Behrouz Jafari
Associate Professor, Medicine
School of Medicine
School of Medicine
M.D.
University of California, Irvine
Research Interests
Sleep breathing disorders and endothelial dysfunction
Research Abstract
My research interests is the vascular health implications of sleep apnea with an emphasis on mechanistic pathways. I am specifically interested in four areas within this larger domain:
1) The prediction of vascular outcomes in patients with sleep apnea;
2) The mechanistic pathways on the development of atherosclerotic health outcomes among patients with sleep apnea;
3) The impact of standard therapy for sleep apnea on reducing the risk for adverse cardiovascular and cerebrovascular outcomes; and
4) The metabolic consequences of sleep deprivation.
1) The prediction of vascular outcomes in patients with sleep apnea;
2) The mechanistic pathways on the development of atherosclerotic health outcomes among patients with sleep apnea;
3) The impact of standard therapy for sleep apnea on reducing the risk for adverse cardiovascular and cerebrovascular outcomes; and
4) The metabolic consequences of sleep deprivation.
Publications
COVID-19: Review of a 21st Century Pandemic from Etiology to Neuro-psychiatric Implications.
Yamamoto V, Bolanos JF, Fiallos J, Strand SE, Morris K, Shahrokhinia S, Cushing TR, Hopp L, Tiwari A, Hariri R, Sokolov R, Wheeler C, Kaushik A, Elsayegh A, Eliashiv D, Hedrick R, Jafari B, Johnson JP, Khorsandi M, Gonzalez N, Balakhani G, Lahiri S, Ghavidel K, Amaya M, Kloor H, Hussain N, Huang E, Cormier J, Wesson Ashford J, Wang JC, Yaghobian S, Khorrami P, Shamloo B, Moon C, Shadi P, Kateb B.
J Alzheimers Dis. 2020;77(2):459-504. doi: 10.3233/JAD-200831.
PMID: 32925078
Evaluation of human obstructive sleep apnea using computational fluid dynamics.
Taherian S, Rahai H, Lopez S, Shin J, Jafari B.
Commun Biol. 2019 Nov 21;2:423. doi: 10.1038/s42003-019-0668-z. eCollection 2019.
PMID: 31799426
An analysis of fear inhibition and fear extinction in a sample of veterans with obstructive sleep apnea (OSA): Implications for co-morbidity with post-traumatic stress disorder (PTSD).
Reist C, Jovanovic T, Kantarovich D, Weingast L, Hollifield M, Novin M, Khalaghizadeh S, Jafari B, George R, Riser M, Woodford J, Norrholm SD.
Behav Brain Res. 2021 Apr 23;404:113172. doi: 10.1016/j.bbr.2021.113172. Epub 2021 Feb 9.
PMID: 33577879
Yamamoto V, Bolanos JF, Fiallos J, Strand SE, Morris K, Shahrokhinia S, Cushing TR, Hopp L, Tiwari A, Hariri R, Sokolov R, Wheeler C, Kaushik A, Elsayegh A, Eliashiv D, Hedrick R, Jafari B, Johnson JP, Khorsandi M, Gonzalez N, Balakhani G, Lahiri S, Ghavidel K, Amaya M, Kloor H, Hussain N, Huang E, Cormier J, Wesson Ashford J, Wang JC, Yaghobian S, Khorrami P, Shamloo B, Moon C, Shadi P, Kateb B.
J Alzheimers Dis. 2020;77(2):459-504. doi: 10.3233/JAD-200831.
PMID: 32925078
Evaluation of human obstructive sleep apnea using computational fluid dynamics.
Taherian S, Rahai H, Lopez S, Shin J, Jafari B.
Commun Biol. 2019 Nov 21;2:423. doi: 10.1038/s42003-019-0668-z. eCollection 2019.
PMID: 31799426
An analysis of fear inhibition and fear extinction in a sample of veterans with obstructive sleep apnea (OSA): Implications for co-morbidity with post-traumatic stress disorder (PTSD).
Reist C, Jovanovic T, Kantarovich D, Weingast L, Hollifield M, Novin M, Khalaghizadeh S, Jafari B, George R, Riser M, Woodford J, Norrholm SD.
Behav Brain Res. 2021 Apr 23;404:113172. doi: 10.1016/j.bbr.2021.113172. Epub 2021 Feb 9.
PMID: 33577879
Truong KK, De Jardin R, Massoudi N, Hashemzadeh M, Jafari B. Nonadherence to CPAP Associated With Increased 30-Day Hospital Readmissions. J Clin Sleep Med. 2018 Feb 15;14(2):183-189. doi: 10.5664/jcsm.6928. PubMed PMID: 29351826; PubMed Central PMCID: PMC5786836.
Jafari B. Rehabilitation of Cardiovascular Disorders and Sleep Apnea. Sleep Med Clin. 2017 Jun;12(2):193-203. doi: 10.1016/j.jsmc.2017.01.001. Epub 2017 Mar 9. Review. PubMed PMID: 28477774.
select
Jafari B. Sleep Architecture and Blood Pressure. Sleep Med Clin. 2017 Jun;12(2):161-166. doi: 10.1016/j.jsmc.2017.02.003. Epub 2017 Mar 25. Review. PubMed PMID: 28477771.
Jafari B. Sleep Architecture and Blood Pressure. Sleep Med Clin. 2017 Jun;12(2):161-166. doi: 10.1016/j.jsmc.2017.02.003. Epub 2017 Mar 25. Review. PubMed PMID: 28477771.
Original Papers :
Jafari B., Mohsenin V, Endothelial dysfunction and hypertension in obstructive sleep apnea- Is it due to intermittent hypoxia? J Cardiovascular Dis Res 4 (2013) 87-91
Li P, Ghadersohi S, Jafari B, Teter B, Sazgar M. Characteristics of Refractory versus Medically-Controlled Epilepsy Patients with Obstructive Sleep Apnea and their Response to CPAP Treatment, Seizure, 2012 Nov;21(9):717-21.
Jafari B, Mohsenin V. Activation of Heme-Oxygenase and suppression of cGMP are associated with impaired Endothelial-Dependent Vasodilation in OSA with hypertention. Am J Hypertens 2012 Aug;25(8):854-61.
Jafari B., Mohsenin V, Overnight Rostral Fluid Shift in Obstructive Sleep Apnea: Does it affect the severity of Sleep-disordered Breathing? Chest 2011 Oct;140(4):991-7
Syrkina O, Jafari B, Hales CA, Quinn DA. Oxidant Stress Mediates Inflammation and Apoptosis in Ventilator-Induced Lung Injury. Respirology 2008 May;13(3):333-40.
Ouyang B, Guan X, Syrkina O, Jafari B, Quinn DA. Oxidant injury mediates TGF beta up-regulation in ventilator induced lung injury. Med J Chin PLA. 2006; 31(1): 18-21.
Jafari B, Hales CA, Quinn DA. Intracellular Glutathione, Role in Stretch-Induced Cytokine Release from Alveolar Type-2 like cells (A549) Respirology 2004; 9(1):43-53.
Choi WI, Quinn DA, Park KM, Moufarrej RK, Jafari B, Syrkina O, Bonventre JV, Hales CA. Systemic Microvascular Leak in an In Vivo Rat Model of Ventilator-induced Lung Injury. Am J Resp Crit Care Med 2003; 167(12): 1627-32.
Li LF, Ouyang B, Choukroun G, Matyal R, Mascarenhas M, Jafari B, Bonventre JV, Force T, Quinn DA. Stretch-Induced IL-8 depends on C-Jun N-Terminal and nuclear factor-{kappa}B-inducing kinases. Am J Physiol Lung Cell Mol Physiol 2003; 285(2): L464-75. Epub 2003 Apr 25.
Chapter Books and review Articles :
Jafari B. Portable home monitoring for Obstructive Sleep Apnea, Treatment Strategies – Respirator 2013; 4(1)
Jafari B, Mohsenin V. Obstructive Sleep Apnea, Stroke and Rehabilitation, Sleep, stroke and cardiovascular disease 2013
Jafari B, Mohsenin V. Polysomnography. Encyclopedia of Sleep ( 2013)
Jafari B, Roux F. Non-Positive Airway Pressure Therapy for Obstructive Sleep Apnea, Current Respiratory Care Reports 2012, 1: 111-122
Jafari B., Mohsenin V, Chapter 36: Clinical Case Studies II: Sleep-breathing Disorders. Review of Sleep Medicine 2011
Jafari B, Mohsenin V. Polysomnography. Clin Chest Med. 2010 Jun;31(2):287-297.
Jafari B., Mohsenin V, Endothelial dysfunction and hypertension in obstructive sleep apnea- Is it due to intermittent hypoxia? J Cardiovascular Dis Res 4 (2013) 87-91
Li P, Ghadersohi S, Jafari B, Teter B, Sazgar M. Characteristics of Refractory versus Medically-Controlled Epilepsy Patients with Obstructive Sleep Apnea and their Response to CPAP Treatment, Seizure, 2012 Nov;21(9):717-21.
Jafari B, Mohsenin V. Activation of Heme-Oxygenase and suppression of cGMP are associated with impaired Endothelial-Dependent Vasodilation in OSA with hypertention. Am J Hypertens 2012 Aug;25(8):854-61.
Jafari B., Mohsenin V, Overnight Rostral Fluid Shift in Obstructive Sleep Apnea: Does it affect the severity of Sleep-disordered Breathing? Chest 2011 Oct;140(4):991-7
Syrkina O, Jafari B, Hales CA, Quinn DA. Oxidant Stress Mediates Inflammation and Apoptosis in Ventilator-Induced Lung Injury. Respirology 2008 May;13(3):333-40.
Ouyang B, Guan X, Syrkina O, Jafari B, Quinn DA. Oxidant injury mediates TGF beta up-regulation in ventilator induced lung injury. Med J Chin PLA. 2006; 31(1): 18-21.
Jafari B, Hales CA, Quinn DA. Intracellular Glutathione, Role in Stretch-Induced Cytokine Release from Alveolar Type-2 like cells (A549) Respirology 2004; 9(1):43-53.
Choi WI, Quinn DA, Park KM, Moufarrej RK, Jafari B, Syrkina O, Bonventre JV, Hales CA. Systemic Microvascular Leak in an In Vivo Rat Model of Ventilator-induced Lung Injury. Am J Resp Crit Care Med 2003; 167(12): 1627-32.
Li LF, Ouyang B, Choukroun G, Matyal R, Mascarenhas M, Jafari B, Bonventre JV, Force T, Quinn DA. Stretch-Induced IL-8 depends on C-Jun N-Terminal and nuclear factor-{kappa}B-inducing kinases. Am J Physiol Lung Cell Mol Physiol 2003; 285(2): L464-75. Epub 2003 Apr 25.
Chapter Books and review Articles :
Jafari B. Portable home monitoring for Obstructive Sleep Apnea, Treatment Strategies – Respirator 2013; 4(1)
Jafari B, Mohsenin V. Obstructive Sleep Apnea, Stroke and Rehabilitation, Sleep, stroke and cardiovascular disease 2013
Jafari B, Mohsenin V. Polysomnography. Encyclopedia of Sleep ( 2013)
Jafari B, Roux F. Non-Positive Airway Pressure Therapy for Obstructive Sleep Apnea, Current Respiratory Care Reports 2012, 1: 111-122
Jafari B., Mohsenin V, Chapter 36: Clinical Case Studies II: Sleep-breathing Disorders. Review of Sleep Medicine 2011
Jafari B, Mohsenin V. Polysomnography. Clin Chest Med. 2010 Jun;31(2):287-297.
Professional Societies
American Thoracic Society (ATS)
American Academy of Sleep Medicine (AASM)
Other Experience
Faculty Pulmonary & Critical Care Section
VAMCLB 2012—Pres
VAMCLB 2012—Pres
Post-doctoral research fellowship in Pulmonary and critical care medicine
Harvard University-MGH 1999
Harvard University-MGH 1999
Graduate Programs
Internal Medicine
Pulmonary Disease and Critical Care Medicine (IM)
Sleep Medicine
Link to this profile
https://faculty.uci.edu/profile/?facultyId=6053
https://faculty.uci.edu/profile/?facultyId=6053
Last updated
05/16/2022
05/16/2022