Eva y Lee

Picture of Eva y Lee
Professor, Biological Chemistry
School of Medicine
Ph.D., Univerisity of California, Berkeley, 1984, Cellular and Molecular Biology
Phone: (949) 824-9766
Fax: (949) 824-9767
Email: elee@uci.edu
University of California, Irvine
109 Hitachi/Plumwood House
Mail Code: 1700
Irvine, CA 92697
Research Interests
cancer, genetics, hormone contribution
Available Technologies
Sigl V, Owusu-Boaitey K, Joshi PA, Kavirayani A, Wirnsberger G, Novatchkova M, Kozieradzki I, Schramek D, Edokobi N, Hersl J, Sampson A, Odai-Afotey A, Lazaro C, Gonzalez-Suarez E, Pujana MA, Cimba F, Heyn H, Vidal E, Cruickshank J, Berman H, Sarao R, Ticevic M, Uribesalgo I, Tortola L, Rao S, Tan Y, Pfeiler G, Lee EY, Bago-Horvath Z, Kenner L, Popper H, Singer C, Khokha R, Jones LP, Penninger JM. RANKL/RANK control Brca1 mutation-driven mammary tumors. Cell Res. 2016 Jul;26(7):761-74. doi: 10.1038/cr.2016.69. Epub 2016 May 31.
Chang MC, Chang YT, Chen JY, Jeng YM, Yang CY, Tien YW, Yang SH, Chen HL, Liang TY, Wang CF, Lee EY, Chang YC, Lee WH. Clinical Significance of Circulating Tumor Microemboli as a Prognostic Marker in Patients with Pancreatic Ductal Adenocarcinoma. Clin Chem. 2016 Mar;62(3):505-13.
Wu HH, Hwang-Verslues WW, Lee WH, Huang CK, Wei PC, Chen CL, Shew JY, Lee EY, Jeng YM, Tien YW, Ma C, Lee WH. Targeting IL-17B-IL-17RB signaling with an anti-IL-17RB antibody blocks pancreatic cancer metastasis by silencing multiple chemokines. J Exp Med. 2015 Mar 9;212(3):333-49.
Hu CM, Zhu J, Guo XE, Chen W, Qiu XL, Ngo B, Chien R, Wang YV, Tsai CY, Wu G, Kim Y, Lopez R, Chamberlin AR, Lee EY, Lee WH. Novel small molecules disrupting Hec1/Nek2 interaction ablate tumor progression by triggering Nek2 degradation through a death-trap mechanism. Oncogene. 2015 Mar 5;34(10):1220-30.
Lee EY, Abbondante S. Tissue-specific tumor suppression by BRCA1. Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4353-4.
Wang S, Li Y, Hsu PH, Lee SY, Kim Y, Lee EY. Progesterone receptor A stability is mediated by glycogen synthase kinase-3ß in the Brca1-deficient mammary gland. J Biol Chem. 2013 Sep 6;288(36):26265-74.
Hwang-Verslues WW, Chang PH, Jeng YM, Kuo WH, Chiang PH, Chang YC, Hsieh TH, Su FY, Lin LC, Abbondante S, Yang CY, Hsu HM, Yu JC, Chang KJ, Shew JY, Lee EY, Lee WH. Loss of corepressor PER2 under hypoxia up-regulates OCT1-mediated EMT gene expression and enhances tumor malignancy. Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12331-6.
Chang PH, Hwang-Verslues WW, Chang YC, Chen CC, Hsiao M, Jeng YM, Chang KJ, Lee EY, Shew JY, Lee WH. Activation of Robo1 signaling of breast cancer cells by Slit2 from stromal fibroblast restrains tumorigenesis via blocking PI3K/Akt/ß-catenin pathway. Cancer Res. 2012 Sep 15;72(18):4652-61.
Chaki M, Airik R, Ghosh AK, Giles RH, Chen R, Slaats GG, Wang H, Hurd TW, Zhou W, Cluckey A, Gee HY, Ramaswami G, Hong CJ, Hamilton BA, Cervenka I, Ganji RS, Bryja V, Arts HH, van Reeuwijk J, Oud MM, Letteboer SJ, Roepman R, Husson H, Ibraghimov-Beskrovnaya O, Yasunaga T, Walz G, Eley L, Sayer JA, Schermer B, Liebau MC, Benzing T, Le Corre S, Drummond I, Janssen S, Allen SJ, Natarajan S, O'Toole JF, Attanasio M, Saunier S, Antignac C, Koenekoop RK, Ren H, Lopez I, Nayir A, Stoetzel C, Dollfus H, Massoudi R, Gleeson JG, Andreoli SP, Doherty DG, Lindstrad A, Golzio C, Katsanis N, Pape L, Abboud EB, Al-Rajhi AA, Lewis RA, Omran H, Lee EY, Wang S, Sekiguchi JM, Saunders R, Johnson CA, Garner E, Vanselow K, Andersen JS, Shlomai J, Nurnberg G, Nurnberg P, Levy S, Smogorzewska A, Otto EA, Hildebrandt F. Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling. Cell. 2012 Aug 3;150(3):533-48.
Hwang-Verslues WW, Lee WH, Lee EY. Biomarkers to Target Heterogeneous Breast Cancer Stem Cells. J Mol Biomark Diagn. 2012;Suppl 8:6.
Tyan SW, Hsu CH, Peng KL, Chen CC, Kuo WH, Lee EY, Shew JY, Chang KJ, Juan LJ, Lee WH. Breast cancer cells induce stromal fibroblasts to secrete ADAMTS1 for cancer invasion through an epigenetic change. PLoS One. 2012;7(4):e35128. doi: 10.1371/journal.pone.0035128. Epub 2012 Apr 13.
Tyan SW, Kuo WH, Huang CK, Pan CC, Shew JY, Chang KJ, Lee EY, Lee WH. Breast cancer cells induce cancer-associated fibroblasts to secrete hepatocyte growth factor to enhance breast tumorigenesis. PLoS One. 2011 Jan 13;6(1):e15313.
Dong Y, Nakagawa-Goto K, Lai CY, Kim Y, Morris-Natschke SL, Lee EY, Bastow KF, Lee KH. Antitumor agents 279. Structure-activity relationship and in vivo studies of novel 2-(furan-2-yl)naphthalen-1-ol (FNO) analogs as potent and selective anti-breast cancer agents. Bioorg Med Chem Lett. 2011 Jan 1;21(1):52-7.
Lee EY, Muller WJ. Oncogenes and tumor suppressor genes. Cold Spring Harb Perspect Biol. 2010 Oct;2(10):a003236.
Dong Y, Shi Q, Pai HC, Peng CY, Pan SL, Teng CM, Nakagawa-Goto K, Yu D, Liu YN, Wu PC, Bastow KF, Morris-Natschke SL, Brossi A, Lang JY, Hsu JL, Hung MC, Lee EY, Lee KH. Antitumor agents. 272. Structure-activity relationships and in vivo selective anti-breast cancer activity of novel neo-tanshinlactone analogues. J Med Chem. 2010 Mar 11;53(5):2299-308.
Hwang-Verslues WW, Kuo WH, Chang PH, Pan CC, Wang HH, Tsai ST, Jeng YM, Shew JY, Kung JT, Chen CH, Lee EY, Chang KJ, Lee WH. Multiple lineages of human breast cancer stem/progenitor cells identified by profiling with stem cell markers. PLoS One. 2009 Dec 21;4(12):e8377.
Pedram A, Razandi M, Evinger AJ, Lee E, Levin ER. Estrogen inhibits ATR signaling to cell cycle checkpoints and DNA repair. Mol Biol Cell. 2009 Jul;20(14):3374-89.
Wang Y, Yang J, Zheng H, Tomasek GJ, Zhang P, McKeever PE, Lee EY, Zhu Y. Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model. Cancer Cell. 2009 Jun 2;15(6):514-26.
Gu B, Sun P, Yuan Y, Moraes RC, Li A, Teng A, Agrawal A, Rhéaume C, Bilanchone V, Veltmaat JM, Takemaru K, Millar S, Lee EY, Lewis MT, Li B, Dai X. Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation. J Cell Biol. 2009 Jun 1;185(5):811-26.
Pan YR, Lee EY. UV-dependent interaction between Cep164 and XPA mediates localization of Cep164 at sites of DNA damage and UV sensitivity. Cell Cycle. 2009 Feb 15;8(4):655-64. Epub 2009 Feb 14
Pedram A, Razandi M, Kim JK, O'Mahony F, Lee EY, Luderer U, Levin ER. Developmental phenotype of a membrane only estrogen receptor alpha (MOER) mouse. J Biol Chem. 2009 Feb 6;284(6):3488-95. doi: 10.1074/jbc.M806249200. Epub 2008 Dec 3.
Hwang-Verslues WW, Chang KJ, Lee EY, Lee WH. Breast cancer stem cells and tumor suppressor genes. J Formos Med Assoc. 2008 Oct;107(10):751-66.
Shafee N, Smith CR, Wei S, Kim Y, Mills GB, Hortobagyi GN, Stanbridge EJ, Lee EY. Cancer stem cells contribute to cisplatin resistance in Brca1/p53-mediated mouse mammary tumors. Cancer Res. 2008 May 1;68(9):3243-50.
Sivasubramaniam S, Sun X, Pan YR, Wang S, Lee EY. Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1. Genes Dev. 2008 Mar 1;22(5):587-600. doi: 10.1101/gad.1627708. Epub 2008 Feb 18
Deeb KK, Michalowska AM, Yoon CY, Krummey SM, Hoenerhoff MJ, Kavanaugh C, Li MC, Demayo FJ, Linnoila I, Deng CX, Lee EY, Medina D, Shih JH, Green JE. Identification of an integrated SV40 T/t-antigen cancer signature in aggressive human breast, prostate, and lung carcinomas with poor prognosis. Cancer Res. 2007 Sep 1;67(17):8065-80. Erratum in: Cancer Res. 2007 Oct 15;67(20):10097.
Poole AJ, Li Y, Kim Y, Lin SC, Lee WH, Lee EY. Prevention of Brca1-mediated mammary tumorigenesis in mice by a progesterone antagonist. Science. 2006 Dec 1;314(5804):1467-70.
Yang JW, Lee EY, Kang KW. ErbB2 overexpression in p53-inactivated mammary epithelial cells. FEBS Lett. 2006 Nov 27;580(27):6501-8. Epub 2006 Nov 3.
Furuta S, Wang JM, Wei S, Jeng YM, Jiang X, Gu B, Chen PL, Lee EY, Lee WH. Removal of BRCA1/CtIP/ZBRK1 repressor complex on ANG1 promoter leads to accelerated mammary tumor growth contributed by prominent vasculature. Cancer Cell. 2006 Jul;10(1):13-24.
Mo L, Cheng J, Lee EY, Sun TT, Wu XR. Gene deletion in urothelium by specific expression of Cre recombinase. Am J Physiol Renal Physiol. 2005 Sep;289(3):F562-8. Epub 2005 Apr 19. P
Chen PL, Liu F, Cai S, Lin X, Li A, Chen Y, Gu B, Lee EY, Lee WH. Inactivation of CtIP leads to early embryonic lethality mediated by G1 restraint and to tumorigenesis by haploid insufficiency. Mol Cell Biol. 2005 May;25(9):3535-42.
Lin SC, Lee KF, Nikitin AY, Hilsenbeck SG, Cardiff RD, Li A, Kang KW, Frank SA, Lee WH, Lee EY. Somatic mutation of p53 leads to estrogen receptor alpha-positive and -negative mouse mammary tumors with high frequency of metastasis. Cancer Res. 2004 May 15;64(10):3525-32.
Sabatier C, Plump AS, Le Ma, Brose K, Tamada A, Murakami F, Lee EY, Tessier-Lavigne M. The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons. Cell. 2004 Apr 16;117(2):157-69.
Post SM, Lee EY. Detection of kinase and phosphatase activities. Methods Mol Biol. 2004;241:285-97
Post SM, Tomkinson AE, Lee EY. The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon. Nucleic Acids Res. 2003 Oct 1;31(19):5568-75.
Yuan SS, Chang HL, Lee EY. Ionizing radiation-induced Rad51 nuclear focus formation is cell cycle-regulated and defective in both ATM(-/-) and c-Abl(-/-) cells. Mutat Res. 2003 Apr 9;525(1-2):85-92.
Green JE, Cardiff R, Hennighausen L, Wakefield L, Wagner U, Lee E, Rosen J, Medina D, Nitkin A, Liu E. Validation of transgenic mammary cancer models: goals of the NCI Mouse Models of Human Cancer Consortium and the mammary cancer CD-ROM. Transgenic Res. 2002 Dec;11(6):635-6.
Zhao S, Renthal W, Lee EY. Functional analysis of FHA and BRCT domains of NBS1 in chromatin association and DNA damage responses. Nucleic Acids Res. 2002 Nov 15;30(22):4815-22.
Yuan SS, Yeh YT, Lee EY. Pax-2 interacts with RB and reverses its repression on the promoter of Rig-1, a Robo member. Biochem Biophys Res Commun. 2002 Aug 30;296(4):1019-25.
Lee EY. BRCA1 and Chk1 in G2/M checkpoint: a new order of regulation. Cell Cycle. 2002 May-Jun;1(3):178-80.
Yazdi PT, Wang Y, Zhao S, Patel N, Lee EY, Qin J. SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint. Genes Dev. 2002 Mar 1;16(5):571-82.
Yuan SS, Su JH, Hou MF, Yang FW, Zhao S, Lee EY. Arsenic-induced Mre11 phosphorylation is cell cycle-dependent and defective in NBS cells. DNA Repair (Amst). 2002 Feb 28;1(2):137-42.
Post S, Weng YC, Cimprich K, Chen LB, Xu Y, Lee EY. Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13102-7. Epub 2001 Oct 30.
Lin SC, Skapek SX, Papermaster DS, Hankin M, Lee EY. The proliferative and apoptotic activities of E2F1 in the mouse retina. Oncogene. 2001 Oct 25;20(48):7073-84.
Skapek SX, Lin SC, Jablonski MM, McKeller RN, Tan M, Hu N, Lee EY. Persistent expression of cyclin D1 disrupts normal photoreceptor differentiation and retina development. Oncogene. 2001 Oct 11;20(46):6742-51.
Chen MJ, Lin YT, Lieberman HB, Chen G, Lee EY. ATM-dependent phosphorylation of human Rad9 is required for ionizing radiation-induced checkpoint activation. J Biol Chem. 2001 May 11;276(19):16580-6. Epub 2001 Feb 6.
Li S, Ting NS, Zheng L, Chen PL, Ziv Y, Shiloh Y, Lee EY, Lee WH. Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response. Nature. 2000 Jul 13;406(6792):210-5.
Zhao S, Weng YC, Yuan SS, Lin YT, Hsu HC, Lin SC, Gerbino E, Song MH, Zdzienicka MZ, Gatti RA, Shay JW, Ziv Y, Shiloh Y, Lee EY. Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products. Nature. 2000 May 25;405(6785):473-7.
Skapek SX, Jansen D, Wei TF, McDermott T, Huang W, Olson EN, Lee EY. Cloning and characterization of a novel Kruppel-associated box family transcriptional repressor that interacts with the retinoblastoma gene product, RB. J Biol Chem. 2000 Mar 10;275(10):7212-23.
Dasika GK, Lin SC, Zhao S, Sung P, Tomkinson A, Lee EY. DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis. Oncogene. 1999 Dec 20;18(55):7883-99. Review.
Kuljis RO, Chen G, Lee EY, Aguila MC, Xu Y. ATM immunolocalization in mouse neuronal endosomes: implications for ataxia-telangiectasia. Brain Res. 1999 Sep 25;842(2):351-8.
Liu Y, Li M, Lee EY, Maizels N. Localization and dynamic relocalization of mammalian Rad52 during the cell cycle and in response to DNA damage. Curr Biol. 1999 Sep 9;9(17):975-8.
Yuan SS, Lee SY, Chen G, Song M, Tomlinson GE, Lee EY. BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo. Cancer Res. 1999 Aug 1;59(15):3547-51.
Chen G, Yuan SS, Liu W, Xu Y, Trujillo K, Song B, Cong F, Goff SP, Wu Y, Arlinghaus R, Baltimore D, Gasser PJ, Park MS, Sung P, Lee EY. Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl. J Biol Chem. 1999 Apr 30;274(18):12748-52.
Chen G, Lee EY. Phenotypic differentiation without permanent cell-cycle arrest by skeletal myocytes with deregulated E2F-1. DNA Cell Biol. 1999 Apr;18(4):305-14.
Yuan SS, Cox LA, Dasika GK, Lee EY. Cloning and functional studies of a novel gene aberrantly expressed in RB-deficient embryos. Dev Biol. 1999 Mar 1;207(1):62-75.
Trujillo KM, Yuan SS, Lee EY, Sung P. Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95. J Biol Chem. 1998 Aug 21;273(34):21447-50.
Hu N, Gulley ML, Kung JT, Lee EY. Retinoblastoma gene deficiency has mitogenic but not tumorigenic effects on erythropoiesis. Cancer Res. 1997 Sep 15;57(18):4123-9.
Lee WH, Lee EY. [The retinoblastoma gene: from its basic understanding as a signal mediator for growth and differentiation to its use in the treatment of cancer]. Gan To Kagaku Ryoho. 1997 Sep;24(11):1368-80. Review.
Lin SC, Skapek SX, Lee EY. Genes in the RB pathway and their knockout in mice. Semin Cancer Biol. 1996 Oct;7(5):279-89. Review.
Chen G, Guy CT, Chen HW, Hu N, Lee EY, Lee WH. Molecular cloning and developmental expression of mouse p130, a member of the retinoblastoma gene family. J Biol Chem. 1996 Apr 19;271(16):9567-72.
Qian YW, Lee EY. Dual retinoblastoma-binding proteins with properties related to a negative regulator of ras in yeast. J Biol Chem. 1995 Oct 27;270(43):25507-13.
Almasan A, Yin Y, Kelly RE, Lee EY, Bradley A, Li W, Bertino JR, Wahl GM. Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis. Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5436-40.
Lee EY. Tumor suppressor genes and their alterations in breast cancer. Semin Cancer Biol. 1995 Jun;6(3):119-25. Review.
Harvey M, Vogel H, Lee EY, Bradley A, Donehower LA. Mice deficient in both p53 and Rb develop tumors primarily of endocrine origin. Cancer Res. 1995 Mar 1;55(5):1146-51
Lee EY, Hu N, Yuan SS, Cox LA, Bradley A, Lee WH, Herrup K. Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation. Genes Dev. 1994 Sep 1;8(17):2008-21.
Hu N, Gutsmann A, Herbert DC, Bradley A, Lee WH, Lee EY. Heterozygous Rb-1 delta 20/+mice are predisposed to tumors of the pituitary gland with a nearly complete penetrance. Oncogene. 1994 Apr;9(4):1021-7.
Hensey CE, Hong F, Durfee T, Qian YW, Lee EY, Lee WH. Identification of discrete structural domains in the retinoblastoma protein. Amino-terminal domain is required for its oligomerization. J Biol Chem. 1994 Jan 14;269(2):1380-7.
Riley DJ, Lee EY, Lee WH. The retinoblastoma protein: more than a tumor suppressor. Annu Rev Cell Biol. 1994;10:1-29. Review.
Cox LA, Chen G, Lee EY. Tumor suppressor genes and their roles in breast cancer. Breast Cancer Res Treat. 1994;32(1):19-38. Review.
Chang CY, Riley DJ, Lee EY, Lee WH. Quantitative effects of the retinoblastoma gene on mouse development and tissue-specific tumorigenesis. Cell Growth Differ. 1993 Dec;4(12):1057-64.
Qian YW, Wang YC, Hollingsworth RE Jr, Jones D, Ling N, Lee EY. A retinoblastoma-binding protein related to a negative regulator of Ras in yeast. Nature. 1993 Aug 12;364(6438):648-52.
Wang NP, To H, Lee WH, Lee EY. Tumor suppressor activity of RB and p53 genes in human breast carcinoma cells. Oncogene. 1993 Feb;8(2):279-88.
Lee EY, Chang CY, Hu N, Wang YC, Lai CC, Herrup K, Lee WH, Bradley A. Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature. 1992 Sep 24;359(6393):288-94.
Huang S, Shin E, Sheppard KA, Chokroverty L, Shan B, Qian YW, Lee EY, Yee AS. The retinoblastoma protein region required for interaction with the E2F transcription factor includes the T/E1A binding and carboxy-terminal sequences. DNA Cell Biol. 1992 Sep;11(7):539-48.
Goodrich DW, Wang NP, Qian YW, Lee EY, Lee WH. The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle. Cell. 1991 Oct 18;67(2):293-302.
Lee EY. Tumor suppressor genes: a new era for molecular genetic studies of cancer. Breast Cancer Res Treat. 1991 Sep;19(1):3-13. Review.
Huang S, Lee WH, Lee EY. A cellular protein that competes with SV40 T antigen for binding to the retinoblastoma gene product. Nature. 1991 Mar 14;350(6314):160-2.
Lee EY, Huang S, Shew JY, Donoso LA, Lee WH. Diverse mutations lead to inactivation of the retinoblastoma gene. Prog Clin Biol Res. 1991;362:221-40. Review.
Lee EY, Bookstein R, Lee WH. Role of the retinoblastoma gene in the oncogenesis of human breast carcinoma. Cancer Treat Res. 1991;53:23-44. Review.
Bignon YJ, Shew JY, Rappolee D, Naylor SL, Lee EY, Schnier J, Lee WH. A single Cys706 to Phe substitution in the retinoblastoma protein causes the loss of binding to SV40 T antigen. Cell Growth Differ. 1990 Dec;1(12):647-51.
Wang NP, Qian YW, Chung AE, Lee WH, Lee EY. Expression of the human retinoblastoma gene product pp110RB in insect cells using the baculovirus system. Cell Growth Differ. 1990 Sep;1(9):429-37.
Sery TW, Lee EY, Lee WH, Bookstein R, Wong V, Shields JA, Augsburger JJ, Donoso LA. Characteristics of two new retinoblastoma cell lines: WERI-Rb24 and WERI-Rb27. J Pediatr Ophthalmol Strabismus. 1990 Jul-Aug;27(4):212-7.
Hensel CH, Hsieh CL, Gazdar AF, Johnson BE, Sakaguchi AY, Naylor SL, Lee WH, Lee EY. Altered structure and expression of the human retinoblastoma susceptibility gene in small cell lung cancer. Cancer Res. 1990 May 15;50(10):3067-72.
Wang NP, Chen PL, Huang S, Donoso LA, Lee WH, Lee EY. DNA-binding activity of retinoblastoma protein is intrinsic to its carboxyl-terminal region. Cell Growth Differ. 1990 May;1(5):233-9.
Lee WH, Bookstein RE, Lee EY. Molecular biology of the human retinoblastoma gene. Immunol Ser. 1990;51:169-200. Review.
Shew JY, Chen PL, Bookstein R, Lee EY, Lee WH. Deletion of a splice donor site ablates expression of the following exon and produces an unphosphorylated RB protein unable to bind SV40 T antigen. Cell Growth Differ. 1990 Jan;1(1):17-25.
Hsieh CL, Lee WH, Lee EY, Killary AM, Lalley PA, Naylor SL. Assignment of retinoblastoma susceptibility gene to mouse chromosome 14. Somat Cell Mol Genet. 1989 Sep;15(5):461-4.
Hong FD, Huang HJ, To H, Young LJ, Oro A, Bookstein R, Lee EY, Lee WH. Structure of the human retinoblastoma gene. Proc Natl Acad Sci U S A. 1989 Jul;86(14):5502-6.
Bookstein R, Lee EY, Peccei A, Lee WH. Human retinoblastoma gene: long-range mapping and analysis of its deletion in a breast cancer cell line. Mol Cell Biol. 1989 Apr;9(4):1628-34.
Donoso LA, Shields CL, Lee EY. Immunohistochemistry of retinoblastoma. A review. Ophthalmic Paediatr Genet. 1989 Mar;10(1):3-32. Review.
Huang HJ, Yee JK, Shew JY, Chen PL, Bookstein R, Friedmann T, Lee EY, Lee WH. Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells. Science. 1988 Dec 16;242(4885):1563-6.
Lee WH, Bookstein R, Lee EY. Studies on the human retinoblastoma susceptibility gene. J Cell Biochem. 1988 Nov;38(3):213-27. Review.
Lee EY, Bookstein R, Young LJ, Lin CJ, Rosenfeld MG, Lee WH. Molecular mechanism of retinoblastoma gene inactivation in retinoblastoma cell line Y79. Proc Natl Acad Sci U S A. 1988 Aug;85(16):6017-21.
Lee EY, To H, Shew JY, Bookstein R, Scully P, Lee WH. Inactivation of the retinoblastoma susceptibility gene in human breast cancers. Science. 1988 Jul 8;241(4862):218-21.
Young LJ, Lee EY, To HA, Bookstein R, Shew JY, Donoso LA, Sery T, Giblin M, Shields JA, Lee WH. Human esterase D gene: complete cDNA sequence, genomic structure, and application in the genetic diagnosis of human retinoblastoma. Hum Genet. 1988 Jun;79(2):137-41.
Bookstein R, Lee EY, To H, Young LJ, Sery TW, Hayes RC, Friedmann T, Lee WH. Human retinoblastoma susceptibility gene: genomic organization and analysis of heterozygous intragenic deletion mutants. Proc Natl Acad Sci U S A. 1988 Apr;85(7):2210-4.
Mendoza AE, Shew JY, Lee EY, Bookstein R, Lee WH. A case of synovial sarcoma with abnormal expression of the human retinoblastoma susceptibility gene. Hum Pathol. 1988 Apr;19(4):487-9.
Lee WH, Shew JY, Hong FD, Sery TW, Donoso LA, Young LJ, Bookstein R, Lee EY. The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity. Nature. 1987 Oct 15-21;329(6140):642-5.
Lee WH, Bookstein R, Wheatley W, Benedict WF, Lee EY. A null allele of esterase D is a marker for genetic events in retinoblastoma formation. Hum Genet. 1987 May;76(1):33-6.
Lee WH, Bookstein R, Hong F, Young LJ, Shew JY, Lee EY. Human retinoblastoma susceptibility gene: cloning, identification, and sequence. Science. 1987 Mar 13;235(4794):1394-9.
Lee EY, Barcellos-Hoff MH, Chen LH, Parry G, Bissell MJ. Transferrin is a major mouse milk protein and is synthesized by mammary epithelial cells. In Vitro Cell Dev Biol. 1987 Mar;23(3):221-6.
Lee WH, Wheatley W, Benedict WF, Huang CM, Lee EY. Purification, biochemical characterization, and biological function of human esterase D. Proc Natl Acad Sci U S A. 1986 Sep;83(18):6790-4.
Lee EY, Lee WH. Molecular cloning of the human esterase D gene, a genetic marker of retinoblastoma. Proc Natl Acad Sci U S A. 1986 Sep;83(17):6337-41.
Lee EY, Lee WH, Kaetzel CS, Parry G, Bissell MJ. Interaction of mouse mammary epithelial cells with collagen substrata: regulation of casein gene expression and secretion. Proc Natl Acad Sci U S A. 1985 Mar;82(5):1419-23.
Parry G, Lee EY, Farson D, Koval M, Bissell MJ. Collagenous substrata regulate the nature and distribution of glycosaminoglycans produced by differentiated cultures of mouse mammary epithelial cells. Exp Cell Res. 1985 Feb;156(2):487-99.
Lee EY, Parry G, Bissell MJ. Modulation of secreted proteins of mouse mammary epithelial cells by the collagenous substrata. J Cell Biol. 1984 Jan;98(1):146-55.
Lee WH, Hollingsworth RE Jr, Qian YW, Chen PL, Hong F, Lee EY. RB protein as a cellular "corral" for growth-promoting proteins. Cold Spring Harb Symp Quant Biol. 1991;56:211-7.
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