patients with advanced cancers. She has over 130 peer -reviewed publications, several of which are published in JAMA Surgery and Annals of Surgical Oncology.
Publications
1. VL Kaiser, Z Sifri, M Senthil, G S Dikdan, Q Lu, DZ Xu, EA. Deitch. Albumin peptide: a molecular marker for trauma / hemorrhagic-shock in rat mesenteric lymph. Peptides 2005; 26(12): 2491-2499
2. M Senthil, M.D., M Brown M.S.N., DZ Xu, M.D.,PhD., Q Lu, M.D., E Feketeova M.D., EA. Deitch, M.D. Gut- Lymph Hypothesis of SIRS/MODS: Validating studies in a Porcine Model. J Trauma 2006; 60(5): 958-65.
3. M Senthil, M.D., A Watkins, M.D., D Barlos, M.D., DZ Xu M.D., PhD, Q Lu M.D., B Abungu B.Sc., R Feinman PhD, EA. Deitch, M.D. Intravenous injection of Trauma- hemorrhagic shock mesenteric lymph causes lung injury that is dependent upon activation of the inducible nitric oxide synthase pathway. Ann Surg 2007; 246(5):822-30.
4. FJ Caputo, B Rupani, AC Watkins, DBarlos, D Vega, M Senthil, EA. Deitch. Trauma hemorrhage-induced gut barrier failure and the production of biologically active intestinal lymph require pancreatic proteases. Shock 2007; 28(4): 441-6
5. EA Deitch, M Senthil, M Brown, F Caputo, A Watkins, D Anjaria, C Badami, V Pisarenko, D Doucet, Q Lu, E Feketeova, DZ Xu. Trauma- Shock-induced gut injury and the production of biologically active intestinal lymph are abrogated by castration in a large animal model. Shock 2008; 30(2): 135-41.
6. C Badami, M Senthil, FJ Caputo, BJ Rupani, Doucet D, Pisarenko V, Xu DZ, EA Deitch. Mesenteric Lymph duct ligation improves survival in lethal shock model.Shock 2008; 30(6):680-5.
7. J Kim, B Mailey, M Senthil , A Artinyan , CL Sun, S Bhatia. Disparities in gastric cancer outcomes among Asian ethnicities in the USA. Ann Surg Oncol 2009; 16(9): 2433-41.
8. M Senthil, LE Harrison. Bicavitary hyperthermic chemotherapy in the management of pseudomyxoma peritoneii with pleural extension. Arch Surg 2009;144(10)970-972
9. M Senthil, B Mailey, L Leong, V Chung, Y Yen, YJ Chen, H Marx, J Kim. Liver-directed therapies in the multidisciplinary management of Hepatocellular cancer. Curr Cancer Ther Rev 2010;6:19-25
10. J Gao, M Senthil, B Ren, J Yan, Q Xing, J Yu, L Zhang, JH Yim. IRF-1 transcriptionally up regulates PUMA, which mediates the mitochondrial apoptotic pathway in IRF-1 induced apoptosis in cancer cells. Cell Death Differ 2010;17(4):699-709
11. M Senthil, V Trisal, IB Paz, LL Lai. Prediction of the adequacy of lymph node retrieval in colon cancer by hospital type. Arch Surg 2010; 145 :840-3.
12. A Holt, DW Wagman, M Senthil, S Mckenzie, H Marx, YJ Chen, N Vora, M.D., J Kim. Transarterial Radioembolization with Yttrium-90 for Regional Management of Hepatocellular Cancer: The Early Results of a Non-Transplant Center. Am Surg 2010; 76(10); 1079-83
13. R Buettner, R Corzano, R Rashid, J Lin, M Senthil, M Hedvat, A Schroeder, A Mao, A Herrmann, J Yim, H Lin, YC Yuan, YC Yuan, K Yakushijin, F Yakushijin, N Vaidehi R Moore, G Gugiu, TD Lee, R Yip, Y Chen, R Jove, DA Horne, JC Williams. Alkylation of cysteine 468 in Stat3 defines a novel site for therapeutic development. ACS Chem Biol 2011; 6: 432-43
14. M Condon, M Senthil , DZ Xu, L Mason, SU Sheth , Z Spolarics, E Feketova, GW Machiedo, EA Deitch. Intravenous injection of mesenteric lymph produced during hemorrhagic shock decreases RBC deformability in the rat. J Trauma 2011;70:489-95
15. J Gao, Y Wang, Q Xing, J Yan, M Senthil, Y Akmal, CM Kowolik, J Kang, DM Lu, M Zhao, Z Lin, CH Cheng, RM Yip, JH Yim. Identification of natural compound by cell-based screening that enhances interferon regulatory factor-1 activity and causes tumor suppression. Mol cancer Ther 2011; 10:1774-83.
16. LJ Wrighton, KR O’ Bosky, JP Namm, M Senthil. Postoperative management after hepatic resection. J Gastrointest Oncol 2012; 3:41-47.
17. ML Wanis, JA Wong, S Rodriguez, JM Wong, B Jabo, A Ashok, SJ Lum, N L Solomon, ME Reeves, CA Garberoglio, M Senthil. Rate of Re-Excision after Breast-Conserving Surgery for Invasive Lobular Carcinoma. Am Surg. 2013 Oct;79(10):1119-22.
18. Senthil M. Assessment of clinical benefit and quality of life in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for management of peritoneal carcinomatosis. J Gastrointest Oncol 2013;4(1):3-4.
19. Kim A, Scharf K, Senthil M, Solomon N, Garberoglio C, Lum SS The Prevalence of overweight and obesity in a breast clinic population: consideration for weight loss as a therapeutic intervention. Surg Obes Relat Dis 2014; 10(2):348-53.
20. Ling TC, Slater JM, Senthil M, Kazanjian K, Howard F, Garberoglio CA, Slater JD, Yang GY. Surgical and radiation therapy management of recurrent anal melanoma. J Gastrointest Oncol 2014; 5(1): E7-12.
21. Tang H, Mirshahidi S, Senthil M, Kazanjian K, Chen CS, Zhang K. Down-regulation of LXR/RXR activation and negative acute phase response pathways in colon adenocarcinoma revealed by proteomics and bioinformatics analysis. Cancer Biomark 2014;4(5):313-24.
22. Prada-Villaverde A, Esquivel J, Lowy AM, Markman M, Chua T, Pelz J, Baratti D, Baumgartner JM, Berri R, Bretcha-Boix P, Deraco M, Flores-Ayala G, Glehen O, Gomez-Portilla A, Gonzalez-Moreno S, Goodman M, Halkia E, Kusamura S, Moller M, Passot G, Pocard M, Slati G, Sardi A, Senthil M, Spiliotis J, Torres-Melero J, Turaga K, Trout R. The American Society of Peritoneal Surface Malignancies evaluation of HIPEC with mitomycin C versus oxaliplatin in 539 patients with colon cancer undergoing a complete cytoreductive surgery. J Surg Oncol 2014;110(7):779-85.
23. Esquivel J, Lowy AM, Markman M, Chua T, Pelz J, Baratti D, Baumgartner JM, Berri R, Bretcha-Boix P, Deraco M, Flores-Ayala G, Glehen O, Gomez-Portilla A, Gonzalez-Moreno S, Goodman M, Halkia E, Kusamura S, Moller M, Passot G, Pocard M, Slati G, Sardi A, Senthil M, Spiliotis J, Torres-Melero J, Turaga K, Trout R. The American Society of Peritoneal Surface Malignancies multi-institution evaluation of the peritoneal surface disease severity score in 1013 patients with colorectal cancer with peritoneal carcinomatosis. Ann Surg Oncol 2014;21(13):4195-201.
24. Senthil M, Chaudhary P, Smith DD, Ventura PE, Frankel PH, Pullarkat V, Trisal V. A shortened activated partial thromoboplastin time predicts the risk of catheter associated venous thrombosis in cancer patients. Thromb Res 2014;134(1):165-8.
25. Choi AH, Surrusco M, Rodriguez S, Bahjri K, Solomon N, Garberoglio C, Lum S, Senthil M. Extranodal extension on sentinel lymph node dissection; why should we treat it differently? Am Surg 2014:80(10): 932-5.
26. Morgan JW, Ji L, Friedman G, Senthil M, Dyke C, Lum SS. Role of the cancer center when using lymph node count as a quality measure for gastric cancer surgery. JAMA Surg 2015;50(1):37-43.
27. Mclean LS, Watkins CN, Campbell P, Zylsatra D, Rowland L, Amis LH, Scott L, Babb CE, Livingston WJ, Darwanto A, Davis WL Jr, Senthil M, Sowers LC, Brantley E. Aryl hydrocarbon receptor ligand 5F203 induces oxidative stress that triggers DNA damage in human Breast cancer cells. Chem Res Toxicol 2015; 28(5):855-71.
28. Choi AH, Blount S, Perez MN, Chavez de Paz CE, Rodriguez SA, Surrusco M, Garberoglio CA, Lum SS, Senthil M. Size of extranodal extension on sentinel lymph node dissection in the American College of Surgeons Oncology Group Z011 trail era. JAMA Surg 2015; 150(12):1141-8; PMID: 26331347.
29. Howarth DR, Lum SS, Esquivel P, Garberoglio CA, Senthil M, Solomon NL. Initial results of multigene panel testing for herditary breast and ovarian cancer and lynch syndrome. Am Surg 2015;81(10):914-4; PMID:26463285.
30. Kam K, Lee E, Pairawan S, Anderson K, Cora C, Bae W, Senthil M, Solomon NL, Lum SS. The effect of breast implants on mammogram outcomes. Am Surg 2015;81(10):1053-6; PMID:26463307.
31. Nottegar A, Veronese N, Senthil M, Roumen RM, Stubbs B, Choi AH, Verheuvel NC, Solmi M, Pea A, Capelli P, Fassan M, Sergi G, Manzato E, Maruzzo M, Bagant F, Koc M, Eryilmaz MA, Bria E, Carbognin L, Bonetti F, Barbareschi M, Luchini C. Extra-nodal extension of sentinel lymph node metastasis is a marker of poor prognosis in breast cancer patients:A systematic review and an exploratory meta-analysis. Eur J Surg Oncol 2016;42(7):919-25; PMID:277005805
32. Selleck M, Senthil M. Implications of preoperative axillary imaging in the post Z011 era. Gland Surg 2016; 5(3):372-4; PMID:27294255.
33. Pairawan SS, Cora C, Olaya W, Deisch J, Garberoglio R, Solomon N, Senthil M, Garberoglio CA, Lum SS. Percutaneous sentinel lymph node biopsy in breast cancer: results of a phase 1 study. Ann Surg Oncol 2016; 23(10):3330-6; PMID:27779979.
34. Bonev V, De Paz Vilanueva CC, Solomon N, Senthil M, Reeves ME, Garberoglio CA, Lum SS. Is sentinel lymph node dissection necessary in all patients with ductal carcinoma in siti undergoing total mastectomy? Am Surg 2016;82(10):982-984; PMID: 27779988.
35. Whelaon MD, Gahagan JV, Sujatha-Bhaskar S, O’Leary MP, Selleck M, Dumitra S, Lee B, Senthil M, Pigazzi A. Is fecal diversion needed in pelvic anastomoses during hyperthermic intraperitoneal chemotherapy (HIPEC)? Ann Surg Oncol 2017;24(8):2122-2128; PMID:28411306.
36. McMullen JRW, Selleck M, Wall NR, Senthil M. Peritoneal Carcinomatosis: limits of diagnosis and the case for liquid biopsy. Oncotarget 2017;8(26): 43481-43490; PMID: 28415645.
37. Selleck MJ, Senthil M, Wall NR. Making meaningful clinical use of biomarkers. Biomark Insights 2017;19: 12: 1177271917715236. PMID:28659713.
38. Chavez de Paz Villanueva C, Bonev V, Senthil M, Solomon N, Reeves ME, Garberoglio CA, Namm JP, Lum SS. Factors associated with underestimation of invasive cancer in patients with ductal carcinoma in situ: precautions for active surveillance. JAMA Surg 2017:152(11);1007-1014; PMID:28700803.
39. Aljehani MA, Morgan JW, Guthrie LA, Jabo B, Ramadan M, Bahjri K, Lum SS, Selleck M, Reeves ME, Garberoglio C, Senthil M. Association of primary tumor site with mortality in patients receiving bevacizumab and cetuximab in metastatic colorectal cancer. JAMA Surg 2018;153(1):60-67; PMID: 28975237.
40. Maroney S, de Paz CC, Reeves ME, Garberoglio C, Raskin E, Senthil M, Namm JP, Solomon N. Benefit of surgical resection of the primary tumor in patients undergoing chemotherapy for stage IV colorectal cancer with unresected metatstasis. J Gastrointest Surg 2018; 22(3): 460-466; PMID:29124549.
41. Jabo B, Selleck MJ, Morgan JW, Lum SS, Bahjri KA, Aljehani M, Garberoglio CA, Reeves ME, Namm JP, Solomon NL, Luca F, Dyke C, Senthil M. Comparison of perioperative chemotherapy with adjuvant chemoradiotherapy for resectable gastric cancer: findings from a population-based study. J Gastrointest Oncol 2018; 9(1):35-45. PMID: 29564169.
42. Babcock BD, Aljehani MA, Jabo B, Choi AH, Morgan JW, Selleck MJ, Luca F, Raskin E, Reeves ME, Garberoglio CA, Lum SS, Senthil M. High- risk stage II colon cancer: Not all risks are created equal. Ann Surg Oncol 2018; 25(7);1980-85. PMID: 29675762.
43. Jabo B, Selleck MJ, Morgan JW, Lum SS, Bahjri KA, Aljehani M, Garberoglio CA, Reeves ME, Namm JP, Solomon NL, Luca F, Yang G, Senthil M. Role of lymph node ratio in selection of adjuvant treatment (chemotherapy vs chemoradiation) in patients with resected gastric cancer. J Gastrointest Oncol 2018; 9(4):708-717; PMID:30151267.
44. Luca F. Craigg DK, Senthil M, Selleck MJ, Babcock BD, Reeves ME, Garberoglio CA. Sexual and urinary outcomes in robotic rectal surgery: review of the literature and technical considerations. Updates Surg 2018; 70(3):415-421; PMID:30120743.
45. Babcock BD, Jabo B, Selleck MJ, Reeves ME, Garberoglio CA, Namm J, Kazanjian K, Senthil M. Factors predictive of outcomes after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for colon and appendiceal carcinomatosis: Single institution experience. Am Surg 2018;84:1575-1579; PMID:30747672.
46. Malek KS, Namm JP, Garberoglio CA, Senthil M, Solomon N, Reeves ME, Lum SS.Attending surgeon variation in operative case length: an opportunity for quality improvement. Am Surg 2018; 84:1595-1599; PMID:30747676.
47. Midthun L, Shaheen S, Deisch J, Senthil M, Tsai J, Hseuh C. Concomitant KRAS and BRAF Mutations in colorectal cancer. J Gastrointest Oncol 2019:10: 577-581; PMID: 31183211.
48. Babcock B, Rodrigues M, Donovan K, Solomon N, Reeves ME, Senthil M, Garberoglio CA, Namm J. Improved survival with immunotherapy but lack of synergistic effect with radiation in stage IV head and neck melanoma. Am Surg 2019;85:1118-1124; PMID:31657306.
49. Thornhill R, Chang J, Selleck MJ, Senthil M, Solomon N, Namm JP, Garberoglio CA, Lum S. From evidence to practice: Are low-risk breast cancer patient still enduring unnecessary costs of radiation? Am Surg 2019; 85:1414-1418; PMID:31908229.
50. Kwong MLM, Denham L, Selleck MJ, Kim C, Kunihira K, Kubba R, Rojas R, Garberoglio C, Senthil M. Response to neoadjuvant treatment is influenced by grade in gastric cancer. Am Surg 2019;85:1419-1422; PMID:31908230.
51. Grossi S, Lin A, Wong A, Namm J, Senthil M, Gomez N, Reeves ME, Garberoglio C, Solomon N. Costs and complications: Delayed gastric emptying after pancreaticoduodenectomy. Am Surg 2019;85:1423-1428; PMID: 31908231.
52. Mudgway R, Chavez de Paz Villanueva C, Lin AC, Senthil M, Garberoglio CA, Lum SS. The impact of primary tumor surgery on survival in HER 2 positive stage IV breast cancer patients in the current era of targeted therapy. Ann Surg Oncol 2020; 27:2711-2720; PMID:32157524.
53. Selleck M, Senthil M. ASO Author reflections: Using the gastric cancer peritoneal carcinomatosis risk score to inform surveillance and treatment. Ann Surg Oncol 2020;27:248-249; PMID: 31659634.
54. Ji L, Selleck MJ, Morgan JW, Xu J, Babcock BD, Shavlik D, Wall NR, Langridge WH, Lum SS, Garberoglio CA, Reeves ME, Solomon N, Namm JP, Senthil M. Gastric cancer peritoneal carcinomatosis risk score. Ann Surg Oncol 2020;27:240-247; PMID: 31346896.
55. Dupont E, Tsangaris T, Garcia-Cantu C, Howard-McNatt M, Chiba A, Berger AC, Levine EA, Gass JS, Gallagher K, Lum SS, Martinez RD, Willis AI, Pandya SV, Brown EA, Fenton A, Mendiola A, Murray M, Solomon NL, Senthil M, Ollila DW, Edmonson D, Lazar M, Namm JP, Li F, Butler M, McGowan NE, Herrera ME, Avitan YP, Yoder B, Walters LL, McPartland T, Chagpar AB. Resection of cavity shave margins in stage 0-III breast cancers patients undergoing breast conserving surgery. Ann Surg 2021;273:876-881; PMID 31290763.
56. Chicago Consensus Working Group. The Chicago consensus guidelines for peritoneal surface malignancies: Introduction. Ann Surg Oncol 2020 ; 27:1737-1740; PMID:32285277.
57. Chicago Consensus Working Group. The Chicago consensus guidelines on peritoneal surface malignancies: Standards. Ann Surg Oncol 2020; 27:1743-1752; PMID:32285276.
58. Chicago Consensus Working Group. The Chicago consensus on peritoneal surface malignancies: Management of Appendiceal Neoplasms. Ann Surg Oncol 2020;27:1753-1760; PMID:32285275.
59. Chicago Consensus Working Group. The Chicago consensus on peritoneal surface malignancies: Management of Neuroendocrine Tumors. Ann Surg Oncol 2020;27:1788-1792; PMID:32285274.
60. Chicago Consensus Working Group. The Chicago consensus on peritoneal surface malignancies: Management of peritoneal mesothelioma. Ann Surg Oncol 2020; 27: 1774-1779; PMID:32285273.
61. Chicago Consensus Working Group. The Chicago consensus on peritoneal surface malignancies: Palliative care considerations. Ann Surg Oncol 2020;27:1798-1804; PMID:32285272.
62. Chicago Consensus Working Group. The Chicago consensus on peritoneal surface malignancies: Management of Ovarian Neoplasms. Ann Surg Oncol 2020;27:1780-1787; PMID:32285271.
63. Chicago Consensus Working Group. The Chicago consensus on peritoneal surface malignancies: Management of colorectal metastases. Ann Surg Oncol 2020;27:1761-1767; PMID:32285270.
64. Chicago Consensus Working Group. The Chicago consensus on peritoneal surface malignancies: Management of gastric metastases. Ann Surg Oncol 2020;27:1768-1773; PMID:32285269.
65. Chicago Consensus Working Group. The Chicago consensus on peritoneal surface malignancies: Management of desmoplastic round cell tumor, breast, and gastrointestinal stromal tumors. Ann Surg Oncol 2020;27:1793-1797; PMID:32285268.
66. Chicago Consensus Working Group. The Chicago consensus on peritoneal surface malignancies: Management of Peritoneal mesothelioma. Cancer 2020;126:2547-2552; PMID: 32282077.
67. Chicago Consensus Working Group. The Chicago consensus on peritoneal surface malignancies: Management of gastric metastases. Cancer 2020;126:2541-2546; PMID: 32282074.
68. Chicago Consensus Working Group. The Chicago consensus on peritoneal surface malignancies: Management of Appendiceal Neoplasms. Cancer 2020;126:2525-2533; PMID:32282073.
69. Chicago Consensus Working Group. The Chicago consensus on peritoneal surface malignancies: Management of desmoplastic round cell tumor, breast, and gastrointestinal stromal tumors. Cancer 2020;126:2566-2570; PMID 32282072.
70. Chicago Consensus Working Group. The Chicago consensus on peritoneal surface malignancies: Management of colorectal metastases. Cancer 2020;126:2534-2540; PMID: 32282070.
71. Chicago Consensus Working Group. The Chicago consensus on peritoneal surface malignancies: Management of Neuroendocrine Tumors. Cancer 2020;126:2561-2565; PMID:32282069.
72. Chicago Consensus Working Group. The Chicago consensus on peritoneal surface malignancies: Management of Ovarian Neoplasms. Cancer 2020;126:2553-2560; PMID: 32282068.
73. Chicago Consensus Working Group. The Chicago consensus guidelines on peritoneal surface malignancies: Standards. Cancer 2020 ;126:2516-2524; PMID: 32282066.
74. Chicago Consensus Working Group. The Chicago consensus guidelines for peritoneal surface malignancies: Introduction. Cancer 2020; 126:2510-2512; PMID: 32282062.
75. Chicago Consensus Working Group. The Chicago consensus on peritoneal surface malignancies: Palliative care considerations. Cancer 2020;126:2571-2576; PMID: 32282059.
76. Choi AH, Farzaneh C, Kejriwal N, Calidas A, Cordero-Caban K, Roman M, Kwong MLM, Selleck MJ, Pigazzi A, Jafari D, Senthil M. Rate of peritoneal carcinomatosis in surgically resected Stage II and III colon cancer. Ann Surg Onc 2020;27:4943-4948; PMID: 32535867.
77. Choi AH, Senthil M. ASO Author reflections: Real- World incidence of peritoneal carcinomatosis after colon resection and why it matters. Ann Surg Oncol 2020; 27:4949; PMID; 32627117.
78. Choi AH, Ji L, Babcock B, Ramos V, Kwong MLM, Morgan JW, Selleck MJ, Langridge WHR, DeLeon M, Wall NR, Lum S, Pigazzi A, Dayyani F, Senthil M. Peritoneal carcinomatosis in Gastric cancer: Are Hispanics at higher risk? J Surg Oncol 2020;122:1624-1629; PMID:32901938.
79. Howard-McNatt M, Dupont E, Tsangaris T, Garcia-Cantu C, Chiba A, Berger AC, Levine EA, Gass JS, Ollila DW, Chagpar AB; SHAVE2 Group. Impact of cavity Shave margin on margin status in patients with pure ductal carcinoma-in situ. J Am Coll Surg 2021;232:373-378; PMID:33346081.
80. Kabagwira J, Gonda A, Vallejos P, Babcock B, Langridge WHR, Senthil M, Wall NR. Optimization of blood handling for plasma extracellular vesicle isolation for clinical studies. J of Nanopart res 2021;23;65. https://doi.org/10.1007/s11051-021-05169-6. Collaborator, performed research & assisted with preparation of manuscript
81. Senthil M. Quality -of -life assessment in patients undergoing palliative chemotherapy: Call for action. Ann Surg Oncol 2021; 28:7-8; PMID: 33140253.
82. Are C, Senthil M, Jayaryaman S, Wenos C, Pramesh CS, D'Ugo D, Charles A. Promoting surgical research in global south. Surgery 2021; 170(5): 1587-1588; PMID:33712308.
83. Sullivan B, Qazi A, Senthil M. Cancer screening programs in low-and middle-income countries: strategies for success. Ann Surg Onc 2021; 28(12):6918-6919; PMID:34296357
84. Chagpar AB, Howard-McNatt M, Chiba A, Levine EA, Gass JS, Gallagher K, Lum S, Martinez R, Willis AL, Fenton A, Solomon NL, Senthil M, Edmonson D, Namm JP, Walters L, Brown E, Murray M, Ollilia D, Dupont E, Garcia-Cantu C. Factors affecting time to surgery in breast cancer patients. Am Surg 2021, Nov 3 EPUB; PMID 34732082.
85. Zhang S, Brazel D, Kumar P, Schafer LN, Eidenschink B, Senthil M, Dayyani F. Utility of tumor-informed circulating tumor DNA in the clinical management of gastrointestinal malignancies. J Gastrointest Oncol 2021; Dec 26:2643-2652. PMID 35070394.
86. Dayyani F, Smith BR, Nguyen NT, Daly S, Hinojosa MW, Seyedin SN, Kuo J, Samarasena JB, Lee JG, Taylor TH, Cho MT, Senthil M. Phase Ib feasibility trial of response adjusted neoadjuvant therapy in gastric cancer (RANT-GC). Future Oncol 2022;18(21):2615-2622. PMID -35603638.
87. Vallejos PA, Fuller RN, Kabagwira J, Kwong ML, Gonda A, McMullen JRW, Le N, Selleck MJ, Miller LD, Perry CC, Senthil M, Wall NR. Exosomal proteins as a source of biomarker in colon cancer peritoneal carcinomatosis- A pilot study. Proteomics Clin Appl. 2022 Oct 11:e2100085. doi: 10.1002/prca.202100085. Online ahead of print. PMID: 36217952.
88. Young S, Ostowari A, Yu J, Eng OS, Dayyani F, Senthil M. Role of Cytoreductive surgery and intraperitoneal chemotherapy in gastric cancer. Clin Adv Hematol Oncol. 2022 Nov;20(11):673-682.PMID: 36331405.
89. Young S, Yu J, Senthil M. Routine Omentectomy during Cytoreductive Surgery for peritoneal surface malignancies. Ann Surg Oncol. 2022 Dec 7. doi: 10.1245/s10434-022-12872-8. Online ahead of print. PMID: 36479660.
90. Yu J, Sullivan BG, Senthil GN, Gonda A, Dehkordi-Vakil F, Campos B, Dayyani F, Senthil M. Prevalence of primary liver cancer is affected by place of birth in Hispanic people residing in the United States: All of Us Research Program report. Am Surg. 2022 Oct;88(10):2565-2571..PMID: 35854430.
91. Sullivan BG, Lo A, Yu J, Gonda A, Dehkordi-Vakil F, Dayyani F, Senthil M. Circulating tumor DNA is unreliable to detect somatic gene alterations in peritoneal carcinomatosis. Ann Surg Oncol. 2023 Jan;30(1):278-284. PMID- 35980549.
92. Sullivan BG, Dayyani F, Senthil M. ASO Author Reflections. Challenges of Circulating tumor DNA in the management of gastrointestinal peritoneal carcinomatosis. Ann Surg Oncol. 2023 Jan;30(1):285-286. PMID - 36100836.
93. Dayyani F, Senthil M. Spontaneous fluctuation of tumor-informed circulating tumor DNA at low levels. JCO Precis Oncol. 2022 Jul;6:e2200177. doi: 10.1200/PO.22.00177.PMID: 35834756
94. Sullivan BG, Lo A, Yu J, Gonda A, Dehkordi-Vakil F, Dayyani F, Senthil M. ASO Visual Abstract. Circulating tumor DNA is unreliable to detect somatic gene alterations in peritoneal carcinomatosis. Ann Surg Oncol. 2023 Jan;30(1):287-288. PMID - 36209325.
95. Yu J, Ostowari A, Gonda A, Mashayekhi K, Dayyani F, Hughes CCW, Senthil M. Exosomes as a source of biomarkers for gastrointestinal cancers. Cancers (Basel). 2023 Feb 16;15(4):1263. doi: 10.3390/cancers15041263. PMID: 36831603.
96. Gonda A, Senthil M. ASO author reflections: Liquid biopsy in gastrointestinal cancers- role of exosomes. Ann Surg Oncol. 2023 Mar 1. doi: 10.1245/s10434-023-13270-4. Online ahead of print. PMID: 36856910.
97. Vallejos PA, Gonda A, Yu J, Sullivan BG, Ostowari A, Kwong ML, Choi A, Selleck MJ, Kabagwira J, Fuller RN, Gironda DJ, Levine EA, Hughes CCW, Wall NR, Miller LD, Senthil M. Plasma exosome gene signature differentiates colon cancer from healthy controls. Ann Surg Oncol. 2023 Mar 2. doi: 10.1245/s10434-023-13219-7. Online ahead of print. PMID 36864326.
98. Senthil M, Dayyani F. Phase II clinical trial of sequential systemic therapy and intraperitoneal paclitaxel in gastric and gastroesophageal junction peritoneal carcinomatosis - STOPGAP trial. BMC Cancer. 2023; Mar 4;23(1):209. doi: 10. PMID: 36870941
99. Kaakour D, Ward G, Senthil M, Dayyani F. Durable response after repeat cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in a patient with extensive mucinous adenocarcinoma of the appendix. Diseases. 2023 Apr 6;11(2):60. doi: 10.3390/diseases11020060. PMID 37092442.
100. Hanse EA, Wang T, Tifrea D, Senthil M, Kim AC, Kong M, Eng OS. A novel assessment of metabolic pathways in peritoneal metastases from low grade appendiceal mucinous neoplasms. Ann Surg Oncol. 2023 May 6. doi: 10.1245/s10434-023-13587-0. Online ahead of print. PMID 37149550.
101. Yu J, Sullivan BG, Nguyen NT, Hohmann SF, Harris AH, Micic D, Turaga KK, Senthil M, Eng OS. Readmission and disposition in patients with malignant bowel obstructions following gastrostomy tube. Am Surg. 2023 May 31:31348231180915. doi: 10.1177/00031348231180915. Online ahead of print. PMID 37257144.
102. Senthil M, Dayyani F. Role of iterative normothermic intraperitoneal paclitaxel combined with systemic chemotherapy in the management of gastric peritoneal carcinomatosis. Ann Surg Oncol. 2023 Sep 8. doi: 10.1245/s10434-023-14258-w. Online ahead of print. PMID 37684365.
103. Krouse RS, Anderson GL, Arnold KB, Thomson CA, Nfonsam VN, Al-Kasspooles MF, Walker JL, Sun V, Alvarez Secord A, Han ES, Leon-Takahashi AM, Isla-Ortiz D, Rodgers P, Hendren S, Sanchez Salcedo M, Laryea JA, Graybill WS, Flaherty DC, Mogal H, Miner TJ, Pimiento JM, Kitano M, Badgwell B, Whalen G, Lamont JP, Guevara OA, Senthil M, Dewdney SB, Silberfein E, Wright JD, Friday B, Fahy B, Anantha Sathyanarayana S, O'Rourke M, Bakitas M, Sloan J, Grant M, Deutsch GB, Deneve JL. Surgical versus non-surgical management of patients with malignant bowel obstruction: a pragmatic comparative effectiveness trial. Lancet Gastroenterol Hepatol. 2023 Oct;8(10):908-918. doi: 10.1016/S2468-1253(23)00191-7. Epub 2023 Aug 1. PMID 37541263.
104. Chandrakanth Are, Shilpa S Murthy, Richard Sullivan, Makayla Schissel, Sanjib Chowdhury, Olesegun Alatise, Daniel Anaya, Madhuri Are, Charles Balch, David Bartlett, Murray Brennan, Lydia Cairncross, Matthew Clark, S V S Deo, Vikas Dudeja, Domenico D’Ugo, Ibtihal Fadhil, Armando Giuliano, Satish Gopal, Lily Gutnik, Andre Ilbawi, Pankaj Jani, Peter Kingham, Laura Lorenzon, Premila Leiphrakpam, Augusto Leon, Hector Martinez-Said, Kelly McMasters, David O Meltzer, Miriam Mutebi, Zafar Nabeel, Vibhavari Naik, Lisa Newman, Alexandre Ferreira Oliveira, Do Joong Park, C S Pramesh, Saieesh Rao, T Subramanyeshwar Rao, Enrique Rocha Bargallo, Anya Romanoff, Anne F Rositch, Isabel Rubio, Heber Salvador de Castro Ribeiro, Eman Sbaity, Maheswari Senthil, Lynette Smith, Masakazi Toi, Kiran Turaga, Ujwal Yanala, Cheng-Har Yip, Ashraf Zaghloul, Benjamin O Anderson. Global Cancer Surgery: pragmatic solutions to improve cancer surgery outcomes worldwide. Lancet Oncol. 2023 Dec;24(12):e472-e518. doi: 10.1016/S1470-2045(23)00412-6. Epub 2023 Nov 2. PMID 37924819.
105. Sedighim S, Khan A, Li AY, Tajik F, Radhakrishnan VK, Eng O, Turaga K, Senthil M. Adoption of cytoreductive surgery in the management of peritoneal carcinomatosis: Global trends. J Surg Oncol. 2023 Nov;128(6):1021-1031. doi: 10.1002/jso.27448. PMID 37818906.
106. Chen AM, Garcia AD, Alexandrescu M, Truong A, Senthil M. Effect of same-day appointment initiative on access- related benchmarks in radiation oncology. Pract Radiat Oncol. 2024 Jan-Feb;14(1):12-19. doi: 10.1016/j.prro.2023.08.010. Epub 2023 Sep 23. PMID 37747390.
107. Sedighim S, Senthil M. Response to editor-" Elevating Standards: A Comprehensive model for peritoneal surface malignancy management in developing health care systems". J Surg Oncol. 2024 Mar;129(3):662. doi: 10.1002/jso.27538. Epub 2023 Dec 4. PMID 38044719.
108. Kabagwira J, Fuller RN, Vallejos PA, Sugiono CS, Andrianarijaona VM, Chism JB, O'Leary MP, Molina DC, Langridge W, Senthil M, Wall NR. Amplifying curcurmin's anti-tumor potential: A heat driven approach in colorectal cancer treatment. Onco Targets Ther. 2024 Jan 30;17:63-78. doi: 10.2147/OTT.S448024. eCollection 2024. PMID 38313386.
109. Li AY, Sedighim S, Tajik F, Khan AM, Radhakrishnan VK, Dayyani F, Senthil M. Regional therapy approaches for gastric cancer with limited peritoneal carcinomatosis. J Surg Oncol 2024; Jan 26. doi: 10.1007/s12029-023-00994-5. Online ahead of print. PMID 38277055.
110. Zohar N, Nevler A, Esquivel J, Yeo CJ, Benvenisti H, Elbaz N, Assaf D, Mor E, Bowne WB, Badgwell BD, Baratti D, Berger Y, Berri RN, Bhatt A, Bowne WB, Guiral DC, Cusack JC, Dineen SP, Esquivel, Gangi A, Goere D, Goodman MD, Guschin VV, Gutman M, Hanna NN, Hingh I, Hoffman A, Johnston FM, Labow DM, Lambert LA, Lee B, Levine EA, Lowy AM, Moran BJ, Morris DL, Nash GM, Nevler A, Nizri E, Qudaror CA, Raoof M, Senthil M, Somashekhar SP, Sugarbaker PH, Turaga KK, Woo Y, Yonemura Y. International TOO HIPEC Consensus Group. International expert consensus on defining textbook oncologic outcomes after cytoreductive surgery in colorectal peritoneal carcinomatosis. J Am Coll Surg. 2024 Apr 1;238(4):387-401Epub 2023 Dec 27.PMID: 38149780
111. Fisher OM, Brown C, Esquivel J, Larsen SG, Liauw W, Alzahrani NA, Morris DL, Kepenekian V, Sourrouille I, Dumont F, Tuech JJ, Ceribelli C, Doussot B, Sgarbura O, Alhosni M, Quenet F, Glehen O, Cashin PH, Flatmark K, Graf W, Takala H, Lowy AM, Chua T, Pelz J, Baratti D, Baumgartener JM, Berri R, Bretcha-Boix P, Deraco M, Flores-Ayala G, Gomez-Portilla A, Gonzalez-Moreno S, Goodman M, Halkia E, Kusamura S, Moller M, Passot G, Pocard M, Salti G, Sardi A, Senthil M, Spiloitis J, Torres-Meler J, Turaga K, Bereder JM, Bernard JL, Bakrin N, Carrere S, Coget J, Cotte E, Facy O, Gelli M, Gilly FN, Ortega-Deballaon P, Passot G, Rat P, Rousset P, Thibaudeau E, Vaudoyer D. Peritoneal Surface Oncology Group International (PSOGI), Nordic Peritoneal Oncology Group (NPOG), American Society for Peritoneal Surface Malignancy (ASPSM) and BIG-RENAPE Groups. Hyperthermic intraperitoneal chemotherapy in colorectal cancer. BJS Open. 2024 May 8;8(3) PMID: 38722737
112. Ostowari A, Hasjim BJ, Lim L, Yu J, Nguyen L, Dayyani F, Zell J, Cho M, Senthil M, Eng OS. Clinical outcomes in patients with Krukenberg tumors in colorectal cancers. J Surg Res. 2024 Jul;299:343-352. Epub 2024 May 24.PMID: 38795557
113. Nee K, Hosohama L, Alobuia W, Kim AC, Senthil M, Eng OS. Defining Colorectal Cancer cells on a single cell level reveals LGR5+ proliferative stem cell expression in peritoneal metastasis. Ann Surg Oncol 2024; 10:6369-6372. PMID 39014167
114. Khorfan R, Sedighim S, Caba-Molina D, TRan TB, Senthil M, O'Leary MP, Eng OS. Improved survival with immunotherapy for microsatellite unstable colorectal cancer with peritoneal metastases. J Surg Oncol 2024. 130:613-621. PMID 39082605
115. Perisa Ruhi-Williams, Jingjing Yu, Christian de Virgilio, Shahrzad Bazargan-Hegazi, Helen E. Ovsepyan, Steven D. Wexner, Katharine A. Kirby, Fatemeh Tajik, Angelina Lo, Aya Fattah, Farin F. Amersi, Kristine E. Calhoun, Lisa A. Cunningham, Paula I. Denoya, Henry R. Govekar, Sara M. Gross, Jukes P. Namm, V. Prasad Poola, Robyn E. Richmond, Christine H. Rohde, Mayank Roy, Tara A. Russell, Nicola Sequeira, Anaar E. Siletz, Tiffany N. Tanner, Brian T. Valerian, Maheswari Senthil. Mentorship across academic programs in Surgery( MAAPS) study- Challenges of Junior surgical faculty. JAMA Surg 2024; 159:1252-1260.. PMID: 39230925
116. Senthil M, Dayyani F. Cytoreduction in gastric cancer peritoneal carcinomatosis: Selection is key. Ann Surg Oncol. 2024:13:8491-8493. PMID: 39394488
117. Sedighim S, Khorfan R, Shin J, Khan A, Tang YL, Li AY, Senthil M, O'Leary MP, Eng OS. Disparities in palliative care treatment utilization in metastatic colorectal cancer patients. Ann Surg Oncol 2024 Nov 22 doi:10.1245/s10434-024-16577. PMID 39576451
118. Nguyen M, Nahmias J, Eng OS, Senthil M, Barrios C, Dolitch M, Lekawa M, Grigorian A. Trauma patients with metastatic cancer undergoing emergent surgery: A matched cohort analysis. Surg Open SCi 2024; 17( 20): 184-188. PMID 39886065
119. Bansal VV, Witmer HDD, Childers CP, Su DG, Turaga KK, RVU Writing Group; PSM Consortium Group. When Benchmarks Fail Us: A Case Study in Cytoreductive Surgery. Ann Surg Oncol 2025; 32 (1):93-23.Epub 2024, Oct 26. PMID 39460818
120. Khorfan R, Sedighim S, Caba-Molina D, TRan TB, Senthil M, O'Leary MP, Eng OS. National trends and outcomes in cytoreductive surgery for colorectal cancer with peritoneal metastasis before and after PRODIGE 7. Ann Surg Oncol 2025; 32(3):1422-1424. PMID 39572948
121. Tajik F, Eyob B, Khan AM, Radhakrishnan VK, Senthil M. Iterative intraperitoneal chemotherapy in gastric peritoneal carcnomatosis. Cancers ( Basel) 2025 Jan 17(2):289 doi: 10.3390/cancers17020289. PMID 39858070.
BOOK CHAPTERS
1. M Senthil, BJ Rupani , JH Jabush, EA Deitch. Principles And Practice of Nutritional Support In Surgical Patients. Acute Care Surgery. Eds. Britt LD, Trunkey DD, Organ CH, Feliciano DV, 2007, Springer Verlag
2. M Senthil, J Deneve. ACS operative standards Vol II – Peritonectomy Procedures. Publication 2021.
3. Sullivan B, Karalis JD, Wang SC, Senthil M. Gastric cancer epidemiology, genetics, and screening. Association of Foregut Surgery Textbook. Published 2023.
4. Yu J, Sullivan B, Swentek L, Senthil M. Miscellaneous Rare Malignancies – Pseudomyxoma Peritonei. Oncologic Surgical Emergencies: A Practical Guide for the General Surgeon. Published 2023.
2. M Senthil, M.D., M Brown M.S.N., DZ Xu, M.D.,PhD., Q Lu, M.D., E Feketeova M.D., EA. Deitch, M.D. Gut- Lymph Hypothesis of SIRS/MODS: Validating studies in a Porcine Model. J Trauma 2006; 60(5): 958-65.
3. M Senthil, M.D., A Watkins, M.D., D Barlos, M.D., DZ Xu M.D., PhD, Q Lu M.D., B Abungu B.Sc., R Feinman PhD, EA. Deitch, M.D. Intravenous injection of Trauma- hemorrhagic shock mesenteric lymph causes lung injury that is dependent upon activation of the inducible nitric oxide synthase pathway. Ann Surg 2007; 246(5):822-30.
4. FJ Caputo, B Rupani, AC Watkins, DBarlos, D Vega, M Senthil, EA. Deitch. Trauma hemorrhage-induced gut barrier failure and the production of biologically active intestinal lymph require pancreatic proteases. Shock 2007; 28(4): 441-6
5. EA Deitch, M Senthil, M Brown, F Caputo, A Watkins, D Anjaria, C Badami, V Pisarenko, D Doucet, Q Lu, E Feketeova, DZ Xu. Trauma- Shock-induced gut injury and the production of biologically active intestinal lymph are abrogated by castration in a large animal model. Shock 2008; 30(2): 135-41.
6. C Badami, M Senthil, FJ Caputo, BJ Rupani, Doucet D, Pisarenko V, Xu DZ, EA Deitch. Mesenteric Lymph duct ligation improves survival in lethal shock model.Shock 2008; 30(6):680-5.
7. J Kim, B Mailey, M Senthil , A Artinyan , CL Sun, S Bhatia. Disparities in gastric cancer outcomes among Asian ethnicities in the USA. Ann Surg Oncol 2009; 16(9): 2433-41.
8. M Senthil, LE Harrison. Bicavitary hyperthermic chemotherapy in the management of pseudomyxoma peritoneii with pleural extension. Arch Surg 2009;144(10)970-972
9. M Senthil, B Mailey, L Leong, V Chung, Y Yen, YJ Chen, H Marx, J Kim. Liver-directed therapies in the multidisciplinary management of Hepatocellular cancer. Curr Cancer Ther Rev 2010;6:19-25
10. J Gao, M Senthil, B Ren, J Yan, Q Xing, J Yu, L Zhang, JH Yim. IRF-1 transcriptionally up regulates PUMA, which mediates the mitochondrial apoptotic pathway in IRF-1 induced apoptosis in cancer cells. Cell Death Differ 2010;17(4):699-709
11. M Senthil, V Trisal, IB Paz, LL Lai. Prediction of the adequacy of lymph node retrieval in colon cancer by hospital type. Arch Surg 2010; 145 :840-3.
12. A Holt, DW Wagman, M Senthil, S Mckenzie, H Marx, YJ Chen, N Vora, M.D., J Kim. Transarterial Radioembolization with Yttrium-90 for Regional Management of Hepatocellular Cancer: The Early Results of a Non-Transplant Center. Am Surg 2010; 76(10); 1079-83
13. R Buettner, R Corzano, R Rashid, J Lin, M Senthil, M Hedvat, A Schroeder, A Mao, A Herrmann, J Yim, H Lin, YC Yuan, YC Yuan, K Yakushijin, F Yakushijin, N Vaidehi R Moore, G Gugiu, TD Lee, R Yip, Y Chen, R Jove, DA Horne, JC Williams. Alkylation of cysteine 468 in Stat3 defines a novel site for therapeutic development. ACS Chem Biol 2011; 6: 432-43
14. M Condon, M Senthil , DZ Xu, L Mason, SU Sheth , Z Spolarics, E Feketova, GW Machiedo, EA Deitch. Intravenous injection of mesenteric lymph produced during hemorrhagic shock decreases RBC deformability in the rat. J Trauma 2011;70:489-95
15. J Gao, Y Wang, Q Xing, J Yan, M Senthil, Y Akmal, CM Kowolik, J Kang, DM Lu, M Zhao, Z Lin, CH Cheng, RM Yip, JH Yim. Identification of natural compound by cell-based screening that enhances interferon regulatory factor-1 activity and causes tumor suppression. Mol cancer Ther 2011; 10:1774-83.
16. LJ Wrighton, KR O’ Bosky, JP Namm, M Senthil. Postoperative management after hepatic resection. J Gastrointest Oncol 2012; 3:41-47.
17. ML Wanis, JA Wong, S Rodriguez, JM Wong, B Jabo, A Ashok, SJ Lum, N L Solomon, ME Reeves, CA Garberoglio, M Senthil. Rate of Re-Excision after Breast-Conserving Surgery for Invasive Lobular Carcinoma. Am Surg. 2013 Oct;79(10):1119-22.
18. Senthil M. Assessment of clinical benefit and quality of life in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for management of peritoneal carcinomatosis. J Gastrointest Oncol 2013;4(1):3-4.
19. Kim A, Scharf K, Senthil M, Solomon N, Garberoglio C, Lum SS The Prevalence of overweight and obesity in a breast clinic population: consideration for weight loss as a therapeutic intervention. Surg Obes Relat Dis 2014; 10(2):348-53.
20. Ling TC, Slater JM, Senthil M, Kazanjian K, Howard F, Garberoglio CA, Slater JD, Yang GY. Surgical and radiation therapy management of recurrent anal melanoma. J Gastrointest Oncol 2014; 5(1): E7-12.
21. Tang H, Mirshahidi S, Senthil M, Kazanjian K, Chen CS, Zhang K. Down-regulation of LXR/RXR activation and negative acute phase response pathways in colon adenocarcinoma revealed by proteomics and bioinformatics analysis. Cancer Biomark 2014;4(5):313-24.
22. Prada-Villaverde A, Esquivel J, Lowy AM, Markman M, Chua T, Pelz J, Baratti D, Baumgartner JM, Berri R, Bretcha-Boix P, Deraco M, Flores-Ayala G, Glehen O, Gomez-Portilla A, Gonzalez-Moreno S, Goodman M, Halkia E, Kusamura S, Moller M, Passot G, Pocard M, Slati G, Sardi A, Senthil M, Spiliotis J, Torres-Melero J, Turaga K, Trout R. The American Society of Peritoneal Surface Malignancies evaluation of HIPEC with mitomycin C versus oxaliplatin in 539 patients with colon cancer undergoing a complete cytoreductive surgery. J Surg Oncol 2014;110(7):779-85.
23. Esquivel J, Lowy AM, Markman M, Chua T, Pelz J, Baratti D, Baumgartner JM, Berri R, Bretcha-Boix P, Deraco M, Flores-Ayala G, Glehen O, Gomez-Portilla A, Gonzalez-Moreno S, Goodman M, Halkia E, Kusamura S, Moller M, Passot G, Pocard M, Slati G, Sardi A, Senthil M, Spiliotis J, Torres-Melero J, Turaga K, Trout R. The American Society of Peritoneal Surface Malignancies multi-institution evaluation of the peritoneal surface disease severity score in 1013 patients with colorectal cancer with peritoneal carcinomatosis. Ann Surg Oncol 2014;21(13):4195-201.
24. Senthil M, Chaudhary P, Smith DD, Ventura PE, Frankel PH, Pullarkat V, Trisal V. A shortened activated partial thromoboplastin time predicts the risk of catheter associated venous thrombosis in cancer patients. Thromb Res 2014;134(1):165-8.
25. Choi AH, Surrusco M, Rodriguez S, Bahjri K, Solomon N, Garberoglio C, Lum S, Senthil M. Extranodal extension on sentinel lymph node dissection; why should we treat it differently? Am Surg 2014:80(10): 932-5.
26. Morgan JW, Ji L, Friedman G, Senthil M, Dyke C, Lum SS. Role of the cancer center when using lymph node count as a quality measure for gastric cancer surgery. JAMA Surg 2015;50(1):37-43.
27. Mclean LS, Watkins CN, Campbell P, Zylsatra D, Rowland L, Amis LH, Scott L, Babb CE, Livingston WJ, Darwanto A, Davis WL Jr, Senthil M, Sowers LC, Brantley E. Aryl hydrocarbon receptor ligand 5F203 induces oxidative stress that triggers DNA damage in human Breast cancer cells. Chem Res Toxicol 2015; 28(5):855-71.
28. Choi AH, Blount S, Perez MN, Chavez de Paz CE, Rodriguez SA, Surrusco M, Garberoglio CA, Lum SS, Senthil M. Size of extranodal extension on sentinel lymph node dissection in the American College of Surgeons Oncology Group Z011 trail era. JAMA Surg 2015; 150(12):1141-8; PMID: 26331347.
29. Howarth DR, Lum SS, Esquivel P, Garberoglio CA, Senthil M, Solomon NL. Initial results of multigene panel testing for herditary breast and ovarian cancer and lynch syndrome. Am Surg 2015;81(10):914-4; PMID:26463285.
30. Kam K, Lee E, Pairawan S, Anderson K, Cora C, Bae W, Senthil M, Solomon NL, Lum SS. The effect of breast implants on mammogram outcomes. Am Surg 2015;81(10):1053-6; PMID:26463307.
31. Nottegar A, Veronese N, Senthil M, Roumen RM, Stubbs B, Choi AH, Verheuvel NC, Solmi M, Pea A, Capelli P, Fassan M, Sergi G, Manzato E, Maruzzo M, Bagant F, Koc M, Eryilmaz MA, Bria E, Carbognin L, Bonetti F, Barbareschi M, Luchini C. Extra-nodal extension of sentinel lymph node metastasis is a marker of poor prognosis in breast cancer patients:A systematic review and an exploratory meta-analysis. Eur J Surg Oncol 2016;42(7):919-25; PMID:277005805
32. Selleck M, Senthil M. Implications of preoperative axillary imaging in the post Z011 era. Gland Surg 2016; 5(3):372-4; PMID:27294255.
33. Pairawan SS, Cora C, Olaya W, Deisch J, Garberoglio R, Solomon N, Senthil M, Garberoglio CA, Lum SS. Percutaneous sentinel lymph node biopsy in breast cancer: results of a phase 1 study. Ann Surg Oncol 2016; 23(10):3330-6; PMID:27779979.
34. Bonev V, De Paz Vilanueva CC, Solomon N, Senthil M, Reeves ME, Garberoglio CA, Lum SS. Is sentinel lymph node dissection necessary in all patients with ductal carcinoma in siti undergoing total mastectomy? Am Surg 2016;82(10):982-984; PMID: 27779988.
35. Whelaon MD, Gahagan JV, Sujatha-Bhaskar S, O’Leary MP, Selleck M, Dumitra S, Lee B, Senthil M, Pigazzi A. Is fecal diversion needed in pelvic anastomoses during hyperthermic intraperitoneal chemotherapy (HIPEC)? Ann Surg Oncol 2017;24(8):2122-2128; PMID:28411306.
36. McMullen JRW, Selleck M, Wall NR, Senthil M. Peritoneal Carcinomatosis: limits of diagnosis and the case for liquid biopsy. Oncotarget 2017;8(26): 43481-43490; PMID: 28415645.
37. Selleck MJ, Senthil M, Wall NR. Making meaningful clinical use of biomarkers. Biomark Insights 2017;19: 12: 1177271917715236. PMID:28659713.
38. Chavez de Paz Villanueva C, Bonev V, Senthil M, Solomon N, Reeves ME, Garberoglio CA, Namm JP, Lum SS. Factors associated with underestimation of invasive cancer in patients with ductal carcinoma in situ: precautions for active surveillance. JAMA Surg 2017:152(11);1007-1014; PMID:28700803.
39. Aljehani MA, Morgan JW, Guthrie LA, Jabo B, Ramadan M, Bahjri K, Lum SS, Selleck M, Reeves ME, Garberoglio C, Senthil M. Association of primary tumor site with mortality in patients receiving bevacizumab and cetuximab in metastatic colorectal cancer. JAMA Surg 2018;153(1):60-67; PMID: 28975237.
40. Maroney S, de Paz CC, Reeves ME, Garberoglio C, Raskin E, Senthil M, Namm JP, Solomon N. Benefit of surgical resection of the primary tumor in patients undergoing chemotherapy for stage IV colorectal cancer with unresected metatstasis. J Gastrointest Surg 2018; 22(3): 460-466; PMID:29124549.
41. Jabo B, Selleck MJ, Morgan JW, Lum SS, Bahjri KA, Aljehani M, Garberoglio CA, Reeves ME, Namm JP, Solomon NL, Luca F, Dyke C, Senthil M. Comparison of perioperative chemotherapy with adjuvant chemoradiotherapy for resectable gastric cancer: findings from a population-based study. J Gastrointest Oncol 2018; 9(1):35-45. PMID: 29564169.
42. Babcock BD, Aljehani MA, Jabo B, Choi AH, Morgan JW, Selleck MJ, Luca F, Raskin E, Reeves ME, Garberoglio CA, Lum SS, Senthil M. High- risk stage II colon cancer: Not all risks are created equal. Ann Surg Oncol 2018; 25(7);1980-85. PMID: 29675762.
43. Jabo B, Selleck MJ, Morgan JW, Lum SS, Bahjri KA, Aljehani M, Garberoglio CA, Reeves ME, Namm JP, Solomon NL, Luca F, Yang G, Senthil M. Role of lymph node ratio in selection of adjuvant treatment (chemotherapy vs chemoradiation) in patients with resected gastric cancer. J Gastrointest Oncol 2018; 9(4):708-717; PMID:30151267.
44. Luca F. Craigg DK, Senthil M, Selleck MJ, Babcock BD, Reeves ME, Garberoglio CA. Sexual and urinary outcomes in robotic rectal surgery: review of the literature and technical considerations. Updates Surg 2018; 70(3):415-421; PMID:30120743.
45. Babcock BD, Jabo B, Selleck MJ, Reeves ME, Garberoglio CA, Namm J, Kazanjian K, Senthil M. Factors predictive of outcomes after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for colon and appendiceal carcinomatosis: Single institution experience. Am Surg 2018;84:1575-1579; PMID:30747672.
46. Malek KS, Namm JP, Garberoglio CA, Senthil M, Solomon N, Reeves ME, Lum SS.Attending surgeon variation in operative case length: an opportunity for quality improvement. Am Surg 2018; 84:1595-1599; PMID:30747676.
47. Midthun L, Shaheen S, Deisch J, Senthil M, Tsai J, Hseuh C. Concomitant KRAS and BRAF Mutations in colorectal cancer. J Gastrointest Oncol 2019:10: 577-581; PMID: 31183211.
48. Babcock B, Rodrigues M, Donovan K, Solomon N, Reeves ME, Senthil M, Garberoglio CA, Namm J. Improved survival with immunotherapy but lack of synergistic effect with radiation in stage IV head and neck melanoma. Am Surg 2019;85:1118-1124; PMID:31657306.
49. Thornhill R, Chang J, Selleck MJ, Senthil M, Solomon N, Namm JP, Garberoglio CA, Lum S. From evidence to practice: Are low-risk breast cancer patient still enduring unnecessary costs of radiation? Am Surg 2019; 85:1414-1418; PMID:31908229.
50. Kwong MLM, Denham L, Selleck MJ, Kim C, Kunihira K, Kubba R, Rojas R, Garberoglio C, Senthil M. Response to neoadjuvant treatment is influenced by grade in gastric cancer. Am Surg 2019;85:1419-1422; PMID:31908230.
51. Grossi S, Lin A, Wong A, Namm J, Senthil M, Gomez N, Reeves ME, Garberoglio C, Solomon N. Costs and complications: Delayed gastric emptying after pancreaticoduodenectomy. Am Surg 2019;85:1423-1428; PMID: 31908231.
52. Mudgway R, Chavez de Paz Villanueva C, Lin AC, Senthil M, Garberoglio CA, Lum SS. The impact of primary tumor surgery on survival in HER 2 positive stage IV breast cancer patients in the current era of targeted therapy. Ann Surg Oncol 2020; 27:2711-2720; PMID:32157524.
53. Selleck M, Senthil M. ASO Author reflections: Using the gastric cancer peritoneal carcinomatosis risk score to inform surveillance and treatment. Ann Surg Oncol 2020;27:248-249; PMID: 31659634.
54. Ji L, Selleck MJ, Morgan JW, Xu J, Babcock BD, Shavlik D, Wall NR, Langridge WH, Lum SS, Garberoglio CA, Reeves ME, Solomon N, Namm JP, Senthil M. Gastric cancer peritoneal carcinomatosis risk score. Ann Surg Oncol 2020;27:240-247; PMID: 31346896.
55. Dupont E, Tsangaris T, Garcia-Cantu C, Howard-McNatt M, Chiba A, Berger AC, Levine EA, Gass JS, Gallagher K, Lum SS, Martinez RD, Willis AI, Pandya SV, Brown EA, Fenton A, Mendiola A, Murray M, Solomon NL, Senthil M, Ollila DW, Edmonson D, Lazar M, Namm JP, Li F, Butler M, McGowan NE, Herrera ME, Avitan YP, Yoder B, Walters LL, McPartland T, Chagpar AB. Resection of cavity shave margins in stage 0-III breast cancers patients undergoing breast conserving surgery. Ann Surg 2021;273:876-881; PMID 31290763.
56. Chicago Consensus Working Group. The Chicago consensus guidelines for peritoneal surface malignancies: Introduction. Ann Surg Oncol 2020 ; 27:1737-1740; PMID:32285277.
57. Chicago Consensus Working Group. The Chicago consensus guidelines on peritoneal surface malignancies: Standards. Ann Surg Oncol 2020; 27:1743-1752; PMID:32285276.
58. Chicago Consensus Working Group. The Chicago consensus on peritoneal surface malignancies: Management of Appendiceal Neoplasms. Ann Surg Oncol 2020;27:1753-1760; PMID:32285275.
59. Chicago Consensus Working Group. The Chicago consensus on peritoneal surface malignancies: Management of Neuroendocrine Tumors. Ann Surg Oncol 2020;27:1788-1792; PMID:32285274.
60. Chicago Consensus Working Group. The Chicago consensus on peritoneal surface malignancies: Management of peritoneal mesothelioma. Ann Surg Oncol 2020; 27: 1774-1779; PMID:32285273.
61. Chicago Consensus Working Group. The Chicago consensus on peritoneal surface malignancies: Palliative care considerations. Ann Surg Oncol 2020;27:1798-1804; PMID:32285272.
62. Chicago Consensus Working Group. The Chicago consensus on peritoneal surface malignancies: Management of Ovarian Neoplasms. Ann Surg Oncol 2020;27:1780-1787; PMID:32285271.
63. Chicago Consensus Working Group. The Chicago consensus on peritoneal surface malignancies: Management of colorectal metastases. Ann Surg Oncol 2020;27:1761-1767; PMID:32285270.
64. Chicago Consensus Working Group. The Chicago consensus on peritoneal surface malignancies: Management of gastric metastases. Ann Surg Oncol 2020;27:1768-1773; PMID:32285269.
65. Chicago Consensus Working Group. The Chicago consensus on peritoneal surface malignancies: Management of desmoplastic round cell tumor, breast, and gastrointestinal stromal tumors. Ann Surg Oncol 2020;27:1793-1797; PMID:32285268.
66. Chicago Consensus Working Group. The Chicago consensus on peritoneal surface malignancies: Management of Peritoneal mesothelioma. Cancer 2020;126:2547-2552; PMID: 32282077.
67. Chicago Consensus Working Group. The Chicago consensus on peritoneal surface malignancies: Management of gastric metastases. Cancer 2020;126:2541-2546; PMID: 32282074.
68. Chicago Consensus Working Group. The Chicago consensus on peritoneal surface malignancies: Management of Appendiceal Neoplasms. Cancer 2020;126:2525-2533; PMID:32282073.
69. Chicago Consensus Working Group. The Chicago consensus on peritoneal surface malignancies: Management of desmoplastic round cell tumor, breast, and gastrointestinal stromal tumors. Cancer 2020;126:2566-2570; PMID 32282072.
70. Chicago Consensus Working Group. The Chicago consensus on peritoneal surface malignancies: Management of colorectal metastases. Cancer 2020;126:2534-2540; PMID: 32282070.
71. Chicago Consensus Working Group. The Chicago consensus on peritoneal surface malignancies: Management of Neuroendocrine Tumors. Cancer 2020;126:2561-2565; PMID:32282069.
72. Chicago Consensus Working Group. The Chicago consensus on peritoneal surface malignancies: Management of Ovarian Neoplasms. Cancer 2020;126:2553-2560; PMID: 32282068.
73. Chicago Consensus Working Group. The Chicago consensus guidelines on peritoneal surface malignancies: Standards. Cancer 2020 ;126:2516-2524; PMID: 32282066.
74. Chicago Consensus Working Group. The Chicago consensus guidelines for peritoneal surface malignancies: Introduction. Cancer 2020; 126:2510-2512; PMID: 32282062.
75. Chicago Consensus Working Group. The Chicago consensus on peritoneal surface malignancies: Palliative care considerations. Cancer 2020;126:2571-2576; PMID: 32282059.
76. Choi AH, Farzaneh C, Kejriwal N, Calidas A, Cordero-Caban K, Roman M, Kwong MLM, Selleck MJ, Pigazzi A, Jafari D, Senthil M. Rate of peritoneal carcinomatosis in surgically resected Stage II and III colon cancer. Ann Surg Onc 2020;27:4943-4948; PMID: 32535867.
77. Choi AH, Senthil M. ASO Author reflections: Real- World incidence of peritoneal carcinomatosis after colon resection and why it matters. Ann Surg Oncol 2020; 27:4949; PMID; 32627117.
78. Choi AH, Ji L, Babcock B, Ramos V, Kwong MLM, Morgan JW, Selleck MJ, Langridge WHR, DeLeon M, Wall NR, Lum S, Pigazzi A, Dayyani F, Senthil M. Peritoneal carcinomatosis in Gastric cancer: Are Hispanics at higher risk? J Surg Oncol 2020;122:1624-1629; PMID:32901938.
79. Howard-McNatt M, Dupont E, Tsangaris T, Garcia-Cantu C, Chiba A, Berger AC, Levine EA, Gass JS, Ollila DW, Chagpar AB; SHAVE2 Group. Impact of cavity Shave margin on margin status in patients with pure ductal carcinoma-in situ. J Am Coll Surg 2021;232:373-378; PMID:33346081.
80. Kabagwira J, Gonda A, Vallejos P, Babcock B, Langridge WHR, Senthil M, Wall NR. Optimization of blood handling for plasma extracellular vesicle isolation for clinical studies. J of Nanopart res 2021;23;65. https://doi.org/10.1007/s11051-021-05169-6. Collaborator, performed research & assisted with preparation of manuscript
81. Senthil M. Quality -of -life assessment in patients undergoing palliative chemotherapy: Call for action. Ann Surg Oncol 2021; 28:7-8; PMID: 33140253.
82. Are C, Senthil M, Jayaryaman S, Wenos C, Pramesh CS, D'Ugo D, Charles A. Promoting surgical research in global south. Surgery 2021; 170(5): 1587-1588; PMID:33712308.
83. Sullivan B, Qazi A, Senthil M. Cancer screening programs in low-and middle-income countries: strategies for success. Ann Surg Onc 2021; 28(12):6918-6919; PMID:34296357
84. Chagpar AB, Howard-McNatt M, Chiba A, Levine EA, Gass JS, Gallagher K, Lum S, Martinez R, Willis AL, Fenton A, Solomon NL, Senthil M, Edmonson D, Namm JP, Walters L, Brown E, Murray M, Ollilia D, Dupont E, Garcia-Cantu C. Factors affecting time to surgery in breast cancer patients. Am Surg 2021, Nov 3 EPUB; PMID 34732082.
85. Zhang S, Brazel D, Kumar P, Schafer LN, Eidenschink B, Senthil M, Dayyani F. Utility of tumor-informed circulating tumor DNA in the clinical management of gastrointestinal malignancies. J Gastrointest Oncol 2021; Dec 26:2643-2652. PMID 35070394.
86. Dayyani F, Smith BR, Nguyen NT, Daly S, Hinojosa MW, Seyedin SN, Kuo J, Samarasena JB, Lee JG, Taylor TH, Cho MT, Senthil M. Phase Ib feasibility trial of response adjusted neoadjuvant therapy in gastric cancer (RANT-GC). Future Oncol 2022;18(21):2615-2622. PMID -35603638.
87. Vallejos PA, Fuller RN, Kabagwira J, Kwong ML, Gonda A, McMullen JRW, Le N, Selleck MJ, Miller LD, Perry CC, Senthil M, Wall NR. Exosomal proteins as a source of biomarker in colon cancer peritoneal carcinomatosis- A pilot study. Proteomics Clin Appl. 2022 Oct 11:e2100085. doi: 10.1002/prca.202100085. Online ahead of print. PMID: 36217952.
88. Young S, Ostowari A, Yu J, Eng OS, Dayyani F, Senthil M. Role of Cytoreductive surgery and intraperitoneal chemotherapy in gastric cancer. Clin Adv Hematol Oncol. 2022 Nov;20(11):673-682.PMID: 36331405.
89. Young S, Yu J, Senthil M. Routine Omentectomy during Cytoreductive Surgery for peritoneal surface malignancies. Ann Surg Oncol. 2022 Dec 7. doi: 10.1245/s10434-022-12872-8. Online ahead of print. PMID: 36479660.
90. Yu J, Sullivan BG, Senthil GN, Gonda A, Dehkordi-Vakil F, Campos B, Dayyani F, Senthil M. Prevalence of primary liver cancer is affected by place of birth in Hispanic people residing in the United States: All of Us Research Program report. Am Surg. 2022 Oct;88(10):2565-2571..PMID: 35854430.
91. Sullivan BG, Lo A, Yu J, Gonda A, Dehkordi-Vakil F, Dayyani F, Senthil M. Circulating tumor DNA is unreliable to detect somatic gene alterations in peritoneal carcinomatosis. Ann Surg Oncol. 2023 Jan;30(1):278-284. PMID- 35980549.
92. Sullivan BG, Dayyani F, Senthil M. ASO Author Reflections. Challenges of Circulating tumor DNA in the management of gastrointestinal peritoneal carcinomatosis. Ann Surg Oncol. 2023 Jan;30(1):285-286. PMID - 36100836.
93. Dayyani F, Senthil M. Spontaneous fluctuation of tumor-informed circulating tumor DNA at low levels. JCO Precis Oncol. 2022 Jul;6:e2200177. doi: 10.1200/PO.22.00177.PMID: 35834756
94. Sullivan BG, Lo A, Yu J, Gonda A, Dehkordi-Vakil F, Dayyani F, Senthil M. ASO Visual Abstract. Circulating tumor DNA is unreliable to detect somatic gene alterations in peritoneal carcinomatosis. Ann Surg Oncol. 2023 Jan;30(1):287-288. PMID - 36209325.
95. Yu J, Ostowari A, Gonda A, Mashayekhi K, Dayyani F, Hughes CCW, Senthil M. Exosomes as a source of biomarkers for gastrointestinal cancers. Cancers (Basel). 2023 Feb 16;15(4):1263. doi: 10.3390/cancers15041263. PMID: 36831603.
96. Gonda A, Senthil M. ASO author reflections: Liquid biopsy in gastrointestinal cancers- role of exosomes. Ann Surg Oncol. 2023 Mar 1. doi: 10.1245/s10434-023-13270-4. Online ahead of print. PMID: 36856910.
97. Vallejos PA, Gonda A, Yu J, Sullivan BG, Ostowari A, Kwong ML, Choi A, Selleck MJ, Kabagwira J, Fuller RN, Gironda DJ, Levine EA, Hughes CCW, Wall NR, Miller LD, Senthil M. Plasma exosome gene signature differentiates colon cancer from healthy controls. Ann Surg Oncol. 2023 Mar 2. doi: 10.1245/s10434-023-13219-7. Online ahead of print. PMID 36864326.
98. Senthil M, Dayyani F. Phase II clinical trial of sequential systemic therapy and intraperitoneal paclitaxel in gastric and gastroesophageal junction peritoneal carcinomatosis - STOPGAP trial. BMC Cancer. 2023; Mar 4;23(1):209. doi: 10. PMID: 36870941
99. Kaakour D, Ward G, Senthil M, Dayyani F. Durable response after repeat cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in a patient with extensive mucinous adenocarcinoma of the appendix. Diseases. 2023 Apr 6;11(2):60. doi: 10.3390/diseases11020060. PMID 37092442.
100. Hanse EA, Wang T, Tifrea D, Senthil M, Kim AC, Kong M, Eng OS. A novel assessment of metabolic pathways in peritoneal metastases from low grade appendiceal mucinous neoplasms. Ann Surg Oncol. 2023 May 6. doi: 10.1245/s10434-023-13587-0. Online ahead of print. PMID 37149550.
101. Yu J, Sullivan BG, Nguyen NT, Hohmann SF, Harris AH, Micic D, Turaga KK, Senthil M, Eng OS. Readmission and disposition in patients with malignant bowel obstructions following gastrostomy tube. Am Surg. 2023 May 31:31348231180915. doi: 10.1177/00031348231180915. Online ahead of print. PMID 37257144.
102. Senthil M, Dayyani F. Role of iterative normothermic intraperitoneal paclitaxel combined with systemic chemotherapy in the management of gastric peritoneal carcinomatosis. Ann Surg Oncol. 2023 Sep 8. doi: 10.1245/s10434-023-14258-w. Online ahead of print. PMID 37684365.
103. Krouse RS, Anderson GL, Arnold KB, Thomson CA, Nfonsam VN, Al-Kasspooles MF, Walker JL, Sun V, Alvarez Secord A, Han ES, Leon-Takahashi AM, Isla-Ortiz D, Rodgers P, Hendren S, Sanchez Salcedo M, Laryea JA, Graybill WS, Flaherty DC, Mogal H, Miner TJ, Pimiento JM, Kitano M, Badgwell B, Whalen G, Lamont JP, Guevara OA, Senthil M, Dewdney SB, Silberfein E, Wright JD, Friday B, Fahy B, Anantha Sathyanarayana S, O'Rourke M, Bakitas M, Sloan J, Grant M, Deutsch GB, Deneve JL. Surgical versus non-surgical management of patients with malignant bowel obstruction: a pragmatic comparative effectiveness trial. Lancet Gastroenterol Hepatol. 2023 Oct;8(10):908-918. doi: 10.1016/S2468-1253(23)00191-7. Epub 2023 Aug 1. PMID 37541263.
104. Chandrakanth Are, Shilpa S Murthy, Richard Sullivan, Makayla Schissel, Sanjib Chowdhury, Olesegun Alatise, Daniel Anaya, Madhuri Are, Charles Balch, David Bartlett, Murray Brennan, Lydia Cairncross, Matthew Clark, S V S Deo, Vikas Dudeja, Domenico D’Ugo, Ibtihal Fadhil, Armando Giuliano, Satish Gopal, Lily Gutnik, Andre Ilbawi, Pankaj Jani, Peter Kingham, Laura Lorenzon, Premila Leiphrakpam, Augusto Leon, Hector Martinez-Said, Kelly McMasters, David O Meltzer, Miriam Mutebi, Zafar Nabeel, Vibhavari Naik, Lisa Newman, Alexandre Ferreira Oliveira, Do Joong Park, C S Pramesh, Saieesh Rao, T Subramanyeshwar Rao, Enrique Rocha Bargallo, Anya Romanoff, Anne F Rositch, Isabel Rubio, Heber Salvador de Castro Ribeiro, Eman Sbaity, Maheswari Senthil, Lynette Smith, Masakazi Toi, Kiran Turaga, Ujwal Yanala, Cheng-Har Yip, Ashraf Zaghloul, Benjamin O Anderson. Global Cancer Surgery: pragmatic solutions to improve cancer surgery outcomes worldwide. Lancet Oncol. 2023 Dec;24(12):e472-e518. doi: 10.1016/S1470-2045(23)00412-6. Epub 2023 Nov 2. PMID 37924819.
105. Sedighim S, Khan A, Li AY, Tajik F, Radhakrishnan VK, Eng O, Turaga K, Senthil M. Adoption of cytoreductive surgery in the management of peritoneal carcinomatosis: Global trends. J Surg Oncol. 2023 Nov;128(6):1021-1031. doi: 10.1002/jso.27448. PMID 37818906.
106. Chen AM, Garcia AD, Alexandrescu M, Truong A, Senthil M. Effect of same-day appointment initiative on access- related benchmarks in radiation oncology. Pract Radiat Oncol. 2024 Jan-Feb;14(1):12-19. doi: 10.1016/j.prro.2023.08.010. Epub 2023 Sep 23. PMID 37747390.
107. Sedighim S, Senthil M. Response to editor-" Elevating Standards: A Comprehensive model for peritoneal surface malignancy management in developing health care systems". J Surg Oncol. 2024 Mar;129(3):662. doi: 10.1002/jso.27538. Epub 2023 Dec 4. PMID 38044719.
108. Kabagwira J, Fuller RN, Vallejos PA, Sugiono CS, Andrianarijaona VM, Chism JB, O'Leary MP, Molina DC, Langridge W, Senthil M, Wall NR. Amplifying curcurmin's anti-tumor potential: A heat driven approach in colorectal cancer treatment. Onco Targets Ther. 2024 Jan 30;17:63-78. doi: 10.2147/OTT.S448024. eCollection 2024. PMID 38313386.
109. Li AY, Sedighim S, Tajik F, Khan AM, Radhakrishnan VK, Dayyani F, Senthil M. Regional therapy approaches for gastric cancer with limited peritoneal carcinomatosis. J Surg Oncol 2024; Jan 26. doi: 10.1007/s12029-023-00994-5. Online ahead of print. PMID 38277055.
110. Zohar N, Nevler A, Esquivel J, Yeo CJ, Benvenisti H, Elbaz N, Assaf D, Mor E, Bowne WB, Badgwell BD, Baratti D, Berger Y, Berri RN, Bhatt A, Bowne WB, Guiral DC, Cusack JC, Dineen SP, Esquivel, Gangi A, Goere D, Goodman MD, Guschin VV, Gutman M, Hanna NN, Hingh I, Hoffman A, Johnston FM, Labow DM, Lambert LA, Lee B, Levine EA, Lowy AM, Moran BJ, Morris DL, Nash GM, Nevler A, Nizri E, Qudaror CA, Raoof M, Senthil M, Somashekhar SP, Sugarbaker PH, Turaga KK, Woo Y, Yonemura Y. International TOO HIPEC Consensus Group. International expert consensus on defining textbook oncologic outcomes after cytoreductive surgery in colorectal peritoneal carcinomatosis. J Am Coll Surg. 2024 Apr 1;238(4):387-401Epub 2023 Dec 27.PMID: 38149780
111. Fisher OM, Brown C, Esquivel J, Larsen SG, Liauw W, Alzahrani NA, Morris DL, Kepenekian V, Sourrouille I, Dumont F, Tuech JJ, Ceribelli C, Doussot B, Sgarbura O, Alhosni M, Quenet F, Glehen O, Cashin PH, Flatmark K, Graf W, Takala H, Lowy AM, Chua T, Pelz J, Baratti D, Baumgartener JM, Berri R, Bretcha-Boix P, Deraco M, Flores-Ayala G, Gomez-Portilla A, Gonzalez-Moreno S, Goodman M, Halkia E, Kusamura S, Moller M, Passot G, Pocard M, Salti G, Sardi A, Senthil M, Spiloitis J, Torres-Meler J, Turaga K, Bereder JM, Bernard JL, Bakrin N, Carrere S, Coget J, Cotte E, Facy O, Gelli M, Gilly FN, Ortega-Deballaon P, Passot G, Rat P, Rousset P, Thibaudeau E, Vaudoyer D. Peritoneal Surface Oncology Group International (PSOGI), Nordic Peritoneal Oncology Group (NPOG), American Society for Peritoneal Surface Malignancy (ASPSM) and BIG-RENAPE Groups. Hyperthermic intraperitoneal chemotherapy in colorectal cancer. BJS Open. 2024 May 8;8(3) PMID: 38722737
112. Ostowari A, Hasjim BJ, Lim L, Yu J, Nguyen L, Dayyani F, Zell J, Cho M, Senthil M, Eng OS. Clinical outcomes in patients with Krukenberg tumors in colorectal cancers. J Surg Res. 2024 Jul;299:343-352. Epub 2024 May 24.PMID: 38795557
113. Nee K, Hosohama L, Alobuia W, Kim AC, Senthil M, Eng OS. Defining Colorectal Cancer cells on a single cell level reveals LGR5+ proliferative stem cell expression in peritoneal metastasis. Ann Surg Oncol 2024; 10:6369-6372. PMID 39014167
114. Khorfan R, Sedighim S, Caba-Molina D, TRan TB, Senthil M, O'Leary MP, Eng OS. Improved survival with immunotherapy for microsatellite unstable colorectal cancer with peritoneal metastases. J Surg Oncol 2024. 130:613-621. PMID 39082605
115. Perisa Ruhi-Williams, Jingjing Yu, Christian de Virgilio, Shahrzad Bazargan-Hegazi, Helen E. Ovsepyan, Steven D. Wexner, Katharine A. Kirby, Fatemeh Tajik, Angelina Lo, Aya Fattah, Farin F. Amersi, Kristine E. Calhoun, Lisa A. Cunningham, Paula I. Denoya, Henry R. Govekar, Sara M. Gross, Jukes P. Namm, V. Prasad Poola, Robyn E. Richmond, Christine H. Rohde, Mayank Roy, Tara A. Russell, Nicola Sequeira, Anaar E. Siletz, Tiffany N. Tanner, Brian T. Valerian, Maheswari Senthil. Mentorship across academic programs in Surgery( MAAPS) study- Challenges of Junior surgical faculty. JAMA Surg 2024; 159:1252-1260.. PMID: 39230925
116. Senthil M, Dayyani F. Cytoreduction in gastric cancer peritoneal carcinomatosis: Selection is key. Ann Surg Oncol. 2024:13:8491-8493. PMID: 39394488
117. Sedighim S, Khorfan R, Shin J, Khan A, Tang YL, Li AY, Senthil M, O'Leary MP, Eng OS. Disparities in palliative care treatment utilization in metastatic colorectal cancer patients. Ann Surg Oncol 2024 Nov 22 doi:10.1245/s10434-024-16577. PMID 39576451
118. Nguyen M, Nahmias J, Eng OS, Senthil M, Barrios C, Dolitch M, Lekawa M, Grigorian A. Trauma patients with metastatic cancer undergoing emergent surgery: A matched cohort analysis. Surg Open SCi 2024; 17( 20): 184-188. PMID 39886065
119. Bansal VV, Witmer HDD, Childers CP, Su DG, Turaga KK, RVU Writing Group; PSM Consortium Group. When Benchmarks Fail Us: A Case Study in Cytoreductive Surgery. Ann Surg Oncol 2025; 32 (1):93-23.Epub 2024, Oct 26. PMID 39460818
120. Khorfan R, Sedighim S, Caba-Molina D, TRan TB, Senthil M, O'Leary MP, Eng OS. National trends and outcomes in cytoreductive surgery for colorectal cancer with peritoneal metastasis before and after PRODIGE 7. Ann Surg Oncol 2025; 32(3):1422-1424. PMID 39572948
121. Tajik F, Eyob B, Khan AM, Radhakrishnan VK, Senthil M. Iterative intraperitoneal chemotherapy in gastric peritoneal carcnomatosis. Cancers ( Basel) 2025 Jan 17(2):289 doi: 10.3390/cancers17020289. PMID 39858070.
BOOK CHAPTERS
1. M Senthil, BJ Rupani , JH Jabush, EA Deitch. Principles And Practice of Nutritional Support In Surgical Patients. Acute Care Surgery. Eds. Britt LD, Trunkey DD, Organ CH, Feliciano DV, 2007, Springer Verlag
2. M Senthil, J Deneve. ACS operative standards Vol II – Peritonectomy Procedures. Publication 2021.
3. Sullivan B, Karalis JD, Wang SC, Senthil M. Gastric cancer epidemiology, genetics, and screening. Association of Foregut Surgery Textbook. Published 2023.
4. Yu J, Sullivan B, Swentek L, Senthil M. Miscellaneous Rare Malignancies – Pseudomyxoma Peritonei. Oncologic Surgical Emergencies: A Practical Guide for the General Surgeon. Published 2023.
Grants
1R01CA290115-1- A vascularized microphysiological system for modeling peritoneal carcinomatosis.
Principal Investigator (20% effort) $3,116,345,
2024-2029
R01CA258692-01A1 - Establishing the Repertoire of Actionable Alterations in Appendiceal Adenocarcinoma.
Co- Investigator (5% effort) $ 2,260,000,
2021-2026
NIH- CTSA programs ICTS grant
Exosomal PD-L1 and gene signature to predict response
To immune checkpoint inhibition in gastrointestinal malignancies
Principal Investigator $ 25,000, 2022-2023
Professional Societies
Society of Surgical Oncology
American College of Surgeons
Alpha Omega Alpha
American Association of Cancer Research
Association of Women Surgeons
Pacific Coast Surgical Association
Arnold P. Gold Humanism foundation
American Association of Cancer Research
Other Experience
Program Director - Surgical Oncology Fellowship
Loma Linda University 2015—2020
Loma Linda University 2015—2020
Chief, Surgical Oncology
Loma Linda University 2014—2020
Loma Linda University 2014—2020
Director of Peritoneal Malignancy Program
Loma Linda University 2010—2020
Loma Linda University 2010—2020
Program Director - Surgical Oncology Fellowship
University of California Irvine 2021—2024
University of California Irvine 2021—2024
Medical Director
UC Irvine Center for Clinical Research 2022—2025
UC Irvine Center for Clinical Research 2022—2025
Graduate Programs
Surgery-General
Research Centers
STERN Center for Clinical Trials
Link to this profile
https://faculty.uci.edu/profile/?facultyId=6754
https://faculty.uci.edu/profile/?facultyId=6754
Last updated
07/13/2025
07/13/2025