Assistant Researcher, Molecular Biology and Biochemistry
School of Biological Sciences

Nutrient/hormonal regulation of gene expression, Signal transduction, Diabetes and obesity, Zonal expression of genes in the liver acinus

The Laverna Titus Award, American Heart Association, 2005 Young Investigators Forum, 2005
Best Poster Award, FASEB Summer Research Conference, 2005
Post-doctoral fellowship (0325131Y), American Heart Association, 2003-2005
The Hamilton D. Eaton Graduate School Fellowship, University of Connecticut, 1995

Project Scientist, 2005-2006
Postgraduate Researcher, 2001-2005
Department of Molecular Biology and Biochemistry
School of Biological Sciences
University of California, Irvine
Advisor: Dr. Timothy F. Osborne

Post-doctoral fellow, 1999-2001
Division of Endocrinology and Metabolism
Department of Medicine
School of Medicine
University of Pittsburgh
Advisor: Dr. Robert M. O’Doherty

Shin, DJ. and Osborne, T. F. (2008) PGC-1alpha activation of CYP7A1 during food restriction and diabetes is still inhibited by small heterodimer partner. J. Biol. Chem. (in press on line)

Bennett M. K., Seo, Y-K., Datta, S., Shin, DJ., and Osborne, T. F. (2008) Selective binding of SREBP isoforms and co-regulatory proteins to promoters for lipid metabolic genes in liver. J. Biol. Chem. (in press on line)

Shin, DJ., Plateroti, M., Samarut, J., and Osborne, T. F. (2006) Two uniquely arranged thyroid hormone response elements in the far upstream 5' flanking region confer direct thyroid hormone regulation to the murine cholesterol 7alpha hydroxylase gene. Nucleic Acids Res. 34: 3853-61

Zhang, C., Shin, DJ., and Osborne, T. F. (2005) A simple promoter containing two Sp1 sites controls the expression of sterol-regulatory-element-binding protein-1a (SREBP-1a). Biochem. J. 386: 161-168

Shin, DJ., Campos, J. A., Gil, G., and Osborne, T. F. (2003) PGC-1alpha activates CYP7A1 and bile acid biosynthesis. J. Biol. Chem. 278: 50047-50052

Shin, DJ. and Osborne, T. F. (2003) Thyroid hormone regulation and cholesterol metabolism are connected through sterol regulatory element-binding protein-2 (SREBP-2). J. Biol. Chem. 278: 34114-34118

Shin, D-J., Odom, D. P., Scribner, K. B., Ghoshal, S., and McGrane, M. M. (2002) Retinoid regulation of the phosphoenolpyruvate carboxykinase gene in liver. Mol. Cell. Endocrinol. 195: 39-54

Shin, D-J. and McGrane, M. M. (1997) Vitamin A regulates genes involved in hepatic gluconeogenesis in mice: phosphoenolpyruvate carboxykinase, fructose-1,6-bisphosphatase and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. J. Nutr. 127: 1274-1278.

Shin, D-J., Tao, A., and McGrane, M. M. (1995) Effects of vitamin A deficiency and retinoic acid treatment on expression of a phosphoenolpyruvate carboxykinase-bovine growth hormone gene in transgenic mice. Biochem. Biophys. Res. Commun. 213: 706-714.

Scientist Development Grant (0730189N), American Heart Association, 01/01/07-12/31/10

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https://faculty.uci.edu/profile/?facultyId=5533

Last updated
05/19/2008