Professor, Developmental & Cell Biology
School of Biological Sciences

Scientific Director, UCI Transgenic Mouse Facility

Associate Member, Chao Family Comprehensive Cancer Center

Member, Developmental Biology Center

Mammalian reproduction, development & homeostasis

2018 Dr. De Gallow Professor of the Year, UCI.

2016 Dean’s Honoree for Teaching Excellence, School of Biological Sciences, UC Irvine.

2012 Honorary Membership, International Golden Key Society.

2006 Honoree of Kappa Alpha Theta / Sigma Phi Epsilon "Apple Polishing" – selected by undergraduate students as 'Teacher that has made a great impact on our college career'.

2006 Golden Apple Award for Excellence in Teaching, School of Biological Sciences, UC Irvine.

2004 UCI Chancellor's Award for Excellence in Fostering Undergraduate Research.

1986 – 1989 Arthritis Foundation Post-Doctoral Fellowship.

1982 – 1985 UK MRC Graduate Research Studentship.

2015 - present Professor, Department of Developmental & Cell Biology, Charlie Dunlop School of Biological Sciences, UC Irvine, Irvine, CA

2002 - 2015 Associate Professor, Department of Developmental & Cell Biology, School of Biological Sciences, UC Irvine, Irvine, CA

1999 - 2002 Associate Professor (Tenured) Center for Molecular Medicine; Adjunct Professor, Dept Human Genetics, Dept Cell Biology, Emory University School of Medicine, Atlanta, GA

1993 - 1999 Assistant Professor, Dept. of Genetics and Molecular Medicine, Emory University School of Medicine, Atlanta, GA.

1992-1993 Post-doctoral Fellow, Laboratory of Philippe Soriano Ph.D., Division of Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, WA.

1989-1992 Post-doctoral Fellow, Laboratory of Paul Overbeek Ph.D., Dept of Cell Biology, Baylor College of Medicine, Houston, TX.

1985-1989 Post-doctoral Fellow, Laboratory of C. Thomas Caskey M.D., Institute for Molecular Genetics (now Human and Molecular Genetics), Baylor College of Medicine, Houston, TX

Since 1993 my laboratory has investigated mammalian reproduction, development and homeostasis, using the mouse as a model genetic system. These studies have contributed to our understanding of mechanisms of germline development, skeletogenesis, behavior, apoptosis, post-translational modification of microtubules, mitochondrial genetics and biology, and most recently, Alzheimer’s Disease (AD).

Our ongoing research interests are in three areas, each of which involves collaborations. First, we are investigating the function of the novel FNDC3 family of proteins in animal reproduction, development, and homeostasis. Second, we participate in MODEL-AD, a NIA/NIH-funded open-science project to develop and characterize new strains of genetically modified mice that can be used to investigate mechanisms of common forms of Alzheimer’s Disease and which can be used to test potential therapeutics. Third, we participate in a collaboratory project between UCI and Cal Tech whose goal is to understand the impact of genetic variation on gene expression and chromatin structure at the single cell level that ultimately comprises the genetic contribution to the phenotypes of different mouse strains.

Johnston KG, Berackey BT, Tran KM, Gelber A, Yu Z, MacGregor GR, Mukamel EA, Tan Z, Green KN, Xu X. (2024) Single-cell spatial transcriptomics reveals distinct patters of dysregulation in non-neuronal and neuronal cells induced by the Trem2R47H Alzheimer’s risk gene mutation. Molecular Psychiatry 29 (published online Aug 5, 2024).

Syage, AR, Pachow C, Murray KM, Henningfield C, Fernandez K, Du A, Cheng Y, Olivarria G, Kawauchi S, MacGregor GR, Green KN, Lane TE. (2024) Cystatin F attenuates neuroinflammation and demyelination following murine coronavirus infection of the central nervous system. Journal of Neuroinflammation 21 157 – 174.

Butler CA, Mendoza Arvilla A, Milinkeviciute G, Da Cunha C, Kawauchi S, Rezaie N, Liang HY, Javonillo D, Thach A, Wang S, Collins S, Walker A, Shi KX, Neumann J, Gomez-Arboledas A, Henningfield CM, Hohsfield LA, Mapstone M, Tenner AJ, LaFerla FM, Mortazavi A, MacGregor GR*, Green KN*. (2024) The Abca7V1613M variant reduces Aß generation, plaque load, and neuronal damage. Alzheimers Dement. doi: 10.1002/alz.13783. PMID: 38506634 * co-corresponding authors.

Dunham SJB, Avelar-Barragan J, Rothman JA, Adams ED, Faraci G, Forner S, Kawauchi S, Tenner AJ, Green KN, LaFerla FM, MacGregor GR, Mapstone M, Whiteson KL. (2024) Sex-specific associations between AD genotype and the microbiome of human amyloid beta knock-in (hAß-KI) mice. Alzheimers Dement. doi: 10.1002/alz.13794. PMID: 38572865.

Soni N, Hohsfield LA, Tran KM, Kawauchi S, Walker A, Javonillo D, Phan J, Matheos D, Da Cunha C, Uyar A, Milinkeviciute G, Gomez-Arboledas A, Tran K, Kaczorowski CC, Wood MA, Tenner AJ, LaFerla FM, Carter GW, Mortazavi A, Swarup V, MacGregor GR*, Green KN*. (2024) Genetic diversity promotes resilience in a mouse model of Alzheimer's disease. Alzheimers Dement. 20(4):2794-2816. doi: 10.1002/alz.13753. PMID: 38426371 * co-corresponding authors.

Garcia-Agudo LF, Shi Z, Smith IF, Kramár EA, Tran K, Kawauchi S, Wang S, Collins S, Walker A, Shi KX, Neumann J, Liang HY, Da Cunha C, Milinkeviciute G, Morabito S, Miyoshi E, Rezaie N, Gomez-Arboledas A, Arvilla AM, Ghaemi DI, Tenner AJ, LaFerla FM, Wood MA, Mortazavi A, Swarup V, MacGregor GR*, Green KN*. (2024) BIN1K358R suppresses glial response to plaques in mouse model of Alzheimer's disease. Alzheimers Dement. 20(4):2922-2942. doi: 10.1002/alz.13767. PMID: 38460121 * co-corresponding authors.

Chen YH, Ta AP, Chen Y, Lee HC, Fan W, Chen PL, Jordan MC, Roos KP, MacGregor GR, Yang Q, Edwards RA, Li J, Wang PH. (2023) Dual roles of myocardial mitochondrial AKT on diabetic cardiomyopathy and whole-body metabolism. Cardiovasc Diabetol. 22(1):294. doi: 10.1186/s12933-023-02020-1. PMID: 37891673

Tran KM, Kawauchi S, Kramár EA, Rezaie N, Liang HY, Sakr JS, Gomez-Arboledas A, Arreola MA, Cunha CD, Phan J, Wang S, Collins S, Walker A, Shi KX, Neumann J, Filimban G, Shi Z, Milinkeviciute G, Javonillo DI, Tran K, Gantuz M, Forner S, Swarup V, Tenner AJ, LaFerla FM, Wood MA, Mortazavi A, MacGregor GR*, Green KN*. (2023) A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques. Mol. Neurodegeneration 18(1):12. doi: 10.1186/s13024-023-00598-4. PMID 36803190. * co-corresponding authors.

Javonillo DI, Tran KM, Phan J, Hingco E, Kramár EA, da Cunha C, Forner S, Kawauchi S, Neumann J, Matheos DP, Rezaie N, Alcantara JA, Mortazavi A, Wood MA, Tenner AJ, MacGregor GR, Green KN and LaFerla FM (2021) Systematic phenotyping and characterization of the 3xTg-AD mouse model of Alzheimer’s disease. Frontiers in Neuroscience, 15:785276. doi: 10.3389/fnins.2021.785276.

Forner S, Kawauchi S, Balderrama-Gutierrez G, Kramár EA, Matheos DP, Phan J, Javonillo DI, Tran KM, Hingco E, da Cunha C, Rezaie N, Alcantara JA, Baglietto-Vargas D, Jansen C, Neumann J, Wood MA, MacGregor GR, Mortazavi A, Tenner AJ, LaFerla FM and Green KN (2021) Systematic Phenotyping and Characterization of the 5xFAD mouse model of Alzheimer’s Disease. Scientific Data, 8(1):270. doi: 10.1038/s41597-021-01054-y.

Baglietto-Vargas D, Forner S, Cai L, Martini AC, Trujillo-Estrada L, Swarup V, Nguyen MMT, Huynh KD, Javonillo DI, Tran KM, Phan J, Jiang S, Kramár EA, Nuñez-Diaz C, Balderrama-Gutierrez G, Garcia F, Childs J, Rodriguez-Ortiz CJ, Garcia-Leon JA, Kitazawa M, Shahnawaz M, Matheos DP, Ma X, Da Cunha C, Walls KC, Ager RR, Soto C, Gutierrez A, Moreno-Gonzalez I, Mortazavi A, Tenner AJ, MacGregor GR, Wood M, Green KN, LaFerla FM. (2021) A humanized Aß knock-in mouse strain: a platform model to study late-onset Alzheimer’s Disease. Nat. Comm., 12(1):2421. doi: 10.1038/s41467-021-22624-z. PubMed PMID: 33893290; PMC8065162.

Das A, Zhu B, Xie Y, Zeng L, Pham A, Neumann J, Safrina O, Benavides D, MacGregor GR, Schutte S, Hunt R, and O'Dowd DK. (2021) Interneuron dysfunction in a new mouse model of SCN1A GEFS+. eNeuro, 8(2). doi: 10.1523/ENEURO.0394-20.2021. PMC8174035.

Y-H Lin H, Chen Y, Chen YH, Ta AP, Lee HC, MacGregor GR, Vaziri ND, Wang PH. (2020) Tubular mitochondrial AKT1 is activated during ischemia reperfusion injury and has a critical role in predisposition to chronic kidney disease. Kidney Int. doi: 10.1016/j.kint.2020.10.038.

Oblak AL, Forner S, Territo PR, Sasner M, Carter GW, Howell GR, Sukoff-Rizzo SJ, Logsdon BA, Mangravite LM, Mortazavi A, Baglietto-Vargas D, Green KN, MacGregor GR, Wood MA, Tenner AJ, LaFerla FM and Lamb BT, and The MODEL-AD Consortium. (2020) Model Organism Development and Evaluation for Late-onset Alzheimer’s disease: MODEL-AD. Alzheimer’s Dement (NY). 6(1):e12110. doi: 10.1002/trc2.12110.

Flesher JL, Paterson-Coleman EK, Vasudeva P, Ruiz-Vega R, Marshall M, Pearlman E, MacGregor GR, Neumann J and Ganesan AK. (2020) Delineating the role of MITF isoforms in pigmentation and tissue homeostasis. Pigment Cell Melanoma Res. 33(2):279-292. doi: 10.1111/pcmr.12828. PubMed PMID: 31562697; PubMed Central PMCID: PMC7822220.

Syed A, Lukacsovich T, Pomeroy M, Bardwell AJ, Decker GT, Waymire KG, Purcell J, Huang W, Gui J, Padilla EM, Park C, Paul A, Pham TBT, Rodriguez Y, Wei S, Worthge S, Zebarjedi R, Zhang B, Bardwell L, Marsh JL and MacGregor GR (2019) Miles to go (mtgo) encodes FNDC3 proteins that interact with the chaperonin subunit CCT3 and are required for NMJ branching and growth in Drosophila. Dev Biol. 445 (1):37-53.

Fonseca MI, Chu S-H, Hernandez MX, Fang MJ, Modarresi L, Selvan P, MacGregor GR and Tenner AJ (2017) Cell-specific deletion of C1qa identifies microglia as the dominant source of C1q in mouse brain. Journal of Neuroinflammation 14: 48.

Kokoszka JE, Waymire KG, Flierl A, MacGregor GR and Wallace DC (2016) The role of mitochondrial adenine nucleotide translocator isoforms 2 in cardiac development and noncompaction. Biochemica et Biophysica Acta 1857: 1203-1212.

Paterson EK, Fielder TJ, MacGregor GR, Ito S, Wakamatsu K, Gillen DE, Eby V, Boissy RE and Ganesan AK (2015) Tyrosinase modulates pigmentation by controlling the distribution of melanin within the maturing melanosome. PLoS One DOI:10.1371/journal.pone.0143702.

Oh JW, Chung O, Cho YS, MacGregor GR and Plikus MV (2015) Gene loss in keratinization programs accompanies adaptation of Cetacean skin to aquatic lifestyle. Experimental Dermatology DOI:10.1111/exd.12756

Reyes de Mochel NS, Luong M, Chiang M, Javier AL, Luu E, Fujimori T, MacGregor GR, Cinquin O and Cho KWY (2015) BMP signaling is required for cell cleavage in pre-implantation stage mouse embryos. Dev. Biol. 397:45-55.

Strong MK, Southwell AL, Yonan JM, Hayden MR, MacGregor GR, Thompson LM, Steward O. (2013) Age-dependent resistance to excitotoxicity in Htt CAG140 mice and the effect of strain background. Journal of Huntington's Disease 2, 221-241.

Lin CS, Sharpley MS, Fan WW, Waymire KG, Sadun AA, Carelli V, Ross-Cisneros FN, Baciu P, McManus MJ, Pan BX, Gil DW, MacGregor GR, Wallace DC (2012) Mouse mtDNA mutant model of Leber hereditary optic neuropathy. Proc. Natl. Acad. Sci. (USA)109, 20065 - 20070.

Sharpley MS, Marciniak C, Eckel-Mahan K, McManus M, Waymire KG, Crimi M, Lin CS, Masubuchi S, Friend N, Koike M, Chalkia M, MacGregor GR, Sassone-Corsi P and Wallace DC (2012) Maternal inheritance of two different mouse mtDNAs is genetically stable and results in altered behavior and cognition. Cell 151, 333-343.

Fielder TJ, Yi CS, Masumi J, Waymire KG, Chen H-W, Wang S, Shi, K-X, Wallace, DC, MacGregor G.R. (2012) Comparison of male chimeric mice generated from microinjection of JM8.N4 embryonic stem cells into C57BL/6J and C57BL/6NTac blastocysts. Transgenic Research 18, DOI 10.1007/s11248-012-9605-3.

Navarro S.J., Trinh T., Lucas C.A., Ross A.J., Waymire K.G., MacGregor G.R. (2012) The C57BL/6J mouse stain background modifies the effect of a mutation in Bcl2l2. G3 : Genes, Genomes, Genetics 2, 99-102.

Nicholson A, Reifsnyder P, Malcolm R, Lucas C, MacGregor GR, Zhang W. and Leiter E. (2010) Diet-induced obesity in two C57BL/6 substrains with intact or mutant nicotinamide nucleotide transhydrogenase (Nnt) gene. Obesity 18, 1902 - 1905.

Ikegami. K, Horigome, D, Mukai, M, Livnat, I, MacGregor, GR, and Setou, M (2008) TTLL10 is a protein polylgycylase that can modify nucleosome assembly protein 1 FEBS Lett. 582, 1129-1134.

Fan, W.-W., Waymire, K.G., Narula, N., Li, P., Rocher, C., Coskun, P.E., Vannan, M.A., Narula, J., MacGregor, GR, Wallace, D.C. (2008) A mouse model of mitochondrial disease reveals germline selection against severe mtDNA mutations. Science 319, 958 - 962.

Yao, I., Takagi, T., Ageta, H., Kahyo, T., Sato, S., Hatanaka, K., Fukuda, Y., Chiba, T., Morone, N., Yuasa, M., Inokuchi, K., Ohtsuka, T., MacGregor, GR, Tanaka, K. and Setou, M. (2007) SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release. Cell, 130, 943-957.

Ikegami K, , Heier RL, Taruishi M, Takagi H, Mukai M, Shimma S, Taira S, Hatanaka K, Morone N, Yao I, Campbell PK, Yuasa S, Janke C, MacGregor GR*, and Setou M* (2007) Loss of Alpha Tubulin Polyglutamylation in ROSA22 Mice is Associated with Abnormal Targeting of KIF1A and Modulated Synaptic Function (*co-corresponding authors) Proc. Natl. Acad. Sci. (USA) 104, p3213 - 3218.

Ikegami K., Mukai, M., Tsuchida J-I, Heier RL, MacGregor GR and Setou M. (2006) TTLL7 is a mammalian beta-tubulin polyglutamylase required for growth of MAP2-positive neurites. Journal of Biological Chemistry 281, 30707 – 30716.

Obholz KL, Akopyan AA, Waymire KG, MacGregor GR (2006) FNDC3A is required for adhesion between spermatids and Sertoli cell in mice. Developmental Biology 298, 498-513.

Kokoszka, JE, Waymire, KG, Levy, SE, Sligh, JE, Cai, J.-Y., Jones, D.P., MacGregor, GR, and Wallace, DC (2004) The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore. Nature, 427, 461-465.

MacGregor, GR (2002) An extreme bias in the germ line of XY C57BL/6 <-> XY FVB/N chimeric mice. Reproduction 124, 377-386.

Campbell, PK, Waymire, KG, Heier, RL, Scharer, C, Day, DE, Reimann, H, Jaje, JM, Friedrich, GA, Burmeister, M, Russell, LD, Bartness, TJ, Young, LJ, Zimmer, M, Jenne, DE and MacGregor, GR (2002) Mutation of a novel gene results in abnormal development of spermatid flagellum, loss of inter-male aggression and reduced body fat in mice. Genetics, 162, 307-320.

Russell, LD, Warren, J, Deblejuk, L, Mahar, PL, Waymire, KG, Richardson, LL, Amy, S P, Ross, AJ and MacGregor, GR (2001) Spermatogenesis in Bclw mutant mice. Biology of Reproduction 65, 318-332.

Ross, AJ, Amy, SP, Mahar, PL, Lindsten, T, Knudson, C.M., Thompson, C.B., Korsmeyer, S. J., MacGregor, GR (2001) BCLW mediates survival of post-mitotic Sertoli cells by regulating BAX activity. Developmental Biology 239, 295-308.

Wei, MC, Zong, W-X, Cheng, EH-Y, Lindsten, T, Panoutsakopoulou, T, Roth, KA, Ross, AJ, MacGregor, GR, Thompson, CB and Korsmeyer, SJ (2001) Pro-apoptotic BAX and BAK are essential for mitochondrial dysfunction and death following diverse apoptotic signals. Science 292, 727-730.

Zong, W-X, Lindsten, T, Ross, AJ, MacGregor, GR and Thompson, CB (2001) BH3-only proteins that bind pro-survival BCL2 family members fail to induce apoptosis in the absence of BAX and BAK. Genes & Development 15, 1481-1486.

Lindsten, T, Ross, AJ, Gottlieb-King, A, Zong, W-X, Rathmell, JC, Shiels, HA, Ulrich, E, Waymire, KG, Mahar, PL, Frauwirth, K, Chen, Y, Wei, M, Eng, VM, Adelman, DM, Simon, MC, Ma, A, Golden, JA, Evan, G Korsmeyer, SJ, MacGregor, GR and Thompson, CB (2000) The combined functions of the pro-apoptotic BCL2 family members BAK and BAX are essential for the normal development of multiple tissues. Molecular Cell 6, 1389-1399.

Sligh, JE, Levy, SE, Waymire, KG, Allard, P, Dillehay, DL, Nusinowitz, S, Heckenlively, JR, MacGregor, GR and Wallace, DC (2000) Maternal germ line transmission of mutant mitochondrial DNAs from embryonic stem cell derived chimeric mice. Proc. Natl. Acad. Sci (USA) 97, 14461-14466.

Esposito, LE, Kokoszka, JE, Waymire, KG, Cottrell, B, MacGregor, GR and Wallace, DC (2000) Mitochondrial oxidative stress in mice lacking glutathione peroxidase 1. Free Radical Biology & Medicine 28, 754-766.

Fedde, KN, Blair, L, Silverstein, J, Coburn, SP, Ryan, LM, Weinstein, RS, Waymire, KG, Narisawa, S, Millán, J-L, MacGregor, GR, and Whyte, MP (1999) Alkaline phosphatase knock-out mice recapitulate the metabolic and skeletal defects of infantile hypophosphatasia. J Bone Miner Res 14, 2015-2026.

Young, LJ, Nilsen, R, Waymire, KG, MacGregor, GR and Insel, TR (1999) Increased affiliative response to vasopressin in mice expressing the V1a receptor from a monogamous vole. Nature, 400, 766-768.

Levy, SE, Waymire, KG, Kim, YL, MacGregor, GR, Wallace, DC (1999) Transfer of chloramphenicol resistant mitochondrial DNA into the adult mouse. Transgenic Research 8, 137-145.

Metcalfe, AD, Gilmore, A, Klinowska, T, Oliver, J, Valentijn, AJ, Brown, R, Ross, AJ, MacGregor, GR, Hickman, JA and Streuli, CH (1999) Developmental regulation of BCL2 family protein expression in the involuting mammary gland. J. Cell Sci. 112, 1771-1783.

Abe, K, Ko, MSH and MacGregor, GR (1998) A systematic molecular genetic approach to study mammalian germ line development. International Journal of Developmental Biology, 42,1051-1066.

Ross, A, Waymire, KG, Moss, JE, Parlow, AF, Skinner, MK, Russell, LD and MacGregor, GR (1998) Testicular degeneration in Bclw deficient mice. Nature Genetics, 18, 251-256.

Graham, BH, Waymire, KG, Cottrell, B, Trounce, IA, MacGregor, GR and Wallace, DC (1997) A mouse model for mitochondrial myopathy and cardiomyopathy resulting from a deficiency in the heart / skeletal muscle isoform of the adenine nucleotide translocator. Nature Genetics 16, 226-234.

Young, LJ, Waymire, KG, Nilsen, R, MacGregor, GR, Wang, Z and Insel, TR (1997) The 5’ flanking region of the monogamous prairie vole oxytocin receptor gene directs tissue specific expression in transgenic mice. Ann. N.Y. Acad. Sci., 807, 514-517.

Abe, K, Hashiyama, M, MacGregor, GR, Yamamura, K-I. and Abe, K (1996) Purification of primordial germ cells from TNAP?-geo mouse embryos using FACS-gal. Developmental Biology 180, 468 - 472.

Waymire, KG, Jaje, JM, Mahuren, D, Guilarte, T, Coburn, SP and MacGregor, GR (1995) Mice lacking tissue non-specific alkaline phosphatase die from seizures due to defective metabolism of vitamin B-6. Nature Genetics, 11, 45-51.

MacGregor, GR, Zambrowicz, BP and Soriano, P (1995) Tissue non-specific alkaline phosphatase is expressed in both embryonic and extra-embryonic lineages during mouse embryogenesis but is not required for migration of primordial germ cells. Development, 121,1487-1496.

Meistrich, ML, Kasai, K, Olds-Clarke, P, MacGregor, GR, Berkowitz, AD and Tung, KSK (1994) Deficiency in fertilization by sperm from Azh mutant mice. Molecular Reproduction & Development, 37, 69-77.

Gelb, BD, Adams, V, Jones, SN, Griffin, LD, MacGregor, GR and McCabe, ERB (1992) Mitochondrial targeting of hexokinase in tumor cells. Proc. Natl. Acad. Sci (USA), 89, 202-206.

MacGregor, GR and Overbeek, PA (1991) Use of a simplified single site PCR to facilitate isolation of genomic DNA flanking a transgene integration site. PCR Methods and Applications 1, 129-135.

Russell, LD, Russell, JA, MacGregor, GR and Meistrich, ML (1991) Linkage of manchette microtubules to the nuclear envelope and observations of the role of the manchette in nuclear shaping during spermiogenesis. Am. J. Anat. 192, 97-120.

Russell, LD, Sinha Hikim, AP, Overbeek, PA and MacGregor, GR (1991) Testis structure in the sys (symplastic spermatids) mouse. Am. J. Anat. 192, 169-182.

MacGregor, GR, Russell, LD, VanBeek, MEAB, Hanten, GR, Kovak, MJ, Kozak, CA, Meistrich, ML and Overbeek, PA (1990) Symplastic spermatids (sys), a recessive insertional mutation in mice causing a defect in spermatogenesis. Proc. Natl. Acad. Sci. (USA) 87, 5016 -5020.

Moore, KA, Fletcher, FA, Alford, RL, Villalon, DK, Hawkins, DH, MacGregor, GR, Caskey, CT and Belmont, JW (1989) Expression vectors for human adenosine deaminase gene therapy. Genome 31, (2) 832 -839.

MacGregor, GR and Caskey, CT (1989) Construction of plasmids that express E.coli beta-galactosidase in mammalian cells. Nucl. Acid Res. 17, (6), 2365.

Griffin, LD, MacGregor, GR, Muzny, DM, Harter, J, Cook, RG and McCabe, ERB (1989) Hexokinase 1 (HK1) cDNA probe synthesis by mixed oligonucleotide primed amplification of cDNA (MOPAC) using high complexity primer mixtures. Biochemical Medicine and Metabolic Biology 41, 125 - 131.

Fletcher, FA, Moore, KA, MacGregor, GR, Belmont, JW and Caskey, CT (1988) Human gene expression in murine haematopoietic cells in vivo. Adv. Exp. Med. Biol. 241, 123-127.

Belmont, JW, MacGregor, GR, Wager-Smith, K, Fletcher, FA, Moore, KA, Hawkins, D, Villalon, D, Chang, SM-W and Caskey, CT (1988) Expression of human adenosine deaminase in murine haematopoietic cells. Mol. Cell Biol. 8, (12) 5116-5125.

MacGregor, GR, Mogg, AE, Burke, JF and Caskey, CT (1987) Histochemical staining of clonal mammalian cell lines expressing E. coli beta-galactosidase indicates heterogeneous expression of the bacterial gene. Somat. Cell Mol. Genet. 13, (3) 253 - 266.

MacGregor, GR, James, MR, Arlett, CF and Burke JF (1987) Analysis of mutations occurring during replication of an SV40 shuttle-vector in mammalian cells. Mut. Res. 183, 273 - 278.

MacGregor, GR and Burke JF (1987) Stability of a bacterial gene in a bovine papilloma virus based shuttle vector maintained extra-chromosomally in mammalian cells. J. Gen. Virol. 68, 247 - 252.

Book Chapters
MacGregor, GR, Fan, W-W, Waymire, KG and Wallace DC (2006) “Generating animal models of human mitochondrial genetic disease using mouse ES cells” In "ES Cells: A Practical Approach”, Eds E. Notarianni, M. Evans. Practical Approach Series, Oxford University Press, England 72-111.

Ross, AJ and MacGregor, GR (2001) “ Analysis of Bcl2 gene function in transgenic mice”, in “Transgenics in Endocrinology” Eds MM Matzuk, CW Brown and TR Kumar. Humana Press Inc, Totowa, NJ 115-145.

MacGregor, GR (1992) Optimization of Electroporation Using Reporter Genes. In "Handbook of Electroporation and Electrofusion". Eds Chang, DC, Chassey, BM, Saunders, JA and Sowers, A E Academic Press Inc., Orlando FL. 465-470.

MacGregor, GR, Nolan, GP, Fiering, S and Herzenberg, LA (1991) Use of the E.coli beta-Galactosidase gene as a reporter gene - In "Methods in Molecular Biology - Volume 7: Gene Expression in vivo " Ed. Murray, EJ Humana Press Inc. Clifton, N.J. 217-235.

MacGregor, GR, Nelson, DL, Chang, SMW and Caskey, CT (1989) Prospects for gene therapy for Lesch-Nyhan disease. In : Molecular Genetics of Disease of Brain, Nerve and Muscle. (Rowland, LP, Ed.) Oxford University Press. 417-425.

Fletcher, FA, Moore, KA, MacGregor, GR, Belmont, JW and Caskey, CT (1988) Human Gene Expression in Murine Haematopoietic Cells in vivo. In - "Molecular Biology of Haematopoiesis". Vol. 241 Eds., Tavassoli, M., Abraham, NG, Ascensao, JL, Zanjani, ED and Levine, A Plenum Publishing Corp. New York, NY 123-127.

Symposium Contributions
MacGregor, GR “The Function of BCLW in Mouse Spermatogenesis”. (2001) 7th International Congress of Andrology, Montreal, Canada, Eds. Robaire, B, Chemes, H and Morales, CR. Medimond Press, Englewood, NJ 153-177.

Cournoyer, D, Scarpa, M, Moore, KA, Fletcher, FA, MacGregor, GR, Belmont, JW and Caskey, CT (1991) Gene Replacement Therapy: Human and Animal Model Progress. In - "Nobel Symposium : Etiology of Human Disease at the DNA Level". Eds, Lindsten, J and Petterson, Lippincott-Raven Press, New York, NY 199-220.

MacGregor, GR, Fletcher,FA, Moore, KA, Chang, SM-W, Belmont, JW and Caskey, CT (1988) Long Term in vivo expression of Human Adenosine Deaminase in Murine Haematopoietic cells. In : Gene Transfer in Animals, UCLA Symposia on Molecular and Cellular Biology, Vol 87. Eds, Verma, IM, Mulligan, RC, and Beaudet, AL Alan R Liss, Inc., New York, NY. 375-396.

MacGregor, GR, Fletcher, FA, Moore, KA, Chang, SM-W, Belmont, JW and Caskey, CT (1988) Towards gene therapy for inherited ocular disease - studies of retro-virally mediated human adenosine deaminase expression in mice. In : Molecular Biology of the Eye : Genes, Vision and Ocular Disease. UCLA Symposia on Molecular and Cellular Biology, Vol 88. Eds, Paitigorsky, J., Zelenka, P. and Shinohara, T. Alan R Liss, Inc., New York, NY. 1-22.

(as PI, Co-PI or Co-I all direct costs)

NIH R21-HL102862 Function of FNDC3B in cardiovascular and pulmonary development. 04/01/2010 – 03/31/2012 $250,000

California Institute for Regenerative Medicine RS1-00416-1 Production of Oocytes from Human ES Cells. 05/01/2007 – 06/30/2010 $623,781

NIH U01-HD045913 A novel gene required for Sertoli-Spermatid adhesion. 12/01/2003 - 11/30/2009 $978,461

DOD OC990138 Role of Oocyte Loss in Ovarian Surface Mesothelial Cell Transformation. 4/1/2000 – 3/31/2003 (Co-PI with J. Tilly PhD @ MGH) $375,000

NIH R01-HD36437 The function of BCLW in mammalian development. 4/1/1998 – 3/31/2003 $567,688

American Cancer Society RPG CCG-88919 Functional analysis of the role of Bclw in mammalian development. 7/1/1998 – 6/30/2001 $268,000 (declined due to overlap with NIH award)

U54 AG054349-01 09/15/17 - 08/31/22 $ 7,500,000 "UC Irvine AD Translational Center for Disease Model Resources"

U54 AG054349-06 09/30/22 - 08/31/27 $ 29,943,385 "UC Irvine AD Translational Center for Disease Model Resources"

UM1 HG012077 07/01/21 - 06/30/26 $8,122,631 “ Center for Mouse Genomic Variation at Single Cell Resolution”

U01 AG076791-01 04/01/2022 - 03/31/2027 $8,944,570 “Cell-type-specific neural circuit connectomes in the mouse models of aging and Alzheimer’s Disease.”

R01 AG082127-01 06/01/2023 – 02/29/2028 $6,409,123 “Single-cell transcriptomic and epigenomic analysis of brain cell vulnerabilities to tauopathies in early AD impacted brain regions”

R01 AG081599-01 03/01/2024 – 02/28/2029 $2,500,000 “Role of Disease-Associated Microglia in Alzheimer's disease”

American Society for Cell Biology

Society for Study of Reproduction

Society for Developmental Biology

American Heart Association

Editorial Board, Spermatogenesis
Landes BioSciences 2010—2019

Cellular and Molecular Biosciences

Link to this profile
https://faculty.uci.edu/profile/?facultyId=5269

Last updated
08/29/2024