Geoffrey Winston Abbott
Professor, Physiology & Biophysics
School of Medicine
School of Medicine
Senior Associate Dean, Academic Personnel
School of Medicine
School of Medicine
Vice Dean, Basic Science Research
School of Medicine
School of Medicine
Ph.D., University of London, UK, 1997, Biochemistry
M.S., University of Leicester, UK, 1993, Molecular Pathology and Toxicology (with Distinction)
B.S., University of Durham, UK, 1991, Zoology (Honours)
M.S., University of Leicester, UK, 1993, Molecular Pathology and Toxicology (with Distinction)
B.S., University of Durham, UK, 1991, Zoology (Honours)
University of California, Irvine
School of Medicine
Department of Physiology and Biophysics
D337 Med Sci I
Mail Code: 4620
Irvine, CA 92697
School of Medicine
Department of Physiology and Biophysics
D337 Med Sci I
Mail Code: 4620
Irvine, CA 92697
Research Interests
herbal medicine, cardiac arrhythmias, epilepsy, KCNE, KCNQ, molecular pharmacology, potassium channels, solute transporters
Websites
Academic Distinctions
2013, Conference Chair, FASEB Science Research Conference on Ion Channel Regulation, Nassau, Bahamas
2013-2015, Chair, Biochemistry and Biophysics of Membranes (BBM) NIH Study Section
2013-2015, Chair, Biochemistry and Biophysics of Membranes (BBM) NIH Study Section
Research Abstract
Research in Dr. Abbott’s lab is focused on elucidating the molecular basis for ion channel and transporter physiology and pathophysiology. One of the main directions of the lab has been to define the roles of the KCNE and KCNQ gene families of potassium channel subunits, using a combination of techniques including mouse and human genetics, electrophysiology, pharmacology, transcriptomics, and state-of-the-art imaging modalities. This includes research stemming from our unexpected discovery that the neurotransmitter GABA and related molecules can bind directly to certain voltage-gated potassium channels to activate them. Another major focus is the discovery of the molecular mechanisms underlying the beneficial actions of traditional herbal and other botanical medicines. Other interests include discovery of novel ion channel subunits and small molecules to modulate ion channel function, ion channel-transporter interactions, and investigation of ion channel trafficking. Abnormal functioning of ion channels can cause disorders including cardiac arrhythmia, epilepsy, myotonia, ataxia, periodic paralysis, hypothyroidism and cancer. We are employing a multidisciplinary approach aimed at understanding the molecular etiologies of, and ultimately developing therapies for, a wide spectrum of “channelopathies” - human diseases arising from ion channel dysfunction.
Available Technologies
Awards and Honors
1997-1999, Wellcome Trust Prize Traveling Postdoctoral Fellowship
2002, Winner, 11th Annual Dept. of Medicine Investigator Award, Weill-Cornell Medical College
2006, Finalist, 15th Annual Dept. of Medicine Investigator Award, Weill-Cornell Medical College
2009, Winner, 18th Annual Dept. of Medicine Investigator Award, Weill-Cornell Medical College
2010-2014, The Irma T. Hirschl Career Scientist Award
2022-2024, Samueli Scholar, Susan Samueli Integrative Health Institute (SSIHI), UCI
2023, Athalie Clarke Integrative Health Scientific Achievement award (Research Associates)
2002, Winner, 11th Annual Dept. of Medicine Investigator Award, Weill-Cornell Medical College
2006, Finalist, 15th Annual Dept. of Medicine Investigator Award, Weill-Cornell Medical College
2009, Winner, 18th Annual Dept. of Medicine Investigator Award, Weill-Cornell Medical College
2010-2014, The Irma T. Hirschl Career Scientist Award
2022-2024, Samueli Scholar, Susan Samueli Integrative Health Institute (SSIHI), UCI
2023, Athalie Clarke Integrative Health Scientific Achievement award (Research Associates)
Publications
157. A novel loss-of-function KCNB1 gene variant in a twin with global developmental delay and seizures. Manville RW, Illeck CL, Santos C, Sidlow R and Abbott GW (2024) Front. Cell. Neurosci. 18:1477989. doi: 10.3389/fncel.2024.1477989
156. Discovery of a potent, Kv7.3-selective potassium channel opener from a Polynesian traditional botanical anticonvulsant. Abbott GW, Manville RW. Commun Chem. 2024 7(1):233. doi: 10.1038/s42004-024-01318-9. PMID: 39390220
155. Polymodal K+ channel modulation contributes to dual analgesic and anti-inflammatory actions of traditional botanical medicines. Manville RW, Yoshimura RF, Yeromin AV, Hogenkamp D, van der Horst J, Zavala A, Chinedu S, Arena G, Lasky E, Fisher M, Tracy CR, Othy S, Jepps TA, Cahalan MD, Abbott GW. Commun Biol. 2024 Aug 28;7(1):1059. doi: 10.1038/s42003-024-06752-y. PMID: 39198706
154. Molecular and circuit determinants in the globus pallidus mediating control of cocaine-induced behavioral plasticity. Tian G, Bartas K, Hui M, Chen L, Vasquez JJ, Azouz G, Derdeyn P, Manville RW, Ho EL, Fang AS, Li Y, Tyler I, Setola V, Aoto J, Abbott GW, Beier KT. Neuron. 2024S0896-6273(24)00540-3. doi: 10.1016/j.neuron.2024.07.018.
PMID: 39153478
153. A novel autism-associated KCNB1 mutation dramatically slows Kv2.1 potassium channel activation, deactivation and inactivation. Manville RW, Block SD, Illeck CL, Kottmeier J, Sidlow R, Abbott GW. Front Cell Neurosci. 2024 18:1438101. doi: 10.3389/fncel.2024.1438101. eCollection 2024. PMID: 39135902
152. Crucial role for sensory nerves and Na/H exchanger inhibition in dapagliflozin and empagliflozin-induced arterial relaxation. Forrester EA, Benítez-Angeles M, Redford KE, Rosenbaum T, Abbott GW, Barrese V, Dora K, Albert AP, Dannesboe J, Salles-Crawley I, Jepps TA, Greenwood IA. Cardiovasc Res. 2024 cvae156. doi: 10.1093/cvr/cvae156. PMID: 39056245
151. Ophthalmate is a new regulator of motor functions via CaSR: Implications for movement disorders. Alhassen S, Hogenkamp D, Nguyen HA, Al Masri S, Abbott GW, Civelli O, Alachkar A. Brain. 2024 awae097. doi: 10.1093/brain/awae097. PMID: 38537648
150. Endogenous currents in HEK 293 cells are inhibited by memantine. Harrison, N. L., Abbott, G. W., McClenaghan, C., Nichols, C. G., Cabrera-Garcia, D. Nature Chemical Biology 2023 https://doi.org/10.1038/s41589-023-01423-1
149. Medicinal plant rosemary relaxes blood vessels by activating vascular smooth muscle KCNQ channels. Manville RW, Baldwin SN, Eriksen EØ, Jepps TA, Abbott GW. FASEB J. 2023 37(9):e23125. doi: 10.1096/fj.202301132R.
PMID: 37535015
148. Ancient medicinal plant rosemary contains a highly efficacious and isoform-selective KCNQ potassium channel opener. Manville RW, Hogenkamp D, Abbott GW. Commun Biol. 2023 6(1):644. doi: 10.1038/s42003-023-05021-8.
PMID: 37322081 Free PMC article.
147. Native American ataxia medicines rescue ataxia-linked mutant potassium channel activity via binding to the voltage sensing domain. Manville RW, Alfredo Freites J, Sidlow R, Tobias DJ, Abbott GW. Nature Communications 2023 14(1):3281. doi: 10.1038/s41467-023-38834-6. PMID: 37280215
146. Behavioral and neuro-functional consequences of eliminating the KCNQ3 GABA binding site in mice. Kiki J. Chen, Ryan Yoshimura, Clarissa Adriana Edmundo, Tri Minh Truong, Olivier Civelli, Amal Alachkar and Geoffrey W. Abbott. Front. Mol. Neurosci., 2023 Sec. Molecular Signalling and Pathways
Volume 16 - 2023 | https://doi.org/10.3389/fnmol.2023.1192628
145. The plant-derived alkaloid aloperine prevents ischemia/reperfusion injury-induced sudden cardiac death. Hu Z, Li J, Liu Q, Manville RW, Abbott GW.
FASEB J. 2023 37(7):e22999. doi: 10.1096/fj.202300253R. PMID: 37249366
144. Remote limb ischemic postconditioning attenuates myocardial dysfunction induced by testicular torsion/detorsion in rats. Liu Q, Abbott GW, Li J, Liu T, Wang Q, Ju F, Hu Z. Am J Physiol Regul Integr Comp Physiol. 2023 324(6):R747-R760. doi: 10.1152/ajpregu.00263.2022. PMID: 37036302
143. Canagliflozin Pretreatment Attenuates Myocardial Dysfunction and Improves Postcardiac Arrest Outcomes After Cardiac Arrest and Cardiopulmonary Resuscitation in Mice. Ju F, Abbott GW, Li J, Wang Q, Liu T, Liu Q, Hu Z.
Cardiovasc Drugs Ther. 2023 Jan 7. doi: 10.1007/s10557-022-07419-8. Online ahead of print. PMID: 36609949
142. Empagliflozin protects against renal ischemia/reperfusion injury in mice.
Wang Q, Ju F, Li J, Liu T, Zuo Y, Abbott GW, Hu Z. Sci Rep. 2022 Nov 11;12(1):19323. doi: 10.1038/s41598-022-24103-x. PMID: 36369319 Free PMC article.
141. Case report: A novel loss-of-function pathogenic variant in the KCNA1 cytoplasmic N-terminus causing carbamazepine-responsive type 1 episodic ataxia.
Manville RW, Sidlow R, Abbott GW. Front Neurol. 2022 Aug 9;13:975849. doi: 10.3389/fneur.2022.975849. eCollection 2022.
140. Harrison NL, Abbott GW, Gentzsch M, Aleksandrov A, Moroni A, Thiel G, Grant S, Nichols CG, Lester HA, Hartel A, Shepard K, Garcia DC, Yazawa M. How many SARS-CoV-2 "viroporins" are really ion channels? Commun Biol. 2022 Aug 25;5(1):859. doi: 10.1038/s42003-022-03669-2.
139. Manville RW, Redford KE, van der Horst J, Hogenkamp DJ, Jepps TA, Abbott GW. KCNQ5 activation by tannins mediates vasorelaxant effects of barks used in Native American botanical medicine. FASEB J. 2022 Sep;36(9):e22457. doi: 10.1096/fj.202200724R. PMID: 35997997
138. Abbott GW. Kv Channel Ancillary Subunits: Where Do We Go from Here?
Physiology (Bethesda). 2022 Sep 1;37(5):0. doi: 10.1152/physiol.00005.2022.
PMID: 35797055 Review.
137. Ramamoorthy K, Yoshimura R, Al-Juburi S, Anandam KY, Kapadia R, Alachkar A, Abbott GW, Said HM.Alzheimer's disease is associated with disruption in thiamin transport physiology: A potential role for neuroinflammation. Neurobiol Dis. 2022 Sep;171:105799. doi: 10.1016/j.nbd.2022.105799. Epub 2022 Jun 21.
PMID: 35750148
136. Huang D, Chen C, Zuo Y, Du L, Liu T, Abbott GW, Hu Z. Protective effect of remote liver ischemic postconditioning on pulmonary ischemia and reperfusion injury in diabetic and non-diabetic rats. PLoS One. 2022 May 26;17(5):e0268571. doi: 10.1371/journal.pone.0268571. eCollection 2022.
135. Papanikolaou M, Crump SM, Abbott GW. The focal adhesion protein Testin modulates KCNE2 potassium channel ß subunit activity. Channels (Austin). 2021 12; 15(1):229-238. PMID: 33464998; PMCID: PMC7833772.
134. Martin-Batista E, Manville RW, Rivero-Pérez B, Bartolomé-Martín D, Alvarez de la Rosa D, Abbott GW, Giraldez T. (2021) Activation of SGK1.1 Upregulates the M-current in the Presence of Epilepsy Mutations. Front Mol Neurosci. 2021 Nov 26;14:798261. doi: 10.3389/fnmol.2021.798261. eCollection 2021. PMID: 34899186
133. Huang D, Ju F, Du L, Liu T, Zuo Y, Abbott GW, Hu Z. (2021)
Empagliflozin Protects against Pulmonary Ischemia/Reperfusion Injury via an ERK1/2-Dependent Mechanism. J Pharmacol Exp Ther. 2021 Dec 10:JPET-AR-2021-000956. doi: 10.1124/jpet.121.000956. Online ahead of print.
PMID: 34893552
132. Geoffrey W Abbott, Kaitlyn E Redford, Ryan Yoshimura, Rían Manville, Luiz Moreira, Kevin Tran, Grey Arena, Alexandra Kookootsedes, Emma Lasky, Elliot Gunnison (2021) KCNQ and KCNE isoform-dependent pharmacology rationalizes Native American dual use of specific plants as both analgesics and gastrointestinal therapeutics. Frontiers in Physiology. 11 November 2021 | https://doi.org/10.3389/fphys.2021.777057
131. Zhaoyang Hu, Feng Ju, Lei Du, Abbott, GW, (2021) Empagliflozin Protects the Heart against Ischemia/Reperfusion-Induced Sudden Cardiac Death. Cardiovascular Diabetology. 20(1):199. doi: 10.1186/s12933-021-01392-6
130. 135. Ip, J., Xu, L., Dai, J., Steegborn, C., Jaffre, F., Evans, T., Cheung, J., Basson, C., Panaghie, G., Krogh-Madsen, T., Abbott, G.W., Lerman, B. (2021) Constitutively Activating GNAS Somatic Mutation in Right Ventricular Outflow Tract Tachycardia. Circulation: Arrhythmia and electrophysiology. CIRCEP121010082. doi: 10.1161/CIRCEP.121.010082. Online ahead of print.
129. Lai, W., Li, S., Zhongtao Du, Xinhua Ma, Junyu Lu, Wei Dong Gao, Abbott, GW, Hu, Z., Kan, Y. (2021) Severe ARDS Patients with COVID-19 Treated with Extracorporeal Membrane Oxygenation in China: a Retrospective Study. Frontiers in Medicine. In Press
128. Redford, K. E., Abbott, G. W. (2021) KCNQ Potassium Channels as Targets of Botanical Folk Medicines. Annual Review of Pharmacology and Toxicology, Volume 62 In Press
127. Manville RW, Abbott GW. (2021) The Amyloid Precursor Protein C99 Fragment Modulates Voltage-Gated Potassium Channels. Cell Physiol Biochem. 2021 Jul 28;55(S3):157-170. doi: 10.33594/000000397.
126. Abbott GW. (2021) Control of Biophysical and Pharmacological Properties of Potassium Channels by Ancillary Subunits. Handb Exp Pharmacol. 2021 Jul 11. doi: 10.1007/164_2021_512.
125. Alhassen S, Chen S, Alhassen L, Phan A, Khoudari M, De Silva A, Barhoosh H, Wang Z, Parrocha C, Shapiro E, Henrich C, Wang Z, Mutesa L, Baldi P, Abbott GW, Alachkar A. (2021) Intergenerational trauma transmission is associated with brain metabotranscriptome remodeling and mitochondrial dysfunction. Commun Biol. 2021 Jun 24;4(1):783. doi: 10.1038/s42003-021-02255-2.
124. Tedeschi G, Scipioni L, Papanikolaou M, Abbott GW, Digman MA. (2021) Fluorescence Fluctuation Spectroscopy enables quantification of potassium channel subunit dynamics and stoichiometry. Sci Rep. 2021 May 21;11(1):10719. doi: 10.1038/s41598-021-90002-2.
123. Cabrera-Garcia D, Bekdash R, Abbott GW, Yazawa M, Harrison NL. (2021) The envelope protein of SARS-CoV-2 increases intra-Golgi pH and forms a cation channel that is regulated by pH. J Physiol. 2021 Jun;599(11):2851-2868. doi: 10.1113/JP281037.
122. Redford KE, Rognant S, Jepps TA, Abbott GW. (2021) KCNQ5 Potassium Channel Activation Underlies Vasodilation by Tea. Cell Physiol Biochem. 2021 Mar 6;55(S3):46-64. doi: 10.33594/000000337.
121. van der Horst J, Rognant S, Abbott GW, Ozhathil LC, Hägglund P, Barrese V, Chuang CY, Jespersen T, Davies MJ, Greenwood IA, Gourdon P, Aalkjær C, Jepps TA. (2021) Dynein regulates Kv7.4 channel trafficking from the cell membrane. J Gen Physiol. 153(3):e202012760.
doi: 10.1085/jgp.202012760.
120. Papanikolaou M, Crump SM, Abbott GW. (2021) The focal adhesion protein Testin modulates KCNE2 potassium channel ß subunit activity. Channels 15(1):229-238. doi: 10.1080/19336950.2021.1874119.
119. Chen S, Alhassen W, Yoshimura R, De Silva A, Abbott GW, Baldi P, Alachkar A. (2020) Metabolomic and transcriptomic signatures of prenatal excessive methionine support nature rather than nurture in schizophrenia pathogenesis. Communications Biology 3(1):409 doi: 10.1038/s42003-020-01124-8.
118. Redford, KE, Abbott, GW. (2020). The ubiquitous flavonoid quercetin is an atypical KCNQ potassium channel activator. Communications Biology 3(1):356 doi: 10.1038/s42003-020-1089-8.
117. Lisewski U, Köhncke C, Schleussner L, Purfürst B, Lee SM, De Silva A, Manville RW, Abbott GW*, Roepke TK*. (2020) Hypochlorhydria reduces mortality in heart failure caused by Kcne2 gene deletion. FASEB J. 2020 Jun 25. doi: 10.1096/fj.202000013RR. Online ahead of print. PMID: 32584506 *co-corresponding authors
116. Abbott, GW (2020) KCNQs: ligand-and voltage-gated potassium channels. Frontiers in Physiology 23;11:583. doi: 10.3389/fphys.2020.00583. eCollection 2020.
115. Llorente-Esteban, A., Manville, R.W., Reyna-Neyra, A., Abbott, G.W., Amzel, A.M., Carrasco, N. (2020) Allosteric regulation of mammalian Na+/I- symporter activity by perchlorate. Nat Struct Mol Biol. https://doi.org/10.1038/s41594-020-0417-5
114. Manville RW, Abbott GW. (2020) Isoform-Selective KCNA1 Potassium Channel Openers Built from Glycine. J Pharmacol Exp Ther. 373(3):391-401. doi: 10.1124/jpet.119.264507. PMID: 32217768 (COVER ARTICLE)
113. van der Horst J, Manville RW, Hayes K, Thomsen MB, Abbott GW, Jepps TA. (2020) Acetaminophen (Paracetamol) Metabolites Induce Vasodilation and Hypotension by Activating Kv7 Potassium Channels Directly and Indirectly. Arterioscler Thromb Vasc Biol. 40(5):1207-1219. doi: 10.1161/ATVBAHA.120.313997. PMID: 32188278
112. Manville RW, Abbott GW. (2020) Potassium channels act as chemosensors for solute transporters. Communications Biology 3(1):90. doi: 10.1038/s42003-020-0820-9.
111. Manville RW, Papanikolaou M, Abbott GW. (2020) M-Channel Activation Contributes to the Anticonvulsant Action of the Ketone Body ß-Hydroxybutyrate. J Pharmacol Exp Ther. 372(2):148-156. doi: 10.1124/jpet.119.263350 (COVER ARTICLE)
110. Manville RW, Abbott GW. (2019) In silico re-engineering of a neurotransmitter to activate KCNQ potassium channels in an isoform-specific manner. Communications Biology 2:401. doi: 10.1038/s42003-019-0648-3. eCollection 2019.
109. Manville RW, van der Horst J, Redford KE, Katz BB, Jepps TA, Abbott GW. (2019) KCNQ5 activation is a unifying molecular mechanism shared by genetically and culturally diverse botanical hypotensive folk medicines. Proc Natl Acad Sci pii: 201907511. doi: 10.1073/pnas.1907511116. [Epub ahead of print]
108. Vawter M.P. · Hamzeh A.R. · Muradyan E. · Civelli O. · Abbott G.W. · Alachkar A. (2019) Association of Myoinositol Transporters with Schizophrenia and Bipolar Disorder: Evidence from Human and Animal Studies. Mol Neuropsychiatry (DOI:10.1159/000501125)
107. Manville RW, Abbott GW. (2019) Cilantro leaf harbors a potent potassium channel-activating anticonvulsant. FASEB J. 33(10):11349-11363. doi: 10.1096/fj.201900485R
106. Zhou L, Köhncke C, Hu Z, Roepke TK, Abbott GW. (2019) The KCNE2 potassium channel ß subunit is required for normal lung function and resilience to ischemia and reperfusion injury. FASEB J. 33(9):9762-9774. doi: 10.1096/fj.201802519R
105. Manville RW, Abbott GW. (2019) Teamwork: ion channels and transporters join forces in the brain. Neuropharmacology. pii: S0028-3908(19)30118-2. doi: 10.1016/j.neuropharm.2019.04.007
104. Hu Z, Jepps T, Zhou L, Liu J, Li M, Abbott GW. (2019) Kcne4 deletion sex-dependently inhibits the RISK pathway response and exacerbates hepatic ischemia-reperfusion injury in mice.
Am J Physiol Regul Integr Comp Physiol. 316(5):R552-R562. doi: 10.1152/ajpregu.00251.2018.
103. Hu Z, Liu J, Zhou L, Tian X, Abbott GW. (2019) AKT and ERK1/2 activation via remote ischemic preconditioning prevents Kcne2-dependent sudden cardiac death. Physiol Rep. 7(3):e13957. doi: 10.14814/phy2.13957.
102. Harkcom WT, Papanikolaou M, Kanda V, Crump SM, Abbott GW. (2019) KCNQ1 rescues TMC1 plasma membrane expression but not mechanosensitive channel activity. J Cell Physiol. 234(8):13361-13369. doi: 10.1002/jcp.28013
101. David JP, Lisewski U, Crump SM, Jepps TA, Bocksteins E, Wilck N, Lossie J, Roepke TK, Schmitt N, Abbott GW. (2019) Deletion in mice of X-linked, Brugada syndrome- and atrial fibrillation-associated Kcne5 augments ventricular KV currents and predisposes to ventricular arrhythmia. FASEB J. 33(2):2537-2552. doi: 10.1096/fj.201800502R
100. De Silva AM, Manville RW, Abbott GW. (2018) Deconstruction of an African folk medicine uncovers a novel molecular strategy for therapeutic potassium channel activation. Science Advances 4(11):eaav0824. doi: 10.1126/sciadv.aav0824
99. Manville RW, Abbott GW. (2018) Ancient and modern anticonvulsants act synergistically in a KCNQ potassium channel binding pocket.
Nature Communications 9(1):3845. doi: 10.1038/s41467-018-06339-2.
98. Manville RW, Abbott GW. (2018) Gabapentin Is a Potent Activator of KCNQ3 and KCNQ5 Potassium Channels. Mol Pharmacol. 94(4):1155-1163. doi: 10.1124/mol.118.112953.
97. Hu Z, Wei W, Zhou L, Chen M, Abbott GW. (2018) Kcne4 deletion sex-specifically predisposes to cardiac arrhythmia via testosterone-dependent impairment of RISK/SAFE pathway induction in aged mice. Sci Rep. ;8(1):8258. doi: 10.1038/s41598-018-26599-8.
96. Luo N, Liu J, Chen Y, Li H, Hu Z, Abbott GW. (2018) Remote ischemic preconditioning STAT3-dependently ameliorates pulmonary ischemia/reperfusion injury. PLoS One. 13(5):e0196186. doi: 10.1371/journal.pone.0196186.
95. Manville R.W., Papanikolaou M., Abbott GW (2018). Direct neurotransmitter activation of voltage-gated potassium channels. Nature Communications. 9:1847. DOI: 10.1038/s41467-018-04266-w
94. Alachkar A, Wang L, Yoshimura R, Hamzeh AR, Wang Z, Sanathara N, Lee SM, Xu X, Abbott GW, Civelli O. (2018). Prenatal one-carbon metabolism dysregulation programs schizophrenia-like deficits. Molecular Psychiatry. 23(2):282-294. doi: 10.1038/mp.2017.164.
93. Abbott GW. (2017). ß Subunits Control the Effects of Human Kv4.3 Potassium Channel Phosphorylation. Front. Physiol. 8:646 | https://doi.org/10.3389/fphys.2017.00646
92. Manville RW, Neverisky DL, Abbott GW. (2017). SMIT1 Modifies KCNQ Channel Function and Pharmacology by Physical Interaction with the Pore. Biophys J. 113(3):613-626. doi: 0.1016/j.bpj.2017.06.055.
91. Abbott GW. (2017) Chansporter complexes in cell signalling. FEBS Letters. doi: 10.1002/1873-3468.12755
90. Hu Z, Chen M, Zhang P, Liu J, Abbott GW. (2017) Remote ischemic preconditioning differentially attenuates post-ischemic cardiac arrhythmia in streptozotocin-induced diabetic versus nondiabetic rats. Cardiovascular Diabetol. 16(1):57. doi: 10.1186/s12933-017-0537-3.
89. King EC, Patel V, Anand M, Zhao X, Crump SM, Hu Z, Weisleder N, Abbott GW. (2017) Targeted deletion of Kcne3 impairs skeletal muscle function in mice. FASEB J. pii: fj.201600965RR. doi: 10.1096/fj.201600965RR.
88. Neverisky, D.L. Abbott, G.W. (2017) KCNQ-SMIT complex formation facilitates ion channel-solute transporter cross talk. FASEB Journal Mar 10. pii: fj.201601334R. doi: 10.1096/fj.201601334R. [Epub ahead of print]
87. Lee, SM., Baik, J., Nguyen, D., Nguyen, V., Liu, S., Hu, Z., Abbott, G.W. (2017) Kcne2 deletion causes Type II Diabetes Mellitus via a primary defect in insulin secretion. FASEB Journal pii: fj.201601347. doi: 10.1096/fj.201601347. [Epub ahead of print]
86. Abbott GW (2017) ß Subunits Functionally Differentiate Human Kv4.3 Potassium Channel Splice Variants. Frontiers in Physiology 8 10.3389/fphys.2017.00066
85. Yang S, Abbott GW, Gao WD, Liu J, Luo C, Hu Z. (2017) Involvement of Glycogen Synthase Kinase-3ß in Liver Ischemic Conditioning Induced Cardioprotection against Myocardial Ischemia and Reperfusion Injury in Rats. J Appl Physiol (1985). 2017 Feb 2:jap.00862.2016. doi: 10.1152/japplphysiol.00862.2016
84. Abbott, G.W. (2016) Regulation of human cardiac potassium channels by full-length KCNE3 and KCNE4. Sci Rep. 2016 Dec 6;6:38412. doi: 10.1038/srep38412
83. Abbott, GW. (2016) Channel-transporter complexes: an emerging theme in cell signaling. Biochemical Journal 473 (21) 3759-3763; DOI: 10.1042/BCJ20160685C
82. Hu Z, Hu S, Yang S, Chen M, Zhang P, Liu J, Abbott GW. (2016) Remote Liver Ischemic Preconditioning Protects against Sudden Cardiac Death via an ERK/GSK-3ß-Dependent Mechanism. PLoS One. 11(10):e0165123. doi: 10.1371/journal.pone.0165123.
81. Abbott, GW., Jepps, TA. (2016) Kcne4 deletion sex-dependently alters vascular reactivity. Journal of Vascular Research 53(3-4):138-148.
80. Abbott, GW. (2016) KCNE4 and KCNE5: K+ channel regulation and cardiac arrhythmogenesis, Gene doi: 10.1016/j.gene.2016.07.069
79. Abbott GW. (2016) Novel exon 1 protein-coding regions N-terminally extend human KCNE3 and KCNE4. FASEB Journal 30(8):2959-69. doi: 10.1096/fj.201600467R.
78. Neverisky DL, Abbott GW. (2016) Ion channel-transporter interactions. Critical Reviews in Biochemistry and Molecular Biology. 51(4):257-67. doi: 10.3109/10409238.2016.1172553.
77. Hu Z, Crump SM, Zhang P, Abbott GW. (2016) Kcne2 deletion attenuates acute post-ischemia/reperfusion myocardial infarction. Cardiovascular Research 110(2):227-37. doi: 10.1093/cvr/cvw048.
76. Lee SM, Nguyen D, Anand M, Kant R, Kohncke C, Lisewski U, Roepke TK, Hu Z, Abbott GW. (2016) Kcne2 deletion causes early-onset nonalcoholic fatty liver idsease via iron deficiency anemia. Scientific Reports 6, 23118; doi: 10.1038/srep23118
75. Abbott GW*, Roepke TK. (2016) KCNE2 in gastric cancer: from bench to bedside. Oncotarget 7(14):17286-7. doi: 10.18632/oncotarget.7921 *First and corresponding author
74. Abbott GW. (2016) KCNE1 and KCNE3: the yin and yang of voltage-gated K+ channel regulation.
Gene 576(1 Pt 1):1-13. doi: 10.1016/j.gene.2015.09.059
73. Crump SM, Hu Z, Kant R, Levy DI, Goldstein SA, Abbott GW. (2016) Kcne4 deletion sex and age specifically impairs cardiac repolarization in mice. FASEB Journal 30(1):360-9. doi: 10.1096/fj.15-278754
72. Lee SM, Nguyen D, Hu Z, Abbott GW. (2015) Kcne2 deletion promotes atherosclerosis and diet-dependent sudden death. J Mol Cell Cardiol. 87:148-151. doi: 10.1016/j.yjmcc.2015.08.013.
71. Abbott GW. (2015) The KCNE2 K+ channel regulatory subunit: ubiquitous influence, complex pathobiology. Gene pii: S0378-1119(15)00771-4. doi: 10.1016/j.gene.2015.06.061. [Epub ahead of print]
70. Abbott GW*, Pitt, GS. (2014) Ion channels under the Sun. FASEB Journal 28(5):1957-62 *First and corresponding author
69. Abbott GW*, Tai KK, Neverisky D, Hansler A, Hu Z, Roepke TK, Lerner DJ, Chen Q, Liu L, Zupan B, Toth M, Haynes R, Huang X, Demirbas D, Buccafusca R, Gross SS, Kanda VA and Berry GT. (2014) KCNQ1, KCNE2, and Na+-Coupled Solute Transporters Form Reciprocally Regulating Complexes that Affect Neuronal Excitability. Science Signaling 7(315):ra22. *First and corresponding author
68. Noam Y, Ehrengruber MU, Koh A, Feyen P, Manders EM, Abbott GW, Wadman WJ, Baram TZ. (2014) Filamin A promotes dynamin-dependent internalization of hyperpolarization-activated cyclic nucleotide-gated type 1 (HCN1) channels and restricts Ih in hippocampal neurons. J Biol Chem. 289(9):5889-903
67. Abbott, G.W. (2014) Biology of the KCNQ1 Potassium Channel. New Journal of Science (in press)
66. Abbott G.W. (2014) Pharmacogenetic diversification by alternative translation initiation: background channels to the fore. British Journal of Pharmacology doi: 10.1111/bph.12630. (epub ahead of print)
65. Crump, SM, Abbott, GW. (2014) Arrhythmogenic KCNE gene variants: current knowledge and future challenges. Frontiers in Genetics. 5:3. doi: 10.3389/fgene.2014.00003
64. Hu Z, Kant R, Anand M, King EC, Krogh-Madsen T, Christini DJ, Abbott GW. (2014) Kcne2 Deletion Creates a Multisystem Syndrome Predisposing to Sudden Cardiac Death. Circulation: Cardiovascular Genetics. doi: 10.1161/CIRCGENETICS.113.000315
63. Hu, Z., Crump, S.M., Anand, M., Kant, R., Levi, R., Abbott, G.W. (2014) Kcne3 deletion initiates extracardiac arrhythmogenesis. FASEB Journal epub fj.13-241828
62. Kant, R., Hu, Z., Malhotra, J.K., Krogh-Madsen, T., Christini, D.J., Heerdt, P.M., Abbott, G.W. (2013) NHE isoform swiching and KChIP2 upregulation in aging porcine atria. PLoS One 8(12):e82951. doi: 10.1371/journal.pone.0082951.
61. Hu ZY, Abbott GW, Fang YD, Huang YS, Liu J. (2013) Emulsified isoflurane postconditioning produces cardioprotection against myocardial ischemia-reperfusion injury in rats. J Physiol Sci. 63(4):251-61
60. Abbott, G.W. (2013) KCNE genetics and pharmacogenomics in cardiac arrhythmias: much ado about nothing? Expert Reviews in Clinical Pharmacology. 6(1):49-60
59. Heerdt PM, Kant R, Hu Z, Kanda VA, Christini DJ, Malhotra JK, Abbott GW. (2012) Transcriptomic analysis reveals atrial KCNE1 down-regulation following lung lobectomy. J Mol Cell Cardiol. 53(3):350-3
58. Purtell K, Paroder-Belenitsky M, Reyna-Neyra A, Nicola JP, Koba W, Fine E, Carrasco N, Abbott GW. (2012) The KCNQ1-KCNE2 K+ channel is required for adequate thyroid I- uptake. FASEB J. 26(8):3252-9
57. Krogh-Madsen T, Abbott GW, Christini DJ. (2012) Effects of electrical and structural remodeling on atrial fibrillation maintenance: a simulation study. PLoS Comput Biol. 8(2):e1002390.
56. Kanda V.A., Abbott G.W. (2012) KCNE Regulation of K+ Channel Trafficking - a Sisyphean Task? Front Physiol. 3:231.
55. Abbott G.W.*, Ramesh B., Srai S.K. (2012) Interaction between Soluble and Membrane-Embedded Potassium Channel Peptides Monitored by Fourier Transform Infrared Spectroscopy. PLoS One. 7(11):e49070. doi: 10.1371/journal.pone.0049070 *First and corresponding author
54. Ying SW, Kanda VA, Hu Z, Purtell K, King EC, Abbott GW, Goldstein PA (2012) Targeted Deletion of Kcne2 Impairs HCN Channel Function in Mouse Thalamocortical Circuits. PLoS One 7(8): e42756
53. Abbott GW. (2012) KCNE2 and the K+ channel: The tail wagging the dog. Channels 6(1) http://dx.doi.org/10.4161/chan.19126
52. Roepke, TK, Kanda, VA, Purtell, K, King, EC, Lerner, DJ, Abbott, G.W. (2011) KCNE2 forms potassium channels with KCNA3 and KCNQ1 in the choroid plexus epithelium. FASEB J. 25(12):4264-73
51. Roepke, T.K., King, E.C., Purtell, K., Kanda, V.A., Lerner, D.J., Abbott, G.W. (2011) Genetic dissection reveals unexpected influence of beta subunits on KCNQ1 K+ channel polarized trafficking in vivo. FASEB J. 25(2):727-36
50. Kanda VA, Lewis A, Xu X, Abbott G.W. (2011) KCNE1 and KCNE2 inhibit forward trafficking of homomeric N-type voltage-gated potassium channels. Biophys J. 101(6):1354-63
49. Kanda VA, Lewis A, Xu X, Abbott G.W. (2011) KCNE1 and KCNE2 provide a checkpoint governing voltage-gated potassium channel subunit composition. Biophys J. 101(6):1364-75
48. Kanda, VA, Purtell, K, Abbott, G.W. (2011) Protein Kinase C downregulates IKs by stimulating KCNQ1-KCNE1 potassium channel endocytosis. Heart Rhythm 8(10):1641-7.
47. Purtell, K., Roepke, T.K., Abbott, G.W. (2010) Cardiac arrhythmia and thyroid dysfunction: a novel genetic link. International Journal of Biochemistry and Cell Biology 42(11): 1767-70
46. Harkcom, W., Abbott, G.W. (2010) Emerging concepts in the pharmacogenomics of arrhythmias: ion channel trafficking. Expert Review of Cardiovascular Therapy 8(8):1161-73
45. Roepke, T.K., Purtell, K., King, E.C., La Perle, K.M.D., Lerner, D.J., Abbott, G.W. (2010) Targeted deletion of Kcne2 causes gastritis cystica profunda and gastric neoplasia. PLoS One 5(7):e11451, 1-10
44. Choi, E., Abbott, G.W. (2010) A shared mechanism for lipid- and beta-subunit-coordinated stabilization of the activated K+ channel voltage sensor. FASEB J. 24(5):1518-24
43. Roepke, T.K., King, E.C., Reyna-Neyra, A., Paroder, M., Purtell, K., Koba, W., Fine, E., Lerner, D.J., Carrasco, N., Abbott, G.W. (2009) Kcne2 deletion uncovers its crucial role in thyroid hormone biosynthesis. Nature Medicine 15(10):1186-94 [Faculty of 1000 Medicine evaluation: http://f1000medicine.com/article/id/1165526/]
42. Abbott, G.W.*, Roepke, T.K. (2009) HERG biosynthesis: the positive influence of negative charge. Am J. Physiol Heart Circ Physiol. 296(5):H1211-2 *First and corresponding author
41. Gaeta, S.A., Bub, G., Abbott, G.W., Christini, D.J. (2009) Dynamical mechanism for subcellular alternans in cardiac myocytes. Circulation Research 105(4):335-42
40. Xu, X., Kanda, V.A., Choi, E., Panaghie, G., Roepke, T.K., Gaeta, S.A., Christini, D.J., Lerner, D.J., Abbott, G.W. (2009) MinK-dependent internalization of the IKs potassium channel. Cardiovascular Research 82(3):430-8
39. McCrossan, Z.A., Roepke, T.K., Lewis, A., Panaghie, G., Abbott, GW. (2009) Regulation of the Kv2.1 Potassium Channel by MinK and MiRP1. J Membr Biol. 228(1):1-14.
38. Abbott, G.W.*, Roepke, T.K. (2008) Pharmacogenetics of drug-induced arrhythmias. Expert Review of Clin. Pharm. 1(1):93-104. *First and corresponding author
37. Yang, L., Soonpaa, M.H., Adler, E.D., Roepke, T.K., Kattman, S.J., Kennedy, M., Henckaerts, E., Bonham, K., Abbott, G.W., Linden, R.M., Field, L.J., Keller, G.M. (2008) Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. Nature 453(7194):524-8.
36. Morrey, C., Estephan, R., Abbott, G.W., Levi, R. (2008) Cardioprotective Effect of Histamine H3-Receptor Activation: Pivotal Role of G beta gamma-Dependent Inhibition of Voltage-Operated Ca2+ Channels. J. Pharm. Exp. Ther. 326(3):871-8
35. Roepke, T.K., Kontogeorgis, A., Ovanez, C., Xu, X., Young, J.B., Purtell, K., Goldstein, P.A., Christini, D.J., Peters, N.S., Akar, F.G., Gutstein, D.E., Lerner, D.J., Abbott, G.W. (2008) Targeted deletion of kcne2 impairs ventricular repolarization via disruption of IK,slow1 and Ito,f. FASEB Journal 22:3648-3660.
34. Gordon, E., Panaghie, G., Deng, L., Bee, K.J., Roepke, T.K., Krogh-Madsen, T., Christini, D.J., Ostrer, H., Basson, C.T., Chung, W., Abbott, G.W. (2008) A KCNE2 mutation in a patient with cardiac arrhythmia induced by auditory stimuli and serum electrolyte imbalance. Cardiovascular Research 77(1):98-106
33. Abbott, G.W.*, Ramesh, B., Srai, S.K.S. (2008) Secondary structure of the MiRP1 (KCNE2) potassium channel ancillary subunit. Protein and Peptide Letters 15(1):63-75. *First and corresponding author
32. Panaghie, G., Purtell, K., Tai, K.-K., Abbott, G.W. (2008) Voltage-dependent C-type inactivation in a constitutively open K+ channel. Biophysical Journal 95(6):2759-78
31. Abbott, G.W.*, Xu, X., Roepke, T.K. (2007) Impact of ancillary subunits on ventricular repolarization. The Journal of Electrocardiology 40(6 Suppl):S42-6. *First and corresponding author
30. Choi, E., Abbott, G.W. (2007) The MiRP2-Kv3.4 potassium channel: muscling in on Alzheimer’s disease. Molecular Pharmacology 72(3):499-501
29. Panaghie, G., Abbott, G.W. (2007) The role of S4 charges in voltage-dependent and voltage-independent KCNQ1 potassium channel complexes. The Journal of General Physiology 129(2):121-133
28. Abbott, G.W. (2006) Molecular mechanisms of cardiac voltage-gated potassium channelopathies. Current Pharmaceutical Design 12(28):3631-3644
27. Roepke, T.K., Anantharam, A., Kirchhoff, P., Busque, S.M., Young, J.B., Geibel, J.P., Lerner, D.J., Abbott, G.W. (2006) The KCNE2 potassium channel ancillary subunit is essential for gastric acid secretion. J. Biol. Chem 281(33):23740-23747 [Faculty of 1000 Biology evaluation: http://f1000biology.com/article/id/1047240/evaluation]
26. Gordon, E., Cohen, J.-L., Engel, R., Abbott, G.W. (2006) 1,4-diazabicyclo[2.2.2]octane derivatives: a novel class of voltage-gated potassium channel blockers. Molecular Pharmacology 69(3):718-726
25. Panaghie, G., Abbott, G.W. (2006) The impact of ancillary subunits on small-molecule interactions with voltage-gated potassium channels. Current Pharmaceutical Design 12(18):2285-2302
24. Gordon, E., Roepke, T.K., Abbott, G.W. (2006) Endogenous KCNE Subunits Govern Kv2.1 K+ Channel Activation Kinetics in Xenopus Oocyte Studies. Biophysical Journal 90(4):1223-31
23. Panaghie, G., Tai, K.-K., Abbott, G.W. (2006) Interaction of KCNE subunits with the KCNQ1 K+ channel pore. Journal of Physiology 570 (Pt 3):455-67
22. Roepke, T.K, Abbott, G.W. (2006) Pharmacogenetics and cardiac ion channels. Vascular Pharmacology 44(2):90-106
21. Abbott, G.W., Butler, M.H., & Goldstein, S.A. (2006) Phosphorylation and protonation of neighboring MiRP2 sites: function and pathophysiology of MiRP2-Kv3.4 potassium channels in periodic paralysis. FASEB Journal 20(2):293-301
20. Anantharam A, Abbott GW. (2005) Does hERG coassemble with a beta subunit? Evidence for roles of MinK and MiRP1. Novartis Found Symp. 2005;266:100-12; discussion 112-7, 155-8.
19. Cacheaux, L.P., Topf, N., Tibbs, G.R., Schaefer, U.R., Levi, R., Harrison, N.L., Abbott, G.W., Goldstein, P.A. (2005) Impairment of hyperpolarization-activated, cyclic nucleotide-gated channel function by the intravenous general anesthetic propofol. J. Pharm. Exp. Ther. 315(2):517-25
18. McCrossan, Z.A., Abbott, G.W. (2004) The MinK-Related Peptides. Neuropharmacology. 47(6):787-821
17. Lewis A., McCrossan Z.A., Abbott, G.W. (2004) MinK, MiRP1 and MiRP2 diversify Kv3.1 and Kv3.2 potassium channel gating. J. Biol. Chem. 279:7884-7892
16. Anantharam, A., Markowitz, S.M., Abbott, G.W. (2003) Pharmacogenetic considerations in diseases of cardiac ion channels. J. Pharm. Exp. Ther. 307:831-838
15. Tai, K.-K., McCrossan, Z.A., Abbott, G.W. (2003) Activation of mitochondrial ATP-sensitive potassium channels increases cell viability against rotenone-induced cell death. Journal of Neurochemistry 84:1193-1200
14. McCrossan, Z.A., Lewis, A., Panaghie, G., Jordan, P.N., Christini, D.J., Lerner, D.J., Abbott, G.W. (2003) MinK-related peptide 2 modulates Kv2.1 and Kv3.1 potassium channels in mammalian brain. Journal of Neuroscience 23:8077-8091
13. Anantharam, A., Lewis, A., Panaghie, G., Gordon, E., McCrossan, Z.A., Lerner, D.J., Abbott, G.W. (2003) RNA interference reveals that endogenous Xenopus MinK-related Peptides govern mammalian K+ channel function in oocyte expression studies. J. Biol. Chem. 278:11739-11745
12. Abbott, G.W., Goldstein, S.A.N. (2002) Disease-associated mutations in KCNE potassium channel subunits (MiRPs) reveal promiscuous disruption of multiple currents and conservation of mechanism. FASEB Journal 16: 390-400
11. Abbott, G.W., Butler, M.H., Bendahhou, S., Dalakas, M.C., Ptacek, L.J., Goldstein, S.A.N. (2001) MiRP2 forms potassium channels in skeletal muscle with Kv3.4 and is associated with periodic paralysis. Cell 104:217-231.
10. Abbott GW, Goldstein SA, Sesti F. (2001) Do all voltage-gated potassium channels use MiRPs? Circ Res. 88(10):981-3.
9. Abbott GW, Goldstein SA. (2001) Potassium channel subunits encoded by the KCNE gene family: physiology and pathophysiology of the MinK-related peptides (MiRPs). Mol Interv. 1(2):95-107.
8. Sesti, F., Abbott, G.W., Wei, J., Murray, K.T., Saksena, S., Schwartz, P.J., Priori, S.G., Roden, D.M., George, Jr., A.L., Goldstein, S.A.N. (2000) A common polymorphism associated with antibiotic-induced cardiac arrhythmia . Proc. Nat. Acad. Sci. 97:10613-10618
7. Abbott, G.W., Sesti, F., Splawski, I., Buck, M.E., Lehmann, M.H., Timothy, K.W., Keating, M.T., Goldstein, S.A.N. (1999) MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. Cell 97: 175-187
6. Abbott GW, Goldstein SA. A superfamily of small potassium channel subunits: form and function of the MinK-related peptides (MiRPs). Q Rev Biophys. 31(4):357-98.
5. Abbott, G.W., Mercer, E.A.J., Miller, R.T., Ramesh, B., Srai, S.K.S. (1998) Conformational changes in a mammalian voltage-dependent potassium channel inactivation peptide. Biochemistry 37:1640-1645
4. Abbott, G.W., Bloemendal, M., Van Stokkum, I.H.M., Mercer, E.A.J., Miller, R.T., Sewing, S., Wolters, M., Pongs, O., Srai, S.K.S. (1997) Secondary structure, stability and tetramerisation of recombinant Kv1.1 potassium channel cytoplasmic N-terminal fragment. Biochim. Biophys. Acta 1341:71-78
3. Mercer, E.A.J., Abbott, G.W., Brazier, S., Ramesh, B., Haris, P.I., Srai, S.K.S. (1997) Synthetic putative transmembrane region of minimal potassium channel protein (minK) adopts an alpha-helical conformation in phospholipid membranes. Biochemical Journal 325 (2) 475-9
2. Abbott, G.W., Mercer, E.A.J., Wolters, M., Sewing, S., Pongs, O., Srai, S.K.S. (1995) Structure analysis of a recombinant voltage-gated potassium channel (Kv1.1) N-terminus using FTIR spectroscopy and thermal denaturation. Biochem. Sci. Trans. 23(3):479S
1. Mercer, E.A.J., Abbott, G.W., Ramesh, B., Haris, P.I., Chapman, D., Srai, S.K.S. (1995) Structural characterization of a slowly activating potassium channel (IsK). Biochem. Sci. Trans. 23(3):478S
156. Discovery of a potent, Kv7.3-selective potassium channel opener from a Polynesian traditional botanical anticonvulsant. Abbott GW, Manville RW. Commun Chem. 2024 7(1):233. doi: 10.1038/s42004-024-01318-9. PMID: 39390220
155. Polymodal K+ channel modulation contributes to dual analgesic and anti-inflammatory actions of traditional botanical medicines. Manville RW, Yoshimura RF, Yeromin AV, Hogenkamp D, van der Horst J, Zavala A, Chinedu S, Arena G, Lasky E, Fisher M, Tracy CR, Othy S, Jepps TA, Cahalan MD, Abbott GW. Commun Biol. 2024 Aug 28;7(1):1059. doi: 10.1038/s42003-024-06752-y. PMID: 39198706
154. Molecular and circuit determinants in the globus pallidus mediating control of cocaine-induced behavioral plasticity. Tian G, Bartas K, Hui M, Chen L, Vasquez JJ, Azouz G, Derdeyn P, Manville RW, Ho EL, Fang AS, Li Y, Tyler I, Setola V, Aoto J, Abbott GW, Beier KT. Neuron. 2024S0896-6273(24)00540-3. doi: 10.1016/j.neuron.2024.07.018.
PMID: 39153478
153. A novel autism-associated KCNB1 mutation dramatically slows Kv2.1 potassium channel activation, deactivation and inactivation. Manville RW, Block SD, Illeck CL, Kottmeier J, Sidlow R, Abbott GW. Front Cell Neurosci. 2024 18:1438101. doi: 10.3389/fncel.2024.1438101. eCollection 2024. PMID: 39135902
152. Crucial role for sensory nerves and Na/H exchanger inhibition in dapagliflozin and empagliflozin-induced arterial relaxation. Forrester EA, Benítez-Angeles M, Redford KE, Rosenbaum T, Abbott GW, Barrese V, Dora K, Albert AP, Dannesboe J, Salles-Crawley I, Jepps TA, Greenwood IA. Cardiovasc Res. 2024 cvae156. doi: 10.1093/cvr/cvae156. PMID: 39056245
151. Ophthalmate is a new regulator of motor functions via CaSR: Implications for movement disorders. Alhassen S, Hogenkamp D, Nguyen HA, Al Masri S, Abbott GW, Civelli O, Alachkar A. Brain. 2024 awae097. doi: 10.1093/brain/awae097. PMID: 38537648
150. Endogenous currents in HEK 293 cells are inhibited by memantine. Harrison, N. L., Abbott, G. W., McClenaghan, C., Nichols, C. G., Cabrera-Garcia, D. Nature Chemical Biology 2023 https://doi.org/10.1038/s41589-023-01423-1
149. Medicinal plant rosemary relaxes blood vessels by activating vascular smooth muscle KCNQ channels. Manville RW, Baldwin SN, Eriksen EØ, Jepps TA, Abbott GW. FASEB J. 2023 37(9):e23125. doi: 10.1096/fj.202301132R.
PMID: 37535015
148. Ancient medicinal plant rosemary contains a highly efficacious and isoform-selective KCNQ potassium channel opener. Manville RW, Hogenkamp D, Abbott GW. Commun Biol. 2023 6(1):644. doi: 10.1038/s42003-023-05021-8.
PMID: 37322081 Free PMC article.
147. Native American ataxia medicines rescue ataxia-linked mutant potassium channel activity via binding to the voltage sensing domain. Manville RW, Alfredo Freites J, Sidlow R, Tobias DJ, Abbott GW. Nature Communications 2023 14(1):3281. doi: 10.1038/s41467-023-38834-6. PMID: 37280215
146. Behavioral and neuro-functional consequences of eliminating the KCNQ3 GABA binding site in mice. Kiki J. Chen, Ryan Yoshimura, Clarissa Adriana Edmundo, Tri Minh Truong, Olivier Civelli, Amal Alachkar and Geoffrey W. Abbott. Front. Mol. Neurosci., 2023 Sec. Molecular Signalling and Pathways
Volume 16 - 2023 | https://doi.org/10.3389/fnmol.2023.1192628
145. The plant-derived alkaloid aloperine prevents ischemia/reperfusion injury-induced sudden cardiac death. Hu Z, Li J, Liu Q, Manville RW, Abbott GW.
FASEB J. 2023 37(7):e22999. doi: 10.1096/fj.202300253R. PMID: 37249366
144. Remote limb ischemic postconditioning attenuates myocardial dysfunction induced by testicular torsion/detorsion in rats. Liu Q, Abbott GW, Li J, Liu T, Wang Q, Ju F, Hu Z. Am J Physiol Regul Integr Comp Physiol. 2023 324(6):R747-R760. doi: 10.1152/ajpregu.00263.2022. PMID: 37036302
143. Canagliflozin Pretreatment Attenuates Myocardial Dysfunction and Improves Postcardiac Arrest Outcomes After Cardiac Arrest and Cardiopulmonary Resuscitation in Mice. Ju F, Abbott GW, Li J, Wang Q, Liu T, Liu Q, Hu Z.
Cardiovasc Drugs Ther. 2023 Jan 7. doi: 10.1007/s10557-022-07419-8. Online ahead of print. PMID: 36609949
142. Empagliflozin protects against renal ischemia/reperfusion injury in mice.
Wang Q, Ju F, Li J, Liu T, Zuo Y, Abbott GW, Hu Z. Sci Rep. 2022 Nov 11;12(1):19323. doi: 10.1038/s41598-022-24103-x. PMID: 36369319 Free PMC article.
141. Case report: A novel loss-of-function pathogenic variant in the KCNA1 cytoplasmic N-terminus causing carbamazepine-responsive type 1 episodic ataxia.
Manville RW, Sidlow R, Abbott GW. Front Neurol. 2022 Aug 9;13:975849. doi: 10.3389/fneur.2022.975849. eCollection 2022.
140. Harrison NL, Abbott GW, Gentzsch M, Aleksandrov A, Moroni A, Thiel G, Grant S, Nichols CG, Lester HA, Hartel A, Shepard K, Garcia DC, Yazawa M. How many SARS-CoV-2 "viroporins" are really ion channels? Commun Biol. 2022 Aug 25;5(1):859. doi: 10.1038/s42003-022-03669-2.
139. Manville RW, Redford KE, van der Horst J, Hogenkamp DJ, Jepps TA, Abbott GW. KCNQ5 activation by tannins mediates vasorelaxant effects of barks used in Native American botanical medicine. FASEB J. 2022 Sep;36(9):e22457. doi: 10.1096/fj.202200724R. PMID: 35997997
138. Abbott GW. Kv Channel Ancillary Subunits: Where Do We Go from Here?
Physiology (Bethesda). 2022 Sep 1;37(5):0. doi: 10.1152/physiol.00005.2022.
PMID: 35797055 Review.
137. Ramamoorthy K, Yoshimura R, Al-Juburi S, Anandam KY, Kapadia R, Alachkar A, Abbott GW, Said HM.Alzheimer's disease is associated with disruption in thiamin transport physiology: A potential role for neuroinflammation. Neurobiol Dis. 2022 Sep;171:105799. doi: 10.1016/j.nbd.2022.105799. Epub 2022 Jun 21.
PMID: 35750148
136. Huang D, Chen C, Zuo Y, Du L, Liu T, Abbott GW, Hu Z. Protective effect of remote liver ischemic postconditioning on pulmonary ischemia and reperfusion injury in diabetic and non-diabetic rats. PLoS One. 2022 May 26;17(5):e0268571. doi: 10.1371/journal.pone.0268571. eCollection 2022.
135. Papanikolaou M, Crump SM, Abbott GW. The focal adhesion protein Testin modulates KCNE2 potassium channel ß subunit activity. Channels (Austin). 2021 12; 15(1):229-238. PMID: 33464998; PMCID: PMC7833772.
134. Martin-Batista E, Manville RW, Rivero-Pérez B, Bartolomé-Martín D, Alvarez de la Rosa D, Abbott GW, Giraldez T. (2021) Activation of SGK1.1 Upregulates the M-current in the Presence of Epilepsy Mutations. Front Mol Neurosci. 2021 Nov 26;14:798261. doi: 10.3389/fnmol.2021.798261. eCollection 2021. PMID: 34899186
133. Huang D, Ju F, Du L, Liu T, Zuo Y, Abbott GW, Hu Z. (2021)
Empagliflozin Protects against Pulmonary Ischemia/Reperfusion Injury via an ERK1/2-Dependent Mechanism. J Pharmacol Exp Ther. 2021 Dec 10:JPET-AR-2021-000956. doi: 10.1124/jpet.121.000956. Online ahead of print.
PMID: 34893552
132. Geoffrey W Abbott, Kaitlyn E Redford, Ryan Yoshimura, Rían Manville, Luiz Moreira, Kevin Tran, Grey Arena, Alexandra Kookootsedes, Emma Lasky, Elliot Gunnison (2021) KCNQ and KCNE isoform-dependent pharmacology rationalizes Native American dual use of specific plants as both analgesics and gastrointestinal therapeutics. Frontiers in Physiology. 11 November 2021 | https://doi.org/10.3389/fphys.2021.777057
131. Zhaoyang Hu, Feng Ju, Lei Du, Abbott, GW, (2021) Empagliflozin Protects the Heart against Ischemia/Reperfusion-Induced Sudden Cardiac Death. Cardiovascular Diabetology. 20(1):199. doi: 10.1186/s12933-021-01392-6
130. 135. Ip, J., Xu, L., Dai, J., Steegborn, C., Jaffre, F., Evans, T., Cheung, J., Basson, C., Panaghie, G., Krogh-Madsen, T., Abbott, G.W., Lerman, B. (2021) Constitutively Activating GNAS Somatic Mutation in Right Ventricular Outflow Tract Tachycardia. Circulation: Arrhythmia and electrophysiology. CIRCEP121010082. doi: 10.1161/CIRCEP.121.010082. Online ahead of print.
129. Lai, W., Li, S., Zhongtao Du, Xinhua Ma, Junyu Lu, Wei Dong Gao, Abbott, GW, Hu, Z., Kan, Y. (2021) Severe ARDS Patients with COVID-19 Treated with Extracorporeal Membrane Oxygenation in China: a Retrospective Study. Frontiers in Medicine. In Press
128. Redford, K. E., Abbott, G. W. (2021) KCNQ Potassium Channels as Targets of Botanical Folk Medicines. Annual Review of Pharmacology and Toxicology, Volume 62 In Press
127. Manville RW, Abbott GW. (2021) The Amyloid Precursor Protein C99 Fragment Modulates Voltage-Gated Potassium Channels. Cell Physiol Biochem. 2021 Jul 28;55(S3):157-170. doi: 10.33594/000000397.
126. Abbott GW. (2021) Control of Biophysical and Pharmacological Properties of Potassium Channels by Ancillary Subunits. Handb Exp Pharmacol. 2021 Jul 11. doi: 10.1007/164_2021_512.
125. Alhassen S, Chen S, Alhassen L, Phan A, Khoudari M, De Silva A, Barhoosh H, Wang Z, Parrocha C, Shapiro E, Henrich C, Wang Z, Mutesa L, Baldi P, Abbott GW, Alachkar A. (2021) Intergenerational trauma transmission is associated with brain metabotranscriptome remodeling and mitochondrial dysfunction. Commun Biol. 2021 Jun 24;4(1):783. doi: 10.1038/s42003-021-02255-2.
124. Tedeschi G, Scipioni L, Papanikolaou M, Abbott GW, Digman MA. (2021) Fluorescence Fluctuation Spectroscopy enables quantification of potassium channel subunit dynamics and stoichiometry. Sci Rep. 2021 May 21;11(1):10719. doi: 10.1038/s41598-021-90002-2.
123. Cabrera-Garcia D, Bekdash R, Abbott GW, Yazawa M, Harrison NL. (2021) The envelope protein of SARS-CoV-2 increases intra-Golgi pH and forms a cation channel that is regulated by pH. J Physiol. 2021 Jun;599(11):2851-2868. doi: 10.1113/JP281037.
122. Redford KE, Rognant S, Jepps TA, Abbott GW. (2021) KCNQ5 Potassium Channel Activation Underlies Vasodilation by Tea. Cell Physiol Biochem. 2021 Mar 6;55(S3):46-64. doi: 10.33594/000000337.
121. van der Horst J, Rognant S, Abbott GW, Ozhathil LC, Hägglund P, Barrese V, Chuang CY, Jespersen T, Davies MJ, Greenwood IA, Gourdon P, Aalkjær C, Jepps TA. (2021) Dynein regulates Kv7.4 channel trafficking from the cell membrane. J Gen Physiol. 153(3):e202012760.
doi: 10.1085/jgp.202012760.
120. Papanikolaou M, Crump SM, Abbott GW. (2021) The focal adhesion protein Testin modulates KCNE2 potassium channel ß subunit activity. Channels 15(1):229-238. doi: 10.1080/19336950.2021.1874119.
119. Chen S, Alhassen W, Yoshimura R, De Silva A, Abbott GW, Baldi P, Alachkar A. (2020) Metabolomic and transcriptomic signatures of prenatal excessive methionine support nature rather than nurture in schizophrenia pathogenesis. Communications Biology 3(1):409 doi: 10.1038/s42003-020-01124-8.
118. Redford, KE, Abbott, GW. (2020). The ubiquitous flavonoid quercetin is an atypical KCNQ potassium channel activator. Communications Biology 3(1):356 doi: 10.1038/s42003-020-1089-8.
117. Lisewski U, Köhncke C, Schleussner L, Purfürst B, Lee SM, De Silva A, Manville RW, Abbott GW*, Roepke TK*. (2020) Hypochlorhydria reduces mortality in heart failure caused by Kcne2 gene deletion. FASEB J. 2020 Jun 25. doi: 10.1096/fj.202000013RR. Online ahead of print. PMID: 32584506 *co-corresponding authors
116. Abbott, GW (2020) KCNQs: ligand-and voltage-gated potassium channels. Frontiers in Physiology 23;11:583. doi: 10.3389/fphys.2020.00583. eCollection 2020.
115. Llorente-Esteban, A., Manville, R.W., Reyna-Neyra, A., Abbott, G.W., Amzel, A.M., Carrasco, N. (2020) Allosteric regulation of mammalian Na+/I- symporter activity by perchlorate. Nat Struct Mol Biol. https://doi.org/10.1038/s41594-020-0417-5
114. Manville RW, Abbott GW. (2020) Isoform-Selective KCNA1 Potassium Channel Openers Built from Glycine. J Pharmacol Exp Ther. 373(3):391-401. doi: 10.1124/jpet.119.264507. PMID: 32217768 (COVER ARTICLE)
113. van der Horst J, Manville RW, Hayes K, Thomsen MB, Abbott GW, Jepps TA. (2020) Acetaminophen (Paracetamol) Metabolites Induce Vasodilation and Hypotension by Activating Kv7 Potassium Channels Directly and Indirectly. Arterioscler Thromb Vasc Biol. 40(5):1207-1219. doi: 10.1161/ATVBAHA.120.313997. PMID: 32188278
112. Manville RW, Abbott GW. (2020) Potassium channels act as chemosensors for solute transporters. Communications Biology 3(1):90. doi: 10.1038/s42003-020-0820-9.
111. Manville RW, Papanikolaou M, Abbott GW. (2020) M-Channel Activation Contributes to the Anticonvulsant Action of the Ketone Body ß-Hydroxybutyrate. J Pharmacol Exp Ther. 372(2):148-156. doi: 10.1124/jpet.119.263350 (COVER ARTICLE)
110. Manville RW, Abbott GW. (2019) In silico re-engineering of a neurotransmitter to activate KCNQ potassium channels in an isoform-specific manner. Communications Biology 2:401. doi: 10.1038/s42003-019-0648-3. eCollection 2019.
109. Manville RW, van der Horst J, Redford KE, Katz BB, Jepps TA, Abbott GW. (2019) KCNQ5 activation is a unifying molecular mechanism shared by genetically and culturally diverse botanical hypotensive folk medicines. Proc Natl Acad Sci pii: 201907511. doi: 10.1073/pnas.1907511116. [Epub ahead of print]
108. Vawter M.P. · Hamzeh A.R. · Muradyan E. · Civelli O. · Abbott G.W. · Alachkar A. (2019) Association of Myoinositol Transporters with Schizophrenia and Bipolar Disorder: Evidence from Human and Animal Studies. Mol Neuropsychiatry (DOI:10.1159/000501125)
107. Manville RW, Abbott GW. (2019) Cilantro leaf harbors a potent potassium channel-activating anticonvulsant. FASEB J. 33(10):11349-11363. doi: 10.1096/fj.201900485R
106. Zhou L, Köhncke C, Hu Z, Roepke TK, Abbott GW. (2019) The KCNE2 potassium channel ß subunit is required for normal lung function and resilience to ischemia and reperfusion injury. FASEB J. 33(9):9762-9774. doi: 10.1096/fj.201802519R
105. Manville RW, Abbott GW. (2019) Teamwork: ion channels and transporters join forces in the brain. Neuropharmacology. pii: S0028-3908(19)30118-2. doi: 10.1016/j.neuropharm.2019.04.007
104. Hu Z, Jepps T, Zhou L, Liu J, Li M, Abbott GW. (2019) Kcne4 deletion sex-dependently inhibits the RISK pathway response and exacerbates hepatic ischemia-reperfusion injury in mice.
Am J Physiol Regul Integr Comp Physiol. 316(5):R552-R562. doi: 10.1152/ajpregu.00251.2018.
103. Hu Z, Liu J, Zhou L, Tian X, Abbott GW. (2019) AKT and ERK1/2 activation via remote ischemic preconditioning prevents Kcne2-dependent sudden cardiac death. Physiol Rep. 7(3):e13957. doi: 10.14814/phy2.13957.
102. Harkcom WT, Papanikolaou M, Kanda V, Crump SM, Abbott GW. (2019) KCNQ1 rescues TMC1 plasma membrane expression but not mechanosensitive channel activity. J Cell Physiol. 234(8):13361-13369. doi: 10.1002/jcp.28013
101. David JP, Lisewski U, Crump SM, Jepps TA, Bocksteins E, Wilck N, Lossie J, Roepke TK, Schmitt N, Abbott GW. (2019) Deletion in mice of X-linked, Brugada syndrome- and atrial fibrillation-associated Kcne5 augments ventricular KV currents and predisposes to ventricular arrhythmia. FASEB J. 33(2):2537-2552. doi: 10.1096/fj.201800502R
100. De Silva AM, Manville RW, Abbott GW. (2018) Deconstruction of an African folk medicine uncovers a novel molecular strategy for therapeutic potassium channel activation. Science Advances 4(11):eaav0824. doi: 10.1126/sciadv.aav0824
99. Manville RW, Abbott GW. (2018) Ancient and modern anticonvulsants act synergistically in a KCNQ potassium channel binding pocket.
Nature Communications 9(1):3845. doi: 10.1038/s41467-018-06339-2.
98. Manville RW, Abbott GW. (2018) Gabapentin Is a Potent Activator of KCNQ3 and KCNQ5 Potassium Channels. Mol Pharmacol. 94(4):1155-1163. doi: 10.1124/mol.118.112953.
97. Hu Z, Wei W, Zhou L, Chen M, Abbott GW. (2018) Kcne4 deletion sex-specifically predisposes to cardiac arrhythmia via testosterone-dependent impairment of RISK/SAFE pathway induction in aged mice. Sci Rep. ;8(1):8258. doi: 10.1038/s41598-018-26599-8.
96. Luo N, Liu J, Chen Y, Li H, Hu Z, Abbott GW. (2018) Remote ischemic preconditioning STAT3-dependently ameliorates pulmonary ischemia/reperfusion injury. PLoS One. 13(5):e0196186. doi: 10.1371/journal.pone.0196186.
95. Manville R.W., Papanikolaou M., Abbott GW (2018). Direct neurotransmitter activation of voltage-gated potassium channels. Nature Communications. 9:1847. DOI: 10.1038/s41467-018-04266-w
94. Alachkar A, Wang L, Yoshimura R, Hamzeh AR, Wang Z, Sanathara N, Lee SM, Xu X, Abbott GW, Civelli O. (2018). Prenatal one-carbon metabolism dysregulation programs schizophrenia-like deficits. Molecular Psychiatry. 23(2):282-294. doi: 10.1038/mp.2017.164.
93. Abbott GW. (2017). ß Subunits Control the Effects of Human Kv4.3 Potassium Channel Phosphorylation. Front. Physiol. 8:646 | https://doi.org/10.3389/fphys.2017.00646
92. Manville RW, Neverisky DL, Abbott GW. (2017). SMIT1 Modifies KCNQ Channel Function and Pharmacology by Physical Interaction with the Pore. Biophys J. 113(3):613-626. doi: 0.1016/j.bpj.2017.06.055.
91. Abbott GW. (2017) Chansporter complexes in cell signalling. FEBS Letters. doi: 10.1002/1873-3468.12755
90. Hu Z, Chen M, Zhang P, Liu J, Abbott GW. (2017) Remote ischemic preconditioning differentially attenuates post-ischemic cardiac arrhythmia in streptozotocin-induced diabetic versus nondiabetic rats. Cardiovascular Diabetol. 16(1):57. doi: 10.1186/s12933-017-0537-3.
89. King EC, Patel V, Anand M, Zhao X, Crump SM, Hu Z, Weisleder N, Abbott GW. (2017) Targeted deletion of Kcne3 impairs skeletal muscle function in mice. FASEB J. pii: fj.201600965RR. doi: 10.1096/fj.201600965RR.
88. Neverisky, D.L. Abbott, G.W. (2017) KCNQ-SMIT complex formation facilitates ion channel-solute transporter cross talk. FASEB Journal Mar 10. pii: fj.201601334R. doi: 10.1096/fj.201601334R. [Epub ahead of print]
87. Lee, SM., Baik, J., Nguyen, D., Nguyen, V., Liu, S., Hu, Z., Abbott, G.W. (2017) Kcne2 deletion causes Type II Diabetes Mellitus via a primary defect in insulin secretion. FASEB Journal pii: fj.201601347. doi: 10.1096/fj.201601347. [Epub ahead of print]
86. Abbott GW (2017) ß Subunits Functionally Differentiate Human Kv4.3 Potassium Channel Splice Variants. Frontiers in Physiology 8 10.3389/fphys.2017.00066
85. Yang S, Abbott GW, Gao WD, Liu J, Luo C, Hu Z. (2017) Involvement of Glycogen Synthase Kinase-3ß in Liver Ischemic Conditioning Induced Cardioprotection against Myocardial Ischemia and Reperfusion Injury in Rats. J Appl Physiol (1985). 2017 Feb 2:jap.00862.2016. doi: 10.1152/japplphysiol.00862.2016
84. Abbott, G.W. (2016) Regulation of human cardiac potassium channels by full-length KCNE3 and KCNE4. Sci Rep. 2016 Dec 6;6:38412. doi: 10.1038/srep38412
83. Abbott, GW. (2016) Channel-transporter complexes: an emerging theme in cell signaling. Biochemical Journal 473 (21) 3759-3763; DOI: 10.1042/BCJ20160685C
82. Hu Z, Hu S, Yang S, Chen M, Zhang P, Liu J, Abbott GW. (2016) Remote Liver Ischemic Preconditioning Protects against Sudden Cardiac Death via an ERK/GSK-3ß-Dependent Mechanism. PLoS One. 11(10):e0165123. doi: 10.1371/journal.pone.0165123.
81. Abbott, GW., Jepps, TA. (2016) Kcne4 deletion sex-dependently alters vascular reactivity. Journal of Vascular Research 53(3-4):138-148.
80. Abbott, GW. (2016) KCNE4 and KCNE5: K+ channel regulation and cardiac arrhythmogenesis, Gene doi: 10.1016/j.gene.2016.07.069
79. Abbott GW. (2016) Novel exon 1 protein-coding regions N-terminally extend human KCNE3 and KCNE4. FASEB Journal 30(8):2959-69. doi: 10.1096/fj.201600467R.
78. Neverisky DL, Abbott GW. (2016) Ion channel-transporter interactions. Critical Reviews in Biochemistry and Molecular Biology. 51(4):257-67. doi: 10.3109/10409238.2016.1172553.
77. Hu Z, Crump SM, Zhang P, Abbott GW. (2016) Kcne2 deletion attenuates acute post-ischemia/reperfusion myocardial infarction. Cardiovascular Research 110(2):227-37. doi: 10.1093/cvr/cvw048.
76. Lee SM, Nguyen D, Anand M, Kant R, Kohncke C, Lisewski U, Roepke TK, Hu Z, Abbott GW. (2016) Kcne2 deletion causes early-onset nonalcoholic fatty liver idsease via iron deficiency anemia. Scientific Reports 6, 23118; doi: 10.1038/srep23118
75. Abbott GW*, Roepke TK. (2016) KCNE2 in gastric cancer: from bench to bedside. Oncotarget 7(14):17286-7. doi: 10.18632/oncotarget.7921 *First and corresponding author
74. Abbott GW. (2016) KCNE1 and KCNE3: the yin and yang of voltage-gated K+ channel regulation.
Gene 576(1 Pt 1):1-13. doi: 10.1016/j.gene.2015.09.059
73. Crump SM, Hu Z, Kant R, Levy DI, Goldstein SA, Abbott GW. (2016) Kcne4 deletion sex and age specifically impairs cardiac repolarization in mice. FASEB Journal 30(1):360-9. doi: 10.1096/fj.15-278754
72. Lee SM, Nguyen D, Hu Z, Abbott GW. (2015) Kcne2 deletion promotes atherosclerosis and diet-dependent sudden death. J Mol Cell Cardiol. 87:148-151. doi: 10.1016/j.yjmcc.2015.08.013.
71. Abbott GW. (2015) The KCNE2 K+ channel regulatory subunit: ubiquitous influence, complex pathobiology. Gene pii: S0378-1119(15)00771-4. doi: 10.1016/j.gene.2015.06.061. [Epub ahead of print]
70. Abbott GW*, Pitt, GS. (2014) Ion channels under the Sun. FASEB Journal 28(5):1957-62 *First and corresponding author
69. Abbott GW*, Tai KK, Neverisky D, Hansler A, Hu Z, Roepke TK, Lerner DJ, Chen Q, Liu L, Zupan B, Toth M, Haynes R, Huang X, Demirbas D, Buccafusca R, Gross SS, Kanda VA and Berry GT. (2014) KCNQ1, KCNE2, and Na+-Coupled Solute Transporters Form Reciprocally Regulating Complexes that Affect Neuronal Excitability. Science Signaling 7(315):ra22. *First and corresponding author
68. Noam Y, Ehrengruber MU, Koh A, Feyen P, Manders EM, Abbott GW, Wadman WJ, Baram TZ. (2014) Filamin A promotes dynamin-dependent internalization of hyperpolarization-activated cyclic nucleotide-gated type 1 (HCN1) channels and restricts Ih in hippocampal neurons. J Biol Chem. 289(9):5889-903
67. Abbott, G.W. (2014) Biology of the KCNQ1 Potassium Channel. New Journal of Science (in press)
66. Abbott G.W. (2014) Pharmacogenetic diversification by alternative translation initiation: background channels to the fore. British Journal of Pharmacology doi: 10.1111/bph.12630. (epub ahead of print)
65. Crump, SM, Abbott, GW. (2014) Arrhythmogenic KCNE gene variants: current knowledge and future challenges. Frontiers in Genetics. 5:3. doi: 10.3389/fgene.2014.00003
64. Hu Z, Kant R, Anand M, King EC, Krogh-Madsen T, Christini DJ, Abbott GW. (2014) Kcne2 Deletion Creates a Multisystem Syndrome Predisposing to Sudden Cardiac Death. Circulation: Cardiovascular Genetics. doi: 10.1161/CIRCGENETICS.113.000315
63. Hu, Z., Crump, S.M., Anand, M., Kant, R., Levi, R., Abbott, G.W. (2014) Kcne3 deletion initiates extracardiac arrhythmogenesis. FASEB Journal epub fj.13-241828
62. Kant, R., Hu, Z., Malhotra, J.K., Krogh-Madsen, T., Christini, D.J., Heerdt, P.M., Abbott, G.W. (2013) NHE isoform swiching and KChIP2 upregulation in aging porcine atria. PLoS One 8(12):e82951. doi: 10.1371/journal.pone.0082951.
61. Hu ZY, Abbott GW, Fang YD, Huang YS, Liu J. (2013) Emulsified isoflurane postconditioning produces cardioprotection against myocardial ischemia-reperfusion injury in rats. J Physiol Sci. 63(4):251-61
60. Abbott, G.W. (2013) KCNE genetics and pharmacogenomics in cardiac arrhythmias: much ado about nothing? Expert Reviews in Clinical Pharmacology. 6(1):49-60
59. Heerdt PM, Kant R, Hu Z, Kanda VA, Christini DJ, Malhotra JK, Abbott GW. (2012) Transcriptomic analysis reveals atrial KCNE1 down-regulation following lung lobectomy. J Mol Cell Cardiol. 53(3):350-3
58. Purtell K, Paroder-Belenitsky M, Reyna-Neyra A, Nicola JP, Koba W, Fine E, Carrasco N, Abbott GW. (2012) The KCNQ1-KCNE2 K+ channel is required for adequate thyroid I- uptake. FASEB J. 26(8):3252-9
57. Krogh-Madsen T, Abbott GW, Christini DJ. (2012) Effects of electrical and structural remodeling on atrial fibrillation maintenance: a simulation study. PLoS Comput Biol. 8(2):e1002390.
56. Kanda V.A., Abbott G.W. (2012) KCNE Regulation of K+ Channel Trafficking - a Sisyphean Task? Front Physiol. 3:231.
55. Abbott G.W.*, Ramesh B., Srai S.K. (2012) Interaction between Soluble and Membrane-Embedded Potassium Channel Peptides Monitored by Fourier Transform Infrared Spectroscopy. PLoS One. 7(11):e49070. doi: 10.1371/journal.pone.0049070 *First and corresponding author
54. Ying SW, Kanda VA, Hu Z, Purtell K, King EC, Abbott GW, Goldstein PA (2012) Targeted Deletion of Kcne2 Impairs HCN Channel Function in Mouse Thalamocortical Circuits. PLoS One 7(8): e42756
53. Abbott GW. (2012) KCNE2 and the K+ channel: The tail wagging the dog. Channels 6(1) http://dx.doi.org/10.4161/chan.19126
52. Roepke, TK, Kanda, VA, Purtell, K, King, EC, Lerner, DJ, Abbott, G.W. (2011) KCNE2 forms potassium channels with KCNA3 and KCNQ1 in the choroid plexus epithelium. FASEB J. 25(12):4264-73
51. Roepke, T.K., King, E.C., Purtell, K., Kanda, V.A., Lerner, D.J., Abbott, G.W. (2011) Genetic dissection reveals unexpected influence of beta subunits on KCNQ1 K+ channel polarized trafficking in vivo. FASEB J. 25(2):727-36
50. Kanda VA, Lewis A, Xu X, Abbott G.W. (2011) KCNE1 and KCNE2 inhibit forward trafficking of homomeric N-type voltage-gated potassium channels. Biophys J. 101(6):1354-63
49. Kanda VA, Lewis A, Xu X, Abbott G.W. (2011) KCNE1 and KCNE2 provide a checkpoint governing voltage-gated potassium channel subunit composition. Biophys J. 101(6):1364-75
48. Kanda, VA, Purtell, K, Abbott, G.W. (2011) Protein Kinase C downregulates IKs by stimulating KCNQ1-KCNE1 potassium channel endocytosis. Heart Rhythm 8(10):1641-7.
47. Purtell, K., Roepke, T.K., Abbott, G.W. (2010) Cardiac arrhythmia and thyroid dysfunction: a novel genetic link. International Journal of Biochemistry and Cell Biology 42(11): 1767-70
46. Harkcom, W., Abbott, G.W. (2010) Emerging concepts in the pharmacogenomics of arrhythmias: ion channel trafficking. Expert Review of Cardiovascular Therapy 8(8):1161-73
45. Roepke, T.K., Purtell, K., King, E.C., La Perle, K.M.D., Lerner, D.J., Abbott, G.W. (2010) Targeted deletion of Kcne2 causes gastritis cystica profunda and gastric neoplasia. PLoS One 5(7):e11451, 1-10
44. Choi, E., Abbott, G.W. (2010) A shared mechanism for lipid- and beta-subunit-coordinated stabilization of the activated K+ channel voltage sensor. FASEB J. 24(5):1518-24
43. Roepke, T.K., King, E.C., Reyna-Neyra, A., Paroder, M., Purtell, K., Koba, W., Fine, E., Lerner, D.J., Carrasco, N., Abbott, G.W. (2009) Kcne2 deletion uncovers its crucial role in thyroid hormone biosynthesis. Nature Medicine 15(10):1186-94 [Faculty of 1000 Medicine evaluation: http://f1000medicine.com/article/id/1165526/]
42. Abbott, G.W.*, Roepke, T.K. (2009) HERG biosynthesis: the positive influence of negative charge. Am J. Physiol Heart Circ Physiol. 296(5):H1211-2 *First and corresponding author
41. Gaeta, S.A., Bub, G., Abbott, G.W., Christini, D.J. (2009) Dynamical mechanism for subcellular alternans in cardiac myocytes. Circulation Research 105(4):335-42
40. Xu, X., Kanda, V.A., Choi, E., Panaghie, G., Roepke, T.K., Gaeta, S.A., Christini, D.J., Lerner, D.J., Abbott, G.W. (2009) MinK-dependent internalization of the IKs potassium channel. Cardiovascular Research 82(3):430-8
39. McCrossan, Z.A., Roepke, T.K., Lewis, A., Panaghie, G., Abbott, GW. (2009) Regulation of the Kv2.1 Potassium Channel by MinK and MiRP1. J Membr Biol. 228(1):1-14.
38. Abbott, G.W.*, Roepke, T.K. (2008) Pharmacogenetics of drug-induced arrhythmias. Expert Review of Clin. Pharm. 1(1):93-104. *First and corresponding author
37. Yang, L., Soonpaa, M.H., Adler, E.D., Roepke, T.K., Kattman, S.J., Kennedy, M., Henckaerts, E., Bonham, K., Abbott, G.W., Linden, R.M., Field, L.J., Keller, G.M. (2008) Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. Nature 453(7194):524-8.
36. Morrey, C., Estephan, R., Abbott, G.W., Levi, R. (2008) Cardioprotective Effect of Histamine H3-Receptor Activation: Pivotal Role of G beta gamma-Dependent Inhibition of Voltage-Operated Ca2+ Channels. J. Pharm. Exp. Ther. 326(3):871-8
35. Roepke, T.K., Kontogeorgis, A., Ovanez, C., Xu, X., Young, J.B., Purtell, K., Goldstein, P.A., Christini, D.J., Peters, N.S., Akar, F.G., Gutstein, D.E., Lerner, D.J., Abbott, G.W. (2008) Targeted deletion of kcne2 impairs ventricular repolarization via disruption of IK,slow1 and Ito,f. FASEB Journal 22:3648-3660.
34. Gordon, E., Panaghie, G., Deng, L., Bee, K.J., Roepke, T.K., Krogh-Madsen, T., Christini, D.J., Ostrer, H., Basson, C.T., Chung, W., Abbott, G.W. (2008) A KCNE2 mutation in a patient with cardiac arrhythmia induced by auditory stimuli and serum electrolyte imbalance. Cardiovascular Research 77(1):98-106
33. Abbott, G.W.*, Ramesh, B., Srai, S.K.S. (2008) Secondary structure of the MiRP1 (KCNE2) potassium channel ancillary subunit. Protein and Peptide Letters 15(1):63-75. *First and corresponding author
32. Panaghie, G., Purtell, K., Tai, K.-K., Abbott, G.W. (2008) Voltage-dependent C-type inactivation in a constitutively open K+ channel. Biophysical Journal 95(6):2759-78
31. Abbott, G.W.*, Xu, X., Roepke, T.K. (2007) Impact of ancillary subunits on ventricular repolarization. The Journal of Electrocardiology 40(6 Suppl):S42-6. *First and corresponding author
30. Choi, E., Abbott, G.W. (2007) The MiRP2-Kv3.4 potassium channel: muscling in on Alzheimer’s disease. Molecular Pharmacology 72(3):499-501
29. Panaghie, G., Abbott, G.W. (2007) The role of S4 charges in voltage-dependent and voltage-independent KCNQ1 potassium channel complexes. The Journal of General Physiology 129(2):121-133
28. Abbott, G.W. (2006) Molecular mechanisms of cardiac voltage-gated potassium channelopathies. Current Pharmaceutical Design 12(28):3631-3644
27. Roepke, T.K., Anantharam, A., Kirchhoff, P., Busque, S.M., Young, J.B., Geibel, J.P., Lerner, D.J., Abbott, G.W. (2006) The KCNE2 potassium channel ancillary subunit is essential for gastric acid secretion. J. Biol. Chem 281(33):23740-23747 [Faculty of 1000 Biology evaluation: http://f1000biology.com/article/id/1047240/evaluation]
26. Gordon, E., Cohen, J.-L., Engel, R., Abbott, G.W. (2006) 1,4-diazabicyclo[2.2.2]octane derivatives: a novel class of voltage-gated potassium channel blockers. Molecular Pharmacology 69(3):718-726
25. Panaghie, G., Abbott, G.W. (2006) The impact of ancillary subunits on small-molecule interactions with voltage-gated potassium channels. Current Pharmaceutical Design 12(18):2285-2302
24. Gordon, E., Roepke, T.K., Abbott, G.W. (2006) Endogenous KCNE Subunits Govern Kv2.1 K+ Channel Activation Kinetics in Xenopus Oocyte Studies. Biophysical Journal 90(4):1223-31
23. Panaghie, G., Tai, K.-K., Abbott, G.W. (2006) Interaction of KCNE subunits with the KCNQ1 K+ channel pore. Journal of Physiology 570 (Pt 3):455-67
22. Roepke, T.K, Abbott, G.W. (2006) Pharmacogenetics and cardiac ion channels. Vascular Pharmacology 44(2):90-106
21. Abbott, G.W., Butler, M.H., & Goldstein, S.A. (2006) Phosphorylation and protonation of neighboring MiRP2 sites: function and pathophysiology of MiRP2-Kv3.4 potassium channels in periodic paralysis. FASEB Journal 20(2):293-301
20. Anantharam A, Abbott GW. (2005) Does hERG coassemble with a beta subunit? Evidence for roles of MinK and MiRP1. Novartis Found Symp. 2005;266:100-12; discussion 112-7, 155-8.
19. Cacheaux, L.P., Topf, N., Tibbs, G.R., Schaefer, U.R., Levi, R., Harrison, N.L., Abbott, G.W., Goldstein, P.A. (2005) Impairment of hyperpolarization-activated, cyclic nucleotide-gated channel function by the intravenous general anesthetic propofol. J. Pharm. Exp. Ther. 315(2):517-25
18. McCrossan, Z.A., Abbott, G.W. (2004) The MinK-Related Peptides. Neuropharmacology. 47(6):787-821
17. Lewis A., McCrossan Z.A., Abbott, G.W. (2004) MinK, MiRP1 and MiRP2 diversify Kv3.1 and Kv3.2 potassium channel gating. J. Biol. Chem. 279:7884-7892
16. Anantharam, A., Markowitz, S.M., Abbott, G.W. (2003) Pharmacogenetic considerations in diseases of cardiac ion channels. J. Pharm. Exp. Ther. 307:831-838
15. Tai, K.-K., McCrossan, Z.A., Abbott, G.W. (2003) Activation of mitochondrial ATP-sensitive potassium channels increases cell viability against rotenone-induced cell death. Journal of Neurochemistry 84:1193-1200
14. McCrossan, Z.A., Lewis, A., Panaghie, G., Jordan, P.N., Christini, D.J., Lerner, D.J., Abbott, G.W. (2003) MinK-related peptide 2 modulates Kv2.1 and Kv3.1 potassium channels in mammalian brain. Journal of Neuroscience 23:8077-8091
13. Anantharam, A., Lewis, A., Panaghie, G., Gordon, E., McCrossan, Z.A., Lerner, D.J., Abbott, G.W. (2003) RNA interference reveals that endogenous Xenopus MinK-related Peptides govern mammalian K+ channel function in oocyte expression studies. J. Biol. Chem. 278:11739-11745
12. Abbott, G.W., Goldstein, S.A.N. (2002) Disease-associated mutations in KCNE potassium channel subunits (MiRPs) reveal promiscuous disruption of multiple currents and conservation of mechanism. FASEB Journal 16: 390-400
11. Abbott, G.W., Butler, M.H., Bendahhou, S., Dalakas, M.C., Ptacek, L.J., Goldstein, S.A.N. (2001) MiRP2 forms potassium channels in skeletal muscle with Kv3.4 and is associated with periodic paralysis. Cell 104:217-231.
10. Abbott GW, Goldstein SA, Sesti F. (2001) Do all voltage-gated potassium channels use MiRPs? Circ Res. 88(10):981-3.
9. Abbott GW, Goldstein SA. (2001) Potassium channel subunits encoded by the KCNE gene family: physiology and pathophysiology of the MinK-related peptides (MiRPs). Mol Interv. 1(2):95-107.
8. Sesti, F., Abbott, G.W., Wei, J., Murray, K.T., Saksena, S., Schwartz, P.J., Priori, S.G., Roden, D.M., George, Jr., A.L., Goldstein, S.A.N. (2000) A common polymorphism associated with antibiotic-induced cardiac arrhythmia . Proc. Nat. Acad. Sci. 97:10613-10618
7. Abbott, G.W., Sesti, F., Splawski, I., Buck, M.E., Lehmann, M.H., Timothy, K.W., Keating, M.T., Goldstein, S.A.N. (1999) MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. Cell 97: 175-187
6. Abbott GW, Goldstein SA. A superfamily of small potassium channel subunits: form and function of the MinK-related peptides (MiRPs). Q Rev Biophys. 31(4):357-98.
5. Abbott, G.W., Mercer, E.A.J., Miller, R.T., Ramesh, B., Srai, S.K.S. (1998) Conformational changes in a mammalian voltage-dependent potassium channel inactivation peptide. Biochemistry 37:1640-1645
4. Abbott, G.W., Bloemendal, M., Van Stokkum, I.H.M., Mercer, E.A.J., Miller, R.T., Sewing, S., Wolters, M., Pongs, O., Srai, S.K.S. (1997) Secondary structure, stability and tetramerisation of recombinant Kv1.1 potassium channel cytoplasmic N-terminal fragment. Biochim. Biophys. Acta 1341:71-78
3. Mercer, E.A.J., Abbott, G.W., Brazier, S., Ramesh, B., Haris, P.I., Srai, S.K.S. (1997) Synthetic putative transmembrane region of minimal potassium channel protein (minK) adopts an alpha-helical conformation in phospholipid membranes. Biochemical Journal 325 (2) 475-9
2. Abbott, G.W., Mercer, E.A.J., Wolters, M., Sewing, S., Pongs, O., Srai, S.K.S. (1995) Structure analysis of a recombinant voltage-gated potassium channel (Kv1.1) N-terminus using FTIR spectroscopy and thermal denaturation. Biochem. Sci. Trans. 23(3):479S
1. Mercer, E.A.J., Abbott, G.W., Ramesh, B., Haris, P.I., Chapman, D., Srai, S.K.S. (1995) Structural characterization of a slowly activating potassium channel (IsK). Biochem. Sci. Trans. 23(3):478S
Grants
National Institute of General Medical Sciences (NIGMS) R35 GM130377
02/01/2019-01/31/2029
Ion Channel Transporter Interactions Abbott (PI)
National Institute of Neurological Disorders and Stroke (NINDS) R01 NS107671 03/01/2019-01/31/2025 (NCE) GABA activation of the M-current Abbott (PI)
National Eye Institute (NEI) R01 EY031587 02/01/2021-01/31/2026 STRUCTURE-FUNCTION STUDIES OF AQUAPORIN 0 IN LENS DEVELOPMENT AND PHYSIOLOGY Tobias (PI) Schilling, Abbott (co-I)
Equipment Supplement to National Institute of General Medical Sciences (NIGMS), R35 3R35GM130377-06S1 02/01/2024-01/31/2025 Ion Channel Transporter Interactions Abbott (PI)
R61AT012544-01 Zhao, R. (Contact PI), Goldstein, S.A. (MPI), Abbott (co-I) 06/08/2023-05/31/2026
NIH/National Center for Complementary and Integrative Health (NCCIH)
Identification of botanical hHv1 channel blockers as analgesics for neuropathic pain
Samueli Scholarship,
Abbott (PI) 01/01/2022-12/31/2024
Susan Samueli Integrative Health Institute
Professional Societies
AAAS
ASPET
Graduate Programs
Cellular and Molecular Biosciences
Interdepartmental Neuroscience Program
Link to this profile
https://faculty.uci.edu/profile/?facultyId=5869
https://faculty.uci.edu/profile/?facultyId=5869
Last updated
10/17/2024
10/17/2024