Professor, Medicine
School of Medicine

Professor, Environmental and Occupational Health
Public Health

Brain aging; Environmental and dietary agents that promote or retard such aging

Graduate Program in Environmental Toxicology

See below for selected publications or click here for additional publication listings available via PubMed

INVITED PRESENTATIONS
“Transgenic Crops” UCI Occupational Heath Residency Didactics, 2016.
“Melatonin, Cancer and Aging” UCI Department of Medicine Research Retreat, Orange, 2017.
“Melatonin can Delay Onset and Progression of Cancer” 3rd World Congress on Oncology and Radiology, San Francisco, 2017.

Committees
2017: Organizing Committee, 3rd World Congress on Oncology and Radiology, San Francisco, USA.

1997-2017 Initial Review Board of Medical and Scientific Advisory Council, Alzheimer’s Association.

2008-2020 Hong Kong University Grants Committee. State Key Laboratory Reviewer.

2007-2019: NIH/NIEHS Special Emphasis Review Panel of Extramural Loan Repayment Program.

2018-2019 UCI Formal Investigations Committee.

2016-2018: Academic Integrity Review Board, UCI.

2017-2018: Medical Scientist Training Program Interview Committee

2017: Program Committee, 3rd World Congress on Oncology and Radiology, San Francisco, 2017.

2018: REPRISE database of expert reviewers of the Italian Ministry of Education, Universities and Research.

2018-2021: UCI Council on Research, Computing and Library Resources (CORCL).

2018-2019: Chair, Committee for 5 Year Review and Continuation Proposal for the UCI Center for Complex Biological Systems (CCBS).

2018: Lead CORCL Reviewer. UCI Center for Virus Research Sunset Review.

2018: Lead CORCL Reviewer. UCI Cancer Research Institute Sunset Review.

2018-2019: Reserve Council on Academic Personnel (RCAP)

EDITORIAL BOARDS:
Occupational Medicine & Health Affairs
Current Aging Science


EXTERNAL THESIS COMMITTEES
2017: Institute of Hematology, “In vitro effects of new antibiotics against clinical isolates of Salmonella enteric subspecies” Baqai Medical University , Karachi, Pakistan.
2018: Sadaf Muhammad Ibrahim, Department of Pharmacology, Baqai Medical University, Karachi, Pakistan.” the Anti-diabetic effect of Guaiacum officinale in streptozotocin induced male Albino rats”.
2018: Muhammad Akbar Mughal, M. D., Department of Physiology, Baqai Medical University, Karachi, Pakistan. “Relationship between C1418T segment of Thrombomodulin Gene Polymorphism with Coronary Artery Disease Patients In General Adult Population of Karachi, Pakistan”.
2019: Tariq Javed. Department of Zoology, University of Karachi, Pakistan. “Toxicological studies of Salvadora persica and Guaiacum officinalis extracts against Maize weevil, Sitophilus zeamais, in comparison with neonicotinoids.
2020: M. Ruqaya. Dept. of Physiology, Baqai Medical University, Karachi, Pakistan. “Gene Polymorphism of Glucagon-Like peptide 1 receptor & its association with Dipeptidyl peptidase IV in normal, impaired glucose tolerant and newly diagnosed type 2 diabetic subjects of Karachi-Pakistan”

UCI PH.D. CANDIDATE ADVANCEMENT AND THESIS COMMITTEES:
2018: Rebecca Johnson, EHS Graduate Program, UCI.
2018: Nicole Chmielewski Stivers, EHS Graduate Program, UCI.
2018: Janielle Vidal, EHS Graduate Program, UCI
2018: Sarah Smith, EHS Graduate Program, UCI.
2020: Jason Killian, Environmental Health Sciences, UCI.
2020: David Herman, Environmental Health Sciences, UCI.
2021: Nicole Stivers, Environmental Health Sciences, UCI.

I have been studying the effects of melatonin on brain aging since 2001. In recent years, my interest has been primarily focused on the ability of melatonin to act as a neuromodulator in optimizing immune responses to exogenous stimuli, while reducing the intrinsic chronic inflammation encountered in the aging brain. The ability of melatonin to regulate, rather than merely inhibit or promote immune function, is also illustrated by our finding that tumor formation in the aging mouse is greatly inhibited by melatonin administration.
I am also investigating the tendency of ingestion of low levels of aluminum salts to promote age-related chronic inflammation and thereby accelerate the appearance of neurodegenerative disease.
Thus overall, my interests are focused on exogenous factors, which can either enhance or slow down age-related and block non-productive inflammatory events.Research focuses on the role of environmental factors in the initiation or potentiation of neurodegenerative diseases. In this context the emphasis is on the contribution of inflammatory events to neural aging. The potential slowing of brain aging by antioxidants and antiinflammatory agents such as melatonin, is also under investigation. Such retardation could reduce the incidence of specific age-related neurodegenerative disorders such as Parkinson's and Alzheimer's diseases.

Stephen Bondy is Professor of Neuroscience in the Center for Occupational and Environmental Health, University of California, Irvine since 1985. The focus of his research concerns the mechanistic processes underlying the effect of environmental or nutritional agents in altering the rate of brain aging. He obtained an M.A. from Cambridge University and a Ph.D. in Biochemistry from the University of Birmingham, UK in 1962. He has held positions at Columbia University, UCLA, University of Colorado, and the National Institute for Environmental Health Sciences where he was Head of the Neurochemistry Section. Dr. Bondy is the author of around 400 articles and reviews.

Nies, I., Hidalgo, K., Bondy, S. C., Campbell, A. Distinctive cellular response to aluminum based adjuvants. Environ. Toxicol. Pharmacol. 78, 103404, 2020. doi.org/10.1016/j.etap.2020.103404.

79. Bondy, S. C. and Campbell, A. Water quality and brain function. Int. J. Env. Res. Pub. Hlth. 14, pii: E2, 2018. PMID: 29267198.

80. Bondy, S. C. Melatonin: Beneficial Aspects and Underlying Mechanisms. In: Melatonin: Medical Uses and Role in Health and Disease. Nova Press, Hauppauge NY, pp. 277-294, (Eds. Correia, L. and Meyers, G), 2018. ISBN: 978-1-53612-987-8.

81. Hsu, H.W., Bondy, S. C., Kitazawa, M. Environmental heavy metal exposure, cellular mechanisms, and Alzheimer’s disease. Toxicol. Sci. 163:338-345, 2018. PMID: 29409005.

82. Bondy, S. C. and Campbell, A. G. Mechanisms underlying tumor suppressive properties of melatonin. In Melatonin from an Antioxidant to a Classic Hormone or a Tissue Factor: Experimental and Clinical Aspects. Special Issue of Int. J. Mol. Sci. 19: 2205, 2018. doi:10.3390/ijms19082205.

83. Prasad, K. N. and Bondy, S. C. Dietary fibers and their fermented short-chain fatty acids in prevention of human disease. Bioactive Carbohydrates and Dietary Fibre 2019. pii: S0047-6374, 30013-7 doi: 10.1016/j.mad.2018.10.003.

84. Prasad, K.N. and Bondy, S. C. Oxidative and inflammatory events in prion disease: can they be therapeutic targets? Current Aging Sci., 2019 , 11:216-225. doi: 10.2174/1874609812666190111100205

85. Prasad, K. N. and Bondy, S. C. Increased oxidative stress, inflammation, and glutamate: potential preventive and therapeutic targets for hearing disorders. Mech. Aging. Devel. 2020,185:11191. doi: 10.3389/fncel.2017.00276

86. Bondy, S. C. Aspects of the immune system that impact brain function. J. Neuroimmunol. 340, 577167, 2020. doi: 10.1016/j.jneuroim.2020.577167.

87. Bondy, S. C. and Campbell, A. Melatonin and regulation of immune function: impact on numerous diseases. Current Aging Sci.2020, 13:92-101. doi: 10.2174/1874609813666200711153223.

88. Bondy, S. C., Wu, M.X. and Prasad K. N. Alternatives to Insulin for the Regulation of Blood Sugar Levels in Type 2 Diabetes. Int. J. Mol. Sci. 2020, 21, 8302. https://doi.org/10.3390/ijms21218302

89. Bondy, S.C., Wu, M, and Prasad, K. N. Attenuation of acute and chronic inflammation using compounds derived from plants. J. Exptl. Biol. 246:406-413, 2021, doi: 10.1177/1535370220960690. Selected as JEB Highlight Article.

90. Bondy, S. C. (Guest Editor) The Molecular Basis for the Environmental Promotion of Neurodegenerative Disease: Special issue of Int. J. Mol.Sci. 2021.

91. Bondy S.C., Campbell A. Aluminum and Neurodegenerative Disease. In: Kostrzewa R.M. (ed) Handbook of Neurotoxicity. 2021. Springer, Cham. https://doi.org/10.1007/978-3-030-71519-9_231-1

92. Prasad, K.N. and Bondy, S. C. Can a Micronutrient Mixture Delay the Onset and Progression of Symptoms of Single-Point Mutation Diseases? J. Am. Coll. Nutrition, 2021. doi.org/10.1080/07315724.2021.1910592

93. Bondy, S. C. Metal Toxicity and Neuroinflammation In: Metal Exposure and Neurodevelopmental Disorders. (Ed. Harischandra, D.), Current Opinions in Toxicol. 26: 8-13, 2021. doi:10.1016/j.cotox.2021.03.008

94. Bondy, S. C. Phytochemical Deflection of Harmful Inflammatory Events
Toward More Effective Immune Activity. In: Micronutrients in Health and Disease, (Ed. Howard, H. A.) Nova Press, Hauppauge, NY. pp 51-80, doi.org/10.1080/07315724.2021.1910592

95. Bondy, S. C. Type 2 Diabetes Optimal Treatment. Encyclopedia, 2021. https://encyclopedia.pub/11387.

96. Prasad, K.N. and Bondy, S. C. Can a Mixture of Micronutrients in Combination with Other Therapeutic Approaches Delay the Onset and Progression of Hutchinson-Gilford Progeria Syndrome? World J. Biol. Pharmaceut. Res. 10, 73-81. 2022. DOI: https://doi.org/10.30574/wjbphs.2022.10.3.0081.

97. Bondy, S. C. Melatonin and Ageing in Biochemistry and Cell Biology of Ageing: Part III Biomedical Science (Eds. Robin Harris, R. J. and Korolchuk, V.I.), Springer Nature, Switzerland, 2022.

96. Prasad, K.N. and Bondy, S. C. Can a Mixture of Micronutrients Delay the Onset and Progression of Hutchinson-Gilford Progeria Syndrome? World J. Biol. Pharmaceut. Res. 10, 73-81. 2022. DOI: https://doi.org/10.30574/wjbphs.2022.10.3.0081.

97. Bondy, S. C. and Wu, M, Immune function is depressed with aging while inflammation is heightened, a paradox. In: Advances in Health and Disease, 57 (Ed. Duncan, L.T.) pp 133-152. Nova Press, Hauppauge, NY. 2022.

98. Bondy, S. C. and Palestini, P. (Guest Editors) Molecular Events Underlying the Furtherance of Neurodegenerative Disorders by Environmental Factors. Special issue of Int. J. Mol.Sci. 2022.

99. Bondy, S.C., Campbell, A. Aluminum and Neurodegenerative Disease. In: Kostrzewa, R.M. (Ed.) Handbook of Neurotoxicity 2nd Edition. Springer, Champagne, IL, pp. 2283–2304, 2023. https://doi.org/10.1007/978-3-031-15080-7_231

100. Bondy, S. C. Relationships between Diabetes and the Intestinal Microbial Population. Int. J. Mol. Sci. 24, 566; 2023. https://doi.org/10.3390 /ijms24010566.

101. Bondy, S. C. Melatonin and Ageing in Biochemistry and Cell Biology of Ageing: Part III Biomedical Science (Eds. Robin Harris, R. J. and Korolchuk, V.I.), Springer Nature, Switzerland. In press, 2023.

102. Campbell, A. and Bondy, S. C. Thimerosal in Encyclopedia of Toxicology, Vol 4. Fourth Edition. (Ed. Wexler, P.) Academic Press, 2023.ISBN-13:978-0323854344 (/2023).

Society for Neuroscience

Toxicology Society

American Aging Association

International Neurotoxicology Association

Environmental Toxicology

Irvine Center for Occupational & Environmental Medicine

Link to this profile
https://faculty.uci.edu/profile/?facultyId=2283

Last updated
02/12/2023