Jefferson Y. Chan

Picture of Jefferson Y. Chan
Professor, Pathology
School of Medicine
M.D., University of California San Francisco
Ph.D., University of California San Francisco
Phone: (949) 824-9605
Fax: (949) 824-2160
University of California, Irvine
D440 Medical Sciences I
Irvine, CA 92697
Research Interests
Molecular pathology
Research Abstract
Our lab is interested in molecular mechanisms underlying cellular stress response. Diverse molecular and genetic approaches are being applied to delineate the functions of Nrf1 and Nrf2 transcription factors in cellular functions; mechanisms by which these factors act; and their roles in stress response and disease pathogenesis.
Most Relevant Publications
Chan, JY, Han, X, Kan, YW.
Cloning of Nrf 1, an NF-E2-related transcription factor by genetic selection in yeast. Proc. Natl. Acad. Sci. USA. 90: 11371-11375 (1993)
Chan, JY, Kwong, M., Lu, R., Chang, J., Wang, B., Yen, T-S.B., Kan, Y.W.
Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice.
Embo J. 17(6): 1779-87 (1998)
Kwong M, Kan YW, Chan JY.
Role for the CNC-bZIP factor, Nrf1, in ?-glutamylcysteine synthetase regulatory subunit gene expression, and cell survival in response to oxidative stress-inducing agents.
J Biol Chem. 274(52) 37491-98 (1999)
Chen L, Kwong M, Lu R, Ginzinger D, Lee C, Leung L, Chan JY.
Nrf1 is critical for redox balance and survival of liver cells during development.
Mol Cell Biol. 23(13):4673-86. (2003)
Leung L, Kwong M, Hou S, Lee C, Chan JY.
Deficiency of the Nrf1 and Nrf2 transcription factors results in early embryonic lethality and severe oxidative stress.
J Biol Chem. 278(48)48021-9 (2003)
Xu Z, Chen L, Leung L, Yen TSB, Lee C, Chan JY.
Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia.
Proc. Natl. Acad. Sci. USA. 102(11):4120-5 (2005)
Wang W and Chan JY.
Nrf1 is targeted to the ER membrane by a N-terminal transmembrane domain: inhibition of nuclear translocation and transacting function.
J Biol Chem. 281(28):19676-87 (2006)
Wang W, Kwok AM, Chan JY.
The p65 isoform of Nrf1 is a dominant negative inhibitor of ARE-mediated transcription.
J Biol Chem. Aug 24;282(34):24670-8 (2007)
Biswas M, Chan JY.
Role of Nrf1 in antioxidant response element-mediated gene expression and beyond.
Toxicol Appl Pharmacol. 244(1):16-20 (2010)
Pi J, Leung L, Xue P, Wang W, Hou Y, Liu D, Yehuda-Shnaidman A, Lee C, Kurtz TW, Chan JY.
Deficiency in the Nrf2 transcription factor results in impaired adipogenesis and protects against diet-induced obesity. J Biol Chem. 285(12):9292-300 (2010)
Radhakrishnan SK, Lee CS, Young P, Beskow A, Chan JY, Deshaies RJ.
Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in
mammalian cells. Mol Cell. 38(1):17-28 (2010)
Lee CS, Lee C, Hu T, Nguyen JM, Zhang J, Martin M, Vawter MP, Huang EJ, Chan JY.
Loss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegeneration.
Proc. Natl. Acad. Sci. USA. 108(20):8408-13 (2011)
Biswas M, Phan D, Watanabe M, Chan JY.
The Fbw7 tumor suppressor regulates nuclear factor E2 related factor 1 (Nrf1) transcription factor turnover through proteasome-mediated proteolysis.
J Biol Chem. 286 (45):39282-9 (2011)
Oh DH, Rigas D, Cho A, Chan JY.
Deficiency in the nuclear-related factor erythroid 2 transcription factor (Nrf1) leads to genetic instability.
FEBS J. 279(22):4121-30 (2012)
Kwong EK, Kim KM, Penalosa PJ, Chan JY.
Characterization of Nrf1b, a novel isoform of the nuclear factor-erythroid-2 related transcription factor-1 that activates antioxidant response element-regulated genes.
PLoS One. 7(10):e48404 (2012)
Pekovic-Vaughan V, Gibbs J, Yoshitane H, Yang N, Pathiranage D, Guo B, Sagami A, Taguchi K, Bechtold D, Loudon A, Yamamoto M, Chan J, van der Horst GT, Fukada Y, Meng QJ.
The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis.
Genes Dev. 15;28(6):548-60 (2014)
Schneider K, Valdez J, Nguyen J, Vawter M, Galke B, Kurtz TW, Chan JY.
Increased Energy Expenditure, Ucp1 Expression, and Resistance to Diet-induced Obesity in Mice Lacking Nuclear Factor-Erythroid-2-related Transcription Factor-2 (Nrf2).
J Biol Chem. 291(14):7754-66 (2016)
Han JW, Valdez JL, Ho DV, Lee CS, Kim HM, Wang X, Huang L, Chan JY.
Nuclear factor-erythroid-2 related transcription factor-1 (Nrf1) is regulated by O-GlcNAc transferase.
Free Radic Biol Med. 110:196-205 (2017)
Professional Societies
American Society of Biochemistry & Molecular Biology
American Society of Hematology
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