Seyed Ahmad Sajjadi

Picture of Seyed Ahmad Sajjadi
Associate Professor, Neurology
School of Medicine
Associate Professor, Pathology
School of Medicine
M.D., Tehran University of Medical Sciences, 2002
Ph.D., University of Cambridge, 2013, Neurosciences
Phone: 714-456-6808
University of California, Irvine

Irvine, CA 92697
Research Interests
Oldest old dementia, TDP-43 pathology, Alzheimer's Disease, Primary progressive aphasia, Frontotemporal dementia
Teng E, Manser PT, Pickthorn K, Brunstein F, Blendstrup M, Sanabria Bohorquez S, Wildsmith KR, Toth B, Dolton M, Ramakrishnan V, Bobbala A, Sikkes SAM, Ward M, Fuji RN, Kerchner GA; Tauriel Investigators. Safety and Efficacy of Semorinemab in Individuals With Prodromal to Mild Alzheimer Disease: A Randomized Clinical Trial. JAMA Neurol. 2022 Aug 1;79(8):758-767. doi: 10.1001/jamaneurol.2022.1375. PMID: 35696185; PMCID: PMC9194753.

Woodworth DC, Sheikh-Bahaei N, Scambray KA, Phelan MJ, Perez-Rosendahl M, Corrada MM, Kawas CH, Sajjadi SA. Dementia is associated with medial temporal atrophy even after accounting for neuropathologies. Brain Commun. 2022;4(2):fcac052. doi: 10.1093/braincomms/fcac052. eCollection 2022. PubMed PMID: 35350552; PubMed Central PMCID: PMC8952251.

Woodworth D, Scambray KA, Corrada MM, Kawas CH, Sajjadi SA (Senior author), Neuroimaging in the Oldest-old: A Review of the Literature; Journal of Alzheimer’s Disease (JAD) (IF: 3.9); 2021 May 10;. doi: 10.3233/JAD-201578. [Epub ahead of print] Review. PubMed PMID: 33998539.

Borders C, Sajjadi SA (Senior author); Diagnosis and Management of Cognitive Concerns in the Oldest Old, Current treatment options in neurology (IF: 3.5) 2021;23(3):10. doi: 10.1007/s11940-021-00665-5. Epub 2021 Mar 26. Review. PubMed PMID: 33786000; PubMed Central PMCID: PMC7994350

Eslami-Amirabadi M, Sajjadi SA (Senior author); The relation between Thyroid dysregulation and impaired cognition/behavior: An integrative review, Journal of Neuroendocrinology (IF: 2.89); 2021 Mar;33(3): e12948. doi: 10.1111/jne.12948. Review. PubMed PMID: 33655583; PubMed Central PMCID: PMC8087167.

Sajjadi SA (Corresponding author), Ash S, Cappa S. Glass half full: Preservation of Memory in Alzheimer-Related Primary Progressive Aphasia. Neurology (IF: 8.8) 2021 Feb 9;96(6):243-244. doi: 10.1212/WNL.0000000000011404. Epub 2021 Jan 13. PubMed PMID: 33441460.

Woodworth DC, Nguyen HL, Khan Z, Kawas CH, Corrada MM, Sajjadi SA (Senior author). Utility of MRI in the identification of hippocampal sclerosis of aging. Alzheimer's Dement. (IF: 17.2); 2020; 1-9.

Ingram RU, Halai AD, Pobric G, Sajjadi S, Patterson K, Lambon Ralph MA. Graded, multidimensional intra- and intergroup variations in primary progressive aphasia and post-stroke aphasia. Brain. (IF: 11.3); 2020 Oct 1;143(10):3121-3135. doi: 10.1093/brain/awaa245. PubMed PMID: 32940648; PubMed Central PMCID: PMC7586084.

Witbracht MG, Bernstein OM, Lin V, Salazar CR, Sajjadi SA, Hoang D, Cox CG, Gillen DL, Grill JD. Education and Message Framing Increase Willingness to Undergo Research Lumbar Puncture: A Randomized Controlled Trial. Front Med (Lausanne) (IF: 3.4). 2020;7: 493. doi: 10.3389/fmed.2020.00493. eCollection 2020. PubMed PMID: 33043024; PubMed Central PMCID: PMC7530193.

Lau WL, Fisher M, Greenia D, Floriolli D, Fletcher E, Singh B, Sajjadi SA, Corrada MM, Whittle C, Kawas C, Paganini-Hill A. Cystatin C, cognition, and brain MRI findings in 90+-year-olds. Neurobiol Aging. (IF: 4.4); 2020 Sep;93:78-84. doi: 10.1016/j.neurobiolaging.2020.04.022. Epub 2020 Apr 29. PubMed PMID: 32473464; PubMed Central PMCID: PMC7307913.

Duncan ES, Donovan NJ, Sajjadi SA (Senior author). Clinical Assessment of Characteristics of Apraxia of Speech in Primary Progressive Aphasia. Am J Speech Lang Pathol. (IF: 1.5); 2019 Aug 16;:1-13. doi: 10.1044/2019_AJSLP-CAC48-18-0225. [Epub ahead of print] PubMed PMID: 31419154.

Sheikh-Bahaei N, Manavaki R, Sajjadi SA, Priest AN, O'Brien JT, Gillard JH. Correlation of Lobar Cerebral Microbleeds with Amyloid, Perfusion, and Metabolism in Alzheimer's Disease. J Alzheimers Dis. (IF: 3.9); 2019;68(4):1489-1497. doi: 10.3233/JAD-180443. PubMed PMID: 30909210.

Sajjadi SA*, Trieu T*, Kawas CH, Nelson PT, Corrada MM. Risk factors of hippocampal sclerosis in the oldest old: The 90+ Study. Neurology (IF: 8.8). 2018 Nov 6;91(19):e1788-e1798. doi: 10.1212/WNL.0000000000006455. Epub 2018 Oct 12. PubMed PMID: 30315072; PubMed Central PMCID: PMC6251605. * Joint first authors

Sheikh-Bahaei N, Sajjadi SA, Manavaki R, McLean M, O'Brien JT, Gillard JH. Positron emission tomography-guided magnetic resonance spectroscopy in Alzheimer disease. Ann Neurol (IF: 9). 2018 Apr;83(4):771-778. PubMed PMID: 29518282.

Sheikh-Bahaei N, Sajjadi SA, Pierce AL. Current Role for Biomarkers in Clinical Diagnosis of Alzheimer Disease and Frontotemporal Dementia. Curr Treat Options Neurol (IF: 3.5). 2017 Nov 14;19(12):46. PubMed PMID: 29134465.

Hoffman P, Sajjadi SA, Patterson K, Nestor PJ. Data-driven classification of patients with primary progressive aphasia. Brain Lang (IF: 2.8). 2017 Nov; 174:86-93. PubMed PMID: 28803212; PubMed Central PMCID: PMC5626563.

Paganini-Hill A, Greenia DE, Perry S, Sajjadi SA, Kawas CH, Corrada MM. Lower likelihood of falling at age 90+ is associated with daily exercise a quarter of a century earlier: The 90+ Study. Age Ageing (IF: 4.5). 2017 Nov 1;46(6):951-957. PubMed PMID: 28369185.

Bennett IJ, Greenia DE, Maillard P, Sajjadi SA, DeCarli C, Corrada MM, Kawas CH. Age-related white matter integrity differences in oldest-old without dementia. Neurobiol Aging (IF: 4.4). 2017 Aug; 56:108-114. PubMed PMID: 28527525; NIHMSID: NIHMS878097; PubMed Central PMCID: PMC5647141.

Sheikh Bahaei N, Sajjadi S, Manavaki R, Gillard JH. Imaging Biomarkers in Alzheimer’s Disease: A Practical Guide for Clinicians. Journal of Alzheimer's disease reports. 2017 July; 1(1):71-88.

Grill JD, Apostolova LG, Bullain S, Burns JM, Cox CG, Dick M, Hartley D, Kawas C, Kremen S, Lingler J, Lopez O, Mapstone M, Pierce AL, Rabinovici, G, Roberts GS, Sajjadi SA, Teng E, Karlawish J. Communicating mild cognitive impairment diagnoses with and without amyloid imaging. Alzheimers Res Ther (IF: 5.0). 2017 May 4;9(1):35. PubMed PMID: 28472970; PubMed Central PMCID: PMC5418690.

Sajjadi SA, Sheikh-Bahaei N, Cross J, Gillard JH, Scoffings D, Nestor PJ. Can MRI Visual Assessment Differentiate the Variants of Primary-Progressive Aphasia?. AJNR Am J Neuroradiol (IF: 3.7). 2017 May;38(5):954-960. PubMed PMID: 28341715.

Sajjadi SA, Nestor PJ. Reply. AJNR Am J Neuroradiol (IF: 3.7). 2017 Sep;38(9): E64. PubMed PMID: 28546245.

Billette O, Sajjadi SA, Patterson K, Nestor PJ. SECT and MAST: new tests to assess grammatical abilities in primary progressive aphasia. Aphasiology. 2015; 29(10):1135-1151.

Sajjadi SA, Patterson K, Nestor PJ. Logopenic, mixed, or Alzheimer-related aphasia?. Neurology. 2014 Apr 1;82(13):1127-31. PubMed PMID: 24574548.

Diaz-de-Grenu LZ, Acosta-Cabronero J, Chong YF, Pereira JM, Sajjadi SA, Williams GB, Nestor PJ. A brief history of voxel-based grey matter analysis in Alzheimer's disease. J Alzheimers Dis. 2014;38(3):647-59. PubMed PMID: 24037033.

Sajjadi SA, Acosta-Cabronero J, Patterson K, Diaz-de-Grenu LZ, Williams GB, Nestor PJ. Diffusion tensor magnetic resonance imaging for single subject diagnosis in neurodegenerative diseases. Brain. 2013 Jul;136(Pt 7):2253-61. PubMed PMID: 23729473.

Sajjadi SA, Patterson K, Arnold RJ, Watson PC, Nestor PJ. Primary progressive aphasia: a tale of two syndromes and the rest. Neurology. 2012 May 22;78(21):1670-7. PubMed PMID: 22573633; PubMed Central PMCID: PMC3359509.

Sajjadi SA, Patterson K, Tomek M, Nestor PJ. Abnormalities of connected speech in the non-semantic variants of primary progressive aphasia. Aphasiology. 2012; 26(10):1219-1237.

Sajjadi SA, Patterson K, Tomek M, Nestor PJ. Abnormalities of connected speech in semantic dementia vs Alzheimer's disease. Aphasiology. 2012; 26:847-866.

Sajjadi SA, Harirchian MH, Sheikhbahaei N, Mohebbi MR, Malekmadani MH, Saberi H. The relation between intracranial and intraocular pressures: study of 50 patients. Ann Neurol. 2006 May;59(5):867-70. PubMed PMID: 16634008.

Larijani B, Bayat M, Khalili M, Sajjadi SA. Association between diabetes and depression. German journal of psychiatry. 2004; :62-65.
R01 AG062706 (PI)
R21 AG075870 (PI)
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