Thomas PoulosChancellor's Professor of Biochemistry, Chemistry, and Pharmaceutical Sciences |
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Research Interests |
Protein crystallography, protein enginering, heme enzyme structure and function. | |
| URL | Poulos Lab Web Site | |
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Academic Distinctions |
Presidential Meritorious Service Award, Univ. Maryland 1991; Chancellor's Professor, UCI 2000 Brodie Award for Drug Metabolism Amer. Soc. of Pharmacology and Experimental Therapeutics Appointments: Research Scientist UCSD Dept. Chemistry from 1973-1983; Principal Res. Scientist at Genex Corp. from 1983-1984; Director of Protein Engineering at Genex Corp. from 1984-1987; Director for the Univ. of Maryland's Center for Advanced Res. in Biotehcnology and Professor of Chemistry, Univ. of Maryland, College Park from 1987-1991; Professor of Biochemistry & Biophysics at UCI since 1992. |
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| Appointments |
Research Scientist UCSD Dept. Chemistry from 1973-1983; Principal Res. Scientist at Genex Corp. from 1983-1984; Director of Protein Engineering at Genex Corp. from 1984-1987; Director for the Univ. of Maryland's Center for Advanced Res. in Biotehcnology and Professor of Chemistry, Univ. of Maryland, College Park from 1987-1991; Professor of Biochemistry&Biophysics at UCI since 1992. |
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| Publications | Kumar MR, Pervistky D, Chen L, Poulos TL, Kundu S, Hargrove MS, Rivera EJ, Diaz AD, Colón JL, Farmer PJ. (2009) Nitrosyl hydride (HNO) as an O2 analogue: long-lived HNO-adducts of ferrous globins. Biochemistry 48, 5018-5025. | |
| Li C, Li H, Zhou S, Sun E, Yoshizawa J, Poulos TL, Gershon PD (2009). Polymerase translocation with respect to single-stranded nucleic acid: looping or wrapping of primer around a poly(A) polymerase. Structure 17, 680-689. | ||
| Ioanoviciu A, Meharenna YT, Poulos TL, Ortiz de Montellano, PR (2009) DevS oxy complex stability identifies this heme protein as a gas sensor in Mycobacterium tuberculosis dormancy. Biochemistry 48, 5839-5848. | ||
| Ji H, Sidartha T, Igarashi J, Li H, Derrick M, Martasek P, Roman LJ, Vasques-Vivar J, Poulos TL, Silverman RB (2009) Selective Neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy Annals Neurol. 65 209-217. | ||
| Ji, H. Li H. Martasek P, Roman LJ, Poulos, TL, Silverman RB (2009). Discovery of highly potent and selective inhibitors of neuronal nitric oxide synthase by fragment hopping. J. Med. Chem. 52, 779-797. | ||
| Igarashi J, Li H, Jamal J, Ji H, Fang H, Lawton GR, Silverman RB, Poulos TL (2009) Crystal structures of constitutive nitric oxide synthases in complex with de novo designed inhibitors J. Med Chem. 52, 2060-2066. | ||
| Li H, Das A, Sibhatu H, Jamal J, Sligar SG, Poulos TL (2008) Exploring the electron transfer properties of nitric oxide synthase by reversal of the FMN redox potential. J. Biol. Chem. 283 34762-34772. | ||
| Meharenna YT, Oertel P, Bhaskar B, Poulos TL (2008) Engineering ascorbate peroxidase activity into cytochrome c peroxidase Biochemistry 47, 10324-10332. | ||
| Fasan R, Meharenna YT, Snow CD, Poulos TL, Arnold FH (2008). Evolutionary history of the mergence of a specialized cytochrome P450. J. Mol. Biol. 383. 1069-1080. | ||
| Gruia FG, Ionascu D, Kubo M, Ye X, Dawson J, Osborn RL, Sligar SG, Denisov I, Das A, Poulos TL, Terner J, Champion PM (2008). Low-frequency dynamics of Caldariomyces fumago chloroperoxidase probed by femtosecond coherence spectroscopy. Biochemistry 47, 5156-5167. | ||
| Ji H, Stanton BZ, Igarashi J, Li H, Martasek P, Roman LJ, Poulos TL, Silverman RB (2008) Minimal pharmacophoric elements and fragment hopping, an approach directed at molecular diversity and isozyme selectivity. Design of selective neuronal nitric oxide synthase inhibitors. J. Amer. Chem. Soc. 130, 3900-3914. | ||
| Meharenna YT, Slessor KE, Cavaignac SM, Poulos TL, De Voss JJ (2008) The critical role of substrate-protein hydrogen bonding in the control of regioselective hydroxylation in P450cin J. Biol. Chem. 283, 10804-1081. | ||
| Ho WW, Li H, Nishida CR, Ortiz de Montellano PR, Poulos TL (2008) Crystal structure and properties of CYP231A2 from the thermoacidophilic archaeon Picrophilus torridus Biochemistry 47, 2071-2079 | ||
| Seo J, Igarashi J, Li H, Martasek P, Roman LJ, Poulos TL, Silverman RB (2007).Structure-Based Design and Synthesis of N(omega)-Nitro-l-Arginine-Containing Peptidomimetics as Selective Inhibitors of Neuronal Nitric Oxide Synthase. Displacement of the Heme Structural Water. J Med Chem. 50, 2089-2099. | ||
| Borjigin, M, Li H, Lanz ND, kerby RL, Roberts GP, Poulos TL (2007). Structure-Based Hypothesis on the Activation of the CO-sensing Transcription Factor CooA. Acta Crys D63, 282-287. | ||
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Professional Societies |
Protein Society American Chemical Society Ameican Crystallographic Association Biophysical Society Amer. Society of Pharmacology and Experimental Therapeutics |
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| Graduate Programs |
Structural Biology and Molecular Biophysics Chemical Biology Medicinal Chemistry and Pharmacology |
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| Link to this profile | http://www.faculty.uci.edu/profile.cfm?faculty_id=2699 | |
| Last updated | 10/16/2009 | |