Anshu AgrawalAssociate Adjunct Professor, Medicine Associate Adjunct Professor, Medicine |
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Research Interests |
Human Immunology, Aging, Dendritic cells, Autoimmunity, Inflammation, Infectious diseases | |
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Academic Distinctions |
2009 Honored as the Faculty mentor of the Month of Septembre ’09 by the undergraduate research program (UROP) of UCI 2009 Invited to Gordon Research Conferences on Aging. 2007 AAI Junior Faculty travel award 2006 New Scholar award in aging from the Ellison Medical Foundation. Postdoctoral Fellowship from La Ligue Nationale Contre le Cancer, Paris, France. Fellowship from Centre International de Etudiants et Stagiaires for Poster Presentation. Research Fellowship from Council for Scientific and Industrial Research, New Delhi. |
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| Appointments |
Research Scientist, ICGEB, India. Post doctoral Fellow,France. Postdoctoral Fellow, Emory Vaccine Center, Emory University Assistant Clinical Professor, Department of Medicine UCI |
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Research Abstract |
Decline in immune function is a hallmark of aging, leading to increased susceptibility to infections and reduced response to vaccination in the elderly population. Paradoxically this decline in immune function is associated with low grade chronic inflammation. The molecular mechanisms underlying this chronic inflammatory condition and reduced immunity during cellular senescence are at present not well understood. The primary focus of my research is to understand the contribution of innate immune cells such as dendritic cells towards age-associated inflammation and reduced immunity in humans. The two major research interests are – 1) Mechanisms leading to age-associated decline in the capacity of dendritic cells to maintain peripheral self tolerance and its contribution to chronic inflammation and autoimmune disorders. 2) Age-associated alterations in the functions of dendritic cells (Myeloid and plasmacytoid) that are responsible for reduced immunity and increased susceptibility to infections particularly, pneumonia and influenza. |
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| Publications | Sridharan A, Esposo M, Kaushal K, Tay J, Osann K , Agrawal S, Gupta S, Agrawal A. Age-associated impaired plasmacytoid dendritic cell functions lead to decreased CD4 and CD8 T cell immunity. AGE. 2010.DOI: 10.1007/s11357-010-9191-3. | |
| Agrawal S, Gupta S and Agrawal A. Human dendritic cells activated via Dectin-1 are efficient at priming Th17, cytotoxic CD8 T and B cell responses. PLoS One. 2010 Oct 18;5(10):e13418. | ||
| Agrawal A and Gupta S. Impact of aging on dendritic cell functions in humans. Ageing Research Reviews. 2010. Jul 7. In Press | ||
| Agrawal A, Tay J, Yang GE, Agrawal S, Gupta S. Age-associated epigenetic modifications in human DNA increases its immunogenicity. Aging.2010. Jan 10. Epub ahead of print. | ||
| Carlson ME, Conboy MJ, Hsu M, Barchas L, Jeong J, Agrawal A, Mikels AJ, Agrawal S, Schaffer DV, Conboy IM. Relative roles of TGF-beta1 and Wnt in the systemic regulation and aging of satellite cell responses. Aging Cell. 2009 Sep 2.Epub ahead of print. | ||
| Agrawal A. Altered expression of NF?B in ex vivo diffentiated dendritic cells from the aged subjects: Implications in immunotherapy. Protocols for Adult Stem Cells. 2009. (in press). | ||
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Gu B, Sun P, Yuan Y, Moraes RC, Li A, Teng A, Agrawal A, Rhéaume C, Bilanchone V, Veltmaat JM, Takemaru KI, Millar S, Lee EYHP, Lewis MT, Li B and Dai? X. Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation. Journal of Cell biology. 2009. 185 : 811-826. Comment in Journal of Cell biology Publication no. 28. Horsley V. Epigenetics, Wnt signaling, and stem cells : the Pygo2 connection. Journal of Cell biology. 2009. 185 : 761-763. |
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| Agrawal A, Tay J, Ton S, Agrawal S, Gupta S. Increased Reactivity of Dendritic Cells from Aged Subjects to Self Antigen, the Human DNA. J Immunol. 2009. 182: 1138-1145. | ||
| Agrawal S, Gupta S, Agrawal A. Vaccinia Virus Proteins Activate Human Dendritic Cells to Induce T Cell Responses in vitro. Vaccine. 2009. 27:88-92. | ||
| Agrawal A, Agrawal S, Gupta S. Role of dendritic cells in aging. Handbook on Immunosenescence. 2008. (T. Fulop eds).499-509. | ||
| Agrawal A. How Aging impacts innate immunity. New Research on Innate Immunity. 2008. (Nova Publishers). 63-72. | ||
| Agrawal A, Lourenco EV, Gupta S, La Cava A. Gender-based differences in leptinemia in healthy aging, non-obese individuals associated with increased marker of oxidative stress. Int J Clin Exp Med. 2008.1 : 305-309. | ||
| Agrawal A, Agrawal S, Tay, J, Gupta S. Biology of Dendritic Cells in Aging. J Clin. Immunol. 2008. 28: 14-20. | ||
| Agrawal A, Agrawal S, Jianing Cao, Houfen Su, Kathryn Osann, Gupta S. Altered innate immune functioning of dendritic cells in aging humans : Role of PI3Kinase signaling pathway. J Immunol. 2007.178:6912-6922. | ||
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Agrawal A, Kaushal P, Agrawal S, Gollapudi S, Gupta S. Thimerosal affects human dendritic cell functions promoting a TH2 response. J Leukocyte Biology. 2007. 81 : 474-483. Agrawal A, Agrawal S, Gupta, S. Dendritic cells in human aging. Experimental Gerontology. 2006. 42(5): 421-426. Agrawal A, Dillon S, Denning TL, and Pulendran B. ERK1-/- mice exhibit Th1 cell polarization and increased susceptibility to Experimental Autoimmune Encephalomyelitis. J Immunol. 2006. 176: 5788 - 5796. Gupta S, Agrawal A, Agrawal S, Su H and Gollapudi S. A paradox of immunodeficiency and inflammation in aging: Lessons learned from apoptosis. Immunity & Ageing. 2006. 3 :5. Nair M, Teng A, Bilanchone V, Agrawal A, Li B, and Dai X. Ovol1 regulates the growth arrest of embryonic epidermal progenitor cells and represses c-Myc transcription. Journal of Cell biology. 2006. 173: 253-264. Pulendran B, Agrawal A, Dillon S, Agrawal S. Dendritic cells: Targets for immune modulation by microbes and immunologists. Vaccine adjuvants -Immunological and Clinical Principles. Dec 2005. 25-38. ( Humana Press). Sharma, SK., Deba, F., Bhattachrya, S., Agrawal, A., Owais, M. Escheriosome entrapped soluble blood stage antigens impart protective immunity against a multi-drug resistant isolate of Plasmodium yoelii nigeriensis in BALB/c mice. Vaccine. 2006. 7: 948-956. Agrawal A and Pulendran B. Anthrax lethal toxin: a weapon of multisystem destruction. Cell Mol Life Sci. 2004. 61(22):2859-65. Dillon S, Agrawal A, Van Dyke T, Landreth G, McCauley L, Maliszewski C, Akira S and Pulendran B. TLR2 AND TLR4 ligands stimulate distinct dendritic cell responses and adaptive immunity, by differential modulation of ERK MAP kinase and c-fos. J Immunol. 2004. 172(8) 4733-43. |
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| Agrawal S, Agrawal A, Doughty B, Gerwitz A, Blenis J, Van Dyke T and Pulendran B. Different TLR agonists instruct dendritic cells to induce distinct T-helper responses, via differential modulation of ERK MAP kinase and c-fos. J Immunol (cutting edge). 2003.171:4984-4989 | ||
| Agrawal A, Lingappa J, Leppa SH, Agrawal S, Jabbar A, Quinn C, Pulendran B. Impairment of dendritic cells and adaptive immunity by Anthrax lethal factor Nature. 2003 Jul 17;424(6946): 329-34. | ||
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Agrawal AK, Agrawal A, Pal A, Guru PY, Gupta CM. Superior chemotherapeutic efficacy of Amphotericin -B in Tuftsin-bearing liposomes against Leishmania donovani infection in hamsters. J drug tar13. Nayak BP, Agarwal A, Nakra P, Rao KVS. B cell responses to a peptide epitope. VIII. Immune complex mediated regulation of memory B cell generation within germinal centers. J Immunol. 1999. 163: 1371-1382. Agarwal A, Nayak BP & Rao KVS .B cell responses to a peptide epitope. VII Antigen-dependent modulation of the germinal center reaction. J Immunol.1998. 161: 5832-5842. Agarwal A & Rao KVS. B cell responses to a peptide epitope. III. Differential T helper cell thresholds in recruitment of B cell fine specifities. J Immunol. 1997. 159: 1077-1085. Tuteja R, Agarwal A, Vijaykrishnan L, Nayak BP , Gupta S, Kumar V & Rao KVS .B cell responses to a peptide epitope. II . Biased recuitment and selective amplification. Immunology & cell biology. 1997. 75: 245-252. Agarwal A, Sarkar S, Nazabal C, Balasundaram G & Rao KVS. B cell responses to a peptide epitope. I . The cellular basis for restricted recognition. J Immunol. 1996. 157: 2779-2788. Pal A, Agarwal A, Guru PY & Katiyar JC. Enhanced efficacy of liposomised pentamidine against experimental visceral leishmaniasis. Indian J Parasitol. 1995. 157: 279 - 288. Agarwal A, Kandpal H, Gupta HP, Singh NB & Gupta CM. Tuftsin bearing liposomes as rifampicin vehicles in treatment of tuberculosis in mice. Antimicrobial Agents & Chemotherapy. 1994. 38: 588-593. geting. 2002.10(1):41-45 |
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| Grants | R21 (PI: A. Agrawal) 08/01/2006- 07/30/2009 NIH/NIA “Dendritic cell mediated modulation of tolerance by apoptotic cells in aged humans.’’ The subject of this grant is about alterations in the function of human monocyte- derived dendritic cells with age and the resulting loss of peripheral self tolerance. | |
| New Scholar award in aging from Ellison Medical foundation (PI: A. Agrawal) 07/15/2006 to 06/14/2010 Role of dendritic cells in aging associated inflammation and immune dysfunction. This grant deals with the contribution of dendritic cells towards age associated inflammation and T cell immune dysfunction. | ||
| College of Medicine grant (PI: A. Agrawal) 4/1/06 -11/30/06 Dendritic cells as inflammatory mediators in aging | ||
| HHV-6 foundation seed grant (PI: A. Agrawal) 10/1/2010- 9/30/2010 Human Herpesvirus-6, dendritic cells and Th17. Grant investigates if HHV-6 primes DCs to induce Th17 cells. | ||
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Professional Societies |
American Associaion of Immunologists Indian Immunologists Association American Age Association |
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| Other Experience |
Postdoctoral Fellow Emory Vaccine Center, Emory University 2002—2005 |
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Post Doctoral Fellow Inserm Unite 255, Institut Curie, Paris, France 1999—2001 |
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Research Scientist International center for Genetic Engineering and Biotechnology (UNIDO), New Delhi, India 1994—1999 |
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| Research Centers | Institute For Immunology | |
| Division of Basic and Clinical Immunology | ||
| Link to this profile | http://www.faculty.uci.edu/profile.cfm?faculty_id=5170 | |
| Last updated | 12/06/2010 | |