Associate Professor, Dermatology
School of Medicine

Director of Resident Research Education, Dermatology
School of Medicine

Vitiligo, Melanocytic nevi, Melanoma

2023 American Academy of Dermatology Skin Care For Developing Countries Grant Project Sponsor
2022 American Skin Association Calder Research Scholar Award Vitiligo/Pigment Disorders
2022 UC Irvine School of Medicine Outstanding Early-Career Faculty Research Award
2021 Vitiligo International Symposium Best Oral Presentation Award
2020 UC Irvine Institute of Clinical and Translational Science KL-2 Scholar
2019 Pan American Society for Pigment Cell Research Travel Award
2017 CalDerm Symposium Resident Symposium Presenter
2017 Society of Investigative Dermatology’s Resident Retreat
2015 Eugene Sydney Bereston Award for Excellence in Dermatology
2015 Charles L. Wisseman, Jr. Award for Excellence in Microbiology & Immunology
(University of Maryland School of Medicine)
2013 Graduate Program in Life Sciences Molecular Microbiology & Immunology program Ollie Eylar Award Winner
2011 University of Maryland GPILS Outstanding PhD Scholar Award Winner
2011 Biolegend Travel Award Recipient
2008 Medical Student Research Day Oral Presentation Winner
2008 American Gatroenterological Association Student Research Fellowship
2007 John Hopkins University Masters Scholarship

I am a Dermatology trained physician scientist interested in understanding tissue homeostatic mechanisms in melanocyte-related disorders in the skin. I was in the Medical Scientist Training Program at the University of Maryland School of Medicine where I completed my PhD training studying the gut immune response to Helicobacter pylori in Dr. Thomas Blanchard’s laboratory. I completed my Dermatology Residency training at UCI and Board Certification in July 2019. Currently, I am an assistant professor and the first fellow in the Physician Scientist Fellowship Track in the Department of Dermatology. I am a KL-2 scholar at the University of California Irvine Institute of Clinical and Translational Research with protected research time and funding.

PUBLICATIONS
1. Yale K, Roux J, Shiu J. A cross-sectional study of cutaneous immune-related adverse effects in Hispanic patients after immune checkpoint inhibitor use of cancer therapy. J Am Acad Dermatol. 2025 Jan;92(1):168-170. PMID: 39341356.
2. Xiao J, Shiu J, Chen CF, Wu J, Zhou P, Telang SS, Rolando RV, Nie Q, Lander AD, Ganesan AK. Uncovering Minimal Pathways in Melanoma Initiation. bioRxiv. 2024 Jan 9:2023.12.08.570336. PMID: 38106189.
3. Suh S, Kassels A, Hinchee-Rodriguez K, Shiu J, Kraus CN. Response to Arbache et al., "Comment on 'Vulvar lichen sclerosus and vitiligo: Overlap and clinical features'". J Am Acad Dermatol. 2024 Sep;91(3):e67. PMID: 38692434.
4. Sun P, Kraus CN, Zhao W, Xu J, Suh S, Nguyen Q, Jia Y, Nair A, Oakes M, Tinoco R, Shiu J, Sun B, Elsensohn A, Atwood SX, Nie Q, Dai X. Single-cell and spatial transcriptomics of vulvar lichen sclerosus reveal multi-compartmental alterations in gene expression and signaling cross-talk. 2024 Aug 17:2024.08.14.607986. PMID: 39211101.
5. Nguyen B, Shiu J. Analyzing Fitzpatrick skin type distribution of vitiligo on Instagram. Int J Womens Dermatol. 2024 Jun 12;10(2):e157. PMID: 38873620.
6. Esse I, Hinchee-Rodriguez K, Kassels A, Shiu J, Kraus CN. Vulvar lichen sclerosus and vitiligo: Overlap and clinical features. J Am Acad Dermatol. 2023 Oct;89(4):839-841. PMID: 37328003.
7. Shiu J, Lentsch G, Polleys CM, Mobasher P, Ericson M, Georgakoudi I, Ganesan AK, Balu M. Non-invasive Imaging Techniques for Monitoring Cellular Response to Treatment in Stable Vitiligo. 2023 Aug 17:2023.08.15.553419. PMID: 37645823.
8. Shobajo M, Abdulkadir S, Kraus CN, Shiu J. Anogenital Skin of Color Images are Underrepresented in Dermatology, Gynecology, and Urology Educational Resources. Int J Womens Dermatol. 2023 Jul 6;9(3):e090. PMID: 37424795.
9. Gu J. Jian H, Wei C, Shiu J, Ganesan AK, Zhao W, Hedde PK. A Low-Cost Modular Imaging System for Rapid, Multiplexed Immunofluorescence Detection in Clinical Tissues. Int J Mol Sci. 2023 Apr 10;24(8):7008. PMID: 37108170.
10. Shin L, Smith J, Shiu J, Elensohn AN, Kraus CN. Association of lichen sclerosus and morphea with immune checkpoint therapy: a systematic review. Int J Womens Dermatol. 2023 Jan 19;19(1):e070.
11. Gu J, Jian H, Wei C, Shiu J, Ganesan A, Zhao W, Hedde PN. A Low-Cost Modular Imaging System for Rapid, Mutliplexed Immunofluorescnece Detection in Clinical Tissues. Int J Mol Sci. 2023 Apr 10;24(8):7008.
12. Shiu J, Zhang L, Lentsch G, Flesher JL, Jin S, Polleys C, Jo SJ, Mizzoni C, Mobasher P, Kwan J, Ruis-diaz F, Tromberj BJ, Georgajoudi I, Nie Q, Balu M, Ganesan AK. Multimodal Analyses of Vitiligo Skin Identifies Tissue Characteristics of Stable Disease. JCI Insight. Jun 2: e154595. Doi: 10.1172.jci.insight.154585
13. Vu T, Vallmitjana, Gu J, La K, Xu Q, Flores J, Zimak J, Shiu J, Hosohama L, Wu J, Douglas C, Waterman M, Ganesan A, Hedde PN, Gratton E, Zhao W. Spatial transcriptomics using combinatorial fluorescence spectral and lifetime encoding, imaging and analysis. Nature Communications. 2022 Jan 10,13(1):169. Doi:10.1038/s41467-021-27798-0.
14. Elsensohn AN, Thomas LW, Shiu J, Smith J. Lower Leg Hyperpigmentation in MYH9-Related Disorder. Cutis. 2022 Jan; 109(1):E39-40.
15. Shiu J, Lander AD. When Oncogenes Do Not Cause Cancer. Elife. 2021 Dec 9;10:e4912.
16. Lehmer L, Choi F, Kraus C, Shiu J, de Feraudy S, Elsensohn AE. Histopathologic PD-L1 Tumor Expression and Prognostic Significance in Nonmelanoma Skin Cancers: A Systematic Review. Am J Dermatopathol. 2021 May 1;43(5)321-330.
17. Mobasher P, Shiu J, Lentsch G, Ganesan AK. Comparing the Efficact of 2 Different Harvesting Techniques for Melanocyte Keratinocyte Transplantation in Vitiligo. Dermatol Surg. 2021 May; 47(5):732-733.
18. Ruiz-Vega R, Chen CF, Razzak E, Vasudeva P, Krasieva TB, Shiu J, Caldwell MG, Yan H, Lowengrub J, Ganesan AK, Lander AD. Dynamics of nevus development implicate cell cooperation in the growth arrest of transformed melanocytes. Elife. 2020 Oct 13;9:e61026.
19. Zachary CMB, Belzer A Fackler NP, Shiu J, Smith J, Ghadially R. Facial psoriasis in a mask-like distribution. JAAD Case Rep. 2020 Nov 24;7:128-30.
20. Duffens A, Kraus CN, Elsensohn AN, Shiu J, Smith J. Ichthyosiform red-brown plaques on bilateral shins. JAAD Case Rep. 2020 Jul 12;6(9)”838-40.
21. Choi FD, Kraus CN, Elsensohn AN, Carley SK, Lehmer LM, Nguyen RT, Linden KG, Shiu J. PD-1 and PD-L1 inhibitors in the treatment of non-melanoma skin cancer: a systematic review. J Am Acad Dermatol. 2020 Feb; 82(2):440-459.
22. Lee K, Pouldar D, Shiu J, Elsensohn A, de Feraudy S. The histological spectrum of Talimogene laherparepvec (TVEC) injections—neutrophilic and chronic granulomatous dermatitis. J Cutan Path. 2019 Feb;46(2):165-7.
23. Hosking AM, Kraus CN, Elsensohn AN, Shiu J, de Feraudy S, Smith J. Ulcerated nodules in a sporotrichoid distribution. JAAD Case Rep. 2019;5(10):925-927.
24. Yale K, Elsensohn A, Shiu J, Amber K, Smith J. Erythematous papular rash with sparing of folds. JAAD Case Rep. 2019 Jan 25;5(2):135-7.
25. Elsensohn AN, Shiu J, Grove N, Hosking AM, Barr R, de Feraudy S. Distinguishing neurofibroma from desmoplastic melanoma: the value of p53. Am J of Surg Path. 2018; 42(3):372-75.
26. Shiu J, Thai M, Elsensohn AN, Nguyen NQ, Lin KY, Cassarino DS. A case series of primary cutaneous coccidioidomycosis after a record-breaking rainy season. JAAD Case Rep. 2018; 4(5): 412-414.
27. Chiang A, Shiu J, Elsensohn AN, Chapman L, Smith J. Classic Autoimmune Type 1 Diabetes Mellitus Following a case of drug reaction with eosinophilia and systemic symptoms (DRESS). JAAD Case Rep. 2018; 4(4): 295-297.
28. Thomas LW, Elsehsohn AN, Bergheim T, Shiu J, Ganesan A. Intramuscular steroids in the treatment of dermatologic disease: a systemic review. J Drugs in Dermatol. 2018; 17(3): 323-329.
29. Elsensohn AN, Getty S, Shiu J, de Feraudy S. Intradermal proliferative fasciitis on the ear occurring with chrondrodermatitis nodularis helicis. Am J of Dermatopath. 2018; 17(3):323-29.
30. Thomas LW, Elsensohn AN, Shiu J, de Feraudy S, Segal, F. Blaschkoid hyperkeratotic plaques in a hemi-distribution since infancy. JAAD Case Rep. 2018; 4(5):412-14.
31. Pouldar, D, Elsensohn AN, Ortenzio F, Shiu J, de Feraudy, S. Nodular vasculitis in a Crohn's disease patient on vedolizumab. Am J of Dermatopath.2018; 40(2): 139-141.
32. Wang L, Ni X, Yang BY, Shiu J, Zhang X, Xi L, Covington KR, Drummond J, Donehower LA, Doddapaneni H, Muzny DM, Gibbs RA, Wheeler DA, Duvic M. Genomic profiling of Sézary Syndrome reveals alteration of key T-cell signaling and differentiation genes. Nature Genetics. 2015; 47:1426-34.
33. Shiu J, Wang CL, Ellis RM, Duvic M. Hyper-IgE, Dermatitis and Staphylococcus aureus in an HIV-positive man. Journal of Infectious Diseases and Therapy 2015; 3(2).
34. Zawahir S, Li G, Banerjee A, Shiu J, Blanchard TG, Okogbule-Wonodi AC. Inflammatory and immune activation in intestinal myofibroblasts is developmentally regulated. J Interferon Cytokine Res. 2015 Jun 23.
35. Shiu J, Gaitens J, Squibb KS, Gucer PW, McDiarmid MA, Gaspari AA. Significance of Dermatologic Findings in a Cohort of Depleted Uranium Exposed Veterans of Iraqi Conflicts. Dermatitis 2015 May/June; 26(3):142-8.
36. Shiu J, Piazuelo BM, Ding H, Czinn S, Drakes ML, Basappa N, Banerjee A, Kobayashi KS, Fricke WF, Blanchard T. Gastric LTi cells promote lymphoid follicle formation but are limited by IRAK-M and do not alter microbial growth. Mucosal Immunology 2015 Jan 21. doi:10.1038/mi.2014.132.
37. Shiu J, Czinn S, Kobayashi KS, Sun Y, Blanchard T.IRAK-M expression limits dendritic cell activation and proinflammatory cytokine production in response to Helicobacter pylori. PLoS One 2013 Jun 11;8(6):e66914.
38. Ding H, Negrud JG, Blanchard TG, Zagorski BM, Li G, Shiu J, Xu J, Czinn SJ. Th1-mediated immunity against Helicobacter pylori can compensate for lack of Th17 cells and can protect mice in the absence of immunization. PLoS One 2013 Jul 11;8(7):e69384
39. Shiu J, Harberts E, Gaspari AA, Nickoloff BJ. Skin: Immunological Defense Mechanisms. (April 2013) Skin: Immunological Defence Mechanisms. In: eLS. John Wiley & Sons Ltd: Chichester http://www.els.net
40. Shiu J, Blanchard T. Dendritic Cell Function in the Host Response to H. pylori in the Gastric Mucosa. Pathogens & Disease. 2013 Feb. 67(1): 46-53.
41. Huang J, Birmingham CL, Shahnazari S, Shiu J, Zheng YT, Smith AC, Campellone KG, Heo WD, Gruenheid S, Meyer T, Welch MD, Ktistakis NT, Kim PK, Klionsky DJ, Brumell JH. Antibacterial autophagy uccors at PI(3)P-enriched domains of the endoplasmic reticulum and requires Rab1 GTPAse. Autophagy. 2011 Jan 4;7(1).
42. Shahnazari S, Yen WL, Birmingham CL, Shiu J, Namolovan A, Zheng YT, Nakayama K, Klionsky DJ, Brumell JH. A diacylglycerol-dependent signaling pathway contributes to regulation of antibacterial autophagy. Cell Host Microbe. 2010 Aug 18; 8 (2): 137-46.
43. Cully M, Shiu J, Muller WJ, Done S, Mak TW. TACC1 is an anti-apoptotic oncogene that promotes transformation and mammary tumorigenesis. Cancer Res. 2005 Nov 15;65(22):10363-70.

BOOK CHAPTERS:
1. Shiu J, Chen JK, Smith J. Angular Cheilitis. In: Treatment of Skin Disease. M Lebwohl, W Heymann, J Berth-Jones, I Coulson eds., Elsevier, 2020
2. Shiu J, Chen JK, Smith J. Geographic Tongue. In: Treatment of Skin Disease. M Lebwohl, W Heymann, J Berth-Jones, I Coulson eds., Elsevier
3. Amber KT, Shiu J, Ferris K, Grando SA. Role of Intravenous Immunoglobulin in Dermatologic Disorders, In: Biologic and Systemic Agents in Dermatology. PS Yamauchi ed., Springer International Publishing, 401- 423, 2018.
4. Shiu J, Gaspari AA. Toll-like Receptors, In: Clinical and Basic Immunodermatology. AA Gaspari, SK Tyring, D Kaplan eds., Springer International Publishing, 11-34, 2017.

Journal Articles, Peer-Reviewed (Submitted)
1. Shobajo M, Abdulkadir S, Kraus CN, Shiu J. Anogenital Skin of Color Images are Underrepresented in Dermatology, Gynecology, and Urology Educational Resources. Accepted to International Journal of Women's Dermatology.
2. Esse I, Hinchee-Rodriguez K, Kassels A, Shiu J, Kraus CN. Vulvar Lichen Sclerosus and Vitiligo: Overlap and Clinical Features. Accepted to JAAD.
3. Yale K, Shiu J. A Cross-sectional Study of Cutaneous Immune-Related Adverse Effects in Hispanic Patients after Immune Checkpoint Inhibitor Use for Cancer Therapy. Submitted to JAAD.
4. Saeed L, Lee B, Shiu J. Granuloma annulare-like cutaneous granulomatous mycosis fungoides : a case report. Submitted to Journal of Cutaneous Pathology.

Journal Articles, Peer-Reviewed (In Preparation)
1. Shiu J, Lentsch G, Polleys C, Mobasher P, Georgakoudi I, Ganesan AK, Balu M. Keratinocyte Metabolism Shifts in Stable Vitiligo Skin Corresponds to Treatment Responses.

05/01/2022-12/30/2022 | American Skin Association Calder Research Scholar Award Vitiligo/Pigment Cell Disorders | Title: Investigating the role of keratinocyte-derived signaling networks in vitiligo initiation | Shiu (PI)

05/01/2022-06/30/2022 | UCI Skin Biology Resource Center Seed Grant | Title: Defining keratinocyte metabolic changes in stable vitiligo treatment response | Shiu (PI)

04/01/2022-12/30/2023 | UCI Interim Covid-19 Research Recovery Program | Shiu (PI)

07/01/2020-06/30/2023 | UCI Institute for Clinical and Translational Science 5KL2TR1416-6 | Title: Elucidating the Role of Keratinocyte Metabolism in Vitiligo Persistence | Caizzo (PI), Shiu (Scholar)

02/01/2021-12/31/2022 | UCI Chao Family Comprehensive Cancer Center | Title: Why do melanomas in Latin X patients evade early detection? | Ganesan (PI), Balu (PI), Kelly (PI), Shiu (PI)

12/01/2020-11/30/2021 | UCI American Cancer Society Institutional Research Grant | Title: Elucidating the role of Oncostatin M-producint macrophages in melanoma tumorigenesis | Shiu (PI)

8/1/2023 | Title: Determining how local factors influence repigmentation in stable vitiligo | Shiu (PI)

3/1/2024 | Title: A Phase 3, Randomized, Placebo-Controlled, Double-Blind Study to Evaluate the Efficacy, Safety, and Tolerability of Upadacitinib in Adult and Adolescent Subjects with Non-segmental Vitiligo Who Are Eligible for Systemic Therapy | Shiu (PI)

5/1/2024 | Title: Elucidating Racial Differences in Vitiligo Presentation & Treatment Response | Shiu (PI)

6/1/2024 | Title: Why do Hispanic Patients Present with Late-Stage Melanoma at a Younger Age? | Shiu (PI)

American Academy of Dermatology

Women’s Dermatologic Society

Society of Investigative Dermatology

Medical Dermatologic Society

PanAmerican Society for Pigment Cell Research

Link to this profile
https://faculty.uci.edu/profile/?facultyId=6720

Last updated
01/16/2025