Chancellor's Professor, Population Health and Disease Prevention
Public Health

Vector-Borne Disease Epidemiology and Vector Biology

Dr. Yan Lab Page

Postdoctoral Positions Available Immediately

Ph.D. and Postdoctoral Fellowships for African Students and Scientists Available Immediately

Dr. Yan's lab members:

Dr. Guofa Zhou, Associate Scientist
Dr. Daibin Zhong, Associate Scientist
Dr. Ming-Chieh (Alex) Lee, Associate Scientist
Dr. Chloe Wang, Research Scientist
Dr. Yan Sun, Visiting Scholar
Harry Le, Laboratory manager

Dr. Yan is a Chancellor’s Professor in the Department of Population Health & Disease Prevention with an emphasis on global health. His research concentrates on epidemiology of vector-borne diseases and vectors. This includes evaluating the effects of environmental modifications and invasive vectors on malaria transmission and disease burden in Africa, assessing the impact of urbanization on dengue transmission and vector ecology in Asia, studying ecological genetics of insecticide resistance, developing adaptive and locally tailored vector intervention strategies.

Dr. Yan also serves as the program director for a Center of Excellence for Malaria Research (ICEMR) in Ethiopia and Kenya funded by the National Institutes of Health (NIH), and is the project director for a global infectious disease training program funded by the Fogarty International Center.

Li, J, Wang, X, Zhang, G, Githure, JI, Yan, G, & James, AA (2013). Genome-block expression-assisted association studies discover malaria resistance genes in Anopheles gambiae. PNAS USA 110(51), 20675-20680.

Chang, X, Zhong, D, Fang, Q, Hartsel, J, Zhou, G, Shi, L, Fang, F, Zhu, C and Yan, G (2014). Multiple resistances and complex mechanisms of Anopheles sinensis mosquito: a major obstacle to mosquito-borne diseases control and elimination in China. PLoS Negl Trop Dis. 8(5):e2889.

Chen, XG, Jiang X, Gu J, Xu M, Wu Y, Deng Y, Zhang C, Bonizzoni M, Dermauw W, Vontas J, Armbruster P, Huang X, Yang Y, Zhang H, He W, Peng H, Liu Y, Wu K, Chen J, Lirakis M, Topalis P, Van Leeuwen T, Hall AB, Jiang X, Thorpe C, Mueller RL, Sun C, Waterhouse RM, Yan G, Tu ZJ, Fang X and James AA (2015). Genome sequence of the Asian Tiger mosquito, Aedes albopictus, reveals insights into its biology, genetics, and evolution. PNAS USA 112(44):E5907-E5915.

Neafsey, D. E., Waterhouse, R. M., Abai, M. R., Aganezov, S. S., Alekseyev, M. A., Allen, J. E., Amon, J., Arca, B., Arensburger, P., Artemov, G., Assour, L. A., Basseri, H., Berlin, A., Birren, B. W., Blandin, S. A., Brockman, A. I., Burkot, T. R., Burt, A., Chan, C. S., Chauve, C., Chiu, J. C., Christensen, M., Costantini, C., Davidson, V. L., Deligianni, E., Dottorini, T., Dritsou, V., Gabriel, S. B., Guelbeogo, W. M., Hall, A. B., Han, M. V., Hlaing, T., Hughes, D. S., Jenkins, A. M., Jiang, X., Jungreis, I., Kakani, E. G., Kamali, M., Kemppainen, P., Kennedy, R. C., Kirmitzoglou, I. K., Koekemoer, L. L., Laban, N., Langridge, N., Lawniczak, M. K., Lirakis, M., Lobo, N. F., Lowy, E., MacCallum, R. M., Mao, C., Maslen, G., Mbogo, C., McCarthy, J., Michel, K., Mitchell, S. N., Moore, W., Murphy, K. A., Naumenko, A. N., Nolan, T., Novoa, E. M., O’Loughlin, S., Oringanje, C., Oshaghi, M. A., Pakpour, N., Papathanos, P. A., Peery, A. N., Povelones, M., Prakash, A., Price, D. P., Rajaraman, A., Reimer, L. J., Rinker, D. C., Rokas, A., Russell, T. L., Sagnon, N., Sharakhova, M. V., Shea, T., Simao, F. A., Simard, F., Slotman, M. A., Somboon, P., Stegniy, V., Struchiner, C. J., Thomas, G. W., Tojo, M., Topalis, P., Tubio, J. M., Unger, M. F., Vontas, J., Walton, C., Wilding, C. S., Willis, J. H., Wu, Y. C., Yan, G., Zdobnov, E. M., Zhou, X., Catteruccia, F., Christophides, G. K., Collins, F. H., Cornman, R. S., Crisanti, A., Donnelly, M. J., Emrich, S. J., Fontaine, M. C., Gelbart, W., Hahn, M. W., Hansen, I. A., Howell, P. I., Kafatos, F. C., Kellis, M., Lawson, D., Louis, C., Luckhart, S., Muskavitch, M. A., Ribeiro, J. M., Riehle, M. A., Sharakhov, I. V., Tu, Z., Zwiebel, L. J. and Besansky, N. J. 2015. Mosquito genomics. Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes. Science 347(6217):1258522. doi: 10.1126/science.1258522

Wanjala, CL, Mbugi, JP, Ototo, E, Gesuge, M, Afrane, YA, Atieli, HE, Zhou, G, Githeko, AK and Yan, G (2015). Pyrethroid and DDT Resistance and Organophosphate Susceptibility among Anopheles spp. Mosquitoes, Western Kenya. Emerg Infect Dis 21:2178-81.

Gunalan, K, E Lo, JB Hostetler, D Yewhalaw, J Mu, DE Neafsey, G Yan and LH Miller (2016). "The role of Plasmodium vivax Duffy binding protein 1 in invasion of Duffy null Africans." PNAS USA 113(22):6271-6.

Hostetler JB, Lo E, Kanjee U, Amaratunga C, Suon S, Sreng S, Mao S, Yewhalaw D, Mascarenhas A, Kwiatkowski DP, Ferreira MU, Rathod PK, Yan G, Fairhurst RM, Duraisingh MT, JC Rayner.2016. Independent Origin and Global Distribution of Distinct Plasmodium vivax Duffy Binding Protein Gene Duplications. PLoS Negl Trop Dis. 2016 Oct 31;10(10):e0005091.

Lo E, Nguyen K, Nguyen J, Hemming-Schroeder E, Xu J, Etemesi H, Githeko A, Yan G. 2017. Plasmodium malariae Prevalence and csp Gene Diversity, Kenya, 2014 and 2015. Emerging Infectious Diseases 23:601-610.

Lo E, Hemming-Schroeder E, Yewhalaw D, Nguyen J, Kebede E, Zemene E, Getachew S, Tushune K, Zhong D, Zhou G, Petros B, Yan G. 2017. Transmission dynamics of co-endemic Plasmodium vivax and P. falciparum in Ethiopia and prevalence of antimalarial resistant genotypes. PLoS neglected tropical diseases 11(7):e0005806.

Wang, X., T. Liu, Y. Wu, D. Zhong, G. Zhou, X. Su, J. Xu, C. F. Sotero, A. A. Sadruddin, K. Wu, X. G. Chen and G. Yan (2018). "Bacterial microbiota assemblage in Aedes albopictus mosquitoes and its impacts on larval development." Mol Ecol 27(14): 2972-2985.

Taffese, H. S., E. Hemming-Schroeder, C. Koepfli, G. Tesfaye, M. C. Lee, J. Kazura, G. Yan and G. Zhou (2018). "Malaria epidemiology and interventions in Ethiopia from 2001 to 2016." Infect Dis Poverty 7(1): 103.

Koepfli, C. and G. Yan (2018). "Plasmodium Gametocytes in Field Studies: Do We Measure Commitment to Transmission or Detectability?" Trends Parasitol 34(5): 378-387.

Hemming-Schroeder, E., Lo, E., Salazar, C., Puente, S. and Yan, G., 2018. Landscape Genetics: A Toolbox for Studying Vector-Borne Diseases. Frontiers in Ecology and Evolution, 6, p.21.

Lo E, Hostetler JB, Yewhalaw D, Pearson RD, Hamid MMA, Gunalan K, Kepple D, Ford A, Janies DA, Rayner JC, Miller LH, G Yan (2019) Frequent expansion of Plasmodium vivax Duffy Binding Protein in Ethiopia and its epidemiological significance. PLoS Negl Trop Dis 13(9): e0007222. https://doi.org/10.1371/journal.pntd.0007222

Ford, A., Kepple, D., Abagero, B.R., Connors, J., Pearson, R., Auburn, S., Getachew, S., Ford, C., Gunalan, K., Miller, L.H., Janies, D.A., Rayner, J. C., G. Yan, D. Yewhalaw, E. Lo. 2020. Whole genome sequencing of Plasmodium vivax isolates reveals frequent sequence and structural polymorphisms in erythrocyte binding genes. PLoS neglected tropical diseases, 14(10), p.e0008234.

Deng, J., Guo, Y., Su, X., Liu, S., Yang, W., Wu, Y., Wu, K., Yan, G. and Chen, X.G., 2021. Impact of deltamethrin-resistance in Aedes albopictus on its fitness cost and vector competence. PLoS neglected tropical diseases, 15(4), p.e0009391.

Oduma, C.O., Ogolla, S., Atieli, H., Ondigo, B.N., Lee, M.C., Githeko, A.K., Dent, A.E., Kazura, J.W., Yan, G. and Koepfli, C., 2021. Increased investment in gametocytes in asymptomatic Plasmodium falciparum infections in the wet season. BMC infectious diseases, 21(1), pp.1-10.

Hemming-Schroeder, E., Zhong, D., Kibret, S., Chie, A., Lee, M.C., Zhou, G., Atieli, H., Githeko, A., Kazura, J.W. and Yan, G., 2021. Microgeographic epidemiology of malaria parasites in an irrigated area of western Kenya by deep amplicon sequencing. The Journal of Infectious Diseases, 223(8), pp.1456-1465.

Zhou, G., Lee, M.C., Wang, X., Zhong, D., Hemming-Schroeder, E. and Yan, G., 2021. An Adaptive Intervention Trial Design for Finding the Optimal Integrated Strategies for Malaria Control and Elimination in Africa: A Model Simulation Study. The American Journal of Tropical Medicine and Hygiene.

Vera-Arias, CA., A Holzschuh, CO. Oduma, K. Badu, M. AJ Yukich, MW Hetzel, BS. Fakih, A Ali, MU. Ferreira, Ladeia-Andrade, F Sáenz, Y Afrane, E Zemene, D Yewhalaw, JW Kazura, G Yan, C Koepfli. 2022. "High-throughput Plasmodium falciparum hrp2 and hrp3 deletion typing by digital PCR to monitor malaria rapid diagnostic test efficacy. ELife 11:e72083.

Zhou, J., Liu, S., Liu, H., Xie, Z., Liu, L., Lin, L., Jiang, J., Yang, M., Zhou, G., Gu, J., Zhou, X., Yan, G., A.A. James, X. Chen 2022. Interspecific mating bias may drive Aedes albopictus displacement of Aedes aegypti during its range expansion. PNAS nexus, 1(2), p.pgac041.

Zhou G, E Hemming-Schroeder, B Jeang, X Wang, D Zhong, M Lee, Y Li, L Bradley, SR Gobran, RE David, BM Ondeto, P Orondo, H Atieli, JI Githure, AK Githeko, J Kazura, G Yan. 2022. Irrigation-induced environmental changes sustain malaria transmission and compromise intervention effectiveness. The Journal of Infectious Diseases 226:1657-1666. doi: 10.1093/infdis/jiac361.

Yan, G., Lee, M.C., Zhou, G., Jiang, A.L., Degefa, T., Zhong, D., Wang, X., Hemming-Schroeder, E., Mukabana, W.R., Dent, A.E., King, C.L., Hsu K, Beeson J, Githure J, Atieli H, Githeko AK, Yewhalaw D, Kazura JW. 2022. Impact of Environmental Modifications on the Ecology, Epidemiology, and Pathogenesis of Plasmodium falciparum and Plasmodium vivax Malaria in East Africa. The American Journal of Tropical Medicine and Hygiene, 107(4_Suppl), pp.5-13.

Hubbard, A., Hemming-Schroeder, E., Machani, M.G., Afrane, Y., Yan, G., Lo, E. and Janies, D., 2023. Implementing landscape genetics in molecular epidemiology to determine drivers of vector-borne disease: A malaria case study. Molecular Ecology, 32(8), pp.1848-1859.

Degefa, T., Yewhalaw, D. and Yan, G., 2024. Methods of sampling malaria vectors and their reliability in estimating entomological indices in Africa. Journal of Medical Entomology, 61(3), pp.573-583.

Funded by NIH: U19 AI129326; D43 TW001505; R21 AI174183; R21 AI178440

Public Health

Link to this profile
https://faculty.uci.edu/profile/?facultyId=5307

Last updated
01/05/2025