Mathew Blurton-Jones
Professor, Neurobiology and Behavior
School of Biological Sciences
School of Biological Sciences
Member, Institute for Memory Impairments and Neurological Disorders (UCI MIND)
Member, Sue and Bill Gross Stem Cell Research Center
Member, Institute for Immunology
Ph.D., University of California, San Diego, 2002, Neuroscience
University of California, Irvine
3014 Gross Hall
Mail Code: 1705
Irvine, CA 92697
3014 Gross Hall
Mail Code: 1705
Irvine, CA 92697
Research Interests
Microglia, Alzheimer Disease, Stem Cells, Neurodegeneration, Cell Therapy
Websites
Appointments
2005-2007 Postgraduate Researcher
Department of Neurobiology and Behavior
University of California, Irvine
Irvine, CA 92697-4545
Mentor: Frank LaFerla, Ph.D.
2002-2005 Postgraduate Researcher
Department of Neurobiology and Behavior
University of California, Irvine
Irvine, CA 92697-4545
Mentor: Carl Cotman, Ph.D.
July 2002 Ph.D. in Neurosciences
University of California, San Diego
Thesis Advisor: Mark Tuszynski, M.D.,Ph.D.
Department of Neurobiology and Behavior
University of California, Irvine
Irvine, CA 92697-4545
Mentor: Frank LaFerla, Ph.D.
2002-2005 Postgraduate Researcher
Department of Neurobiology and Behavior
University of California, Irvine
Irvine, CA 92697-4545
Mentor: Carl Cotman, Ph.D.
July 2002 Ph.D. in Neurosciences
University of California, San Diego
Thesis Advisor: Mark Tuszynski, M.D.,Ph.D.
Research Abstract
The Blurton-Jones lab uses human induced pluripotent stem cells (iPSCs), CRISPR engineering, and chimeric mouse models to examine the underlying molecular mechanisms that drive the development and progression of neurodegenerative diseases. Our lab previously developed one of the most widely adopted approaches to differentiate patient-derived iPSCs into microglia. We continue to use this approach to examine the impact of Alzheimer’s Disease (AD) risk genes on human microglia function. To further examine and manipulate the interactions between human microglia and AD pathologies in vivo, we have also developed novel chimeric mouse models of AD and other neurodegenerative diseases. Ongoing studies in the Blurton-Jones lab are combining iPSCs, CRISPR gene editing and chimeric modeling to examine the impact of AD-associated risk genes on human microglial function and disease progression in vivo and to develop and test novel microglial-based cell therapies for neurodegenerative diseases.
Awards and Honors
2023 UCI Applied Innovation, Emerging Innovation of the Year
2020-present Member, Cure Alzheimer’s Fund Research Leadership Group
2006-2007 Postdoctoral Fellowship in Stem Cell Biology (California Institute for Regenerative Medicine)
2002-2004 NIA Neurobiology of Aging Training Grant (PI: CW Cotman)
1997-2001 NIA Neuroplasticity of Aging Training Grant (PI: Rusty Gage )
2001-2002 Merck fellowship/UCSD Neurosciences Graduate Training Program
1997-1998 Markey Fellowship, UC San Diego
2020-present Member, Cure Alzheimer’s Fund Research Leadership Group
2006-2007 Postdoctoral Fellowship in Stem Cell Biology (California Institute for Regenerative Medicine)
2002-2004 NIA Neurobiology of Aging Training Grant (PI: CW Cotman)
1997-2001 NIA Neuroplasticity of Aging Training Grant (PI: Rusty Gage )
2001-2002 Merck fellowship/UCSD Neurosciences Graduate Training Program
1997-1998 Markey Fellowship, UC San Diego
Publications
Peer Reviewed Publications since 2017:
42. iPSC-derived human microglia-like cells to study neurological diseases. Abud EM, Ramirez RN, Martinez ES, Healy LM, Nguyen CHH, Newman SA, Yeromin AV, Scarfone VM, Marsh SE, Fimbres C, Caraway CA, Fote GM, Madany AM, Agrawal A, Kayed R Gylys KH, Cahahlan MD, Cummings BJ, Antel JP, Mortazavi A, Carson MJ, Poon WW, Blurton-Jones M. Neuron. 2017 Apr 19;94(2):278-293. PMCID: 5482419.
43. Humanized monoclonal antibody armanezumab specific to N-terminus of pathological tau: characterization and therapeutic potency. Agadjanyan MG, Zagorski K, Petrushina I, Davtyan H, Kazarian K, Antonenko M, Davis J, Bon C, Blurton-Jones M, Cribbs DH, Ghochikyan A. Molecular Neurodegeneration. 2017, 12(1):33. PMCID: 5418694.
44. MultiTEP Platform-based DNA Vaccines for alpha-Synucleinopathies: Pre-clinical Evaluation of Immunogenicity and Therapeutic Potency. Davtyan H., Zagorsky Z., Petrushina I., Kazarian K., Goldberg, N.R.S., , Petrosyan J, Blurton-Jones M, Masliah E., Cribbs D.H., Agadjanyana M.G., Ghochikyana A. Neurobiology of Aging. 2017, 59:156-170. PMID: 28870518.
45. Mathur V, Burai R, Vest RT, Bonanno LN, Lehallier B, Zardeneta ME, Mistry KN, Do D, Marsh SE, Abud EM, Blurton-Jones M, Li L, Lashuel HA, Wyss-Coray T. (2017). Activation of the STING-Dependent Type I Interferon Response Reduces Microglial Reactivity and Neuroinflammation. Neuron 96(6):1290-1302. PMID: 29268096.
46. Human Neural Stem Cell Transplantation Rescues Functional Deficits in R6/2 and Q140 Huntington's Disease Mice. Reidling JC, Relaño-Ginés A, Holley SM, Ochaba J, Moore C, Fury B, Lau A, Tran AH, Yeung S, Salamati D, Zhu C, Hatami A, Cepeda C, Barry JA, Kamdjou T, King A, Coleal-Bergum D, Franich NR, LaFerla FM, Steffan JS, Blurton-Jones M, Meshul CK, Bauer G, Levine MS, Chesselet MF, Thompson LM. (2017). Stem Cell Reports. PMID: 29233555.
47. Gamma oscillations in the entorhinal-hippocampal circuit underlying memory and dementia. Nakazono T, Jun H, Blurton-Jones M, Green KN, Igarashi KM. Neurosci Research. 2018 Feb 10. S0168-0102(17)30657-0. PMID: 29438778
48. Development and validation of a simplified method to generate human microglia from pluripotent stem cells. McQuade A, Coburn M, Tu CH, Hasselmann J, Davtyan H, Blurton-Jones, M. Molecular Neurodegeneration. 2018 Dec 22;13(1):67. PMCID:6303871.
49. CD11a expression distinguishes infiltrating myeloid cells from plaque-associated microglia in Alzheimer's disease. Shukla AK, McIntyre LL, Marsh SE, Schneider CA, Hoover EM, Walsh CM, Lodoen MB, Blurton-Jones M, Inlay MA. Glia. 2019 May;67(5):844-856.
50. Microglia in Alzheimer's Disease: Exploring How Genetics and Phenotype Influence Risk. McQuade A, Blurton-Jones M. J Molecular Bio. 2019 Apr 19;431(9):1805-1817.
51. Induction of Mesoderm and Neural Crest-Derived Pericytes from Human Pluripotent Stem Cells to Study Blood-Brain Barrier Interactions. Faal T, Phan DTT, Davtyan H, Scarfone VM, Varady E, Blurton-Jones M, Hughes CCW, Inlay MA. Stem Cell Reports. 2019 Mar 5;12(3):451-460.
52. Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations. Rojo R, Raper A, Ozdemir DD, Lefevre L, Grabert K, Wollscheid-Lengeling E, Bradford B, Caruso M, Gazova I, Sánchez A, Lisowski ZM, Alves J, Molina-Gonzalez I, Davtyan H, Lodge RJ, Glover JD, Wallace R, Munro DAD, David E, Amit I, Miron VE, Priller J, Jenkins SJ, Hardingham GE, Blurton-Jones M, Mabbott NA, Summers KM, Hohenstein P, Hume DA, Pridans C. Nature Communications. 2019 Jul 19;10(1):3215. PMID: 31324781.
53. Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo. Hasselmann J, Coburn MA, England W, Figueroa Velez DX, Kiani Shabestari S, Tu CH, McQuade A, Kolahdouzan M, Echeverria K, Claes C, Nakayama T, Azevedo R, Coufal NG, Han CZ, Cummings BJ, Davtyan H, Glass CK, Healy LM, Gandhi SP, Spitale RC, Blurton-Jones M. Neuron. 2019 Sep 25;103(6):1016-1033. PMCID: 7138101.
54. Amyloid-beta impairs TOM1-mediated IL-1R1 signaling. Martini AC, Gomez-Arboledas A, Forner S, Rodriguez-Ortiz CJ, McQuade A, Danhash E, Phan J, Javonillo D, Ha JV, Tram M, Trujillo-Estrada L, da Cunha C, Ager RR, Davila JC, Kitazawa M, Blurton-Jones M, Gutierrez A, Baglietto-Vargas D, Medeiros R, LaFerla FM. Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):21198-21206. PMID: 31570577.
55. Testing a MultiTEP-based combination vaccine to reduce Aß and tau pathology in Tau22/5xFAD bigenic mice. Davtyan H, Hovakimyan A, Kiani Shabestari S, Antonyan T, Coburn MA, Zagorski K, Chailyan G, Petrushina I, Svystun O, Danhash E, Petrovsky N, Cribbs DH, Agadjanyan MG, Blurton-Jones M, Ghochikyan A. Alzheimers Research and Therapy. 2019 Dec 17;11(1):107. PMID: 31847886.
56. Human iPSC-derived microglia: A growing toolset to study the brain's innate immune cells. Hasselmann J, Blurton-Jones M. Glia. 2020 Apr;68(4):721-739. doi: 10.1002/glia.23781. PMID: 31926038.
57. Characterization and preclinical evaluation of the cGMP grade DNA based vaccine, AV-1959D to enter the first-in-human clinical trials. Petrushina I, Hovakimyan A, Harahap-Carrillo IS, Davtyan H, Antonyan T, Chailyan G, Kazarian K, Antonenko M, Jullienne A, Hamer MM, Obenaus A, King O, Zagorski K, Blurton-Jones M, Cribbs DH, Lander H, Ghochikyan A, Agadjanyan MG. Neurobiology of Disease. 2020 Jun;139:104823. PMID: 32119976.
58. Multi-omic comparison of Alzheimer's variants in human ESC-derived microglia reveals convergence at APOE. Liu T, Zhu B, Liu Y, Zhang X, Yin J, Li X, Jiang L, Hodges AP, Rosenthal SB, Zhou L, Yancey J, McQuade A, Blurton-Jones M, Tanzi RE, Huang TY, Xu H. Journal of Experimental Medicine. 2020 Dec 7;217(12). PMID: 32941599.
59. Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer’s disease. McQuade A, Kang YJ, Hasselmann J, Jairaman A, Sotelo A, Coburn M, Shabestari SK, Chaderevian JP, Fote G, Tu CH, Danhash E, Silva J, Martinez E, Cotman C, Prieto A, Thompson LM, Steffan JS, Smith I, Davtyan H, Cahalan M, Cho H, Blurton-Jones M. Nature Communications. 2020 Oct 23;11(1):5370. PMID: 33097708.
60. A Bump-Hole Strategy for Increased Stringency of Cell-Specific Metabolic Labeling of RNA. Nguyen K, Kubota M, Arco JD, Feng C, Singha M, Beasley S, Sakr J, Gandhi SP, Blurton-Jones M, Fernández Lucas J, Spitale RC. ACS Chem Biol. 2020 Nov 21. PMID: 33222436.
61. PapRIV, a BV-2 microglial cell activating quorum sensing peptide. Janssens Y, Debunne N, De Spiegeleer A, Wynendaele E, Planas M, Feliu L, Quarta A, Claes C, Van Dam D, De Deyn PP, Ponsaerts P, Blurton-Jones M, De Spiegeleer B. Scientific Reports. 2021 May 21;11(1):10723. PMID: 34021199.
62. C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation. Lall D, Lorenzini I, Mota TA, Bell S, Mahan TE, Ulrich JD, Davtyan H, Rexach JE, Muhammad AKMG, Shelest O, Landeros J, Vazquez M, Kim J, Ghaffari L, O'Rourke JG, Geschwind DH, Blurton-Jones M, Holtzman DM, Sattler R, Baloh RH. Neuron. 2021 Jun 5:S0896-6273(21)00373-1. PMID: 34133945.
63. Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer's disease. Claes C, Danhash EP, Hasselmann J, Chadarevian JP, Shabestari SK, England WE, En Li T, Silva Hidalgo JL, Spitale RC, Davtyan H, Blurton-Jones M. Molecular Neurodegeneration. 2021 Jul 23;16(1):50. doi: 10.1186/s13024-021-00473-0. PMID: 34301296.
64. Modeling Sporadic Alzheimer's Disease in Human Brain Organoids under Serum Exposure. Chen X, Sun G, Tian E, Zhang M, Davtyan H, Beach TG, Reiman EM, Blurton-Jones M, Holtzman DM, Shi Y. Advanced Science. 2021 Aug 2;e2101462. doi: 10.1002/advs.202101462. PMID: 34337898.
65. Human Induced Pluripotent Stem Cell-Derived Microglia (hiPSC-Microglia). McQuade A, Blurton-Jones M. Methods Molecular Biology. 2021 Nov 13. doi: 10.1007/7651_2021_429. PMID: 34773245.
66. The CD22-IGF2R interaction is a therapeutic target for microglial lysosome dysfunction in Niemann-Pick type C. Pluvinage JV, Sun J, Claes C, Flynn RA, Haney MS, Iram T, Meng X, Lindemann R, Riley NM, Danhash E, Chadarevian JP, Tapp E, Gate D, Kondapavulur S, Cobos I, Chetty S, Pa?ca AM, Pa?ca SP, Berry-Kravis E, Bertozzi CR, Blurton-Jones M, Wyss-Coray T.Science Translational Medicine. 2021 Dec;13(622). PMID: 34851695.
67. Human neural cell type-specific extracellular vesicle proteome defines disease-related molecules associated with activated astrocytes in Alzheimer's disease brain.You Y, Muraoka S, Jedrychowski MP, Hu J, McQuade AK, Young-Pearse T, Aslebagh R, Shaffer SA, Gygi SP, Blurton-Jones M, Poon WW, Ikezu T. Journal of Extracellular Vesicles. 2022 Jan;11(1):e12183. PMID: 35029059.
68. The P522R protective variant of PLCG2 promotes the expression of antigen presentation genes by human microglia in an Alzheimer's disease mouse model. Claes C, England WE, Danhash EP, Kiani Shabestari S, Jairaman A, Chadarevian JP, Hasselmann J, Tsai AP, Coburn MA, Sanchez J, Lim TE, Hidalgo JLS, Tu C, Cahalan MD, Lamb BT, Landreth GE, Spitale RC, Blurton-Jones M, Davtyan H. Alzheimers Dement. 2022 Feb 9. PMID: 35142046. *MBJ and HD contributed equally.
69. TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia. Jairaman A, McQuade A, Granzotto A, Kang YJ, Chadarevian JP, Gandhi S, Parker I, Smith I, Cho H, Sensi SL, Othy S, Blurton-Jones M*, Cahalan MD*. Elife. 2022 Feb 22;11:e73021.PMID: 35191835. *MBJ and CMD contributed equally.
70. A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant inhibitory impact on CSF1R signalling. Stables J, Green EK, Sehgal A, Patkar OL, Keshvari S, Taylor I, Ashcroft ME, Grabert K, Wollscheid-Lengeling E, Szymkowiak S, McColl BW, Adamson A, Humphreys NE, Mueller W, Starobova H, Vetter I, Shabestari SK, Blurton-Jones MM, Summers KM, Irvine KM, Pridans C, Hume DA. Development. 2022 Apr 15;149(8):dev200237. PMID: 35333324.
71. Immunogenicity of MultiTEP-Platform-Based Recombinant Protein Vaccine, PV-1950R, Targeting Three B-Cell Antigenic Determinants of Pathological a-Synuclein. Zagorski K, Chailyan G, Hovakimyan A, Antonyan T, Kiani Shabestari S, Petrushina I, Davtyan H, Cribbs DH, Blurton-Jones M, Masliah E, Agadjanyan MG, Ghochikyan A. Int J Mol Sci. 2022 May 29;23(11):6080.PMID: 35682759
72. Absence of microglia promotes diverse pathologies and early lethality in Alzheimer's disease mice. Kiani Shabestari S, Morabito S, Danhash EP, McQuade A, Sanchez JR, Miyoshi E, Chadarevian JP, Claes C, Coburn MA, Hasselmann J, Hidalgo J, Tran KN, Martini AC, Chang Rothermich W, Pascual J, Head E, Hume DA, Pridans C, Davtyan H, Swarup V, Blurton-Jones M. Cell Reports. 2022 Jun 14;39(11):110961.
PMID: 35705056
73. Using Advanced Diffusion-Weighted Imaging to Predict Cell Counts in Gray Matter: Potential and Pitfalls. Radhakrishnan H, Shabestari SK, Blurton-Jones M, Obenaus A, Stark CEL. Front Neurosci. 2022 Jun 3;16:881713. PMID: 35720733.
74. Microglia states and nomenclature: A field at its crossroads. Paolicelli RC, Sierra A, Stevens B, Tremblay ME, Aguzzi A, Ajami B, Amit I, Audinat E, Bechmann I, Bennett M, Bennett F, Bessis A, Biber K, Bilbo S, Blurton-Jones M, Boddeke E, Brites D, Brône B, Brown GC, Butovsky O, Carson MJ, Castellano B, Colonna M, Cowley SA, Cunningham C, Davalos D, De Jager PL, de Strooper B, Denes A, Eggen BJL, Eyo U, Galea E, Garel S, Ginhoux F, Glass CK, Gokce O, Gomez-Nicola D, González B, Gordon S, Graeber MB, Greenhalgh AD, Gressens P, Greter M, Gutmann DH, Haass C, Heneka MT, Heppner FL, Hong S, Hume DA, Jung S, Kettenmann H, Kipnis J, Koyama R, Lemke G, Lynch M, Majewska A, Malcangio M, Malm T, Mancuso R, Masuda T, Matteoli M, McColl BW, Miron VE, Molofsky AV, Monje M, Mracsko E, Nadjar A, Neher JJ, Neniskyte U, Neumann H, Noda M, Peng B, Peri F, Perry VH, Popovich PG, Pridans C, Priller J, Prinz M, Ragozzino D, Ransohoff RM, Salter MW, Schaefer A, Schafer DP, Schwartz M, Simons M, Smith CJ, Streit WJ, Tay TL, Tsai LH, Verkhratsky A, von Bernhardi R, Wake H, Wittamer V, Wolf SA, Wu LJ, Wyss-Coray T. Neuron. 2022 Nov 2;110(21):3458-3483. PMID: 36327895.
75. Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits. Reyes-Ortiz AM, Abud EM, Burns MS, Wu J, Hernandez SJ, McClure N, Wang KQ, Schulz CJ, Miramontes R, Lau A, Michael N, Miyoshi E, Van Vactor D, Reidling JC, Blurton-Jones M, Swarup V, Poon WW, Lim RG, Thompson LM. iScience. 2022 Dec 6;26(1):105732. PMID: 3659016.
76. Engineering an inhibitor resistant human CSF1R variant for microglia replacement. Chadarevian JP, Lombroso SI, Peet GC, Hasselmann J, Tu CH, Marzan DE, Capocchi J, Purnel FS, Nemec KM, Lahian A, Escobar A, England W, Chaluvadi S, O’Brien CA, Yaqoob F, Aisenberg WH, Porras-Paniagua M, Bennett ML, Davtyan H, Spitale RC, Blurton-Jones M# Bennett FC. *MBJ and FCB contributed equally to this work. 2023 Journal of Experimental Medicine. Mar 6;220(3):e20220857. PMID: 36584406.
77. Moderate intrinsic phenotypic alterations in C9orf72 ALS/FTD iPSC-microglia despite the presence of C9orf72 pathological features. Lorenzini I, Alsop E, Levy J, Gittings LM, Lall D, Rabichow BE, Moore S, Pevey R, Bustos LM, Burciu C, Bhatia D, Singer M, Saul J, McQuade A, Tzioras M, Mota TA, Logemann A, Rose J, Almeida S, Gao FB, Marks M, Donnelly CJ, Hutchins E, Hung ST, Ichida J, Bowser R, Spires-Jones T, Blurton-Jones M, Gendron TF, Baloh RH, Van Keuren-Jensen K, Sattler R. Front Cell Neurosci. 2023 Jun 6;17:1179796. PMID: 37346371.
78. Novel Vaccine against Pathological Pyroglutamate-Modified Amyloid Beta for Prevention of Alzheimer's Disease. Zagorski K, King O, Hovakimyan A, Petrushina I, Antonyan T, Chailyan G, Ghazaryan M, Hyrc KL, Chadarevian JP, Davtyan H, Blurton-Jones M, Cribbs DH, Agadjanyan MG, Ghochikyan A. Int J Mol Sci. 2023 Jun 6;24(12):9797. PMID: 37372944.
79. Astrocytic response mediated by the CLU risk allele inhibits OPC proliferation and myelination in a human iPSC model. Liu Z, Chao J, Wang C, Sun G, Roeth D, Liu W, Chen X, Li L, Tian E, Feng L, Davtyan H, Blurton-Jones M, Kalkum M, Shi Y. Cell Reports. 2023 Aug 29;42(8):112841. PMID: 37494190.
80. Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro. Dolan MJ, Therrien M, Jereb S, Kamath T, Gazestani V, Atkeson T, Marsh SE, Goeva A, Lojek NM, Murphy S, White CM, Joung J, Liu B, Limone F, Eggan K, Hacohen N, Bernstein BE, Glass CK, Leinonen V, Blurton-Jones M, Zhang F, Epstein CB, Macosko EZ, Stevens B. Nature Immunol. 2023 Aug;24(8):1382-1390. PMID: 37500887.
81. CRISPR generation of CSF1R-G795A human microglia for robust microglia replacement in a chimeric mouse model. Chadarevian JP, Davtyan H, Lombroso SI, Bennett FC, Blurton-Jones M. STAR Protocols. 2023 Jul 29;4(3):102490. PMID: 37516973.
82. Mitochondria dysregulation contributes to secondary neurodegeneration progression post-contusion injury in human 3D in vitro triculture brain tissue model. Liaudanskaya V, Fiore NJ, Zhang Y, Milton Y, Kelly MF, Coe M, Barreiro A, Rose VK, Shapiro MR, Mullis AS, Shevzov-Zebrun A, Blurton-Jones M, Whalen MJ, Symes AJ, Georgakoudi I, Nieland TJF, Kaplan DL. Cell Death Dis. 2023 Aug 3;14(8):496. PMID: 37537168.
83. Alteration of microglial metabolism and inflammatory profile contributes to neurotoxicity in a hiPSC-derived microglia model of frontotemporal dementia 3. Haukedal H, Syshøj Lorenzen S, Winther Westi E, Corsi GI, Gadekar VP, McQuade A, Davtyan H, Doncheva NT, Schmid B, Chandrasekaran A, Seemann SE, Cirera S, Blurton-Jones M, Meyer M, Gorodkin J, Aldana BI, Freude K. Brain Behav Immun. 2023 Oct;113:353-373. PMID: 37543250.
84. Human microglia maturation is underpinned by specific gene regulatory networks. Han CZ, Li RZ, Hansen E, Trescott S, Fixsen BR, Nguyen CT, Mora CM, Spann NJ, Bennett HR, Poirion O, Buchanan J, Warden AS, Xia B, Schlachetzki JCM, Pasillas MP, Preissl S, Wang A, O'Connor C, Shriram S, Kim R, Schafer D, Ramirez G, Challacombe J, Anavim SA, Johnson A, Gupta M, Glass IA; Birth Defects Research Laboratory; Levy ML, Haim SB, Gonda DD, Laurent L, Hughes JF, Page DC, Blurton-Jones M, Glass CK, Coufal NG. Immunity. 2023 Sep 12;56(9):2152-2171.e13. PMID: 37582369.
85. Microglia promote anti-tumour immunity and suppress breast cancer brain metastasis. Evans KT, Blake K, Longworth A, Coburn MA, Insua-Rodríguez J, McMullen TP, Nguyen QH, Ma D, Lev T, Hernandez GA, Oganyan AK, Orujyan D, Edwards RA, Pridans C, Green KN, Villalta SA, Blurton-Jones M, Lawson DA. Nature Cell Biology. 2023 Nov 13. PMID: 37957324.
86. Microglial APOE4: more is less and less is more. Eskandari-Sedighi G, Blurton-Jones M. Molecular Neurodegeneration. 2023 Dec 19;18(1):99. doi: 10.1186/s13024-023-00693-6. PMID: 38115077.
87. Neurotoxic Microglial Activation via IFN?-Induced Nrf2 Reduction Exacerbating Alzheimer's Disease. Kang YJ, Hyeon SJ, McQuade A, Lim J, Baek SH, Diep YN, Do KV, Jeon Y, Jo DG, Lee CJ, Blurton-Jones M, Ryu H, Cho H. Advanced Sciences. 2024 Mar 14. PMID: 38482922.
88. Genetic contribution to microglial activation in schizophrenia. Koskuvi M, Pörsti E, Hewitt T, Räsänen N, Wu YC, Trontti K, McQuade A, Kalyanaraman S, Ojansuu I, Vaurio O, Cannon TD, Lönnqvist J, Therman S, Suvisaari J, Kaprio J, Blurton-Jones M, Hovatta I, Lähteenvuo M, Rolova T, Lehtonen Š, Tiihonen J, Koistinaho J. Molecular Psychiatry. 2024 Mar 22. doi: 10.1038/s41380-024-02529-1. PMID: 38519640.
89. Therapeutic potential of human microglial transplantation in a chimeric model of CSF1R-related leukoencephalopathy. Jean Paul Chadarevian, Jonathan Hasselmann, Alina Lahian , Joia Capocchi, Adrian Escobar, Tau En Lim, Christina Tu, Lauren Le, Jasmine Nguyen, Sepideh Kiani Shabestari, William Carlen-Jones, Sunil Gandhi, Guojun Bu, David A. Hume, Clare Pridans, Zbigniew K. Wszolek, Robert C. Spitale, Hayk Davtyan, Mathew Blurton-Jones. 2024. Neuron, Aug 21;112(16):2686-2707.e8. PMID: 38897209.
90. Microglia protect against age-associated brain pathologies. Munro DAD, Bestard-Cuche N, McQuaid C, Chagnot A, Shabestari SK, Chadarevian JP, Maheshwari U, Szymkowiak S, Morris K, Mohammad M, Corsinotti A, Bradford B, Mabbott N, Lennen RJ, Jansen MA, Pridans C, McColl BW, Keller A, Blurton-Jones M, Montagne A, Williams A, Priller J. Neuron. 2024 Aug 21;112(16):2732-2748. PMID: 38897208.
91. Sex-dependent APOE4 neutrophil-microglia interactions drive cognitive impairment in Alzheimer’s Disease. Neta Rosenzweig, Kilian L. Kleemann, Thomas Rust, Madison Carpenter, Madeline Grucci, Michael Aronchik, Nieske Brouwer, Isabel Valenbreder, Joya Cooper-Hohn, Malvika Iyer, Rajesh K. Krishnan, Kisha Sivanathan, Wesley Brandão, Taha Yahya, Ana Durao, Zhuoran Yin, Jean Paul Chadarevian, Michael Properzi, Roni Nowarski, Hayk Davtyan, Howard L. Weiner, Mathew Blurton-Jones, Hyun-Sik Yang, Bart J. L. Eggen, Reisa Sperling, Oleg Butovsky. 2024 Nature Medicine. Oct;30(10):2990-3003.
92. ER and SOCE Ca2+ signals are not required for directed cell migration in human iPSC-derived microglia. Granzotto A, McQuade A, Chadarevian JP, Davtyan H, Sensi SL, Parker I, Blurton-Jones M, Smith IF. Cell Calcium. 2024 Nov;123:102923. PMID: 38970922.
93. Organelle phenotyping and multi-dimensional microscopy identify C1q as a novel regulator of microglial function. Sakthivel PS, Scipioni L, Karam J, Keulen Z, Blurton-Jones M, Gratton E, Anderson AJ. J Neurochem. 2024 Sep;168(9):3095-3107. PMID: 39018376.
94. Microglia are not necessary for maintenance of blood-brain barrier properties in health, but PLX5622 alters brain endothelial cholesterol metabolism. Profaci CP, Harvey SS, Bajc K, Zhang TZ, Jeffrey DA, Zhang AZ, Nemec KM, Davtyan H, O'Brien CA, McKinsey GL, Longworth A, McMullen TP, Capocchi JK, Gonzalez JG, Lawson DA, Arnold TD, Davalos D, Blurton-Jones M, Dabertrand F, Bennett FC, Daneman R. Neuron. 2024 Sep 4;112(17):2910-2921.e7. PMID: 39142282.
95. Microglial APOE3 Christchurch protects neurons from Tau pathology in a human iPSC-based model of Alzheimer's disease. Sun GG, Wang C, Mazzarino RC, Perez-Corredor PA, Davtyan H, Blurton-Jones M, Lopera F, Arboleda-Velasquez JF, Shi Y. Cell Rep. 2024 Dec 24;43(12):114982. PMID: 39612244.
96. Inhaled xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy. Brandao W, Jain N, Yin Z, Kleemann KL, Carpenter M, Bao X, Serrano JR, Tycksen E, Durao A, Barry JL, Baufeld C, Guneykaya D, Zhang X, Litvinchuk A, Jiang H, Rosenzweig N, Pitts KM, Aronchik M, Yahya T, Cao T, Takahashi MK, Krishnan R, Davtyan H, Ulrich JD, Blurton-Jones M, Ilin I, Weiner HL, Holtzman DM, Butovsky O. Science Translational Medicine. 2025 Jan 15;17(781). PMID: 39813317.
42. iPSC-derived human microglia-like cells to study neurological diseases. Abud EM, Ramirez RN, Martinez ES, Healy LM, Nguyen CHH, Newman SA, Yeromin AV, Scarfone VM, Marsh SE, Fimbres C, Caraway CA, Fote GM, Madany AM, Agrawal A, Kayed R Gylys KH, Cahahlan MD, Cummings BJ, Antel JP, Mortazavi A, Carson MJ, Poon WW, Blurton-Jones M. Neuron. 2017 Apr 19;94(2):278-293. PMCID: 5482419.
43. Humanized monoclonal antibody armanezumab specific to N-terminus of pathological tau: characterization and therapeutic potency. Agadjanyan MG, Zagorski K, Petrushina I, Davtyan H, Kazarian K, Antonenko M, Davis J, Bon C, Blurton-Jones M, Cribbs DH, Ghochikyan A. Molecular Neurodegeneration. 2017, 12(1):33. PMCID: 5418694.
44. MultiTEP Platform-based DNA Vaccines for alpha-Synucleinopathies: Pre-clinical Evaluation of Immunogenicity and Therapeutic Potency. Davtyan H., Zagorsky Z., Petrushina I., Kazarian K., Goldberg, N.R.S., , Petrosyan J, Blurton-Jones M, Masliah E., Cribbs D.H., Agadjanyana M.G., Ghochikyana A. Neurobiology of Aging. 2017, 59:156-170. PMID: 28870518.
45. Mathur V, Burai R, Vest RT, Bonanno LN, Lehallier B, Zardeneta ME, Mistry KN, Do D, Marsh SE, Abud EM, Blurton-Jones M, Li L, Lashuel HA, Wyss-Coray T. (2017). Activation of the STING-Dependent Type I Interferon Response Reduces Microglial Reactivity and Neuroinflammation. Neuron 96(6):1290-1302. PMID: 29268096.
46. Human Neural Stem Cell Transplantation Rescues Functional Deficits in R6/2 and Q140 Huntington's Disease Mice. Reidling JC, Relaño-Ginés A, Holley SM, Ochaba J, Moore C, Fury B, Lau A, Tran AH, Yeung S, Salamati D, Zhu C, Hatami A, Cepeda C, Barry JA, Kamdjou T, King A, Coleal-Bergum D, Franich NR, LaFerla FM, Steffan JS, Blurton-Jones M, Meshul CK, Bauer G, Levine MS, Chesselet MF, Thompson LM. (2017). Stem Cell Reports. PMID: 29233555.
47. Gamma oscillations in the entorhinal-hippocampal circuit underlying memory and dementia. Nakazono T, Jun H, Blurton-Jones M, Green KN, Igarashi KM. Neurosci Research. 2018 Feb 10. S0168-0102(17)30657-0. PMID: 29438778
48. Development and validation of a simplified method to generate human microglia from pluripotent stem cells. McQuade A, Coburn M, Tu CH, Hasselmann J, Davtyan H, Blurton-Jones, M. Molecular Neurodegeneration. 2018 Dec 22;13(1):67. PMCID:6303871.
49. CD11a expression distinguishes infiltrating myeloid cells from plaque-associated microglia in Alzheimer's disease. Shukla AK, McIntyre LL, Marsh SE, Schneider CA, Hoover EM, Walsh CM, Lodoen MB, Blurton-Jones M, Inlay MA. Glia. 2019 May;67(5):844-856.
50. Microglia in Alzheimer's Disease: Exploring How Genetics and Phenotype Influence Risk. McQuade A, Blurton-Jones M. J Molecular Bio. 2019 Apr 19;431(9):1805-1817.
51. Induction of Mesoderm and Neural Crest-Derived Pericytes from Human Pluripotent Stem Cells to Study Blood-Brain Barrier Interactions. Faal T, Phan DTT, Davtyan H, Scarfone VM, Varady E, Blurton-Jones M, Hughes CCW, Inlay MA. Stem Cell Reports. 2019 Mar 5;12(3):451-460.
52. Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations. Rojo R, Raper A, Ozdemir DD, Lefevre L, Grabert K, Wollscheid-Lengeling E, Bradford B, Caruso M, Gazova I, Sánchez A, Lisowski ZM, Alves J, Molina-Gonzalez I, Davtyan H, Lodge RJ, Glover JD, Wallace R, Munro DAD, David E, Amit I, Miron VE, Priller J, Jenkins SJ, Hardingham GE, Blurton-Jones M, Mabbott NA, Summers KM, Hohenstein P, Hume DA, Pridans C. Nature Communications. 2019 Jul 19;10(1):3215. PMID: 31324781.
53. Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo. Hasselmann J, Coburn MA, England W, Figueroa Velez DX, Kiani Shabestari S, Tu CH, McQuade A, Kolahdouzan M, Echeverria K, Claes C, Nakayama T, Azevedo R, Coufal NG, Han CZ, Cummings BJ, Davtyan H, Glass CK, Healy LM, Gandhi SP, Spitale RC, Blurton-Jones M. Neuron. 2019 Sep 25;103(6):1016-1033. PMCID: 7138101.
54. Amyloid-beta impairs TOM1-mediated IL-1R1 signaling. Martini AC, Gomez-Arboledas A, Forner S, Rodriguez-Ortiz CJ, McQuade A, Danhash E, Phan J, Javonillo D, Ha JV, Tram M, Trujillo-Estrada L, da Cunha C, Ager RR, Davila JC, Kitazawa M, Blurton-Jones M, Gutierrez A, Baglietto-Vargas D, Medeiros R, LaFerla FM. Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):21198-21206. PMID: 31570577.
55. Testing a MultiTEP-based combination vaccine to reduce Aß and tau pathology in Tau22/5xFAD bigenic mice. Davtyan H, Hovakimyan A, Kiani Shabestari S, Antonyan T, Coburn MA, Zagorski K, Chailyan G, Petrushina I, Svystun O, Danhash E, Petrovsky N, Cribbs DH, Agadjanyan MG, Blurton-Jones M, Ghochikyan A. Alzheimers Research and Therapy. 2019 Dec 17;11(1):107. PMID: 31847886.
56. Human iPSC-derived microglia: A growing toolset to study the brain's innate immune cells. Hasselmann J, Blurton-Jones M. Glia. 2020 Apr;68(4):721-739. doi: 10.1002/glia.23781. PMID: 31926038.
57. Characterization and preclinical evaluation of the cGMP grade DNA based vaccine, AV-1959D to enter the first-in-human clinical trials. Petrushina I, Hovakimyan A, Harahap-Carrillo IS, Davtyan H, Antonyan T, Chailyan G, Kazarian K, Antonenko M, Jullienne A, Hamer MM, Obenaus A, King O, Zagorski K, Blurton-Jones M, Cribbs DH, Lander H, Ghochikyan A, Agadjanyan MG. Neurobiology of Disease. 2020 Jun;139:104823. PMID: 32119976.
58. Multi-omic comparison of Alzheimer's variants in human ESC-derived microglia reveals convergence at APOE. Liu T, Zhu B, Liu Y, Zhang X, Yin J, Li X, Jiang L, Hodges AP, Rosenthal SB, Zhou L, Yancey J, McQuade A, Blurton-Jones M, Tanzi RE, Huang TY, Xu H. Journal of Experimental Medicine. 2020 Dec 7;217(12). PMID: 32941599.
59. Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer’s disease. McQuade A, Kang YJ, Hasselmann J, Jairaman A, Sotelo A, Coburn M, Shabestari SK, Chaderevian JP, Fote G, Tu CH, Danhash E, Silva J, Martinez E, Cotman C, Prieto A, Thompson LM, Steffan JS, Smith I, Davtyan H, Cahalan M, Cho H, Blurton-Jones M. Nature Communications. 2020 Oct 23;11(1):5370. PMID: 33097708.
60. A Bump-Hole Strategy for Increased Stringency of Cell-Specific Metabolic Labeling of RNA. Nguyen K, Kubota M, Arco JD, Feng C, Singha M, Beasley S, Sakr J, Gandhi SP, Blurton-Jones M, Fernández Lucas J, Spitale RC. ACS Chem Biol. 2020 Nov 21. PMID: 33222436.
61. PapRIV, a BV-2 microglial cell activating quorum sensing peptide. Janssens Y, Debunne N, De Spiegeleer A, Wynendaele E, Planas M, Feliu L, Quarta A, Claes C, Van Dam D, De Deyn PP, Ponsaerts P, Blurton-Jones M, De Spiegeleer B. Scientific Reports. 2021 May 21;11(1):10723. PMID: 34021199.
62. C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation. Lall D, Lorenzini I, Mota TA, Bell S, Mahan TE, Ulrich JD, Davtyan H, Rexach JE, Muhammad AKMG, Shelest O, Landeros J, Vazquez M, Kim J, Ghaffari L, O'Rourke JG, Geschwind DH, Blurton-Jones M, Holtzman DM, Sattler R, Baloh RH. Neuron. 2021 Jun 5:S0896-6273(21)00373-1. PMID: 34133945.
63. Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer's disease. Claes C, Danhash EP, Hasselmann J, Chadarevian JP, Shabestari SK, England WE, En Li T, Silva Hidalgo JL, Spitale RC, Davtyan H, Blurton-Jones M. Molecular Neurodegeneration. 2021 Jul 23;16(1):50. doi: 10.1186/s13024-021-00473-0. PMID: 34301296.
64. Modeling Sporadic Alzheimer's Disease in Human Brain Organoids under Serum Exposure. Chen X, Sun G, Tian E, Zhang M, Davtyan H, Beach TG, Reiman EM, Blurton-Jones M, Holtzman DM, Shi Y. Advanced Science. 2021 Aug 2;e2101462. doi: 10.1002/advs.202101462. PMID: 34337898.
65. Human Induced Pluripotent Stem Cell-Derived Microglia (hiPSC-Microglia). McQuade A, Blurton-Jones M. Methods Molecular Biology. 2021 Nov 13. doi: 10.1007/7651_2021_429. PMID: 34773245.
66. The CD22-IGF2R interaction is a therapeutic target for microglial lysosome dysfunction in Niemann-Pick type C. Pluvinage JV, Sun J, Claes C, Flynn RA, Haney MS, Iram T, Meng X, Lindemann R, Riley NM, Danhash E, Chadarevian JP, Tapp E, Gate D, Kondapavulur S, Cobos I, Chetty S, Pa?ca AM, Pa?ca SP, Berry-Kravis E, Bertozzi CR, Blurton-Jones M, Wyss-Coray T.Science Translational Medicine. 2021 Dec;13(622). PMID: 34851695.
67. Human neural cell type-specific extracellular vesicle proteome defines disease-related molecules associated with activated astrocytes in Alzheimer's disease brain.You Y, Muraoka S, Jedrychowski MP, Hu J, McQuade AK, Young-Pearse T, Aslebagh R, Shaffer SA, Gygi SP, Blurton-Jones M, Poon WW, Ikezu T. Journal of Extracellular Vesicles. 2022 Jan;11(1):e12183. PMID: 35029059.
68. The P522R protective variant of PLCG2 promotes the expression of antigen presentation genes by human microglia in an Alzheimer's disease mouse model. Claes C, England WE, Danhash EP, Kiani Shabestari S, Jairaman A, Chadarevian JP, Hasselmann J, Tsai AP, Coburn MA, Sanchez J, Lim TE, Hidalgo JLS, Tu C, Cahalan MD, Lamb BT, Landreth GE, Spitale RC, Blurton-Jones M, Davtyan H. Alzheimers Dement. 2022 Feb 9. PMID: 35142046. *MBJ and HD contributed equally.
69. TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia. Jairaman A, McQuade A, Granzotto A, Kang YJ, Chadarevian JP, Gandhi S, Parker I, Smith I, Cho H, Sensi SL, Othy S, Blurton-Jones M*, Cahalan MD*. Elife. 2022 Feb 22;11:e73021.PMID: 35191835. *MBJ and CMD contributed equally.
70. A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant inhibitory impact on CSF1R signalling. Stables J, Green EK, Sehgal A, Patkar OL, Keshvari S, Taylor I, Ashcroft ME, Grabert K, Wollscheid-Lengeling E, Szymkowiak S, McColl BW, Adamson A, Humphreys NE, Mueller W, Starobova H, Vetter I, Shabestari SK, Blurton-Jones MM, Summers KM, Irvine KM, Pridans C, Hume DA. Development. 2022 Apr 15;149(8):dev200237. PMID: 35333324.
71. Immunogenicity of MultiTEP-Platform-Based Recombinant Protein Vaccine, PV-1950R, Targeting Three B-Cell Antigenic Determinants of Pathological a-Synuclein. Zagorski K, Chailyan G, Hovakimyan A, Antonyan T, Kiani Shabestari S, Petrushina I, Davtyan H, Cribbs DH, Blurton-Jones M, Masliah E, Agadjanyan MG, Ghochikyan A. Int J Mol Sci. 2022 May 29;23(11):6080.PMID: 35682759
72. Absence of microglia promotes diverse pathologies and early lethality in Alzheimer's disease mice. Kiani Shabestari S, Morabito S, Danhash EP, McQuade A, Sanchez JR, Miyoshi E, Chadarevian JP, Claes C, Coburn MA, Hasselmann J, Hidalgo J, Tran KN, Martini AC, Chang Rothermich W, Pascual J, Head E, Hume DA, Pridans C, Davtyan H, Swarup V, Blurton-Jones M. Cell Reports. 2022 Jun 14;39(11):110961.
PMID: 35705056
73. Using Advanced Diffusion-Weighted Imaging to Predict Cell Counts in Gray Matter: Potential and Pitfalls. Radhakrishnan H, Shabestari SK, Blurton-Jones M, Obenaus A, Stark CEL. Front Neurosci. 2022 Jun 3;16:881713. PMID: 35720733.
74. Microglia states and nomenclature: A field at its crossroads. Paolicelli RC, Sierra A, Stevens B, Tremblay ME, Aguzzi A, Ajami B, Amit I, Audinat E, Bechmann I, Bennett M, Bennett F, Bessis A, Biber K, Bilbo S, Blurton-Jones M, Boddeke E, Brites D, Brône B, Brown GC, Butovsky O, Carson MJ, Castellano B, Colonna M, Cowley SA, Cunningham C, Davalos D, De Jager PL, de Strooper B, Denes A, Eggen BJL, Eyo U, Galea E, Garel S, Ginhoux F, Glass CK, Gokce O, Gomez-Nicola D, González B, Gordon S, Graeber MB, Greenhalgh AD, Gressens P, Greter M, Gutmann DH, Haass C, Heneka MT, Heppner FL, Hong S, Hume DA, Jung S, Kettenmann H, Kipnis J, Koyama R, Lemke G, Lynch M, Majewska A, Malcangio M, Malm T, Mancuso R, Masuda T, Matteoli M, McColl BW, Miron VE, Molofsky AV, Monje M, Mracsko E, Nadjar A, Neher JJ, Neniskyte U, Neumann H, Noda M, Peng B, Peri F, Perry VH, Popovich PG, Pridans C, Priller J, Prinz M, Ragozzino D, Ransohoff RM, Salter MW, Schaefer A, Schafer DP, Schwartz M, Simons M, Smith CJ, Streit WJ, Tay TL, Tsai LH, Verkhratsky A, von Bernhardi R, Wake H, Wittamer V, Wolf SA, Wu LJ, Wyss-Coray T. Neuron. 2022 Nov 2;110(21):3458-3483. PMID: 36327895.
75. Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits. Reyes-Ortiz AM, Abud EM, Burns MS, Wu J, Hernandez SJ, McClure N, Wang KQ, Schulz CJ, Miramontes R, Lau A, Michael N, Miyoshi E, Van Vactor D, Reidling JC, Blurton-Jones M, Swarup V, Poon WW, Lim RG, Thompson LM. iScience. 2022 Dec 6;26(1):105732. PMID: 3659016.
76. Engineering an inhibitor resistant human CSF1R variant for microglia replacement. Chadarevian JP, Lombroso SI, Peet GC, Hasselmann J, Tu CH, Marzan DE, Capocchi J, Purnel FS, Nemec KM, Lahian A, Escobar A, England W, Chaluvadi S, O’Brien CA, Yaqoob F, Aisenberg WH, Porras-Paniagua M, Bennett ML, Davtyan H, Spitale RC, Blurton-Jones M# Bennett FC. *MBJ and FCB contributed equally to this work. 2023 Journal of Experimental Medicine. Mar 6;220(3):e20220857. PMID: 36584406.
77. Moderate intrinsic phenotypic alterations in C9orf72 ALS/FTD iPSC-microglia despite the presence of C9orf72 pathological features. Lorenzini I, Alsop E, Levy J, Gittings LM, Lall D, Rabichow BE, Moore S, Pevey R, Bustos LM, Burciu C, Bhatia D, Singer M, Saul J, McQuade A, Tzioras M, Mota TA, Logemann A, Rose J, Almeida S, Gao FB, Marks M, Donnelly CJ, Hutchins E, Hung ST, Ichida J, Bowser R, Spires-Jones T, Blurton-Jones M, Gendron TF, Baloh RH, Van Keuren-Jensen K, Sattler R. Front Cell Neurosci. 2023 Jun 6;17:1179796. PMID: 37346371.
78. Novel Vaccine against Pathological Pyroglutamate-Modified Amyloid Beta for Prevention of Alzheimer's Disease. Zagorski K, King O, Hovakimyan A, Petrushina I, Antonyan T, Chailyan G, Ghazaryan M, Hyrc KL, Chadarevian JP, Davtyan H, Blurton-Jones M, Cribbs DH, Agadjanyan MG, Ghochikyan A. Int J Mol Sci. 2023 Jun 6;24(12):9797. PMID: 37372944.
79. Astrocytic response mediated by the CLU risk allele inhibits OPC proliferation and myelination in a human iPSC model. Liu Z, Chao J, Wang C, Sun G, Roeth D, Liu W, Chen X, Li L, Tian E, Feng L, Davtyan H, Blurton-Jones M, Kalkum M, Shi Y. Cell Reports. 2023 Aug 29;42(8):112841. PMID: 37494190.
80. Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro. Dolan MJ, Therrien M, Jereb S, Kamath T, Gazestani V, Atkeson T, Marsh SE, Goeva A, Lojek NM, Murphy S, White CM, Joung J, Liu B, Limone F, Eggan K, Hacohen N, Bernstein BE, Glass CK, Leinonen V, Blurton-Jones M, Zhang F, Epstein CB, Macosko EZ, Stevens B. Nature Immunol. 2023 Aug;24(8):1382-1390. PMID: 37500887.
81. CRISPR generation of CSF1R-G795A human microglia for robust microglia replacement in a chimeric mouse model. Chadarevian JP, Davtyan H, Lombroso SI, Bennett FC, Blurton-Jones M. STAR Protocols. 2023 Jul 29;4(3):102490. PMID: 37516973.
82. Mitochondria dysregulation contributes to secondary neurodegeneration progression post-contusion injury in human 3D in vitro triculture brain tissue model. Liaudanskaya V, Fiore NJ, Zhang Y, Milton Y, Kelly MF, Coe M, Barreiro A, Rose VK, Shapiro MR, Mullis AS, Shevzov-Zebrun A, Blurton-Jones M, Whalen MJ, Symes AJ, Georgakoudi I, Nieland TJF, Kaplan DL. Cell Death Dis. 2023 Aug 3;14(8):496. PMID: 37537168.
83. Alteration of microglial metabolism and inflammatory profile contributes to neurotoxicity in a hiPSC-derived microglia model of frontotemporal dementia 3. Haukedal H, Syshøj Lorenzen S, Winther Westi E, Corsi GI, Gadekar VP, McQuade A, Davtyan H, Doncheva NT, Schmid B, Chandrasekaran A, Seemann SE, Cirera S, Blurton-Jones M, Meyer M, Gorodkin J, Aldana BI, Freude K. Brain Behav Immun. 2023 Oct;113:353-373. PMID: 37543250.
84. Human microglia maturation is underpinned by specific gene regulatory networks. Han CZ, Li RZ, Hansen E, Trescott S, Fixsen BR, Nguyen CT, Mora CM, Spann NJ, Bennett HR, Poirion O, Buchanan J, Warden AS, Xia B, Schlachetzki JCM, Pasillas MP, Preissl S, Wang A, O'Connor C, Shriram S, Kim R, Schafer D, Ramirez G, Challacombe J, Anavim SA, Johnson A, Gupta M, Glass IA; Birth Defects Research Laboratory; Levy ML, Haim SB, Gonda DD, Laurent L, Hughes JF, Page DC, Blurton-Jones M, Glass CK, Coufal NG. Immunity. 2023 Sep 12;56(9):2152-2171.e13. PMID: 37582369.
85. Microglia promote anti-tumour immunity and suppress breast cancer brain metastasis. Evans KT, Blake K, Longworth A, Coburn MA, Insua-Rodríguez J, McMullen TP, Nguyen QH, Ma D, Lev T, Hernandez GA, Oganyan AK, Orujyan D, Edwards RA, Pridans C, Green KN, Villalta SA, Blurton-Jones M, Lawson DA. Nature Cell Biology. 2023 Nov 13. PMID: 37957324.
86. Microglial APOE4: more is less and less is more. Eskandari-Sedighi G, Blurton-Jones M. Molecular Neurodegeneration. 2023 Dec 19;18(1):99. doi: 10.1186/s13024-023-00693-6. PMID: 38115077.
87. Neurotoxic Microglial Activation via IFN?-Induced Nrf2 Reduction Exacerbating Alzheimer's Disease. Kang YJ, Hyeon SJ, McQuade A, Lim J, Baek SH, Diep YN, Do KV, Jeon Y, Jo DG, Lee CJ, Blurton-Jones M, Ryu H, Cho H. Advanced Sciences. 2024 Mar 14. PMID: 38482922.
88. Genetic contribution to microglial activation in schizophrenia. Koskuvi M, Pörsti E, Hewitt T, Räsänen N, Wu YC, Trontti K, McQuade A, Kalyanaraman S, Ojansuu I, Vaurio O, Cannon TD, Lönnqvist J, Therman S, Suvisaari J, Kaprio J, Blurton-Jones M, Hovatta I, Lähteenvuo M, Rolova T, Lehtonen Š, Tiihonen J, Koistinaho J. Molecular Psychiatry. 2024 Mar 22. doi: 10.1038/s41380-024-02529-1. PMID: 38519640.
89. Therapeutic potential of human microglial transplantation in a chimeric model of CSF1R-related leukoencephalopathy. Jean Paul Chadarevian, Jonathan Hasselmann, Alina Lahian , Joia Capocchi, Adrian Escobar, Tau En Lim, Christina Tu, Lauren Le, Jasmine Nguyen, Sepideh Kiani Shabestari, William Carlen-Jones, Sunil Gandhi, Guojun Bu, David A. Hume, Clare Pridans, Zbigniew K. Wszolek, Robert C. Spitale, Hayk Davtyan, Mathew Blurton-Jones. 2024. Neuron, Aug 21;112(16):2686-2707.e8. PMID: 38897209.
90. Microglia protect against age-associated brain pathologies. Munro DAD, Bestard-Cuche N, McQuaid C, Chagnot A, Shabestari SK, Chadarevian JP, Maheshwari U, Szymkowiak S, Morris K, Mohammad M, Corsinotti A, Bradford B, Mabbott N, Lennen RJ, Jansen MA, Pridans C, McColl BW, Keller A, Blurton-Jones M, Montagne A, Williams A, Priller J. Neuron. 2024 Aug 21;112(16):2732-2748. PMID: 38897208.
91. Sex-dependent APOE4 neutrophil-microglia interactions drive cognitive impairment in Alzheimer’s Disease. Neta Rosenzweig, Kilian L. Kleemann, Thomas Rust, Madison Carpenter, Madeline Grucci, Michael Aronchik, Nieske Brouwer, Isabel Valenbreder, Joya Cooper-Hohn, Malvika Iyer, Rajesh K. Krishnan, Kisha Sivanathan, Wesley Brandão, Taha Yahya, Ana Durao, Zhuoran Yin, Jean Paul Chadarevian, Michael Properzi, Roni Nowarski, Hayk Davtyan, Howard L. Weiner, Mathew Blurton-Jones, Hyun-Sik Yang, Bart J. L. Eggen, Reisa Sperling, Oleg Butovsky. 2024 Nature Medicine. Oct;30(10):2990-3003.
92. ER and SOCE Ca2+ signals are not required for directed cell migration in human iPSC-derived microglia. Granzotto A, McQuade A, Chadarevian JP, Davtyan H, Sensi SL, Parker I, Blurton-Jones M, Smith IF. Cell Calcium. 2024 Nov;123:102923. PMID: 38970922.
93. Organelle phenotyping and multi-dimensional microscopy identify C1q as a novel regulator of microglial function. Sakthivel PS, Scipioni L, Karam J, Keulen Z, Blurton-Jones M, Gratton E, Anderson AJ. J Neurochem. 2024 Sep;168(9):3095-3107. PMID: 39018376.
94. Microglia are not necessary for maintenance of blood-brain barrier properties in health, but PLX5622 alters brain endothelial cholesterol metabolism. Profaci CP, Harvey SS, Bajc K, Zhang TZ, Jeffrey DA, Zhang AZ, Nemec KM, Davtyan H, O'Brien CA, McKinsey GL, Longworth A, McMullen TP, Capocchi JK, Gonzalez JG, Lawson DA, Arnold TD, Davalos D, Blurton-Jones M, Dabertrand F, Bennett FC, Daneman R. Neuron. 2024 Sep 4;112(17):2910-2921.e7. PMID: 39142282.
95. Microglial APOE3 Christchurch protects neurons from Tau pathology in a human iPSC-based model of Alzheimer's disease. Sun GG, Wang C, Mazzarino RC, Perez-Corredor PA, Davtyan H, Blurton-Jones M, Lopera F, Arboleda-Velasquez JF, Shi Y. Cell Rep. 2024 Dec 24;43(12):114982. PMID: 39612244.
96. Inhaled xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy. Brandao W, Jain N, Yin Z, Kleemann KL, Carpenter M, Bao X, Serrano JR, Tycksen E, Durao A, Barry JL, Baufeld C, Guneykaya D, Zhang X, Litvinchuk A, Jiang H, Rosenzweig N, Pitts KM, Aronchik M, Yahya T, Cao T, Takahashi MK, Krishnan R, Davtyan H, Ulrich JD, Blurton-Jones M, Ilin I, Weiner HL, Holtzman DM, Butovsky O. Science Translational Medicine. 2025 Jan 15;17(781). PMID: 39813317.
Grants
NIH/NINDS RF1-NS139975 9/2024 - 8/2027
Vascular-immune mechanisms of cerebral amyloid angiopathy and Alzheimer’s pathology
Role: MPI
Cure Alzheimer’s Fund Neuroimmunology Consortium 11/16/24 - 11/15/26
Examining the role of human microglia in the transition between parenchymal and vascular beta-amyloid pathology
Role: MPI
Alzheimer’s Association, Vascular Neuroimmune Consortium 6/1/24 – 5/31/26
Role: MPI
Revealing key brain vascular-neuroimmune interactions in Alzheimer's disease.
NIH/NIA R01-AG082255 6/1/24 - 5/31/29
Contribution of AD genetic risk and microglial BIN1 to tauopathy.
Role: MPI
NIH/NIA U19-AG06970101 07/01/21 - 06/30/26
Biology and Pathobiology of ApoE in Aging and Alzheimer’s Disease
Role: Co-PI Project 5 (U19 PI: Goate and Holtzman)
NIH/NIA P30-AG066519 10/1/13 – 3/31/25
UC Irvine Alzheimer Disease Research Center. Core F: iPS Cell Core
Role: Core Leader (PI: Frank LaFerla)
Professional Societies
2006-present International Society for Stem Cell Research
1998-present Society for Neuroscience
Graduate Programs
Interdepartmental Neuroscience Program
Link to this profile
https://faculty.uci.edu/profile/?facultyId=5530
https://faculty.uci.edu/profile/?facultyId=5530
Last updated
02/20/2025
02/20/2025