Associate Professor in Residence, Pediatrics
School of Medicine

Associate Professor in Residence, Neurology
School of Medicine

Autism/ autistic spectrum disorders, language disorders, reading disorder, dyslexia, attention deficit hyperactivity disorder, MRI morphometry, quantitative MRI, volumetrics

www.ucihs.uci.edu/com/index.html?top.html&menu.html&com06.htm

Dr. Filipek's primary clinical and research interests focus on the neurobiology and genetics of autism. She is the Co-Director of the UC Irvine Autism Research Project, and is directly involved in this research into specific autistic phenotypes, including autistic regression, familial recurrence, sibling risk factors, and the association of anomalies on chromosome 15q and autism.

Dr. Filipek is the Chair of the American Academy of Neurology/ Child Neurology Society Committee to develop Practice Parameters on Screening and Diagnosis, and Treatment, of Autism. In addition, she serves on the National Academy of Science Committee on Educational Interventions for Autistic Children.

Dr. Filipek has also developed a method of using specifically-adapted magnetic resonance imaging (MRI) to investigate developmental brain anomalies of size (volume) in the developmental disorders, primarily autism, learning disabilities and attention-deficit hyperactivity disorder. Semi-automated computer algorithms are used to positionally normalize and segment the brain for full morphometric analysis of whole brain, individual substructures and (functional) cortical parcellation units. The ultimate goal of this research is to combine this structural morphometric analysis with functional MRI (fMRI) studies for a more complete evaluation of the brain in the developmental disorders of childhood.

Patents:
Kennedy DN, Filipek PA, Caviness VS. Morphometric Analysis of Anatomic Tomographic Data. U.S. Patent 4,961,425: 1990.

Kennedy DN, Filipek PA, Caviness VS. Morphometric Analysis of Anatomic Tomographic Data. U.S. Patent 5,185,809: 1993.

American Academy of Neurology. Practice parameter: Screening and diagnosis of autistic spectrum disorders. Neurology 55(4): 468-479, 22 Aug 2000

Filipek PA, Accardo PJ, Baranek GT, Cook EH Jr, Dawson G, Gordon B, Gravel JS, Johnson CP, Kallan RJ, Levy SE, Minshew NJ, Ozonoff S, Prizant BM, Rapin I, Rogers SJ, Stone WL, Teplin SW, Tuchman RF, Volkmar FR. The screening and diagnosis of autistic spectrum disorders. Journal of Autism and Developmental Disorders. 29: 437-482, Dec 1999

Pennington BF, Filipek PA, Chhabildas N, Kennedy DN, Lefly D, Simon JH, Filley CM, Galaburda AM, DeFries J. A twin study of size variations in the human brain. Journal of Cognitive Neuroscience. 12(1): 223-32, Jan 2000

Pennington BF, Filipek PA, Churchwell J, Kennedy DN, Lefly D, Simon JH, Filley CM, Galaburda AM, DeFries J. Brain morphometry in reading-disabled twins. Neurology. 53(4): 723-729, 11 Sep 1999

Filipek PA. Neuroimaging in the developmental disorders: The state of the science. Journal of Child Psychology and Psychiatry. 40(1): 113-128, Jan 1999

Fellow, American Academy of Pediatrics; Fellow, American Academy of Neurology; Child Neurology Society; International Neuropsychology Society; American Neurological Association; Society for Pediatric Research; Society for Neurosicence; American Medical Association; Orange County Medical Society

UCI Mental Retardation Research Center (MRRC)

Link to this profile
https://faculty.uci.edu/profile/?facultyId=2353

Last updated
04/17/2002