William Ernest Karnes

Picture of William Ernest Karnes
Clinical Professor, Medicine
School of Medicine
M.D., University of Minnesota, Minneapolis, 1982
Phone: (714) 456-6745
Email: karnesw@uci.edu
University of California, Irvine
101 The City Drive South
Bldg. 22C
Mail Code: 3298
Orange, CA 92868
Research Interests
Colon cancer screening, Risk assessment for colon cancer, Artificial Intelligence-Assisted Colonoscopy
Academic Distinctions
2019-2021 Super Doctors, Southern California Super Doctors
Research Abstract
1. Goldschmeidt M, Karnes WE, Feldman M. Relationship between Helicobacter pylori (HP) and gastric acid secretion/serum gastrin concentrations in healthy humans. Gastroenterology 98(5):A50, 1990.
2. Chen MC, Martin M, Wu V, Karnes W, Kim R, Walsh J, Soll AH. Autocrine control of oxyntic stem cell growth by TGF-alpha. Gastroenterology 98(5):A406, 1990.
3. Craig PM, Karnes WE, Territo MC, Walsh JH. Helicobacter pylori secretes a chemotactic factor for monocytes and neutrophils. Gastroenterology 98(5):A33, 1990.
4. Karnes WE, Kim RS, Wu SV, Martin MG, Cuttitta F, Gazdar AF, Mendelsohn J, Walsh JH. EGF receptor mediates autocrine growth of human colon cancer cell line SNU-C1. Gastroenterology 98(5):A502, 1990.
5. Karnes WE, Matin A, Olson CE, Walsh JH. Ammonium reduces ability of canine chief cell monolayers to maintain high transepithelial resistance at low apical pH. Gastroenterology 100(5):A588, 1991.
6. Anderson BD, Karnes WE, Pearson RK. Conjugated bile acids stimulate proliferation of human colon carcinoma cells in vitro. The American Society for Cell Biology, 1992.
7. Anderson BD, Karnes WE, Pearson RK. Bile acids regulate the growth rate of transformed colonic epithelium and increase TGF-a mRNA levels in vitro. Gastroenterology 104(4):A384, 1993.
8. Kuwada SK, Karnes WE Jr, Maihle NJ. A 36-kilodalton phosphoprotein binds to the carboxy-terminal domain of the c-erbB1 oncogene product. Gastroenterology 104(4):A418, 1993.
9. Karnes WE Jr, Adelsman MA, Kuwada SK, Maihle NJ. An hsp70 protein binds to bacterially expressed avian c-erbB1 carboxyl-terminal fusion proteins. Gastroenterology 104(4):A414, 1993.
10. Rand A, Boardman LA, Thibodeau SN, Cunningham J, Karnes WE Jr. A unique p53 mutant behaves as a dominant “hot spot” mutant in an autonomous colon cancer cell line. Gastroenterology 108(4):A527, 1995.
11. Rand A, Boardman LA, Thibodeau SN, Cunningham J, Kovach JS, Karnes WE Jr. A unique p53 mutant in an autonomous colon cancer cell line. Presented at the 86th Annual Meeting of the American Association for Cancer Research, 1995.
12. Karnes WE Jr, Banoub R, Rand A, Glenn KS. Constitutive proliferative signals mediated through PKC via p21ras-dependent and -independent pathways in autonomous colon cancer cell lines. Proc Ann Meet Am Assoc Cancer Res 37:A368, 1996.
13. Karnes WE Jr, Rand A. Role of distinct PKC isoforms in apoptosis and proliferation of colon cancer cell lines. Gastroenterology 110:A540, 1996.
14. Karnes WE Jr, Banoub R, Glenn K, Rand A. PKC and p21ras-mediated proliferative signaling in autonomous EGFR ligand-independent colon cancer cells. Gastroenterology 110:A540, 1996.
15. Karnes WE Jr, Rand A. PKC agonists stimulate proliferation of colon cancer cells independently of enhanced TGF-? release. Gastroenterology 110:A539, 1996.
16. Karnes WE Jr, Glenn K, Rand A, Banoub R. P53 and Waf-1-independent apoptosis induced by selective EGFR kinase inhibitors is associated with proteolysis of Bcl-2 and Cdc-2. Gastroenterology 110:A539, 1996.
17. Limburg PJ, Ahlquist DA, Karnes WE Jr, Roche PC, Klee GG. Immunomagnetic isolation of malignant colonocytes from stool: feasibility study in a model system. Gastroenterology 110:A551, 1996.
18. Sorbi D, Karnes WE Jr. Recurrent paraganglioma: an unusual cause of abdominal pain. Am J Gastroenterol 92:1732, 1997.
19. Boardman LA, Batts KP, Rand A, Ahlquist DA, Zaheer S, Pemberton J, Karnes WE Jr. Relevance of occult nodal metastases by immunodetection in rectal cancer. Gastroenterology 112:A539, 1997.
20. Weller SG, Klein IK, Graves-Deal R, Bogatcheva G, Coffey R Jr, Karnes WE Jr. PKC agonists stimulate mitogenesis of SNU-C4 colon cancer cells by augmenting autocrine stimulation of epidermal growth factor receptor. Gastroenterology 114:A703(G2906), 1998.
21. Weller SG, Klein IK, Karnes WE Jr. Distinct PKC isoforms mediate proliferative and apoptotic effects of phorbol esters in human colon cancer cell lines. Gastroenterology 114:A702(G2905), 1998.
22. Timmons LJ, Carlson EC, King JE, Lindor NM, Ahlquist DA, Treder CE, Karnes WE Jr. A computerized colorectal cancer registry and risk assessment tool. Gastroenterology 114:A689(G2848), 1998.
23. Klein IK, Ritland SR, Ziesmer SC, Burgart LJ, Roche PC, Gendler SJ, Karnes WE Jr. Colorectal Neoplasia Group. PKC isoforms in intestinal mucosa and adenomas of APCMIN mice. Gastroenterology 114:A626(G2576), 1998.
24. Kim KB, Herrington JJ, Devens ME, Grabau Cm, Klee GG, Ahlquist DA, Karnes WE Jr. Prospective evaluation of urinary transforming growth factor alpha levels for predicting clinical important colorectal neoplasia. Gastroenterology 114:A624(G2566), 1998.
25. Karnes WE Jr, Dubois RN Jr, Shattuck-Brand R, Burgart LJ, Tester DJ, Thibodeau SN. Reduced COX-2 protein expression in human colorectal cancer exhibiting defective mismatch repair. Gastroenterology 114:A618(G2541), 1998.
26. Weller S, Penington R, Karnes WE Jr. Apoptosis induced by phorbol ester in SNU-C4 colon cancer cells is associated with, but progresses independently of caspase-3-mediated cleavage of PKC-delta. Gastroenterology 116:G1898, 1999.
27. Ritland SR, Gendler, Burgart LJ, Fry DW, Nelson JM, Bridges Aj, Andress L, Karnes WE Jr. Inhibition of epidermal growth factor receptor fails to suppress adenoma formation in APCMIN mice but induces flat hyperproliferative duodenal lesions. Gastroenterology 116:G1897, 1999.
28. Penington RC, Weller SG, Karnes WE Jr. Protein kinase C-mediated MAPK activation is mediated through autocrine EGFR activationin SNU-C4 colon cancer cells. Gastroenterology 116:G1896, 1999.
29. Itzkowitz SH, Shattuck R, Thibodeau S, Karnes WEJr, Burgart L. Relationship between siayl-tn (STN) antigen expression and microsatellite instability (MSI) in sporadic colorectal cancers (SCC). Gastroenterology 116:G1870, 1999.
30. Chinery R, Morrow J, Lamps LW, Green DR, Karnes WEJr. Potential role of cyclooxygenase-2 products on tumor immune escape. Gastroenterology 116:G1705, 1999.
31. Boardman L, Rand A, Batts KP, McDonnell SK, Peterson BJ, Zaheer S, Pemberton JH, Karnes WE Jr. P53 overexpression and K-ras mutation in early stage rectal cancer do not correlate with recurrence. Gastroenterology 116:G1660, 1999.
32. Desai DS, Ritland SH, Klein I, Karnes WE Jr. Protein kinase C-alpha is a target of ?-catenin/Tcf-4 transcriptional regulation. Gastroenterology 188:A878, 2000.
33. Penington RC, Weller SG, Karnes WE Jr. Protein kinase C signals mitogenesis and ERK activation through metalloproteinase-dependent release of autocrine TGF-? in SNU-C4 colon cancer cells. Gastroenterology 188:A538, 2000.
34. Weller SG, Penington RC, Karnes WE Jr. PMA Induces apoptosis in the SNU-C4 colon cancer cells through caspase-9 independently of caspase-3 and -8. Gastroenterology 188:A542, 2000.
35. Desai DS, Karnes WE Jr?-catenin and retinoic acid receptor beta. Gastroenterology 188:A878, 2000.
36. Chinery R, Watson AJ, Karnes WE Jr. Evidence for Fas ligand-mediated tumor immune evasion in a murine model of colorectal carcinogenesis. Gastroenterology 188:A530, 2000.
37. Chinery R, Lund PE, Reyes DA, Bentley MD, Karnes WE Jr, Ritman EL. Applications of micro-CT imaging to study tumor neovascularization in murine models of colon cancer. Gastroenterology 188:A765, 2000.
38. Farid Jalali, Argyrios Ziogas, Jason A. Zell, Michael J. Stamos, Hoda Anton-Culver, William E. Karnes. Effect of Delay in Surgical Treatment of Colon Cancer on Survival. Su1789, DDW 2014
39. Sarah L. Flores, Argyrios Ziogas, Gregory Albers, Hoda Anton-Culver, William E. Karnes. Variable Recognition of Sessile Serrated Adenomas Among Colonoscopists and Pathologists - a Compounded Roadblock to Reducing Interval Colon Cancers 742 DDW 2014 (Oral)
40. Matthew A. Chin, Chien-Lin Chen, William E. Karnes. Improved polyp detection among high risk patients with endocuff. DDW 2015
41. Jasleen Grewal, Matthew Chin, Chien-Lin Chen, Williams Karnes. Endocuff-assisted colonoscopy improves sessile serrated adenoma detection rate: A single academic center observational study. ACG 2015
42. Matthew Chin, Williams Karnes, M. Mazen Jamal, Jason Samarasena, Robert Lee, John Lee, C. Gregory Albers, Matthew Bechtold, MD, Douglas Nguyen. Optimizing Adenoma Detection Rate Through the Use of Endocuff: A Meta-analysis. ACG 2015
43. Matthew Chin, Jasleen Grewal, Chien-Lin Chen, Williams Karnes. Endocuff®-assisted Colonoscopy: A Single-center Experience with an Average-risk, Asymptomatic Population ACG 2015
1. Jason B. Samarasena, Marielle Reataza, Nathan Kwak, Joshua Steichen, Gregory Albers, Nimisha K. Parekh, William Karnes, Douglas Nguyen, Robert H. Lee, M. Mazen Jamal. Single Day Low Residue Diet Prior to Colonoscopy Shows Improved Tolerance and Bowel Preparation Quality Over Clear Liquid Diet: Interim Results From a U.S. Multicenter Randomized Controlled Trial. DDW 2016 (Oral)
2. Anish Patel, Jasleen K. Grewal, William E. Karnes. Endocuff Improves GI Fellows Colonoscopy Performance (PDR, ADR and number of polyps/colonoscopy) Without Affecting Time of Procedure. DDW 2016
3. Jasleen K. Grewal, Gregory Albers, William E. Karnes. Endocuff-Assisted Colonoscopy Increases Detection of Sessile Serrated Adenomas in Middle-Aged Women. DDW 2016 (Oral)
4. Jasleen K. Grewal, Jacqueline Kulwin, Argyrios Ziogas, Jason Zell, William E. Karnes. Increased Detection of Precancerous Colorectal Polyps in Young Obese Males. DDW 2016
5. Shawn Kaye, Mohit Mittal, Katherine Kim, Williams Karnes. Endocuff increases sessile serrated adenoma detection rates in the right colon. DDW 2016
6. Daniel M. Kim, Anish H Patel, Robert Lee, William E. Karnes. The Awake Patient: Unsedated colonoscopies are associated with higher adenoma detection rates. ACG 2016
7. Talal Alkayali, Jason Samarasena, William Karnes. NICE&Easy way to ignore rectal polyps? ACG 2016
8. J. Grewal, A. Patel, J. Kulwin, W. Karnes. Increased Detection of Precancerous Colorectal Polyps in Young Obese Patients. ACG 2016
9. Anish Patel and William Karnes. Endocuff Improves Polyp Detection by GI Fellows Across Multiple Stages of Training. ACG 2016
10. Karnes, William E.; Alkayali, Talal; Mittal, Mohit; Patel, Anish; Kim, Junhee; Chang, Kenneth J.; Ninh, Andrew; Urban, Gregor; Baldi, Pierre. Automated polyp detection using deep learning: leveling the field. DDW 2017
11. Kulwin, Jacqueline; Grewal, Jasleen; Karnes, William E. Colonoscopy Quality Measures of GI Fellow Colonoscopy Performance by Quarter of Training. DDW 2017
12. Grewal, Jasleen; Patel, Anish; Ali, Mohammed F.; Karnes, William E. Size, Serration, and Specific Solutions: Details on the Successes of Split Bowel Prep. DDW 2017 (Oral)
13. Ali, Mohammed F.; Patel, Anish; Grewal, Jasleen; Mittal, Mohit, William E. Karnes. Precancerous polyp detection rates among Asian males undergoing screening colonoscopy. DDW 2017
14. Anish H. Patel, Jasleen K. Grewal, Mohammed F. Ali, William E. Karnes. Underwater colonoscopy is associated with higher detection rates of proximal sessile serrated polyps. DDW 2017 (Oral Plenary)
15. Allen R. Yu, Jason B. Samarasena, Talal Alkayali, Grace J. Lee, William E. Karnes. Usability of AmplifEYE- and Endocuff Vision-Assisted Colonoscopy Compared to Conventional Colonoscopy during Colonoscopy. ACG 2017
16. Talal Alkayali, Allen R. Yu, Jason B. Samarasena, Grace J. Lee, William E. Karnes. First Side-by-Side Comparison of AmplifEYE, Endocuff Vision and Conventional Colonoscopy for PDR, ADR and SDR. ACG 2017
17. Meredith Clary, Lauren C. Dedecker, William E. Karnes. Measuring Colonoscopy Value Without Penalizing Polyp Detection. ACG 2017 (Oral)
18. William E. Karnes, Andrew Ninh, Gregor Urban, Pierre Baldi. Adenoma Detection Through Deep Learning. ACG 2017
19. Mohammed F. Ali, Anish H. Patel, Jasleen Grewal, Daniel M. Kim, William E. Karnes. Higher Rates of Proximal Sessile Serrated Adenomas Among Whites Compared to Asians, Hispanics and Blacks. ACG 2017
20. Daniel Kim, William Karnes. The Obese Patient: Effects of Split-dose Preparation During Colonoscopy on Adenoma Detection Rate. ACG 2017
21. Grace Lee, William Karnes. Should Sessile Serrated Polyp Detection Rate be Added as a Marker for Colonoscopy Quality? ACG 2017
22. Anish Patel, Jasleen Grewal, Daniel Kim, Mohammed Ali, William Karnes. Clean and Clear Colonoscopy: Underwater Insertion Techniques Associated with Higher Rates of Adequate Bowel Prep. ACG 2017
23. Mohammed F. Ali, Anish H. Patel, Jasleen Grewal, Daniel M. Kim, William E. Karnes. Turning the Tides of Training: Underwater Colonoscopy is Associated with Higher Polyp, Adenoma and Sessile Serrated Adenoma Detection Rates Among Gastroenterology Fellows. ACG 2017
24. Jasleen K. Grewal, Anish H. Patel, Daniel M. Kim, Mohammed F. Ali, William E. Karnes. From Mississippi to Caribbean: The Additive Benefit of Underwater Colonoscopy to Split Dose Bowel Prep. ACG 2017
25. Jasleen K. Grewal, Anish H. Patel, Mohammed F. Ali, Daniel M. Kim, William E. Karnes. No Polyp Left Behind: Endocuff Significantly Improves Polyp Detection in Underwater Colonoscopy. ACG 2017
26. Karnes, William E., Ninh, Andrew, Dao, Tyler, Requa, James, Samarasena, Jason. Real-Time Identification of Anatomic Landmarks During Colonoscopy Using Deep Learning. DDW 2018
27. Tripathi PV, Urban G, Alkayali T, Mittal M, Jalali F, Patel A, Kim J, Ninh AQ, Albers G, Chang KJ, Samarasena JB, Baldi P, Karnes WE. Computer-assisted polyp detection identifies all polyps found by expert colonoscopists - and then some. DDW 2018 (Oral)
28. Kim D, Ali MF, Karnes WE. Advantage of cap-assisted devices for adenoma detection rate is not enhanced by concomitant use of underwater intubation during colonoscopy. DDW 2018 (Oral)
29. Karnes WE, Ninh A, Dao T, Requa J, Samarasena J. Unambiguous real-time scoring of bowel preparation using artificial intelligence. DDW 2018.
30. Turkiewicz J, Clary M, Karnes WE. Variable classification of right-sided serrated colon polyps among pathologists. DDW 2018.
31. DeDecker L, Hubbard L, Clary M, Yu A, Karnes WE. Beyond ADR and cost: the colonoscopy value index. DDW2018.
32. Kim D, Ali MF, Berry R, Karnes WE. Should your next colonoscopy be performed by a GI fellow? DDW 2018.
33. Ali M, Kim D, Karnes WE. Frequency of right-sided precancerous polyps remains high despite the absence of polyps in the left colon. DDW 2018.
34. Han JY, Rani B, Kim DM, Karnes WE. The effect of longer withdrawal times beyond 6 minutes on adenoma detection rate. DDW 2018.
35. Jasleen Grewal, William Karnes, MD. Screening Colonoscopy Polyp, Adenoma and Sessile Serrated Adenoma Detection Rate Differences in Hispanics and Whites in Age-Matched Cohorts. ACG 2018.
36. Alexander P. Abadir, James Requa, Andrew Ninh, William Karnes, Mark Mattar, MD. Unambiguous Real-Time Endoscopic Scoring of Ulcerative Colitis Using a Convolutional Neural Network. ACG 2018.
37. Jason Samarasena, MD, Allen R. Yu, BS, Ericson John Torralba, BSc,Daniel Mai, BSc, David P. Lee, MPH, Zain Moosvi, Vincent Chao Chang, Tyler Dao, James Requa, Andrew Ninh, William Karnes, MD; Artificial Intelligence Can Accurately Detect Tools Used During Colonoscopy: Another Step Forward Toward Autonomous Report Writing. ACG 2018. Presidential Poster Award
38. Jasleen Grewal, Mohammed F. Ali, Anish H. Patel, William Karnes, MD; ADR of 'Average Risk' Males Aged 45-50 and >50 Screening Population Are Equivalent. ACG 2018.
39. Daniel M. Kim, Zain Moosvi, William Karnes, MD. Is It Necessary to Sedate the Pain Associated With Colonoscopies? ACG 2018
40. Daniel M. Kim, Michelle Park, William Karnes, MD. No Difference in Pain Based on Insufflation Technique Used During Colonoscopy. ACG 2018.
41. Anish H. Patel, Jasleen Grewal, Rasha Ahmed, DO, William Karnes, MD. Underwater Insertion Improves Polyp Detection in Young Adults Undergoing Colonoscopy. ACG 2018
42. James Requa, Tyler Dao, Andrew Ninh, William Karnes, MD; Can a Convolutional Neural Network Solve the Polyp Size Dilemma? ACG 2018. (Category Award/Presidential Poster Award)
43. James Han, Rani Berry, Daniel Kim, Mohammed Ali, William Karnes, MD. Is 6 Minutes of Withdrawal Time Still Enough? A Re-examination of Withdrawal Time in Colonoscopy at a Contemporary Academic Setting. ACG 2018.
44. Felix Lui, Yash Rusconi-Rodrigues, BA, Andrew Ninh, James Requa, William Karnes, MD. Highly Sensitive and Specific Identification of Anatomical Landmarks and Mucosal Abnormalities in Video Capsule Endoscopy with Convolutional Neural Networks. ACG 2018. (Presidential Poster Award)
45. Robin Zachariah, Andrew Ninh, Tyler Dao, James Requa, William Karnes, MD; Can Artificial Intelligence (AI) Achieve Real-Time 'Resect and Discard' Thresholds Independently of Device or Operator? ACG 2018. (Oral Plenary)
46. Rintaro Hashimoto MD PhD, Michael Lugo, Daniel Mai, Nabil El Hage Chehade Elise Tran, Tyler Dao, John Lee, Kenneth Chang, Andrew Ninh, James Requa, William Karnes, Jason Samarasena MD. Artificial Intelligence Dysplasia Detection (Aidd) Algorithm For Barrett’s Esophagus. DDW 2019 (Oral)
47. Rombaoa, Christopher; Kalra, Ankush; Dao, Tyler; Requa, James; Ninh, Andrew; Samarasena, Jason B.; Karnes, William E. Automated Insertion Time, Cecal Intubation, And Withdrawal Time During Live Colonoscopy Using Convolutional Neural Networks - A Video Validation Study. DDW 2019
48. Felix H Lui Andrew Ninh, Yash Rusconi, James Requa, William E Karnes. Video Validation Of Small Bowel Convolutional Neural Networks (Cnns) In Identification Of Anatomical Landmarks And Mucosal Abnormalities In Video Capsule Endoscopy. DDW 2019 (Oral)
49. Robin Zachariah,Andrew Ninh,Tyler Dao, James Requa, Jason Samarasena, William Karnes. Video Validation Of A Novel Multiclass Convolutional Neural Network For Real Time Optical Pathology Of Adenomas, Sessile Serrated Polyps And Hyperplastic Polyps. DDW 2019 (Oral)
50. Tarek Eid, Mohamed Fahad Ali, Erica Duh, Paul Kang, William Karnes. Increasing Prevalence Of Sessile Serrated Polyps Among Caucasians Undergoing Screening Colonoscopy. DDW 2019
51. Arias Torres, Everardo; Yu, Allen R; Ali, Mohammed F; Eid, Tarek I; Karnes, William E. Effect Of Colonoscopy Assisted Devices On Adr, Sdr, And Procedure Times Among Gastroenterology Fellows. DDW 2019
52. Ali, Mohammed F.; Moosvi, Zain; Abadir Alexander; Karnes, William E. Gastroenterology Fellows Have Similar Polyp, Adenoma And Sessile Serrated Adenoma Detection Rates With Underwater Colonoscopy Vs Air-insufflation Colonoscopy Each Quarter Of Fellowship. DDW 2019
53. Ali, Mohammed F.; Eid, Tarek I.; Arias Torres, Everardo; Karnes, William E. Pdr, Adr And Ssadr In Screening Colonoscopies In Those Aged 45-50 Vs =50 Are Similar Across Different Ethnicities. Ddw 2019
54. Tarek Eid, Mohamed Fahad Ali, Erica Duh, Paul Kang, William Karnes. Increasing Prevalence Of Sessile Serrated Polyps Among Caucasians Undergoing Screening Colonoscopy. DDW2019
55. Ankush Kalra, Christopher Rombaoa, William E. Karnes. Adenoma Detection Rate And Polyp Distribution: Top Performers Find Disproportionately More Right-sided Polyps. DDW 2019
56. Alexander Abadir, Zain Moosvi, Fahad Ali. William Karnes MD. Which Combo Works Best? A Comparison Of Endocuff And Amplifeye In Underwater And Air-insufflation Colonoscopy. DDW 2019
57. Zain Moosvi, Alexander Abadir, Mary Kate Roccato, Fahad Ali, William Karnes MD. Detection Rates By Anatomic Location In Caucasians, Hispanics, And Asians. DDW 2019
58. Zain Moosvi, Alexander Abadir, Fahad Ali, William Karnes. Proximal Serrated Polyp Detection Rate Is A Surrogate Marker For Clinically Significant Serrated Polyps In Fellows. DDW2019
59. Alexander Abadir, Zain Moosvi, Robin Zachariah, Fahad Ali , William Karnes MD. A Look At How Endocuff Affects Quality Metrics During Fellowship Training Time. DDW 2019
60. Mary Kathryn Roccato, Tyler Dao, Rani Berry, William Karnes, Efren Rael. Artificial Intelligence-Aided Colonoscopy - A Retrospective Analysis of Effect on Procedure Time. ACG 2019
61. James Requa, Tyler Dao, Andrew Ninh, William Karnes. Beyond polyp detection: Novel method to track individual polyps using neural networks. ACG 2019.
62. Alexander Abadir, Zain Moosvi, William Karnes. Variable Classification of Sessile Serrated Colon Polyps Among Pathologists in an Academic Center. ACG 2019 (Oral Plenary)
63. Erica Duh, Piotr Sowa, Roberts B. Mary, William Karnes. Traditional Serrated Adenomas (TSA) and the Company They Keep: TSA Presence Predicts Synchronous Advanced Lesions. ACG 2019
64. Piotr Sowa, William Karnes. Increased Synchronous Neoplasms Among Patients With Small and Diminutive Proximal Hyperplastic Polyps. ACG 2019
65. Zain Moosvi, Erica Duh, James Y. Han, William E. Karnes. ORAL IBGARDTM Before Colonoscopy - A Single Center Double-Blinded Placebo-Controlled Study. DDW 2020.
66. Christopher Rombaoa, Mary Kathryn Roccato, Andrew Ninh, William E. Karnes. Automated Polypectomy Time During Live Colonoscopy Using Convolutional Neural Networks - A Video Validation Study. DDW 2020.
67. Duminda Suraweera, Kimberly Wong, William E. Karnes. AI vs Human: CNN-Assisted Small Bowel Video Capsule Endoscopy Is Associated With Higher Detection Of Clinically Relevant Lesions. DDW 2020.
68. Alyssa Y. Choi, Rintaro Hashimoto, Kimberly R. Cavaliere, James Requa, Nabil El Hage Chehade, Andrew Ninh, Tyler Dao, Michael Lugo, Daniel Mai, Kenneth J. Chang, William E. Karnes, Arvind J. Trindade, Jason Samarasena. High Accurancy And Effectiveness With Deep Neural Networks and Artificial Intelligence in Detection of Early Esophageal Neoplasia In Barrett’s Esophagus: An External Video Validation Study. DDW 2020.
1. Karnes WE Jr, Jabobs R. ras gene mutations in colorectal cancer. Gastroenterology 93(6):1440-1441, 1987.
2. Karnes WE Jr, Maxwell V, Sytnik B, Chew P, Walsh JH. Prolonged inhibition of meal-stimulated acid secretion and gastrin release following single subcutaneous administration of octreotide (SMS 201-995) in man. Aliment Pharmacol Ther 3:527-538, 1989.
3. Karnes WE Jr, Walsh JH. Perspectives. In: Campylobacter Pylori in Gastritis and Peptic Disease, M Blaser, ed. Igaku-Shoin Medical Publishers, New York, 1989, pp 241-9.
4. Karnes WE Jr, Guth P. C. pylori: innocent until proven guilty. In: Debates in Gastroenterology, Volume 3. G Gitnik, ed. Year Book Medical Publishers, Chicago, 1990, pp 321-334.
5. Karnes WE Jr, Walsh JH. The gastrin hypothesis. Implications for selection of drug therapy. J Clin Gastroenterol 12 (Suppl. 2):S7-S12, 1990.
6. Karnes WE Jr, Berlin RG, Maxwell V, Sytnik B, Root JK, Walsh JH. Prolonged inhibition of acid secretion causes hypergastrinemia without altering pH inhibition of gastrin release in humans. Aliment Pharmacol Ther 4:443-456, 1990.
7. Karnes WE Jr, Cuttitta F, Walker A., Walsh JH. Autocrine growth factors and solid tumor malignancy. West J Med 155:152-163, 1991.
8. Karnes WE Jr, Samloff IM, Siurala M, Kekki M, Sipponen P, Kim SWR, Walsh JH. Positive serum antibody and negative tissue staining for Helicobacter pylori infection in subjects with atrophic body gastritis. Gastroenterology 101:167-174, 1991.
9. Karnes WE Jr, Ohning GV, Sytnik B, Kim SWR, Walsh JH. Elevated meal-stimulated gastrin release in subjects with Helicobacter pylori infection: Reversal by low intragastric pH. Reviews of Infectious Diseases 13 (Suppl. 8):S665-S670, 1991.
10. Goldschmiedt M, Barnett CC, Schwarz BE, Karnes WE Jr, Redfern JS, Feldman M. Effects of aging on gastric acid secretion and on serum pepsinogen concentrations in healthy men and women: Relationships with serum gastrin and Helicobacter pylori infection. Gastroenterology 101:1-9, 1991.
11. Walsh JH, Karnes WE Jr, Cuttitta F, Walker A. Autocrine growth factors and solid tumor malignancy. West J Med 155:152-163, 1991.
12. Craig PM, Territo MC, Karnes WE Jr, Walsh JH. Helicobacter pylori secretes a chemotactic factor for monocytes and neutrophils. Gut 33:1020-1023, 1992.
13. Karnes WE Jr, Walsh JH, Wu SV, Kim RS, Martin MG, Wong HC, Mendelsohn J, Gazdar AF, Cuttitta F. Autonomous proliferation of colon cancer cells that coexpress transforming growth factor-a and its receptor. Gastroenterology 102:474-85, 1992.
14. Chen MC, Lee A, Karnes WE Jr, Avedian D, Sorvillo J, Soll AH. Paracrine control of gastric epithelial cell growth in culture by transforming growth factor-a. Am J Physiol 264(2 Pt 1):G390-6, 1993.
15. Karnes WE Jr. Epidemiology and etiology of sporadic colorectal adenocarcinoma. Curr Opin Gastroenterol 10:19-26, 1994.
16. Karnes WE Jr. Growth factors and gastrointestinal malignancies. In: Gut Peptides, JH Walsh G Dockrey, eds. Raven Press, New York, 1994, pp 825-850.
17. Karnes WE Jr. Epidermal growth factor and transforming growth factor alpha. In: Gut Peptides, JH Walsh, G Dockrey, eds. Raven Press, New York, 1994, pp 553-586.
18. Boardman LA, Karnes WE Jr. Src family of tyrosine kinases: A roles of c-yes in colon carcinogenesis. Gastroenterology 108:291-294, 1995.
19. Boardman LA, Karnes WE Jr. Epidemiology and etiology of colorectal cancer. In: Surgery of the Colon and Rectum, RJ Nicholls, RR Dozois, eds. VK Churchill-Liviningston. 1996
20. Rand A, Glenn KS, Alvares CP, White MB, Thibodeau SN, Karnes WEJr (senior author). P53 functional loss in a colon cancer cell line with two missense mutations (218leu and 248 trp) on separate alleles. Cancer Letters 98:183-191, 1996.
21. Karnes WE Jr, Boardman LA. Colorectal Neoplasms - Epidemiology & Etiology. In: Surgery of the Colon and Rectum. RJ Nicholls and RR Dozois, eds. Churchill Livingston, London, UK. 1997.
22. Karnes WE Jr, Weller SG, Adjei PN, Kottke TJ, Glenn KS, Gores GJ, Kaufmann SH. Inhibition of epidermal growth factor receptor kinase induces protease-dependent apoptosis in human colon cancer cells. Gastroenterology 114:930-939, 1998.
23. Karnes WE Jr, Shattuck-Brandt R, Burgart LJ, et al. Reduced COX-2 protein in colorectal cancer with defective mismatch repair. Cancer Res 58:5473-5477, 1998.
24. Weller SG, Klein IK, Karnes WE Jr (senior author). Distinct protein kinase C isozymes signal mitogenesis and apoptosis in human colon cancer cells. Gastroenterology 117:848-857, 1999.
25. Desai DS, Hirai SI, Karnes WE Jr, Niles RM, Ohno S. Cloning and characterization of the murine PKC a promoter: identification of a retinoic acid response element. Biochem Biophys Res Comm 263:28-34, 1999.
26. Karnes WE Jr. Implications of low COX-2 expression in colorectal neoplasms with defective DNA mismatch repair. J Cell Biochem 77 (Suppl 34):23-27, 2000.
27. Klein IK, Ritland SR, Burgart LJ, Ziesmer SC, Roch, PC, Gendler SJ, Karnes WE Jr (senior author). Adenoma-specific alterations of protein kinase C isozyme expression in ApcMIN mice. Cancer Res. 60(8):2077-80, 2000.
28. Ritland SR, Gendler SJ, Burgart LJ, Fry DW, Nelson JM, Bridges AJ, Andress L, Karnes WE Jr (senior author). Inhibition of epidermal growth factor receptor kinase fails to suppress adenoma formation in ApcMIN mice but induces duodenal injury. Cancer Res. 60(17):4678-4681, 2000.
29. Lindor NM, Dozois R, Nelson H, Wolff B, King J, Boardman L, Wilson M, Greene MH, Karnes W, Mesa R, Welch T, Edmonson J, Limburg P. Desmoid tumors in familial adenomatous polyposis: a pilot project evaluating efficacy of treatment with pirfenidone. Am J Gastroenterol. 98(8):1868-74, 2003.
30. Chaitali Singh Nangia, Thomas H. Taylor, Walter Tsang, Jason Wong, Joseph Carmichael, William Karnes, and Jason A. Zell Journal of Clinical. Risk of second primary cancers after treatment for locoregional rectal cancer. Oncology 31:15_suppl, 3578-3578 2013.
31. Tsang, WY, Ziogas A, Lin BS, Seery TE, Karnes W, Stamos MJ, Zell JA. Role of Primary Tumor Resection Among Chemotherapy-Treated Patients with Synchronous Stage IV Colorectal Cancer: A Survival Analysis. J Gastrointest Surg. 18(3):592-8, 2014
32. Chin M, Karnes W, Jamal MM, Lee JG, Lee R, Samarasena J, Bechtold ML, Nguyen DL. Use of the Endocuff during routine colonoscopy examination improves adenoma detection: A meta-analysis. World J Gastroenterol. 22(43):9642-9649 2016
33. Gregor Urban, Priyam Tripathi, Talal Alkayali, Mohit Mittal, Farid Jalali, William Karnes, Pierre Bald. Deep Learning Localizes and Identifies Polyps in Real Time With 96% Accuracy in Screening Colonoscopy. Gastroenterology, Volume 155 , Issue 4 , 1069 - 1078. 2018 (Corresponding Author)
34. Zachariah R, Ninh A, Karnes W. Artificial Intelligence for Colon Polyp Detection: Why should we embrace this? Tech Innov Gastrointest Endoscopy 22:48-51, 2020. (Senior Author)
35. Zachariah R, Samarasena J, Luba, D, Duh, E, Dao T, Requa J, Ninh A, Karnes, W. Prediction of Polyp Pathology Using Convolutional Neural Networks Achieves 'Resect and Discard' Thresholds. Am J Gastroenterol, 115(1):138-144, 2020. (Senior Author)
36. Abadir A, Ali M, Karnes W, Samarasena J. Artificial Intelligence in Gastrointestinal Endoscopy. Clin Endosc, 53(2):132-141, 2020.
37. Hashimoto R, Requa J, Dao T, Ninh A, Tran E, Mai D, Lugo M, Chehade N, Chang K, Karnes W, Samarasena J. Artificial intelligence using convolutional neural networks for real-time detection of early esophageal neoplasia in Barrett’s esophagus (with video). GIE 2020. https://doi.org/10.1016/j.gie.2019.12.049
38. Duh E, Sowa P, Roberts M, Karnes W. Traditional serrated adenomas (TSA) and the company they keep: TSA presence predicts advanced neoplasm states. Int J Colorectal Dis 2020. https://doi.org/10.1007/s00384-020-03587-x (Senior Author)
39. Han J, Moosvi Z, Duh E, Park S, Albers G, Samarasena J, Karnes W. Oral IBGard Before Colonoscopy: A Single Center Double-Blinded, Randomized, Placebo-Controlled Study. Dig Dis Sci 2021. doi: 10.1007/s10620-020-06383-3 (Senior Author)
40. Klaus G, Daperno D, Sands B, Usiskin K, Ahmad H, Howden C, Karnes W, Oh Y, Modesto I, Marano C, Stidham R, Reinisch W. Endoscopy and Central Reading in Inflammatory Bowel Disease Clinical Trials: Achievements, Challenges and Future Developments. Gut 2021. doi: 10.1136/gutjnl-2020-320690
41. Klaus G, Requa J, Karnes W, Gudivada RC, Shen J, Rael E, Arora V, Dao T, Ninh A, McGill J. Central reading of ulcerative colitis clinical trial videos using neural networks. Gastroenterology 2020, doi:10.1053/j.gastro.2020.10.024.
42. Ahmad O, Mori Y, Misawa M, Kudo S, Anderson J, Bernal J, Berzin T, Bisschops R, Byrne M, Chen P, East J, Eelbode T, Elson D, Gurudu S, Histace A, Karnes W, Repici A, Singh R, Valdastri P, Wallace M, Wang Pu, Stoyanov D, Lovat L. Establishing key research questions for the implementation of artificial intelligence in colonoscopy - an international study using a modified Delphi method. Endoscopy 2020 https://doi.org/10.1055/a-1306-7590.
43. Zachariah R, Rombaoa C, Samarasena J, Suraweera D, Wong K, Karnes W. The Potential of Deep learning for Gastrointestinal Endoscopy - a Disruptive New Technology. In: Artificial Intelligence in Medicine: Technical Basis and Clinical Applications. Ed: Drs. Xing, Giger, and Min. 2021 https://doi.org/10.1016/B978-0-12-821259-2.00012-0 (Senior Author)
44. DeDecker L, Coppedge B, Avelar-Barragan J, Karnes W, Whiteson K. Microbiome Distinctions Between the CRC Carcinogenic Pathways. Gut Microbes 2021 https://doi.org/10.1080/19490976.2020.1854641
45. Julio Avelar-Barragan, Lauren DeDecker, Zachary Lu, Bretton Coppedge, William E. Karnes, Katrine L. Whiteson. Distinct Colon Mucosa Microbiomes associated with Tubular Adenomas and Serrated Polyps. bioRxiv 2021 https://doi.org/10.1101/2021.07.20.453135
46. William E. Karnes, David A. Johnson, Tyler M. Berzin, Seth A. Gross, John J. Vargo, MD, Prateek Sharma, MD, Robin Zachariah, MD, Jason B. Samarasena, MD, and Joseph C. Anderson. A Polyp Worth Removing: A Paradigm for Measuring Colonoscopy Quality and Performance of Novel Technologies for Polyp Detection. J Clin Gastroenterol 2021, https://doi.org/10.1097/MCG.0000000000001594 (First Author)
47. Abadir A, Moosvi M, Kwon J, Chin M,Vallone J, Karnes W. Variable Classification of Sessile Serrated Colon Polyps Among Pathologists in an Academic Center. (In Preparation)
48. Grewal J, Hozouri N, Karnes W. Quantifying the Relationship Between BMI & Surveillance Relevant Polyps in Young Patients: A Multivariate Analysis. (In Preparation)
Other Experience
Associate Professor of Medicine
Mayo Clinic 1992—2001
Research Fellowship
Mayo Clinic, Rochester, MN 1990—1992
Private Practice, Gastroenterology
Chief Medical Officer
Docbot 2018—2021
Graduate Programs
Gastroenterology (IM)
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